{"id":"https://openalex.org/W2767313170","doi":"https://doi.org/10.1111/cas.13441","title":"Xanthohumol inhibits angiogenesis by suppressing nuclear factor\u2010\u03baB activation in pancreatic cancer","display_name":"Xanthohumol inhibits angiogenesis by suppressing nuclear factor\u2010\u03baB activation in pancreatic cancer","publication_year":2017,"publication_date":"2017-11-09","ids":{"openalex":"https://openalex.org/W2767313170","doi":"https://doi.org/10.1111/cas.13441","mag":"2767313170","pmid":"https://pubmed.ncbi.nlm.nih.gov/29121426","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5765302"},"language":"en","primary_location":{"id":"doi:10.1111/cas.13441","doi":"https://doi.org/10.1111/cas.13441","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.13441","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.13441","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.13441","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101507907","display_name":"Kenta Saito","orcid":"https://orcid.org/0000-0003-3590-2189","observed_orcids":["https://orcid.org/0000-0003-3590-2189"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenta Saito","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3590-2189","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102713327","display_name":"Yoichi Matsuo","orcid":"https://orcid.org/0000-0001-9654-6080","observed_orcids":["https://orcid.org/0000-0001-9654-6080"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoichi Matsuo","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058792658","display_name":"Hiroyuki Imafuji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Imafuji","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109591087","display_name":"Tomotaka Okubo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomotaka Okubo","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100919999","display_name":"Yuzo Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuzo Maeda","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101623706","display_name":"Takafumi Sato","orcid":"https://orcid.org/0009-0004-6086-3462","observed_orcids":["https://orcid.org/0009-0004-6086-3462"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Sato","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000176667","display_name":"Tomoya Shamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoya Shamoto","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110900319","display_name":"Ken Tsuboi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Tsuboi","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007065982","display_name":"Mamoru Morimoto","orcid":"https://orcid.org/0000-0002-7837-9642","observed_orcids":["https://orcid.org/0000-0002-7837-9642"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mamoru Morimoto","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023093481","display_name":"Hiroki Takahashi","orcid":"https://orcid.org/0000-0003-0528-0446","observed_orcids":["https://orcid.org/0000-0003-0528-0446"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Takahashi","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110264480","display_name":"Hideyuki Ishiguro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Ishiguro","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034428643","display_name":"Shuji Takiguchi","orcid":"https://orcid.org/0000-0002-1339-354X","observed_orcids":["https://orcid.org/0000-0002-1339-354X"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Takiguchi","raw_affiliation_strings":["Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102713327"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":8.9224,"has_fulltext":true,"cited_by_count":130,"citation_normalized_percentile":{"value":0.98562237,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"109","issue":"1","first_page":"132","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.14480000734329224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthohumol","display_name":"xanthohumol","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7609999775886536},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/prenylated-chalcones","display_name":"prenylated chalcones","score":0.8640000224113464},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/tumor-microvessel-density","display_name":"tumor microvessel density","score":0.7260000109672546},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.7429999709129333},{"id":"https://openalex.org/keywords/bxpc-3-cells","display_name":"BxPC-3 cells","score":0.796999990940094},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2779642036","wikidata":"https://www.wikidata.org/wiki/Q408088","display_name":"Xanthohumol","level":3,"score":0.9976632595062256},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7380023002624512},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6936920881271362},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5798969864845276},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5655044913291931},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5143615007400513},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4853474199771881},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4458942711353302},{"id":"https://openalex.org/C2779421835","wikidata":"https://www.wikidata.org/wiki/Q104212","display_name":"Humulus lupulus","level":3,"score":0.42648324370384216},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3904540538787842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3135930001735687},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27815473079681396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2636147737503052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2564881145954132},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18305349349975586},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2776242653","wikidata":"https://www.wikidata.org/wiki/Q22907699","display_name":"Pepper","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011427","descriptor_name":"Propiophenones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011427","descriptor_name":"Propiophenones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051996","descriptor_name":"Transcription Factor RelA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/cas.13441","doi":"https://doi.org/10.1111/cas.13441","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.13441","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.13441","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmid:29121426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29121426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5765302","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5765302/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/cas.13441","doi":"https://doi.org/10.1111/cas.13441","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.13441","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.13441","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5068377243","display_name":"The effect of polyphenols on Bcl-xL expression in colon and pancreatic cancer cells","funder_award_id":"17K10644","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5595194804","display_name":"Analysis of IGF 1 signal in pancreatic cancer angiogenesis","funder_award_id":"16K10606","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8163122746","display_name":"Investigation of cancer stem cell marker CXCR4 in gemcitabine-resistant pancreatic cance","funder_award_id":"15K10192","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8879442672","display_name":"The elucidation of the antitumor effect of Xanthohumol in pancreatic cancer","funder_award_id":"17K10708","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8998724457","display_name":"Elucidation of mechanisms of pancreatic cancer lymphangiogenesis","funder_award_id":"16K19947","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2767313170.pdf","grobid_xml":"https://content.openalex.org/works/W2767313170.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W20888715","https://openalex.org/W35937105","https://openalex.org/W72344367","https://openalex.org/W1775867546","https://openalex.org/W1919468083","https://openalex.org/W1931508686","https://openalex.org/W1966648374","https://openalex.org/W1968812902","https://openalex.org/W1970203307","https://openalex.org/W1970406868","https://openalex.org/W1974684736","https://openalex.org/W1975176400","https://openalex.org/W1993344078","https://openalex.org/W1996683003","https://openalex.org/W2001396780","https://openalex.org/W2003683047","https://openalex.org/W2032900860","https://openalex.org/W2049023072","https://openalex.org/W2049669401","https://openalex.org/W2050608244","https://openalex.org/W2051961864","https://openalex.org/W2058301168","https://openalex.org/W2078543826","https://openalex.org/W2097224369","https://openalex.org/W2105441033","https://openalex.org/W2126750639","https://openalex.org/W2126917669","https://openalex.org/W2151253787","https://openalex.org/W2153724103","https://openalex.org/W2155139733","https://openalex.org/W2159603425","https://openalex.org/W2160972799","https://openalex.org/W2162385894","https://openalex.org/W2165480504","https://openalex.org/W2166994863","https://openalex.org/W2235523093","https://openalex.org/W2316875490"],"related_works":["https://openalex.org/W3102215470","https://openalex.org/W2002076477","https://openalex.org/W2112955690","https://openalex.org/W1970406868","https://openalex.org/W1993344078","https://openalex.org/W561888050","https://openalex.org/W2739217242","https://openalex.org/W4206059312","https://openalex.org/W2179561346","https://openalex.org/W2097093549"],"abstract_inverted_index":{"Xantohumol,":[0],"a":[1,44,208],"prenylated":[2],"chalcone":[3],"from":[4],"hops":[5],"(Humulus":[6],"lupulus":[7],"L.),":[8],"has":[9],"been":[10],"shown":[11],"to":[12],"inhibit":[13],"proliferation":[14,80],"in":[15,27,47,49,65,68,71,84,114,131,157,201],"some":[16],"cancers.":[17],"However,":[18],"little":[19],"is":[20],"known":[21],"regarding":[22],"the":[23,37,96,109,147,190,213],"effects":[24],"of":[25,36,98,149,164,215],"xanthohumol":[26,58,77,93,140,169,194,205],"pancreatic":[28,50,66,85,115,202,216],"cancer.":[29,51,203,217],"We":[30,73,119],"have":[31],"previously":[32],"reported":[33],"that":[34,76,92,122,168,193],"activation":[35,64,83],"transcription":[38],"factor":[39,102],"nuclear":[40],"factor-\u03baB":[41],"(NF-\u03baB)":[42],"plays":[43],"key":[45],"role":[46],"angiogenesis":[48,60,196],"In":[52,145],"this":[53,143],"study,":[54],"we":[55,90],"investigated":[56],"whether":[57],"inhibited":[59,79,170,195],"by":[61,197],"blocking":[62],"NF-\u03baB":[63,82,176,199],"cancer":[67,86,116],"vitro":[69],"and":[70,81,104,111,137,179,181],"vivo.":[72],"initially":[74],"confirmed":[75],"significantly":[78,94,127,141,155],"cell":[87,117],"lines.":[88,118],"Next,":[89],"demonstrated":[91],"suppressed":[95],"expression":[97],"vascular":[99],"endothelial":[100,135],"growth":[101],"(VEGF)":[103],"interleukin-8":[105],"(IL-8)":[106],"at":[107],"both":[108],"mRNA":[110],"protein":[112],"levels":[113],"also":[120],"found":[121],"coculture":[123],"with":[124,139,160],"BxPC-3":[125,150],"cells":[126],"enhanced":[128],"tube":[129],"formation":[130],"human":[132],"umbilical":[133],"vein":[134],"cells,":[136],"treatment":[138],"blocked":[142],"effect.":[144],"vivo,":[146],"volume":[148],"subcutaneous":[151],"xenograft":[152],"tumors":[153],"was":[154],"reduced":[156],"mice":[158],"treated":[159],"weekly":[161],"intraperitoneal":[162],"injections":[163],"xanthohumol.":[165],"Immunohistochemistry":[166],"revealed":[167],"Ki-67":[171],"expression,":[172,178],"CD31-positive":[173],"microvessel":[174],"density,":[175],"p65":[177],"VEGF":[180],"IL-8":[182],"levels.":[183],"Taken":[184],"together,":[185],"these":[186],"results":[187],"showed,":[188],"for":[189,212],"first":[191],"time,":[192],"suppressing":[198],"activity":[200],"Accordingly,":[204],"may":[206],"represent":[207],"novel":[209],"therapeutic":[210],"agent":[211],"management":[214]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-11-17T00:00:00"}
