{"id":"https://openalex.org/W2767354682","doi":null,"title":"Development of Nickel-Catalyzed Cross-Coupling Reactions","display_name":"Development of Nickel-Catalyzed Cross-Coupling Reactions","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2767354682","mag":"2767354682"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt9zg7z83s","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9zg7z83s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063130557","display_name":"Liana Hie","orcid":"https://orcid.org/0000-0002-5196-8260","observed_orcids":["https://orcid.org/0000-0002-5196-8260"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liana Hie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5196-8260","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063130557"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nickel-catalysis","display_name":"nickel catalysis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cross-coupling-reactions","display_name":"cross-coupling reactions","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aryl-sulfamates","display_name":"aryl sulfamates","score":0.7020000219345093},{"id":"https://openalex.org/keywords/aryl-carbamates","display_name":"aryl carbamates","score":0.8159999847412109},{"id":"https://openalex.org/keywords/amination","display_name":"amination","score":0.7630000114440918},{"id":"https://openalex.org/keywords/biaryls","display_name":"biaryls","score":0.7129999995231628},{"id":"https://openalex.org/keywords/aryl-halides","display_name":"aryl halides","score":0.8230000138282776},{"id":"https://openalex.org/keywords/phenol-derivatives","display_name":"phenol derivatives","score":0.6309999823570251},{"id":"https://openalex.org/keywords/aromatic-amines","display_name":"aromatic amines","score":0.8560000061988831},{"id":"https://openalex.org/keywords/benzamide","display_name":"benzamide","score":0.9449999928474426},{"id":"https://openalex.org/keywords/aliphatic-amides","display_name":"aliphatic amides","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oxidative-addition","display_name":"oxidative addition","score":0.7099999785423279},{"id":"https://openalex.org/keywords/methyl-esters","display_name":"methyl esters","score":0.8569999933242798},{"id":"https://openalex.org/keywords/anilides","display_name":"anilides","score":0.8130000233650208},{"id":"https://openalex.org/keywords/decarbonylation","display_name":"decarbonylation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/quaternary-stereocenters","display_name":"quaternary stereocenters","score":0.8119999766349792},{"id":"https://openalex.org/keywords/heck-cyclization","display_name":"Heck cyclization","score":0.9750000238418579},{"id":"https://openalex.org/keywords/oxindoles","display_name":"oxindoles","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.7935127019882202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6924750804901123},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6754587888717651},{"id":"https://openalex.org/C504270822","wikidata":"https://www.wikidata.org/wiki/Q744","display_name":"Nickel","level":2,"score":0.6260359883308411},{"id":"https://openalex.org/C198503264","wikidata":"https://www.wikidata.org/wiki/Q471635","display_name":"Amination","level":3,"score":0.6247931122779846},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5704483985900879},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.5342390537261963},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.5272504091262817},{"id":"https://openalex.org/C20950531","wikidata":"https://www.wikidata.org/wiki/Q161940","display_name":"Heteroatom","level":3,"score":0.5261873006820679},{"id":"https://openalex.org/C48424934","wikidata":"https://www.wikidata.org/wiki/Q898912","display_name":"Coupling reaction","level":3,"score":0.5042134523391724},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.48002782464027405},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.18578976392745972},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt9zg7z83s","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9zg7z83s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt9zg7z83s","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/9zg7z83s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hie, Liana. (2016). Development of Nickel-Catalyzed Cross-Coupling Reactions. UCLA: Chemistry 0153. Retrieved from: http://www.escholarship.org/uc/item/9zg7z83s","raw_type":"dissertation"},{"id":"mag:2767354682","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9zg7z83s","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7052620077","https://openalex.org/W7030462609","https://openalex.org/W3158822604","https://openalex.org/W4287446731","https://openalex.org/W2255718217","https://openalex.org/W7100692187","https://openalex.org/W2781108583","https://openalex.org/W2442844984","https://openalex.org/W2901308605","https://openalex.org/W2761619364"],"abstract_inverted_index":{"Transition":[0],"metal-catalyzed":[1],"cross-couplings":[2,104,141],"provide":[3,252],"a":[4,28],"powerful":[5],"means":[6],"to":[7,32,63,111,147,173,175,191,251,259,273],"assemble":[8],"carbon\u2013carbon":[9,193],"(C\u2013C)":[10],"and":[11,36,56,66,71,88,108,127,145,152,171,194,207,272,282,288],"carbon\u2013heteroatom":[12,54,195],"(C\u2013X)":[13],"bonds.":[14,179,196],"Although":[15],"Pd":[16],"catalysis":[17,26,44],"is":[18,308],"most":[19],"commonly":[20,121],"used":[21,258],"in":[22,123,128,248,310,321],"these":[23],"transformations,":[24],"Ni":[25,43],"offers":[27],"valuable":[29],"alternative":[30],"due":[31],"the":[33,49,74,83,100,115,129,137,155,200,211,223,227,261,275,279,286,291,296,301,311],"low":[34],"cost":[35],"high":[37],"reactivity":[38,65],"of":[39,51,76,85,102,105,117,139,142,157,202,205,213,216,226,231,278,290,303,313],"Ni.":[40],"More":[41],"importantly,":[42],"has":[45],"proven":[46],"effective":[47],"for":[48,300],"activation":[50,204,215,225],"traditionally":[52,164],"inert":[53],"bonds":[55,230],"therefore":[57],"provides":[58],"exciting":[59],"opportunities":[60],"with":[61],"regard":[62],"chemical":[64],"synthetic":[67],"applications.Chapter":[68],"one,":[69],"two,":[70],"three":[72,135],"describe":[73],"development":[75,101,138,201,212],"practical":[77],"cross-coupling":[78,161],"methodologies.":[79],"Chapter":[80,97,134,197,220],"one":[81],"explains":[82],"amination":[84],"aryl":[86,109,143,149],"sulfamates":[87,144],"carbamates":[89],"that":[90,183],"relies":[91],"on":[92,285,295],"an":[93,235],"air-stable":[94],"Ni(II)":[95],"precatalyst.":[96],"two":[98],"introduces":[99,210],"green":[103,140],"phenolic":[106],"derivatives":[107],"halides":[110],"form":[112,148,176],"biaryls.":[113],"Subsequently,":[114],"couplings":[116],"heterocycles,":[118],"which":[119,316],"are":[120,132,167,257,317],"encountered":[122],"natural":[124],"product":[125],"synthesis":[126,312],"pharmaceutical":[130],"sector,":[131],"described.":[133],"describes":[136,199,222],"chlorides":[146],"amines.Chapter":[150],"four":[151,198],"seven":[153,209],"concern":[154],"utility":[156],"amides":[158,184],"as":[159,187],"electrophilic":[160],"partners.":[162],"These":[163],"unreactive":[165],"moieties":[166],"activated":[168],"by":[169],"nickel":[170,245],"coupled":[172],"alcohols":[174],"acyl":[177,228],"C\u2013O":[178],"This":[180,306],"study":[181],"suggests":[182],"may":[185],"serve":[186],"useful":[188],"building":[189],"blocks":[190],"construct":[192],"nickel-catalyzed":[203,214,224,297],"benzamides":[206],"chapter":[208],"aliphatic":[217],"amide":[218],"derivatives.":[219],"five":[221],"carbon\u2013oxygen":[229],"methyl":[232],"esters":[233],"through":[234],"oxidative":[236,240],"addition":[237,241],"process.":[238],"The":[239],"adducts,":[242],"formed":[243],"using":[244],"catalysis,":[246],"undergo":[247],"situ":[249],"trapping":[250],"anilide":[253],"products.":[254],"DFT":[255],"calculations":[256],"support":[260],"proposed":[262],"reaction":[263],"mechanism,":[264],"understand":[265],"why":[266],"decarbonylation":[267],"does":[268],"not":[269],"occur":[270],"competitively,":[271],"elucidate":[274],"beneficial":[276],"role":[277],"substrate":[280],"structure":[281],"Al(OtBu)3":[283],"additive":[284],"kinetics":[287],"thermodynamics":[289],"reaction.Chapter":[292],"six":[293],"focus":[294],"Heck":[298],"cyclization":[299],"construction":[302],"quaternary":[304],"stereocenters.":[305],"transformation":[307],"demonstrated":[309],"3,3-disubstituted":[314],"oxindoles,":[315],"prevalent":[318],"motifs":[319],"seen":[320],"bioactive":[322],"molecules.":[323]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2017-11-17T00:00:00"}