{"id":"https://openalex.org/W2766547381","doi":"https://doi.org/10.1021/acs.analchem.7b03026","title":"Integrated Bottom-Up and Top-Down Liquid Chromatography\u2013Mass Spectrometry for Characterization of Recombinant Human Growth Hormone Degradation Products","display_name":"Integrated Bottom-Up and Top-Down Liquid Chromatography\u2013Mass Spectrometry for Characterization of Recombinant Human Growth Hormone Degradation Products","publication_year":2017,"publication_date":"2017-11-03","ids":{"openalex":"https://openalex.org/W2766547381","doi":"https://doi.org/10.1021/acs.analchem.7b03026","mag":"2766547381","pmid":"https://pubmed.ncbi.nlm.nih.gov/29096433"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.7b03026","doi":"https://doi.org/10.1021/acs.analchem.7b03026","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.7b03026","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089288680","display_name":"Annie Yu Wang","orcid":"https://orcid.org/0000-0001-6872-6375","observed_orcids":["https://orcid.org/0000-0001-6872-6375"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Annie Wang","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":"https://orcid.org/0000-0001-6872-6375","affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101687131","display_name":"Di Wu","orcid":"https://orcid.org/0000-0002-1269-4260","observed_orcids":["https://orcid.org/0000-0002-1269-4260"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Di Wu","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027145969","display_name":"Jared R. Auclair","orcid":"https://orcid.org/0000-0002-3094-1544","observed_orcids":["https://orcid.org/0000-0002-3094-1544"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared R. Auclair","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":"https://orcid.org/0000-0002-3094-1544","affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004760366","display_name":"Joseph Peter Salisbury","orcid":"https://orcid.org/0000-0002-9448-9024","observed_orcids":["https://orcid.org/0000-0002-9448-9024"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P. Salisbury","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052080502","display_name":"Richa Sarin","orcid":"https://orcid.org/0000-0002-2953-428X","observed_orcids":["https://orcid.org/0000-0002-2953-428X"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richa Sarin","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101815860","display_name":"Yang Tang","orcid":"https://orcid.org/0000-0002-7599-9651","observed_orcids":["https://orcid.org/0000-0002-7599-9651","https://orcid.org/0000-0003-3640-8924"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Tang","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062638543","display_name":"Nicholas J. Mozdzierz","orcid":"https://orcid.org/0000-0002-2078-5883","observed_orcids":["https://orcid.org/0000-0002-2078-5883"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Mozdzierz","raw_affiliation_strings":["Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065730083","display_name":"Kartik Shah","orcid":"https://orcid.org/0000-0002-7826-3105","observed_orcids":["https://orcid.org/0000-0002-7826-3105"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kartik Shah","raw_affiliation_strings":["Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001642474","display_name":"Anna Fan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Fan Zhang","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038728411","display_name":"Shiaw\u2010Lin Wu","orcid":"https://orcid.org/0000-0001-5131-9298","observed_orcids":["https://orcid.org/0000-0001-5131-9298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiaw-lin Wu","raw_affiliation_strings":["BioAnalytix Inc., 790 Memorial Drive, Cambridge, Massachusetts 02139, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioAnalytix Inc., 790 Memorial Drive, Cambridge, Massachusetts 02139, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052079094","display_name":"Jeffrey N. Agar","orcid":"https://orcid.org/0000-0003-2645-1873","observed_orcids":["https://orcid.org/0000-0003-2645-1873"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery N. Agar","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":"https://orcid.org/0000-0003-2645-1873","affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001076999","display_name":"John Christopher Love","orcid":"https://orcid.org/0000-0003-0921-3144","observed_orcids":["https://orcid.org/0000-0003-0921-3144"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Christopher Love","raw_affiliation_strings":["Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032296327","display_name":"Kerry Routenberg Love","orcid":"https://orcid.org/0000-0003-1840-3820","observed_orcids":["https://orcid.org/0000-0003-1840-3820"]},"institutions":[{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kerry R. Love","raw_affiliation_strings":["Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koch\rInstitute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008968439","display_name":"William S. Hancock","orcid":"https://orcid.org/0009-0004-0666-5879","observed_orcids":["https://orcid.org/0009-0004-0666-5879"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William S. Hancock","raw_affiliation_strings":["Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barnett\rInstitute and Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008968439"],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3564,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.5668388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"89","issue":"23","first_page":"12771","last_page":"12777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.2969000041484833,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.18809999525547028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-human-growth-hormone","display_name":"recombinant human growth hormone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/degradation-products","display_name":"degradation products","score":0.9039999842643738},{"id":"https://openalex.org/keywords/top-down-proteomics","display_name":"top-down proteomics","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bottom-up-proteomics","display_name":"shotgun proteomics","score":0.996999979019165},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8679999709129333},{"id":"https://openalex.org/keywords/oxidation","display_name":"oxidation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/deamidation","display_name":"deamidation","score":1.0},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.9929999709129333},{"id":"https://openalex.org/keywords/komagataella-phaffii","display_name":"Pichia pastoris","score":0.8539999723434448},{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.8399999737739563},{"id":"https://openalex.org/keywords/biopharmaceutical-quality-control","display_name":"biopharmaceutical quality control","score":0.8109999895095825},{"id":"https://openalex.org/keywords/continuous-bioprocessing","display_name":"continuous bioprocessing","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8204011917114258},{"id":"https://openalex.org/C2780784506","wikidata":"https://www.wikidata.org/wiki/Q4859711","display_name":"Deamidation","level":3,"score":0.7417383193969727},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4979217052459717},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4913010001182556},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.47508493065834045},{"id":"https://openalex.org/C2994100043","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Human growth hormone","level":4,"score":0.42534738779067993},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.4187985956668854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3356478810310364},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.21132507920265198},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20754468441009521},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1370725929737091},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10130038857460022},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059451","descriptor_name":"Biosimilar Pharmaceuticals","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D059451","descriptor_name":"Biosimilar Pharmaceuticals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.7b03026","doi":"https://doi.org/10.1021/acs.analchem.7b03026","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.7b03026","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:29096433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29096433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1974035050","display_name":null,"funder_award_id":"N66001\u201313\u2010C\u20104025","funder_id":"https://openalex.org/F4320337532","funder_display_name":"Space and Naval Warfare Systems Command"},{"id":"https://openalex.org/G3936045998","display_name":null,"funder_award_id":"N66001\u2010 13\u2010C\u20104025","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"}],"funders":[{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320337532","display_name":"Space and Naval Warfare Systems Command","ror":"https://ror.org/000ztjy10"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1530371703","https://openalex.org/W1589725141","https://openalex.org/W1699915580","https://openalex.org/W1972249283","https://openalex.org/W1976520273","https://openalex.org/W1978186633","https://openalex.org/W1997290803","https://openalex.org/W1998530305","https://openalex.org/W2003832326","https://openalex.org/W2028904839","https://openalex.org/W2049324939","https://openalex.org/W2073795625","https://openalex.org/W2078612085","https://openalex.org/W2090640604","https://openalex.org/W2111979014","https://openalex.org/W2142004497","https://openalex.org/W2143418321","https://openalex.org/W2228771684","https://openalex.org/W2338567558","https://openalex.org/W2339124487","https://openalex.org/W2475920490","https://openalex.org/W2591162147"],"related_works":["https://openalex.org/W2011794560","https://openalex.org/W2084378278","https://openalex.org/W2794490249","https://openalex.org/W3137268800","https://openalex.org/W1982446250","https://openalex.org/W2004185819","https://openalex.org/W1606868849","https://openalex.org/W2119425965","https://openalex.org/W152909406","https://openalex.org/W2050488655"],"abstract_inverted_index":{"With":[0],"the":[1,6,27,39,74,89,92,95,112,122,129,135,144,147,156,178,216,225],"advent":[2],"of":[3,30,37,59,73,91,105,111,134,146,158,170,181,218,227,231,236],"biosimilars":[4],"to":[5,12,17,23,177,191,214],"U.S.":[7],"market,":[8],"it":[9],"is":[10,50,64,173],"important":[11],"have":[13],"better":[14],"analytical":[15],"tools":[16],"ensure":[18],"product":[19,45,232],"quality":[20,48],"from":[21,119,241],"batch":[22],"batch.":[24],"In":[25],"addition,":[26],"recent":[28],"popularity":[29],"using":[31],"a":[32,98,102,150,174,228],"continuous":[33],"process":[34],"for":[35,44,61,109,155],"production":[36],"biopharmaceuticals,":[38],"traditional":[40],"bottom-up":[41,153,221],"method,":[42,154],"alone":[43],"characterization":[46,157,226],"and":[47,63,66,84,107,116,131,152,202,207,220],"analysis":[49,62,110],"no":[51],"longer":[52],"sufficient.":[53],"Bottom-up":[54],"method":[55,100],"requires":[56,101],"large":[57],"amounts":[58,169],"material":[60],"labor-intensive":[65],"time-consuming.":[67],"Additionally,":[68],"in":[69,234],"this":[70,186],"analysis,":[71],"digestion":[72],"protein":[75,114,136,194],"with":[76,137],"enzymes":[77],"such":[78,199],"as":[79,200],"trypsin":[80],"could":[81],"induce":[82],"artifacts":[83],"modifications":[85,198],"which":[86,172,223],"would":[87],"increase":[88],"complexity":[90],"analysis.":[93],"On":[94],"other":[96],"hand,":[97],"top-down":[99,151,219],"minimum":[103],"amount":[104],"sample":[106,179],"allows":[108],"intact":[113],"mass":[115],"sequence":[117],"generated":[118],"fragmentation":[120,125],"within":[121],"instrument.":[123],"However,":[124],"usually":[126],"occurs":[127],"at":[128],"N-terminal":[130],"C-terminal":[132],"ends":[133],"less":[138],"internal":[139],"fragmentation.":[140],"Herein,":[141],"we":[142,188,211],"combine":[143],"use":[145],"complementary":[148],"techniques,":[149],"human":[159,237],"growth":[160,238],"hormone":[161,239],"degradation":[162],"products.":[163],"Notably,":[164],"our":[165],"approach":[166],"required":[167],"small":[168,182],"sample,":[171],"requirement":[175],"due":[176],"constraints":[180],"scale":[183],"manufacturing.":[184],"Using":[185],"approach,":[187],"were":[189,212],"able":[190,213],"characterize":[192],"various":[193],"variants,":[195],"including":[196],"post-translational":[197],"oxidation":[201],"deamidation,":[203],"residual":[204],"leader":[205],"sequence,":[206],"proteolytic":[208],"cleavage.":[209],"Thus,":[210],"highlight":[215],"complementarity":[217],"approaches,":[222],"achieved":[224],"wide":[229],"range":[230],"variants":[233],"samples":[235],"secreted":[240],"Pichia":[242],"pastoris.":[243]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-11-10T00:00:00"}
