{"id":"https://openalex.org/W2767366399","doi":null,"title":"Molecular Mechanisms Regulating Local Protein Translation During Homeostatic Synaptic Plasticity","display_name":"Molecular Mechanisms Regulating Local Protein Translation During Homeostatic Synaptic Plasticity","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2767366399","mag":"2767366399"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt0fp6t1gk","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0fp6t1gk","pdf_url":"https://escholarship.org/uc/item/0fp6t1gk","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/0fp6t1gk","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070747557","display_name":"Marta E. Soden","orcid":"https://orcid.org/0000-0002-0695-8653","observed_orcids":["https://orcid.org/0000-0002-0695-8653"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marta E. Soden","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0695-8653","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070747557"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.5048999786376953,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeostatic-plasticity","display_name":"homeostatic plasticity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/local-protein-translation","display_name":"local protein translation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dendritic-translation","display_name":"dendritic translation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glur1","display_name":"GluR1","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/fmrp","display_name":"FMRP","score":0.9120000004768372},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.7900000214576721},{"id":"https://openalex.org/keywords/synaptic-scaling","display_name":"synaptic scaling","score":0.7429999709129333},{"id":"https://openalex.org/keywords/mir-96","display_name":"miR-96","score":0.925000011920929},{"id":"https://openalex.org/keywords/mir-182","display_name":"miR-182","score":1.0},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.5849999785423279},{"id":"https://openalex.org/keywords/extrasynaptic-receptors","display_name":"extrasynaptic receptors","score":0.621999979019165},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6079999804496765},{"id":"https://openalex.org/keywords/glutamatergic-synapses","display_name":"glutamatergic synapses","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.8045319318771362},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.7668570876121521},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.7223412990570068},{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.6706777811050415},{"id":"https://openalex.org/C125667969","wikidata":"https://www.wikidata.org/wiki/Q7662036","display_name":"Synaptic fatigue","level":4,"score":0.6679062247276306},{"id":"https://openalex.org/C26410512","wikidata":"https://www.wikidata.org/wiki/Q3906363","display_name":"Nonsynaptic plasticity","level":5,"score":0.6178886890411377},{"id":"https://openalex.org/C2779063550","wikidata":"https://www.wikidata.org/wiki/Q905435","display_name":"FMR1","level":4,"score":0.6068764328956604},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5563805103302002},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5308163166046143},{"id":"https://openalex.org/C95293801","wikidata":"https://www.wikidata.org/wiki/Q7662035","display_name":"Synaptic augmentation","level":4,"score":0.5117285251617432},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.4897487163543701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4764716625213623},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.46192046999931335},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.45812615752220154},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44784748554229736},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.36752521991729736},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.24770033359527588},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.22306784987449646},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.22142565250396729},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15393397212028503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08611735701560974},{"id":"https://openalex.org/C3020422209","wikidata":"https://www.wikidata.org/wiki/Q221472","display_name":"Fragile x","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt0fp6t1gk","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0fp6t1gk","pdf_url":"https://escholarship.org/uc/item/0fp6t1gk","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt0fp6t1gk","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/0fp6t1gk","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Soden, Marta. (2010). Molecular Mechanisms Regulating Local Protein Translation During Homeostatic Synaptic Plasticity. UC Berkeley: Neuroscience. Retrieved from: http://www.escholarship.org/uc/item/0fp6t1gk","raw_type":"dissertation"},{"id":"mag:2767366399","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt0fp6t1gk/qt0fp6t1gk.pdf?t=mtgqbs","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt0fp6t1gk","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0fp6t1gk","pdf_url":"https://escholarship.org/uc/item/0fp6t1gk","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2767366399.pdf","grobid_xml":"https://content.openalex.org/works/W2767366399.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W46804812","https://openalex.org/W1482915690","https://openalex.org/W1501571963","https://openalex.org/W1514853588","https://openalex.org/W1531396004","https://openalex.org/W1541267199","https://openalex.org/W1542136448","https://openalex.org/W1588326306","https://openalex.org/W1588809921","https://openalex.org/W1658796519","https://openalex.org/W1965513983","https://openalex.org/W1966612206","https://openalex.org/W1968311418","https://openalex.org/W1969498835","https://openalex.org/W1970889111","https://openalex.org/W1972989638","https://openalex.org/W1973191527","https://openalex.org/W1974958116","https://openalex.org/W1975841935","https://openalex.org/W1978922003","https://openalex.org/W1980269624","https://openalex.org/W1983553517","https://openalex.org/W1983988073","https://openalex.org/W1984618862","https://openalex.org/W1991587102","https://openalex.org/W1992856813","https://openalex.org/W1995314293","https://openalex.org/W1997836836","https://openalex.org/W1998254077","https://openalex.org/W2000124573","https://openalex.org/W2002364516","https://openalex.org/W2002903762","https://openalex.org/W2005811224","https://openalex.org/W2008461178","https://openalex.org/W2010157600","https://openalex.org/W2011046807","https://openalex.org/W2014064723","https://openalex.org/W2015701831","https://openalex.org/W2016032579","https://openalex.org/W2016112105","https://openalex.org/W2020423506","https://openalex.org/W2022959185","https://openalex.org/W2027699509","https://openalex.org/W2031017877","https://openalex.org/W2031779883","https://openalex.org/W2031785254","https://openalex.org/W2031898618","https://openalex.org/W2033303608","https://openalex.org/W2036338927","https://openalex.org/W2038651628","https://openalex.org/W2039189257","https://openalex.org/W2042310987","https://openalex.org/W2042993576","https://openalex.org/W2047535883","https://openalex.org/W2047636274","https://openalex.org/W2049810777","https://openalex.org/W2050066016","https://openalex.org/W2050519369","https://openalex.org/W2051013729","https://openalex.org/W2051288265","https://openalex.org/W2054091111","https://openalex.org/W2054109341","https://openalex.org/W2054499757","https://openalex.org/W2059117412","https://openalex.org/W2060578299","https://openalex.org/W2060711522","https://openalex.org/W2060901333","https://openalex.org/W2062535336","https://openalex.org/W2063798177","https://openalex.org/W2066358338","https://openalex.org/W2069243189","https://openalex.org/W2074775898","https://openalex.org/W2074838566","https://openalex.org/W2080075277","https://openalex.org/W2080787823","https://openalex.org/W2082372907","https://openalex.org/W2084889756","https://openalex.org/W2090116050","https://openalex.org/W2094993063","https://openalex.org/W2096609303","https://openalex.org/W2096744132","https://openalex.org/W2098756736","https://openalex.org/W2099503180","https://openalex.org/W2100358595","https://openalex.org/W2100699923","https://openalex.org/W2104580322","https://openalex.org/W2104921672","https://openalex.org/W2106836999","https://openalex.org/W2107314617","https://openalex.org/W2110811750","https://openalex.org/W2114559471","https://openalex.org/W2116190619","https://openalex.org/W2116276594","https://openalex.org/W2117038257","https://openalex.org/W2117874342","https://openalex.org/W2120211068","https://openalex.org/W2120821369","https://openalex.org/W2121410013","https://openalex.org/W2123214754","https://openalex.org/W2124161234","https://openalex.org/W2124705257","https://openalex.org/W2124859239","https://openalex.org/W2126156195","https://openalex.org/W2126487937","https://openalex.org/W2131956972","https://openalex.org/W2134063049","https://openalex.org/W2135837360","https://openalex.org/W2138473891","https://openalex.org/W2138954682","https://openalex.org/W2140382995","https://openalex.org/W2141545756","https://openalex.org/W2141851583","https://openalex.org/W2146678743","https://openalex.org/W2146768442","https://openalex.org/W2147033427","https://openalex.org/W2149174578","https://openalex.org/W2149580098","https://openalex.org/W2151285111","https://openalex.org/W2160769038","https://openalex.org/W2162520530","https://openalex.org/W2162983737","https://openalex.org/W2168028420","https://openalex.org/W2168221097","https://openalex.org/W2168230240","https://openalex.org/W2168976498","https://openalex.org/W2170952313","https://openalex.org/W2171230529","https://openalex.org/W2242059436","https://openalex.org/W4232072708"],"related_works":["https://openalex.org/W2025011598","https://openalex.org/W1600692362","https://openalex.org/W1968311418","https://openalex.org/W4283161814","https://openalex.org/W2109383336","https://openalex.org/W2002760096","https://openalex.org/W2056758768","https://openalex.org/W1976666730","https://openalex.org/W2031195859","https://openalex.org/W2047636274"],"abstract_inverted_index":{"Precise":[0],"control":[1],"of":[2,21,32,40,61,79,92,96,105,115,149,169,182,197,209,226,235,256,269,298,307,335,340,350,355,370,373,383,392,395,406],"protein":[3,130,134,194,300],"translation":[4,8,60,168,372],"in":[5,10,57,84,140,152,162,199,216,223,281,301,319,332,403],"neurons,":[6,165,302],"particularly":[7,379],"occurring":[9],"dendrites":[11],"near":[12],"synaptic":[13,22,72,74,97,100,141,207,243,384],"sites,":[14],"is":[15,35,136,160,172,176,186],"critical":[16,49],"for":[17,138,179,214],"the":[18,30,38,48,59,62,77,89,121,153,180,203,236,253,282,305,333,348,353,368,377,393,404],"proper":[19],"regulation":[20,369],"strength.":[23],"The":[24],"most":[25],"direct":[26],"way":[27],"to":[28,36,240,252,277,328,357,401],"affect":[29],"strength":[31,78,101,142],"glutamatergic":[33],"synapses":[34,80],"alter":[37],"abundance":[39,334,349],"AMPA-type":[41],"glutamate":[42,374],"receptors":[43,375],"(AMPARs).":[44],"Here":[45],"I":[46,118,265],"demonstrate":[47],"role":[50,213],"that":[51,120,131,390],"two":[52,231],"separate":[53],"translational":[54],"regulators":[55],"play":[56],"controlling":[58],"AMPAR":[63,218],"subunit":[64],"GluR1,":[65],"both":[66,189,341],"under":[67],"steady-state":[68],"conditions":[69],"and":[70,113,192,206,258,272,285,295,303,315],"during":[71,81,380],"plasticity.Homeostatic":[73],"plasticity":[75,184,309],"adjusts":[76],"global":[82],"changes":[83,331],"neural":[85,93,150],"activity,":[86],"thereby":[87],"stabilizing":[88],"overall":[90],"activity":[91,98,151,311],"networks.":[94],"Suppression":[95],"increases":[99,139],"by":[102,144,147,310],"inducing":[103],"synthesis":[104,112,159],"retinoic":[106],"acid":[107],"(RA),":[108],"which":[109,185,250,274],"activates":[110],"postsynaptic":[111,221],"insertion":[114],"AMPARs.":[116],"Here,":[117],"show":[119],"Fragile":[122],"X":[123],"Mental":[124],"Retardation":[125],"Protein":[126],"(FMRP),":[127],"an":[128],"RNA-binding":[129],"regulates":[132],"dendritic":[133,167],"synthesis,":[135],"essential":[137],"induced":[143],"RA":[145,158,190],"or":[146,352],"blockade":[148],"mouse":[154],"hippocampus.":[155],"Although":[156],"activity-dependent":[157,330],"maintained":[161],"Fmr1":[163],"knockout":[164,200,224],"RA-dependent":[166],"GluR1-type":[170],"AMPARs":[171],"impaired.":[173],"Intriguingly,":[174],"FMRP":[175,198,215],"only":[177],"required":[178],"form":[181],"homeostatic":[183,308,359,407],"dependent":[187],"on":[188,347],"signaling":[191],"local":[193,371],"synthesis.":[195],"Expression":[196],"neurons":[201,225,356],"reduced":[202],"total,":[204],"surface,":[205],"levels":[208,297],"AMPARs,":[210],"implying":[211],"a":[212,262,267,278],"regulating":[217],"abundance.":[219],"Critically,":[220],"expression":[222],"wild-type":[227],"FMRP,":[228],"but":[229],"not":[230],"different":[232],"mutant":[233],"forms":[234,382],"protein,":[237],"was":[238],"able":[239],"fully":[241],"restore":[242],"scaling.microRNAs":[244],"(miRNAs)":[245],"are":[246,317],"small":[247],"RNA":[248],"molecules":[249],"bind":[251,275],"untranslated":[254],"regions":[255],"mRNAs":[257],"inhibit":[259],"translation.":[260,288],"Using":[261],"bioinformatics":[263],"approach,":[264],"identified":[266],"pair":[268],"miRNAs,":[270],"miR-96":[271,314],"miR-182,":[273],"specifically":[276],"known":[279],"sequence":[280],"GluR1":[283,299,351],"mRNA":[284],"prevent":[286,304],"its":[287],"When":[289],"overexpressed,":[290],"these":[291,362],"miRNAs":[292,342],"reduce":[293],"total":[294],"extrasynaptic":[296],"induction":[306,405],"blockade.":[312],"Both":[313],"miR-182":[316],"expressed":[318],"cortex":[320],"throughout":[321],"postnatal":[322],"development,":[323],"although":[324],"we":[325],"were":[326],"unable":[327],"detect":[329],"either":[336],"miRNA.":[337],"Attempted":[338],"knockdown":[339],"revealed":[343],"no":[344],"significant":[345,365],"effect":[346],"ability":[354],"undergo":[358],"plasticity.Taken":[360],"together,":[361],"data":[363],"offer":[364],"insight":[366],"into":[367],"at":[376],"synapse,":[378],"specific":[381],"plasticity.":[385,408],"These":[386],"results":[387],"also":[388],"suggest":[389],"some":[391],"symptoms":[394],"Fragile-X":[396],"syndrome":[397],"may":[398],"be":[399],"attributed":[400],"defects":[402]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-11-17T00:00:00"}