{"id":"https://openalex.org/W2766092986","doi":null,"title":"Aging and the Plasma Metabolome: Relation to Physiological Function","display_name":"Aging and the Plasma Metabolome: Relation to Physiological Function","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2766092986","mag":"2766092986"},"language":"en","primary_location":{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1061","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/60","pdf_url":"https://scholar.colorado.edu/iphy_gradetds/60","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholar.colorado.edu/iphy_gradetds/60","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042771710","display_name":"Lawrence Cody Johnson","orcid":"https://orcid.org/0000-0001-8547-072X","observed_orcids":["https://orcid.org/0000-0001-8547-072X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lawrence C. Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042771710"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14141639,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9399999976158142},{"id":"https://openalex.org/keywords/plasma-metabolome","display_name":"plasma metabolome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/physiological-decline","display_name":"physiological decline","score":0.5830000042915344},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.6650000214576721},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7609999775886536},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":1.0},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.6890000104904175},{"id":"https://openalex.org/keywords/blood-based-biomarkers","display_name":"blood-based biomarkers","score":0.699999988079071},{"id":"https://openalex.org/keywords/healthy-aging","display_name":"healthy aging","score":0.6679999828338623},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.5180000066757202},{"id":"https://openalex.org/keywords/metabolic-signaling","display_name":"metabolic signaling","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7063910365104675},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.5430989861488342},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5175628066062927},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35901230573654175},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31734031438827515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25060516595840454},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19538411498069763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18509182333946228},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.15583744645118713},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.15066954493522644}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1061","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/60","pdf_url":"https://scholar.colorado.edu/iphy_gradetds/60","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},{"id":"pmh:oai:cuscholar:7p88cg57g","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/7p88cg57g","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:oai:cuscholar:br86b3677","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/br86b3677","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1086","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/85","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},{"id":"mag:2766092986","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/85/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1061","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/60","pdf_url":"https://scholar.colorado.edu/iphy_gradetds/60","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1457936996","display_name":"Clinical Translation of Curcumin Therapy to Treat Arterial Aging","funder_award_id":"R21AG042795","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3733990746","display_name":null,"funder_award_id":"UL1TR001082","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G5853261428","display_name":"Colorado Clinical and Translational Sciences Institute","funder_award_id":"UL1TR001082","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8427820148","display_name":"Mayo Clinic Metabolomics Resource Core","funder_award_id":"U24DK100469","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2766092986.pdf","grobid_xml":"https://content.openalex.org/works/W2766092986.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1496582607","https://openalex.org/W1498875373","https://openalex.org/W1541101804","https://openalex.org/W1583921993","https://openalex.org/W1608393181","https://openalex.org/W1960796618","https://openalex.org/W1965743301","https://openalex.org/W1966327575","https://openalex.org/W1969158591","https://openalex.org/W1971296725","https://openalex.org/W1972868637","https://openalex.org/W1973744659","https://openalex.org/W1974047233","https://openalex.org/W1974777883","https://openalex.org/W1985058290","https://openalex.org/W1986760556","https://openalex.org/W1989674299","https://openalex.org/W1993355054","https://openalex.org/W1994581503","https://openalex.org/W2010337922","https://openalex.org/W2014671368","https://openalex.org/W2015080774","https://openalex.org/W2016119264","https://openalex.org/W2016752484","https://openalex.org/W2031018090","https://openalex.org/W2038503582","https://openalex.org/W2048776985","https://openalex.org/W2051771016","https://openalex.org/W2063523286","https://openalex.org/W2072130124","https://openalex.org/W2076381841","https://openalex.org/W2079195246","https://openalex.org/W2082952138","https://openalex.org/W2084703853","https://openalex.org/W2086893498","https://openalex.org/W2096205265","https://openalex.org/W2105017519","https://openalex.org/W2105427226","https://openalex.org/W2105557181","https://openalex.org/W2106258006","https://openalex.org/W2118689874","https://openalex.org/W2121091193","https://openalex.org/W2121544545","https://openalex.org/W2126104386","https://openalex.org/W2126525177","https://openalex.org/W2129155846","https://openalex.org/W2129971447","https://openalex.org/W2132481390","https://openalex.org/W2138313909","https://openalex.org/W2138673074","https://openalex.org/W2145200932","https://openalex.org/W2153029275","https://openalex.org/W2159671087","https://openalex.org/W2159914115","https://openalex.org/W2160234571","https://openalex.org/W2160375807","https://openalex.org/W2162568242","https://openalex.org/W2166107397","https://openalex.org/W2168228291","https://openalex.org/W2168257591","https://openalex.org/W2169829560","https://openalex.org/W2171267119","https://openalex.org/W2191745121","https://openalex.org/W2192658008","https://openalex.org/W2195512150","https://openalex.org/W2277846589","https://openalex.org/W2278341454","https://openalex.org/W2284984697","https://openalex.org/W2287045594","https://openalex.org/W2293782839","https://openalex.org/W2296761075","https://openalex.org/W2323202746","https://openalex.org/W2507936136","https://openalex.org/W2520222164","https://openalex.org/W2555189237","https://openalex.org/W2559588208","https://openalex.org/W2564295209","https://openalex.org/W2568684118","https://openalex.org/W2576174750","https://openalex.org/W2587940603"],"related_works":["https://openalex.org/W2983588999","https://openalex.org/W2807745308","https://openalex.org/W4378907182","https://openalex.org/W4417076979","https://openalex.org/W4225389400","https://openalex.org/W7221802247","https://openalex.org/W3145682598","https://openalex.org/W2994725613","https://openalex.org/W4381716300","https://openalex.org/W4293585862"],"abstract_inverted_index":{"Advancing":[0],"age":[1,195,210,245],"is":[2,23,32],"associated":[3,225],"with":[4,119,137,243],"declines":[5,102,282],"across":[6],"numerous":[7,155,200],"physiological":[8,29,42,55,83,101,175,203,249,281],"systems,":[9],"leading":[10],"to":[11,46,66,80,92,154,167,181,214,239,248],"an":[12],"increased":[13],"risk":[14],"of":[15,41,88,107,124,159,173,184,191,205,231,279],"chronic":[16],"disease":[17],"and":[18,99,111,130,139,202,218,227],"disability.":[19],"Whereas":[20],"aging":[21],"itself":[22],"inevitable,":[24],"the":[25,39,51,63,86,94,170,240],"rate":[26],"at":[27],"which":[28],"impairments":[30,56],"occur":[31],"highly":[33],"variable":[34],"among":[35],"individuals.":[36],"Differences":[37],"in":[38,71,76,82,103,116,148,162,251,283],"trajectory":[40],"decline":[43],"are":[44,57,246],"due":[45],"complex":[47],"biological":[48,185,194,209,232],"processes;":[49],"however,":[50],"molecular":[52,69,171],"mechanisms":[53],"underlying":[54],"not":[58,257],"well":[59],"understood.":[60],"Metabolomics":[61],"provides":[62],"unique":[64],"opportunity":[65],"investigate":[67,169],"systemic":[68],"changes":[70,81,115,147,238],"vivo":[72],"by":[73,198],"capturing":[74],"perturbations":[75],"metabolic":[77],"signaling":[78],"linked":[79],"function.":[84],"Therefore,":[85],"purpose":[87],"this":[89],"dissertation":[90],"was":[91,196,211],"determine":[93],"relation":[95],"between":[96],"metabolomic":[97,117,141,216],"signatures":[98,118,222],"age-associated":[100,174,280],"humans.\\nGlobal":[104],"metabolomics":[105,177],"profiling":[106],"plasma":[108,215,241],"from":[109],"young":[110],"older":[112,192,252],"adults":[113],"demonstrated":[114],"advancing":[120,244],"age.":[121],"Pathway":[122],"analysis":[123],"altered":[125],"metabolites":[126],"identified":[127],"amino":[128],"acid":[129],"lipid":[131],"metabolism":[132],"as":[133],"primary":[134],"pathways":[135,263],"modified":[136],"age,":[138],"targeted":[140],"approaches":[142],"confirmed":[143],"these":[144,219,234,255],"differences.":[145],"Furthermore,":[146],"small":[149,220],"molecule":[150,221],"profiles":[151],"were":[152,179,223],"related":[153,213,247],"clinically":[156],"relevant":[157],"indicators":[158],"human":[160,206],"healthspan.\\nAdditionally,":[161],"a":[163,182,188],"systems":[164],"biology":[165],"approach":[166],"further":[168],"underpinnings":[172],"declines,":[176],"analyses":[178],"applied":[180],"model":[183],"aging.":[186],"In":[187],"longitudinal":[189],"study":[190],"adults,":[193],"quantified":[197],"integrating":[199],"clinical":[201],"measures":[204],"health.":[207],"Importantly,":[208],"significantly":[212],"profiles,":[217],"also":[224,271],"with,":[226],"predictive":[228],"of,":[229],"rates":[230],"aging.\\nCollectively,":[233],"studies":[235],"indicate":[236],"that":[237,264],"metabolome":[242],"dysfunction":[250],"adults.":[253],"Moreover,":[254],"findings":[256],"only":[258],"present":[259],"valuable":[260],"insight":[261],"into":[262],"may":[265],"modulate":[266],"healthy":[267],"aging,":[268],"our":[269],"results":[270],"provide":[272],"evidence":[273],"for":[274],"easily":[275],"accessible":[276],"blood-based":[277],"markers":[278],"humans.":[284]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2017-11-10T00:00:00"}
