{"id":"https://openalex.org/W2767090199","doi":"https://doi.org/10.1158/1078-0432.ccr-17-2228","title":"Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms","display_name":"Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms","publication_year":2017,"publication_date":"2017-10-26","ids":{"openalex":"https://openalex.org/W2767090199","doi":"https://doi.org/10.1158/1078-0432.ccr-17-2228","mag":"2767090199","pmid":"https://pubmed.ncbi.nlm.nih.gov/29074605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8487012"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-17-2228","doi":"https://doi.org/10.1158/1078-0432.ccr-17-2228","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-17-2228","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC8487012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007281732","display_name":"Jong Bok Lee","orcid":"https://orcid.org/0000-0002-4744-6021","observed_orcids":["https://orcid.org/0000-0002-4744-6021"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"JongBok Lee","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","2Department of Immunology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"2Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026397928","display_name":"Mark David Minden","orcid":"https://orcid.org/0000-0002-9089-8816","observed_orcids":["https://orcid.org/0000-0002-9089-8816"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mark D. Minden","raw_affiliation_strings":["3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079872301","display_name":"Weihsu Claire Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Weihsu C. Chen","raw_affiliation_strings":["3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052950431","display_name":"Elena Streck","orcid":"https://orcid.org/0000-0003-3661-068X","observed_orcids":["https://orcid.org/0000-0003-3661-068X"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elena Streck","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060040461","display_name":"Branson Chen","orcid":"https://orcid.org/0000-0002-4224-0753","observed_orcids":["https://orcid.org/0000-0002-4224-0753"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Branson Chen","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966826","display_name":"Hyeonjeong Kang","orcid":"https://orcid.org/0009-0002-6566-0950","observed_orcids":["https://orcid.org/0009-0002-6566-0950"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hyeonjeong Kang","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083780768","display_name":"Andrea Arruda","orcid":"https://orcid.org/0000-0003-2516-8005","observed_orcids":["https://orcid.org/0000-0003-2516-8005"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrea Arruda","raw_affiliation_strings":["3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074940171","display_name":"Dalam Ly","orcid":"https://orcid.org/0000-0002-1177-0225","observed_orcids":["https://orcid.org/0000-0002-1177-0225"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dalam Ly","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967154","display_name":"Sandy D. Der","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sandy D. Der","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033883885","display_name":"Sohyeong Kang","orcid":"https://orcid.org/0000-0002-1352-2508","observed_orcids":["https://orcid.org/0000-0002-1352-2508"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sohyeong Kang","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054689552","display_name":"Paulina Achita","orcid":"https://orcid.org/0000-0002-3462-7739","observed_orcids":["https://orcid.org/0000-0002-3462-7739"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paulina Achita","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","5Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"5Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025863373","display_name":"Cheryl A. D\u2019Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cheryl D'Souza","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617032","display_name":"Yueyang Li","orcid":"https://orcid.org/0000-0003-4356-9451","observed_orcids":["https://orcid.org/0000-0003-4356-9451","https://orcid.org/0009-0007-0465-3745"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yueyang Li","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112507028","display_name":"Richard W. Childs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W. Childs","raw_affiliation_strings":["6National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090356933","display_name":"John Edgar Dick","orcid":"https://orcid.org/0000-0002-9527-8317","observed_orcids":["https://orcid.org/0000-0002-9527-8317"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John E. Dick","raw_affiliation_strings":["3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada","7Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"raw_affiliation_string":"7Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Li Zhang","raw_affiliation_strings":["1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","2Department of Immunology, University of Toronto, Toronto, Ontario, Canada","4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","5Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441"]},{"raw_affiliation_string":"2Department of Immunology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"5Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100425554"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750"],"apc_list":null,"apc_paid":null,"fwci":2.3758,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.89144227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"24","issue":"2","first_page":"370","last_page":"382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cellular-immunotherapy","display_name":"cellular immunotherapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dnam-1","display_name":"DNAM-1","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6200000047683716},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/xenogeneic-graft-versus-host-disease","display_name":"xenogeneic graft-versus-host disease","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7697254419326782},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6762452125549316},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5516036748886108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5092328786849976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4918670654296875},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4614250957965851},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4537912905216217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.356579065322876},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22849777340888977}],"mesh":[{"descriptor_ui":"D000098862","descriptor_name":"T Lineage-Specific Activation Antigen 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006087","descriptor_name":"Graft vs Host Reaction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055655","descriptor_name":"NK Cell Lectin-Like Receptor Subfamily K","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-17-2228","doi":"https://doi.org/10.1158/1078-0432.ccr-17-2228","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-17-2228","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:29074605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29074605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:7379477","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8487012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8487012","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8487012/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7379477","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8487012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1453600622","display_name":"G protein regulation of N-type calcium channels","funder_award_id":"14172_3","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G1560498385","display_name":null,"funder_award_id":"704121","funder_id":"https://openalex.org/F4320320118","funder_display_name":"Canadian Cancer Society"},{"id":"https://openalex.org/G4705346009","display_name":null,"funder_award_id":"Z99 HL999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4868109349","display_name":null,"funder_award_id":"# 6265-13","funder_id":"https://openalex.org/F4320308295","funder_display_name":"Leukemia and Lymphoma Society"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320320118","display_name":"Canadian Cancer Society","ror":"https://ror.org/017343w90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1642873092","https://openalex.org/W1647507681","https://openalex.org/W1922412259","https://openalex.org/W1964444828","https://openalex.org/W1969464492","https://openalex.org/W1981137720","https://openalex.org/W1990453662","https://openalex.org/W1991817150","https://openalex.org/W1995945086","https://openalex.org/W1999191024","https://openalex.org/W2004191344","https://openalex.org/W2007765039","https://openalex.org/W2014144836","https://openalex.org/W2014751400","https://openalex.org/W2017936518","https://openalex.org/W2022881751","https://openalex.org/W2023283620","https://openalex.org/W2028069487","https://openalex.org/W2033172239","https://openalex.org/W2033548186","https://openalex.org/W2035953198","https://openalex.org/W2039500930","https://openalex.org/W2048547214","https://openalex.org/W2050752215","https://openalex.org/W2055670125","https://openalex.org/W2061864121","https://openalex.org/W2069773259","https://openalex.org/W2076438776","https://openalex.org/W2077994554","https://openalex.org/W2097172614","https://openalex.org/W2105400883","https://openalex.org/W2112818491","https://openalex.org/W2113664558","https://openalex.org/W2117269475","https://openalex.org/W2120028488","https://openalex.org/W2125395855","https://openalex.org/W2130830673","https://openalex.org/W2145231631","https://openalex.org/W2159738043","https://openalex.org/W2162256896","https://openalex.org/W2165635676","https://openalex.org/W2165813814","https://openalex.org/W2168459600","https://openalex.org/W2172283401","https://openalex.org/W2253944138","https://openalex.org/W2260702256","https://openalex.org/W2288029921","https://openalex.org/W2298503769","https://openalex.org/W2521461373","https://openalex.org/W4231346141"],"related_works":["https://openalex.org/W2578427280","https://openalex.org/W2397071140","https://openalex.org/W2317886629","https://openalex.org/W2300532045","https://openalex.org/W2033172239","https://openalex.org/W4410258234","https://openalex.org/W7148630607","https://openalex.org/W6989847122","https://openalex.org/W3095419444","https://openalex.org/W4393280322"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"To":[2],"explore":[3],"the":[4,104,181,200],"potential":[5],"of":[6,34,67,90,144,160,183,202,234,242],"ex":[7],"vivo":[8],"expanded":[9,38],"healthy":[10,35,62,84,216],"donor\u2013derived":[11,63,217],"allogeneic":[12,117,218],"CD4":[13],"and":[14,39,43,54,61,75,101,131,146,171,199,209,229,237],"CD8":[15],"double-negative":[16],"cells":[17,124,185],"(DNT)":[18],"as":[19,220],"a":[20,87,112,221],"novel":[21],"cellular":[22],"immunotherapy":[23],"for":[24],"leukemia":[25,105],"patients.":[26],"Experimental":[27],"Design:":[28],"Clinical-grade":[29],"DNTs":[30,82,118,140,163,219],"from":[31,83],"peripheral":[32],"blood":[33],"donors":[36,85],"were":[37,45],"their":[40],"antileukemic":[41],"activity":[42],"safety":[44],"examined":[46],"using":[47,71],"flow":[48],"cytometry\u2013based":[49],"in":[50,99,107,111,137,239],"vitro":[51],"killing":[52],"assays":[53,74],"xenograft":[55,109],"models":[56,110],"against":[57],"AML":[58,92,156,161,176,184,191,228,243],"patient":[59,97],"blasts":[60],"hematopoietic":[64,123,127],"cells.":[65,157,177],"Mechanism":[66],"action":[68],"was":[69],"investigated":[70],"antibody-mediated":[72],"blocking":[73],"recombinant":[76],"protein":[77],"treatment":[78,204],"assays.":[79],"Results:":[80],"Expanded":[81],"target":[86],"majority":[88],"(36/46)":[89],"primary":[91,190],"cells,":[93,162],"including":[94,189],"9":[95],"chemotherapy-resistant":[96,227],"samples":[98,192],"vitro,":[100],"significantly":[102],"reduce":[103],"load":[106],"patient-derived":[108],"DNT":[113],"donor\u2013unrestricted":[114],"manner.":[115],"Importantly,":[116],"do":[119],"not":[120],"attack":[121],"normal":[122],"or":[125,133],"affect":[126],"stem/progenitor":[128],"cell":[129],"engraftment":[130],"differentiation,":[132],"cause":[134],"xenogeneic":[135],"GVHD":[136],"recipients.":[138],"Mechanistically,":[139],"express":[141],"high":[142],"levels":[143],"NKG2D":[145,170,208],"DNAM-1":[147,172],"that":[148,193],"bind":[149],"to":[150,186,197,223],"cognate":[151],"ligands":[152],"preferentially":[153],"expressed":[154],"on":[155,175],"Upon":[158],"recognition":[159],"rapidly":[164],"release":[165],"IFN\u03b3,":[166],"which":[167],"further":[168],"increases":[169],"ligands\u2019":[173],"expression":[174],"IFN\u03b3":[178,203,238],"pretreatment":[179],"enhances":[180],"susceptibility":[182],"DNT-mediated":[187],"cytotoxicity,":[188],"are":[194],"otherwise":[195],"resistant":[196],"DNTs,":[198],"effect":[201],"is":[205],"abrogated":[206],"by":[207,244],"DNAM-1\u2013blocking":[210],"antibodies.":[211],"Conclusions:":[212],"This":[213],"study":[214],"supports":[215],"therapy":[222],"treat":[224],"patients":[225],"with":[226],"also":[230],"reveals":[231],"interrelated":[232],"roles":[233],"NKG2D,":[235],"DNAM-1,":[236],"selective":[240],"targeting":[241],"DNTs.":[245],"Clin":[246],"Cancer":[247],"Res;":[248],"24(2);":[249],"370\u201382.":[250],"\u00a92017":[251],"AACR.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-11-10T00:00:00"}
