{"id":"https://openalex.org/W2767275374","doi":"https://doi.org/10.5858/arpa.2016-0579-cp","title":"Worldwide Frequency of Commonly Detected EGFR Mutations","display_name":"Worldwide Frequency of Commonly Detected EGFR Mutations","publication_year":2017,"publication_date":"2017-11-06","ids":{"openalex":"https://openalex.org/W2767275374","doi":"https://doi.org/10.5858/arpa.2016-0579-cp","mag":"2767275374","pmid":"https://pubmed.ncbi.nlm.nih.gov/29106293"},"language":"en","primary_location":{"id":"doi:10.5858/arpa.2016-0579-cp","doi":"https://doi.org/10.5858/arpa.2016-0579-cp","is_oa":true,"landing_page_url":"https://doi.org/10.5858/arpa.2016-0579-cp","pdf_url":"https://meridian.allenpress.com/aplm/article-pdf/142/2/163/1447744/arpa_2016-0579-cp.pdf","source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://meridian.allenpress.com/aplm/article-pdf/142/2/163/1447744/arpa_2016-0579-cp.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046724542","display_name":"Rondell Patrell Graham","orcid":"https://orcid.org/0000-0002-8686-4867","observed_orcids":["https://orcid.org/0000-0002-8686-4867"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I15839263","display_name":"College of American Pathologists","ror":"https://ror.org/035h6e956","country_code":"US","type":"education","lineage":["https://openalex.org/I15839263"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rondell P. Graham","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","Surveys Department, College of American Pathologists, Northfield, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Surveys Department, College of American Pathologists, Northfield, Illinois","institution_ids":["https://openalex.org/I15839263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084891097","display_name":"Amanda L. Treece","orcid":"https://orcid.org/0000-0002-6083-7166","observed_orcids":["https://orcid.org/0000-0002-6083-7166"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I15839263","display_name":"College of American Pathologists","ror":"https://ror.org/035h6e956","country_code":"US","type":"education","lineage":["https://openalex.org/I15839263"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda L. Treece","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , Minnesota (","Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","Surveys Department, College of American Pathologists, Northfield, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , Minnesota (","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Surveys Department, College of American Pathologists, Northfield, Illinois","institution_ids":["https://openalex.org/I15839263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035004148","display_name":"Neal Ian Lindeman","orcid":"https://orcid.org/0000-0002-7092-6859","observed_orcids":["https://orcid.org/0000-0002-7092-6859"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I15839263","display_name":"College of American Pathologists","ror":"https://ror.org/035h6e956","country_code":"US","type":"education","lineage":["https://openalex.org/I15839263"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal I. Lindeman","raw_affiliation_strings":["Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","Surveys Department, College of American Pathologists, Northfield, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Surveys Department, College of American Pathologists, Northfield, Illinois","institution_ids":["https://openalex.org/I15839263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056981084","display_name":"Patricia Vasalos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I15839263","display_name":"College of American Pathologists","ror":"https://ror.org/035h6e956","country_code":"US","type":"education","lineage":["https://openalex.org/I15839263"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Vasalos","raw_affiliation_strings":["Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","Surveys Department, College of American Pathologists, Northfield, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Surveys Department, College of American Pathologists, Northfield, Illinois","institution_ids":["https://openalex.org/I15839263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109447236","display_name":"Mu Shan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I15839263","display_name":"College of American Pathologists","ror":"https://ror.org/035h6e956","country_code":"US","type":"education","lineage":["https://openalex.org/I15839263"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mu Shan,","raw_affiliation_strings":["Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","Surveys Department, College of American Pathologists, Northfield, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Surveys Department, College of American Pathologists, Northfield, Illinois","institution_ids":["https://openalex.org/I15839263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084339424","display_name":"Lawrence J. Jennings","orcid":"https://orcid.org/0000-0001-8669-7774","observed_orcids":["https://orcid.org/0000-0001-8669-7774"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I15839263","display_name":"College of American Pathologists","ror":"https://ror.org/035h6e956","country_code":"US","type":"education","lineage":["https://openalex.org/I15839263"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence J. Jennings","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","Surveys Department, College of American Pathologists, Northfield, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Surveys Department, College of American Pathologists, Northfield, Illinois","institution_ids":["https://openalex.org/I15839263"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I15839263","display_name":"College of American Pathologists","ror":"https://ror.org/035h6e956","country_code":"US","type":"education","lineage":["https://openalex.org/I15839263"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Rimm","raw_affiliation_strings":["Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","Surveys Department, College of American Pathologists, Northfield, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mr Graham) ; the Department of Pathology and Laboratory Medicine , Children's Hospital Colorado , Denver (","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts (Dr Lindeman); the","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Children's Hospital Colorado, Denver (Dr Treece); the Department of Pathology,","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Mr Graham); the Department of Pathology and Laboratory Medicine,","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Surveys Department, College of American Pathologists, Northfield, Illinois","institution_ids":["https://openalex.org/I15839263"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5046724542"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1283280774","https://openalex.org/I1330342723","https://openalex.org/I15839263","https://openalex.org/I32971472","https://openalex.org/I4210096275"],"apc_list":null,"apc_paid":null,"fwci":7.2893,"has_fulltext":true,"cited_by_count":200,"citation_normalized_percentile":{"value":0.97948286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"142","issue":"2","first_page":"163","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/mutation-frequency","display_name":"mutation frequency","score":0.7409999966621399},{"id":"https://openalex.org/keywords/exon-19-deletion","display_name":"exon 19 deletion","score":0.8100000023841858},{"id":"https://openalex.org/keywords/exon-21-l858r","display_name":"exon 21 L858R","score":0.9070000052452087},{"id":"https://openalex.org/keywords/exon-20-insertion","display_name":"exon 20 insertion","score":0.890999972820282},{"id":"https://openalex.org/keywords/egfr-t790m-mutation","display_name":"T790M mutation","score":0.984000027179718},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.7820000052452087},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.4449999928474426},{"id":"https://openalex.org/keywords/regional-variation","display_name":"regional variation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4490000009536743},{"id":"https://openalex.org/keywords/south-asia","display_name":"South Asia","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.7947264909744263},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7561783790588379},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.7312383651733398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5260436534881592},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5170658230781555},{"id":"https://openalex.org/C102306862","wikidata":"https://www.wikidata.org/wiki/Q6943735","display_name":"Mutation frequency","level":4,"score":0.5154920220375061},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5154867768287659},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44364020228385925},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.42971891164779663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3961614668369293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34929603338241577},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32314687967300415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3060073256492615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2909129858016968},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018773","descriptor_name":"Genes, erbB-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059021","descriptor_name":"Laboratory Proficiency Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5858/arpa.2016-0579-cp","doi":"https://doi.org/10.5858/arpa.2016-0579-cp","is_oa":true,"landing_page_url":"https://doi.org/10.5858/arpa.2016-0579-cp","pdf_url":"https://meridian.allenpress.com/aplm/article-pdf/142/2/163/1447744/arpa_2016-0579-cp.pdf","source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:29106293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29106293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5858/arpa.2016-0579-cp","doi":"https://doi.org/10.5858/arpa.2016-0579-cp","is_oa":true,"landing_page_url":"https://doi.org/10.5858/arpa.2016-0579-cp","pdf_url":"https://meridian.allenpress.com/aplm/article-pdf/142/2/163/1447744/arpa_2016-0579-cp.pdf","source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2767275374.pdf","grobid_xml":"https://content.openalex.org/works/W2767275374.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W47254371","https://openalex.org/W1966011301","https://openalex.org/W1978236936","https://openalex.org/W2012815363","https://openalex.org/W2017389411","https://openalex.org/W2040299716","https://openalex.org/W2043696829","https://openalex.org/W2065350134","https://openalex.org/W2095618958","https://openalex.org/W2109774663","https://openalex.org/W2126491616","https://openalex.org/W2137749537","https://openalex.org/W2138200001","https://openalex.org/W2145322551","https://openalex.org/W2150420036","https://openalex.org/W2161821474","https://openalex.org/W2166084034","https://openalex.org/W2333407433"],"related_works":["https://openalex.org/W3008564975","https://openalex.org/W2999144789","https://openalex.org/W2021146681","https://openalex.org/W2060452880","https://openalex.org/W2999969947","https://openalex.org/W2040299716","https://openalex.org/W2782611472","https://openalex.org/W2112839333","https://openalex.org/W2174214551","https://openalex.org/W3032811381"],"abstract_inverted_index":{"CONTEXT:":[0],"-":[1,73,107,182,317],"Recurrent":[2],"epidermal":[3],"growth":[4],"factor":[5],"receptor":[6],"(":[7],"EGFR)":[8],"mutations":[9,19,45,80,194,234,324,338,351],"are":[10,20,26,52,191,231,294,325],"seen":[11,277],"in":[12,46,81,87,91,102,121,163,178,250,278,295,328],"a":[13,27],"subset":[14],"of":[15,42,56,63,69,78,94,124,140,168,199,204,218,223,238,243,262,267,284,303,308,335,349],"pulmonary":[16],"adenocarcinomas.":[17],"These":[18],"targeted":[21],"by":[22,170],"EGFR":[23,32,44,79,101,127,323,337],"inhibitors":[24],"and":[25,151,154,172,208,227,288,297,306,313,331,347],"biomarker":[28],"for":[29,100],"response":[30],"to":[31,165,173],"inhibitor":[33],"therapies.":[34],"Initial":[35],"data":[36,319],"have":[37],"indicated":[38],"an":[39],"increased":[40],"frequency":[41,77,167,275,346],"activating":[43,150,186,273,291,322,336],"nonsmoking":[47],"Asian":[48],"females.":[49],"However,":[50],"there":[51],"very":[53],"few":[54],"studies":[55],"global":[57],"scope":[58],"that":[59,119,321,332],"address":[60],"the":[61,67,76,92,110,122,137,184,188,209,228,254,289,333,342,345],"question":[62],"mutation":[64,146,169,179,213,249,258,274,292],"distribution":[65,334,348],"across":[66,341],"population":[68],"lung":[70],"cancer.":[71],"OBJECTIVE:":[72],"To":[74],"determine":[75],"exons":[82],"18":[83],"through":[84],"21":[85,211],"detected":[86],"clinical":[88,114],"laboratories":[89,115],"participating":[90],"College":[93,123],"American":[95,125],"Pathologists":[96,126],"proficiency":[97,128,132],"testing":[98,129,133],"program":[99],"calendar":[103],"year":[104],"2013.":[105],"DESIGN:":[106],"We":[108],"reviewed":[109],"surveys":[111],"from":[112,116],"170":[113],"20":[117,233,252],"countries":[118],"participated":[120],"program.":[130],"The":[131,247,271],"includes":[134],"questions":[135],"regarding":[136],"total":[138,205,224,244],"numbers":[139],"tests":[141],"performed":[142],"at":[143],"each":[144],"common":[145,190,230,256,327],"site,":[147],"including":[148],"both":[149],"resistance":[152,257,350],"mutations,":[153,187],"their":[155],"frequency.":[156],"Countries":[157],"were":[158],"grouped":[159],"into":[160],"regional":[161],"groups":[162],"order":[164],"assess":[166,175],"type,":[171],"indirectly":[174],"ethnic":[176],"differences":[177],"frequencies.":[180],"RESULTS:":[181],"Among":[183],"treatment-sensitive":[185],"most":[189],"exon":[192,210,232,251],"19":[193],"(n":[195,214,235,259,281,300],"=":[196,215,236,260,282,301],"10":[197,216],"802":[198],"136":[200,219,239,263],"533":[201,220,240,264],"cases;":[202,221,241,265,286,311],"7.9%":[203],"cases":[206,225,245,269,305],"tested)":[207,226],"L858R":[212],"351":[217],"7.6%":[222],"least":[229],"466":[237],"0.3%":[242],"tested).":[246,270],"T790M":[248],"is":[253,276],"more":[255,326],"1010":[261],"0.7%":[266],"all":[268],"highest":[272],"southern":[279,329,358],"Asia":[280,330,359],"4260":[283],"9337":[285],"46%)":[287],"lowest":[290],"frequencies":[293],"South":[296],"North":[298],"America":[299],"113":[302],"1439":[304],"7926":[307],"86":[309],"654":[310],"8%":[312],"9%,":[314],"respectively).":[315],"CONCLUSIONS:":[316],"Our":[318],"confirm":[320],"varies":[339],"significantly":[340],"regions.":[343,362],"Similarly,":[344],"also":[352],"show":[353],"significant":[354],"variation":[355],"when":[356],"comparing":[357],"with":[360],"other":[361]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-11-17T00:00:00"}