{"id":"https://openalex.org/W2767328646","doi":"https://doi.org/10.1021/acs.analchem.7b03070","title":"Integrated, Continuous Emulsion Creamer","display_name":"Integrated, Continuous Emulsion Creamer","publication_year":2017,"publication_date":"2017-11-10","ids":{"openalex":"https://openalex.org/W2767328646","doi":"https://doi.org/10.1021/acs.analchem.7b03070","mag":"2767328646","pmid":"https://pubmed.ncbi.nlm.nih.gov/29124927","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5736441"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.7b03070","doi":"https://doi.org/10.1021/acs.analchem.7b03070","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.7b03070","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5736441","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024484329","display_name":"Wesley G. Cochrane","orcid":"https://orcid.org/0000-0002-3325-6921","observed_orcids":["https://orcid.org/0000-0002-3325-6921"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley G. Cochrane","raw_affiliation_strings":["Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055163027","display_name":"Amber L. Hackler","orcid":"https://orcid.org/0000-0003-2856-226X","observed_orcids":["https://orcid.org/0000-0003-2856-226X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber L. Hackler","raw_affiliation_strings":["Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081641289","display_name":"Valerie J. Cavett","orcid":"https://orcid.org/0000-0003-2859-6355","observed_orcids":["https://orcid.org/0000-0003-2859-6355"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie J. Cavett","raw_affiliation_strings":["Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015679090","display_name":"Alexander K. Price","orcid":"https://orcid.org/0000-0002-4562-5798","observed_orcids":["https://orcid.org/0000-0002-4562-5798"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander K. Price","raw_affiliation_strings":["Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018062150","display_name":"Brian M. Paegel","orcid":"https://orcid.org/0000-0002-6531-6693","observed_orcids":["https://orcid.org/0000-0002-6531-6693"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian M. Paegel","raw_affiliation_strings":["Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States"],"raw_orcid":"https://orcid.org/0000-0002-6531-6693","affiliations":[{"raw_affiliation_string":"Doctoral\rProgram in the Chemical and Biological Sciences and \u2021Department of\rChemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018062150"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7381,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68105907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"89","issue":"24","first_page":"13227","last_page":"13234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/droplet-microfluidics","display_name":"droplet microfluidics","score":0.9459999799728394},{"id":"https://openalex.org/keywords/assay-miniaturization","display_name":"assay miniaturization","score":0.6100000143051147},{"id":"https://openalex.org/keywords/enzyme-activity-assay","display_name":"enzyme activity assay","score":0.7020000219345093},{"id":"https://openalex.org/keywords/phosphodiesterase","display_name":"phosphodiesterase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/kinase-assay","display_name":"kinase activity assay","score":0.8420000076293945},{"id":"https://openalex.org/keywords/single-turnover-kinetics","display_name":"single-turnover kinetics","score":0.6620000004768372},{"id":"https://openalex.org/keywords/high-throughput-compound-screening","display_name":"high-throughput compound screening","score":0.746999979019165},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9801920652389526},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.5974649786949158},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1795838177204132}],"mesh":[{"descriptor_ui":"D004655","descriptor_name":"Emulsions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/acs.analchem.7b03070","doi":"https://doi.org/10.1021/acs.analchem.7b03070","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.7b03070","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:29124927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29124927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5265831","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5736441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5736441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5736441","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5265831","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5736441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1666957132","display_name":null,"funder_award_id":"1255250","funder_id":"https://openalex.org/F4320337397","funder_display_name":"Division of Molecular and Cellular Biosciences"},{"id":"https://openalex.org/G212978433","display_name":"Microfluidic High-Throughput Droplet-Scale Screening of DNA-Encoded Compound Libraries for Activators of the Bacterial Target ClpP","funder_award_id":"K25AI128000","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3958606638","display_name":null,"funder_award_id":"GM120491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G486073441","display_name":null,"funder_award_id":"AI128000","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7400896604","display_name":"High-Throughput Droplet-Scale Functional Screening of DNA-Encoded Combinatorial Libraries","funder_award_id":"R01GM120491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337397","display_name":"Division of Molecular and Cellular Biosciences","ror":"https://ror.org/002jdaq33"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1587481053","https://openalex.org/W1629183529","https://openalex.org/W1908102479","https://openalex.org/W1964814211","https://openalex.org/W1975581000","https://openalex.org/W1976147756","https://openalex.org/W1980221373","https://openalex.org/W1991001144","https://openalex.org/W1991472738","https://openalex.org/W1992496867","https://openalex.org/W1993554361","https://openalex.org/W1996442566","https://openalex.org/W1998857762","https://openalex.org/W2001801206","https://openalex.org/W2009434334","https://openalex.org/W2009797503","https://openalex.org/W2025915013","https://openalex.org/W2026896696","https://openalex.org/W2026908430","https://openalex.org/W2026909340","https://openalex.org/W2029886517","https://openalex.org/W2030609318","https://openalex.org/W2034386905","https://openalex.org/W2035055504","https://openalex.org/W2040331257","https://openalex.org/W2041190259","https://openalex.org/W2041677432","https://openalex.org/W2050255833","https://openalex.org/W2055489543","https://openalex.org/W2062857909","https://openalex.org/W2067921722","https://openalex.org/W2072689095","https://openalex.org/W2083628117","https://openalex.org/W2090690176","https://openalex.org/W2100850508","https://openalex.org/W2101475717","https://openalex.org/W2108193327","https://openalex.org/W2110460556","https://openalex.org/W2114406337","https://openalex.org/W2118131251","https://openalex.org/W2121057697","https://openalex.org/W2121733433","https://openalex.org/W2140548175","https://openalex.org/W2152904553","https://openalex.org/W2165042301","https://openalex.org/W2265121542","https://openalex.org/W2270090559","https://openalex.org/W2274643653","https://openalex.org/W2313698209","https://openalex.org/W2323549833","https://openalex.org/W2323809913","https://openalex.org/W2336955395","https://openalex.org/W2512259981","https://openalex.org/W2559994063","https://openalex.org/W2588529552","https://openalex.org/W2614175391"],"related_works":["https://openalex.org/W2078989726","https://openalex.org/W2986520732","https://openalex.org/W2323990297","https://openalex.org/W2967479817","https://openalex.org/W2106811669","https://openalex.org/W2053165404","https://openalex.org/W3107700527","https://openalex.org/W4361013404","https://openalex.org/W2149719109","https://openalex.org/W3138375112"],"abstract_inverted_index":{"Automated":[0],"and":[1,13,48,100,139,152,172],"reproducible":[2],"sample":[3,69],"handling":[4,56],"is":[5,173],"a":[6],"key":[7,66],"requirement":[8],"for":[9,51,113],"high-throughput":[10],"compound":[11],"screening":[12,22,27],"currently":[14],"demands":[15],"heavy":[16],"reliance":[17],"on":[18],"expensive":[19],"robotics":[20],"in":[21,184],"centers.":[23],"Integrated":[24],"droplet":[25,41,53],"microfluidic":[26,76,161],"processors":[28,44,165],"are":[29],"poised":[30],"to":[31,39,105,137],"replace":[32],"robotic":[33],"automation":[34],"by":[35,84],"miniaturizing":[36],"biochemical":[37],"reactions":[38],"the":[40,65,103,107,110,156],"scale.":[42],"These":[43],"must":[45],"generate,":[46],"incubate,":[47],"sort":[49],"droplets":[50,59,83,108],"continuous":[52,131],"screening,":[54],"passively":[55],"millions":[57],"of":[58,68,142,177],"with":[60,97,158,175],"complete":[61],"uniformity,":[62],"especially":[63],"during":[64],"step":[67],"incubation.":[70],"Here,":[71],"we":[72],"disclose":[73],"an":[74],"integrated":[75,160],"emulsion":[77,99,116,132],"creamer":[78,133],"that":[79],"packs":[80],"(\"creams\")":[81],"assay":[82,117],"draining":[85],"away":[86],"excess":[87],"oil":[88,95,104],"through":[89],"microfabricated":[90],"drain":[91],"channels.":[92],"The":[93,129],"drained":[94],"coflows":[96],"creamed":[98],"then":[101],"reintroduces":[102],"disperse":[106],"at":[109],"circuit":[111],"terminus":[112],"analysis.":[114],"Creamed":[115],"incubation":[118],"time":[119],"dispersion":[120],"was":[121,135],"1.7%,":[122],"3-fold":[123],"less":[124],"than":[125],"other":[126],"reported":[127],"incubators.":[128],"integrated,":[130],"(ICEcreamer)":[134],"used":[136],"miniaturize":[138],"optimize":[140],"measurements":[141],"various":[143],"enzymatic":[144],"activities":[145,181],"(phosphodiesterase,":[146],"kinase,":[147],"bacterial":[148],"translation)":[149],"under":[150],"multiple-":[151],"single-turnover":[153],"conditions.":[154],"Combining":[155],"ICEcreamer":[157],"current":[159],"DNA-encoded":[162],"library":[163],"bead":[164],"eliminates":[166],"potentially":[167],"cumbersome":[168],"instrumentation":[169],"engineering":[170],"challenges":[171],"compatible":[174],"assays":[176],"diverse":[178],"target":[179],"class":[180],"commonly":[182],"investigated":[183],"drug":[185],"discovery.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-11-17T00:00:00"}
