{"id":"https://openalex.org/W2767052081","doi":null,"title":"Os efeitos antidepressivos da ayahuasca, suas bases neurais e rela\u00e7\u00e3o com a experi\u00eancia psicod\u00e9lica","display_name":"Os efeitos antidepressivos da ayahuasca, suas bases neurais e rela\u00e7\u00e3o com a experi\u00eancia psicod\u00e9lica","publication_year":2017,"publication_date":"2017-07-28","ids":{"openalex":"https://openalex.org/W2767052081","mag":"2767052081"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3342224","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/jspui/handle/123456789/24156","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFRN","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.ufrn.br/jspui/handle/123456789/24156","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000955196","display_name":"Fernanda Palhano-Fontes","orcid":"https://orcid.org/0000-0002-1612-6703","observed_orcids":["https://orcid.org/0000-0002-1612-6703"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fernanda Palhano Xavier de Fontes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000955196"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ayahuasca","display_name":"ayahuasca","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.984000027179718},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.8539999723434448},{"id":"https://openalex.org/keywords/psychedelic-therapy","display_name":"psychedelic therapy","score":0.4339999854564667},{"id":"https://openalex.org/keywords/n-n-dimethyltryptamine","display_name":"N,N-dimethyltryptamine","score":0.828000009059906},{"id":"https://openalex.org/keywords/harmane","display_name":"harmane","score":0.4580000042915344},{"id":"https://openalex.org/keywords/harmine","display_name":"harmine","score":0.7689999938011169},{"id":"https://openalex.org/keywords/harmaline","display_name":"harmaline","score":0.7739999890327454},{"id":"https://openalex.org/keywords/monoamine-oxidase-a-inhibitors","display_name":"monoamine oxidase A inhibitors","score":0.6779999732971191},{"id":"https://openalex.org/keywords/serotonergic-receptors","display_name":"serotonergic receptors","score":0.6570000052452087},{"id":"https://openalex.org/keywords/sigma-1-receptor","display_name":"sigma-1 receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.6869999766349792},{"id":"https://openalex.org/keywords/fmri","display_name":"functional MRI","score":0.5669999718666077},{"id":"https://openalex.org/keywords/neural-correlates","display_name":"neural correlates","score":0.5199999809265137},{"id":"https://openalex.org/keywords/single-dose-administration","display_name":"single-dose administration","score":0.41600000858306885},{"id":"https://openalex.org/keywords/amazonian-traditional-medicine","display_name":"Amazonian traditional medicine","score":0.42899999022483826},{"id":"https://openalex.org/keywords/psilocybin","display_name":"psilocybin","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.514214038848877},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41733455657958984},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.37388119101524353},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.13704857230186462}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:3342224","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/jspui/handle/123456789/24156","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFRN","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositorio.ufrn.br:123456789/24156","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/jspui/handle/123456789/24156","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2767052081","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ufrn.br/bitstream/123456789/24156/1/FernandaPalhanoXavierDeFontes_TESE.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3342224","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/jspui/handle/123456789/24156","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UFRN","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7017515955","https://openalex.org/W3101181456","https://openalex.org/W4388431292","https://openalex.org/W4221066480","https://openalex.org/W2239427196","https://openalex.org/W7080006357","https://openalex.org/W3143574083","https://openalex.org/W3214152988","https://openalex.org/W3136118965","https://openalex.org/W4311834218"],"abstract_inverted_index":{"Ensaios":[0],"cl\u00ednicos":[1,161],"recentes":[2],"t\u00eam":[3],"sugerido":[4],"o":[5,149,313,437,519,527,551],"potencial":[6],"antidepressivo":[7],"de":[8,26,41,52,111,113,115,121,143,168,186,199,217,220,237,241,265,276,292,338,344,347,370,389,393,429,439,458,477,483,486,498,529,558],"alguns":[9],"psicod\u00e9licos":[10,422,451],"seroton\u00e9rgicos,":[11],"como":[12,68],"a":[13,16,39,46,69,88,93,96,105,109,119,134,156,274,366,368,391,413,456,481,496,525,534,548,564,566],"ayahuasca":[14,19,200,283,377,382,400,406],"e":[15,55,72,95,118,206,222,227,255,267,270,297,360,419,436,492,509,550],"psilocibina.":[17],"A":[18,57,244],"\u00e9":[20,36,153,518],"uma":[21,44,89,196,218,238,530],"subst\u00e2ncia":[22,531],"utilizada":[23],"h\u00e1":[24],"centenas":[25],"anos":[27],"por":[28,101,139,229,250],"povos":[29],"ind\u00edgenas":[30],"da":[31,64,210,212,246,282,301,308,320,424,473,554],"bacia":[32],"amaz\u00f4nica.":[33],"Essa":[34],"bebida":[35],"geralmente":[37],"preparada":[38],"partir":[40],"duas":[42,251],"plantas,":[43],"contendo":[45],"triptamina":[47],"psicod\u00e9lica":[48,532],"N,Ndimetiltriptamina,":[49],"um":[50,75,169,207,261,484,489,493,559],"agonista":[51],"receptores":[53],"seroton\u00e9rgicos":[54],"sigma-1.":[56],"outra":[58],"planta":[59],"cont\u00e9m":[60],"potentes":[61],"inibidores":[62],"revers\u00edveis":[63],"monoamina":[65],"oxidase":[66],"A,":[67],"harmina,":[70],"harmalina":[71],"tetrahidroharmina.":[73],"Em":[74,539],"ensaio":[76,170,521],"cl\u00ednico":[77,171],"recente,":[78],"17":[79],"pacientes":[80,177,194,215],"com":[81,92,178,312],"depress\u00e3o":[82,179,247,535],"resistente":[83,181,536],"ao":[84,182,286,537],"tratamento":[85],"foram":[86,259,303,322,351],"submetidos":[87],"\u00fanica":[90,197],"sess\u00e3o":[91,239,275,497],"ayahuasca,":[94,309,425,474,555],"severidade":[97,245],"dos":[98,470],"sintomas":[99],"avaliados":[100,294,426],"escalas":[102,225,252],"cl\u00ednicas":[103],"para":[104,162,340,353,465,533,562],"depress\u00e3o,":[106],"nesse":[107],"caso":[108],"Escala":[110,428],"Avalia\u00e7\u00e3o":[112,430],"Depress\u00e3o":[114],"Montgomery-\u00c5sberg":[116],"(MADRS)":[117],"escala":[120],"Hamilton":[122],"(HAM-D).":[123],"Os":[124,193,299,330,446],"resultados":[125,447,542],"sugerem":[126,448],"melhora":[127],"significativa":[128],"j\u00e1":[129],"nas":[130],"primeiras":[131],"horas":[132],"ap\u00f3s":[133,273,365,495],"ingest\u00e3o,":[135],"efeito":[136,150,333],"esse":[137,145],"mantido":[138],"21":[140],"dias.":[141,243],"Apesar":[142],"promissor,":[144],"estudo":[146],"n\u00e3o":[147],"controlou":[148],"placebo,":[151],"que":[152,378,401,449,546],"alto,":[154],"chegando":[155],"alcan\u00e7ar":[157],"40%,":[158],"em":[159,175,288,310],"ensaios":[160],"depress\u00e3o.":[163,567],"Esta":[164],"tese":[165],"faz":[166],"parte":[167],"duplo-cego":[172],"randomizado":[173],"placebo-controlado":[174],"35":[176],"unipolar":[180],"tratamento.":[183,277,499,538],"Um":[184,203],"grupo":[185,307,376,399],"volunt\u00e1rios":[187],"controles":[188],"saud\u00e1veis":[189],"tamb\u00e9m":[190],"foi":[191,248,372,395],"avaliado.":[192],"receberam":[195],"dose":[198],"ou":[201],"placebo.":[202,314],"dia":[204,208,262,490,494],"antes":[205,263,491],"depois":[209],"administra\u00e7\u00e3o":[211],"subst\u00e2ncia,":[213],"os":[214,290,326,335,355,416,420],"participaram":[216],"s\u00e9rie":[219],"testes":[221],"avalia\u00e7\u00f5es,":[223],"incluindo":[224],"psicom\u00e9tricas":[226],"imagem":[228],"resson\u00e2ncia":[230],"magn\u00e9tica":[231],"funcional":[232],"(fMRI),":[233],"realizados":[234],"no":[235,306,328,375,379,398,402,461],"decurso":[236],"experimental":[240],"quatro":[242],"aferida":[249],"cl\u00ednicas:":[253],"MADRS":[254,302],"HAM-D.":[256],"As":[257,342],"avalia\u00e7\u00f5es":[258],"realizadas":[260],"(linha":[264],"base),":[266],"um,":[268],"dois":[269],"sete":[271,363],"dias":[272,358,364],"Observamos":[278,500],"efeitos":[279,417,421,450,471],"antidepressivos":[280,418,472],"significativos":[281],"quando":[284],"comparados":[285],"placebo":[287,380,403],"todos":[289],"instantes":[291],"tempo":[293],"(D1,":[295],"D2":[296],"D7).":[298],"escores":[300],"significativamente":[304,323,373],"menores":[305],"compara\u00e7\u00e3o":[311],"Da":[315],"mesma":[316],"forma,":[317],"as":[318,467],"pontua\u00e7\u00f5es":[319],"HAM-D":[321],"diferentes":[324],"entre":[325,334,415],"grupos":[327,336,356],"D7.":[329,341,462],"tamanhos":[331],"do":[332,513,515],"aumentaram":[337],"D1":[339,359],"taxas":[343,457],"resposta":[345,371,459],"(redu\u00e7\u00e3o":[346],"50%":[348],"nos":[349,357],"sintomas)":[350],"elevadas":[352],"ambos":[354],"D2.":[361],"J\u00e1":[362],"sess\u00e3o,":[367],"taxa":[369,392],"maior":[374,397],"(64%":[381],"x":[383,407],"27%":[384],"placebo).":[385,409],"Nesse":[386],"mesmo":[387],"ponto":[388],"avalia\u00e7\u00e3o,":[390],"remiss\u00e3o":[394],"marginalmente":[396],"(p<0.056,":[404],"36%":[405],"7%":[408],"Al\u00e9m":[410],"disso,":[411],"investigamos":[412],"rela\u00e7\u00e3o":[414],"agudos":[423],"pela":[427],"Alucin\u00f3gena":[431],"(HRS,":[432],"Hallucinogenic":[433],"Rating":[434],"Scale)":[435],"Question\u00e1rio":[438],"Experi\u00eancia":[440],"M\u00edstica":[441],"(MEQ30,":[442],"Mystical":[443],"Experience":[444],"Questionnaire).":[445],"mais":[452],"intensos":[453],"est\u00e3o":[454],"correlacionados":[455],"maiores":[460],"Por":[463],"fim,":[464],"investigar":[466],"bases":[468],"neurais":[469],"utilizamos":[475],"dados":[476],"fMRI":[478],"adquiridos":[479],"durante":[480],"realiza\u00e7\u00e3o":[482],"protocolo":[485],"regula\u00e7\u00e3o":[487],"emocional":[488],"mudan\u00e7as":[501],"na":[502,510],"am\u00edgdala,":[503],"\u00ednsula":[504],"anterior,":[505],"c\u00f3rtex":[506],"pr\u00e9-frontal":[507],"ventrolateral":[508],"por\u00e7\u00e3o":[511],"subgenual":[512],"giro":[514],"c\u00edngulo.":[516],"Este":[517],"primeiro":[520],"cl\u00ednico,":[522],"duplocego,":[523],"controlado,":[524],"testar":[526],"uso":[528],"conjunto,":[540],"nossos":[541],"trazem":[543],"novas":[544],"evid\u00eancias":[545],"apoiam":[547],"seguran\u00e7a":[549],"valor":[552],"terap\u00eautico":[553],"administrada":[556],"dentro":[557],"cen\u00e1rio":[560],"apropriado,":[561],"ajudar":[563],"tratar":[565]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-11-10T00:00:00"}
