{"id":"https://openalex.org/W2767346907","doi":"https://doi.org/10.1007/s00431-017-3043-4","title":"A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients","display_name":"A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients","publication_year":2017,"publication_date":"2017-11-11","ids":{"openalex":"https://openalex.org/W2767346907","doi":"https://doi.org/10.1007/s00431-017-3043-4","mag":"2767346907","pmid":"https://pubmed.ncbi.nlm.nih.gov/29128883"},"language":"en","primary_location":{"id":"doi:10.1007/s00431-017-3043-4","doi":"https://doi.org/10.1007/s00431-017-3043-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00431-017-3043-4","pdf_url":null,"source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073377233","display_name":"Mengxue He","orcid":"https://orcid.org/0000-0003-0069-6100","observed_orcids":["https://orcid.org/0000-0003-0069-6100"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengxue He","raw_affiliation_strings":["Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022840613","display_name":"Binghua Zhang","orcid":"https://orcid.org/0000-0001-6689-2214","observed_orcids":["https://orcid.org/0000-0001-6689-2214"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Binghua Zhang","raw_affiliation_strings":["Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhangbinghua@scmc.com.cn","Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhangbinghua@scmc.com.cn","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]},{"raw_affiliation_string":"Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083371392","display_name":"Nanping Shen","orcid":"https://orcid.org/0000-0001-7643-4364","observed_orcids":["https://orcid.org/0000-0001-7643-4364"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nanping Shen","raw_affiliation_strings":["Department of Nursing,, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing,, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101892816","display_name":"Na Qiong Wu","orcid":"https://orcid.org/0000-0002-6752-8729","observed_orcids":["https://orcid.org/0000-0002-6752-8729"]},"institutions":[{"id":"https://openalex.org/I4210153623","display_name":"Shanghai First Maternity and Infant Hospital","ror":"https://ror.org/05myyzn85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153623"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Wu","raw_affiliation_strings":["Labor Room, Shanghai First Maternity and Infant Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Labor Room, Shanghai First Maternity and Infant Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210153623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113143990","display_name":"Jiwen Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiwen Sun","raw_affiliation_strings":["Department of Nursing,, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing,, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022840613"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":null,"fwci":1.3993,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.82751092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"177","issue":"1","first_page":"7","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemotherapy-induced-oral-mucositis","display_name":"chemotherapy-induced oral mucositis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/mucositis-prevention","display_name":"mucositis prevention","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mucositis-severity","display_name":"mucositis severity","score":0.972000002861023},{"id":"https://openalex.org/keywords/oral-pain","display_name":"oral pain","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/supportive-cancer-care","display_name":"cancer supportive care","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.9688012599945068},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.91773521900177},{"id":"https://openalex.org/C2778023920","wikidata":"https://www.wikidata.org/wiki/Q1872556","display_name":"Low level laser therapy","level":4,"score":0.6209909319877625},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6004185676574707},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.5042275190353394},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5039560198783875},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4814962148666382},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.46457892656326294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4645414650440216},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.45919832587242126},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4515322148799896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4371792674064636},{"id":"https://openalex.org/C2993195213","wikidata":"https://www.wikidata.org/wiki/Q851186","display_name":"Laser therapy","level":3,"score":0.2635471820831299},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.261923611164093},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.13335326313972473},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07866591215133667},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013280","descriptor_name":"Stomatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013280","descriptor_name":"Stomatitis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013280","descriptor_name":"Stomatitis","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028022","descriptor_name":"Low-Level Light Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00431-017-3043-4","doi":"https://doi.org/10.1007/s00431-017-3043-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00431-017-3043-4","pdf_url":null,"source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:29128883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29128883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1537972189","https://openalex.org/W1846516945","https://openalex.org/W1849066042","https://openalex.org/W1964129659","https://openalex.org/W1966390770","https://openalex.org/W1979804303","https://openalex.org/W2004613565","https://openalex.org/W2017999670","https://openalex.org/W2021394202","https://openalex.org/W2029551405","https://openalex.org/W2037350881","https://openalex.org/W2043992983","https://openalex.org/W2049835536","https://openalex.org/W2062645311","https://openalex.org/W2071611038","https://openalex.org/W2073124733","https://openalex.org/W2074518609","https://openalex.org/W2074523499","https://openalex.org/W2090535835","https://openalex.org/W2092093742","https://openalex.org/W2093541061","https://openalex.org/W2133020320","https://openalex.org/W2134898616","https://openalex.org/W2136963688","https://openalex.org/W2146162119","https://openalex.org/W2158334747","https://openalex.org/W2214927028","https://openalex.org/W2409179383","https://openalex.org/W2478652285","https://openalex.org/W2559682225","https://openalex.org/W2606890745","https://openalex.org/W2725359183","https://openalex.org/W3190697283"],"related_works":["https://openalex.org/W4311887342","https://openalex.org/W3181307035","https://openalex.org/W4400136273","https://openalex.org/W3202773748","https://openalex.org/W4387454284","https://openalex.org/W2409179383","https://openalex.org/W3097477475","https://openalex.org/W3004901497","https://openalex.org/W2043992983","https://openalex.org/W1849066042"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-11-17T00:00:00"}