{"id":"https://openalex.org/W2767167306","doi":"https://doi.org/10.1007/s11418-017-1145-y","title":"18\u03b2-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-\u03b1/ERK pathway","display_name":"18\u03b2-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-\u03b1/ERK pathway","publication_year":2017,"publication_date":"2017-11-02","ids":{"openalex":"https://openalex.org/W2767167306","doi":"https://doi.org/10.1007/s11418-017-1145-y","mag":"2767167306","pmid":"https://pubmed.ncbi.nlm.nih.gov/29098529"},"language":"en","primary_location":{"id":"doi:10.1007/s11418-017-1145-y","doi":"https://doi.org/10.1007/s11418-017-1145-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11418-017-1145-y","pdf_url":null,"source":{"id":"https://openalex.org/S165299079","display_name":"Journal of Natural Medicines","issn_l":"1340-3443","issn":["1340-3443","1861-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Medicines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hongke Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongke Cai","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329857","display_name":"Xi Chen","orcid":"https://orcid.org/0000-0001-7271-2953","observed_orcids":["https://orcid.org/0000-0001-7271-2953"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Chen","raw_affiliation_strings":["Center of Molecular Medicine and Cancer Research, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Molecular Medicine and Cancer Research, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328427","display_name":"Jianbo Zhang","orcid":"https://orcid.org/0000-0002-8177-6817","observed_orcids":["https://orcid.org/0000-0002-8177-6817"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianbo Zhang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 149956847@qq.com","Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 149956847@qq.com","institution_ids":["https://openalex.org/I4210097509"]},{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063619667","display_name":"Jijian Wang","orcid":"https://orcid.org/0000-0001-8323-9903","observed_orcids":["https://orcid.org/0000-0001-8323-9903"]},"institutions":[{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jijian Wang","raw_affiliation_strings":["Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 18223138243@163.com","Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 18223138243@163.com","institution_ids":["https://openalex.org/I4210097509"]},{"raw_affiliation_string":"Department of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China","institution_ids":["https://openalex.org/I4210097509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063619667","https://openalex.org/A5100328427"],"corresponding_institution_ids":["https://openalex.org/I4210097509"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":5.2319,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95795195,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"72","issue":"1","first_page":"252","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/18beta-glycyrrhetinic-acid","display_name":"18\u03b2-glycyrrhetinic acid","score":1.0},{"id":"https://openalex.org/keywords/licorice-root","display_name":"licorice root","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8999999761581421},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.9039999842643738},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7897680997848511},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6698380708694458},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6133240461349487},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6077418327331543},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5971224904060364},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5926856994628906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5400730967521667},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5229806900024414},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5064111948013306},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4661964476108551},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.45434969663619995},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4199139177799225},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.41572511196136475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3868582248687744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30037426948547363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23739442229270935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2135118544101715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2017804980278015},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14491915702819824},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.13785246014595032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04849687218666077}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006034","descriptor_name":"Glycyrrhetinic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006034","descriptor_name":"Glycyrrhetinic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11418-017-1145-y","doi":"https://doi.org/10.1007/s11418-017-1145-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11418-017-1145-y","pdf_url":null,"source":{"id":"https://openalex.org/S165299079","display_name":"Journal of Natural Medicines","issn_l":"1340-3443","issn":["1340-3443","1861-0293"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Medicines","raw_type":"journal-article"},{"id":"pmid:29098529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29098529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural medicines","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W904590016","https://openalex.org/W1757407923","https://openalex.org/W1828400840","https://openalex.org/W1905017574","https://openalex.org/W1964847767","https://openalex.org/W1969343369","https://openalex.org/W1970658377","https://openalex.org/W1975517407","https://openalex.org/W1977063445","https://openalex.org/W1977828927","https://openalex.org/W1982088633","https://openalex.org/W1988655372","https://openalex.org/W1993368552","https://openalex.org/W1995097523","https://openalex.org/W1997238548","https://openalex.org/W2012184744","https://openalex.org/W2018586378","https://openalex.org/W2027534714","https://openalex.org/W2052060298","https://openalex.org/W2058028489","https://openalex.org/W2069100318","https://openalex.org/W2073251119","https://openalex.org/W2080232352","https://openalex.org/W2093010592","https://openalex.org/W2093904239","https://openalex.org/W2094785318","https://openalex.org/W2095976471","https://openalex.org/W2117419186","https://openalex.org/W2132546029","https://openalex.org/W2142641037","https://openalex.org/W2144055188","https://openalex.org/W2148157244","https://openalex.org/W2255672707","https://openalex.org/W2286612125","https://openalex.org/W2336257193","https://openalex.org/W2413233739","https://openalex.org/W2416862384","https://openalex.org/W2564584499","https://openalex.org/W2567153326","https://openalex.org/W3164338394","https://openalex.org/W4211233744"],"related_works":["https://openalex.org/W4414602601","https://openalex.org/W2086868423","https://openalex.org/W1980782263","https://openalex.org/W4293075655","https://openalex.org/W2360265845","https://openalex.org/W3018326445","https://openalex.org/W4376128915","https://openalex.org/W4380768729","https://openalex.org/W4380730392","https://openalex.org/W4401520867"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-11-10T00:00:00"}