{"id":"https://openalex.org/W2765822397","doi":"https://doi.org/10.1111/aos.13581","title":"Randomized controlled trial of electro\u2010stimulation therapies to modulate retinal blood flow and visual function in retinitis pigmentosa","display_name":"Randomized controlled trial of electro\u2010stimulation therapies to modulate retinal blood flow and visual function in retinitis pigmentosa","publication_year":2017,"publication_date":"2017-11-11","ids":{"openalex":"https://openalex.org/W2765822397","doi":"https://doi.org/10.1111/aos.13581","mag":"2765822397","pmid":"https://pubmed.ncbi.nlm.nih.gov/29130647","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5920686"},"language":"en","primary_location":{"id":"doi:10.1111/aos.13581","doi":"https://doi.org/10.1111/aos.13581","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.13581","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5920686","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058421098","display_name":"Ava Katherine Bittner","orcid":"https://orcid.org/0000-0002-9498-2230","observed_orcids":["https://orcid.org/0000-0002-9498-2230"]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ava K. Bittner","raw_affiliation_strings":["College of Optometry Nova Southeastern University Fort Lauderdale FL USA","College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-9498-2230","affiliations":[{"raw_affiliation_string":"College of Optometry Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013227503","display_name":"Kenneth R. Seger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Seger","raw_affiliation_strings":["College of Optometry Nova Southeastern University Fort Lauderdale FL USA","College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Optometry Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001742056","display_name":"Rachel M Salveson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Salveson","raw_affiliation_strings":["College of Osteopathic Medicine Nova Southeastern University Fort Lauderdale FL USA","College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Osteopathic Medicine Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109443882","display_name":"Samantha Kayser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Kayser","raw_affiliation_strings":["College of Optometry Nova Southeastern University Fort Lauderdale FL USA","College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Optometry Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014885526","display_name":"Natalia Morrison","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Morrison","raw_affiliation_strings":["Healing Blossom \u2013 Acupuncture and Holistic Medicine Miami FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Healing Blossom \u2013 Acupuncture and Holistic Medicine Miami FL USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091535666","display_name":"Patricia Vargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Vargas","raw_affiliation_strings":["Medical Sonography Program College of Health Care Sciences Nova Southeastern University Fort Lauderdale FL USA","Medical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Sonography Program College of Health Care Sciences Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"Medical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000483671","display_name":"Deborah Mendelsohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Mendelsohn","raw_affiliation_strings":["Medical Sonography Program College of Health Care Sciences Nova Southeastern University Fort Lauderdale FL USA","Medical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Sonography Program College of Health Care Sciences Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"Medical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041588749","display_name":"Jorge Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Han","raw_affiliation_strings":["Medical Sonography Program College of Health Care Sciences Nova Southeastern University Fort Lauderdale FL USA","Medical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Sonography Program College of Health Care Sciences Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"Medical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100537912","display_name":"Hua Bi","orcid":"https://orcid.org/0000-0003-0456-3575","observed_orcids":["https://orcid.org/0000-0003-0456-3575"]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Bi","raw_affiliation_strings":["College of Optometry Nova Southeastern University Fort Lauderdale FL USA","College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Optometry Nova Southeastern University Fort Lauderdale FL USA","institution_ids":["https://openalex.org/I203088144"]},{"raw_affiliation_string":"College of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044910336","display_name":"Gislin Dagnelie","orcid":"https://orcid.org/0000-0001-6707-9735","observed_orcids":["https://orcid.org/0000-0001-6707-9735"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gislin Dagnelie","raw_affiliation_strings":["Johns Hopkins Wilmer Eye Institute Baltimore MD USA","Johns Hopkins Wilmer Eye Institute, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Wilmer Eye Institute Baltimore MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Johns Hopkins Wilmer Eye Institute, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066060589","display_name":"Alexandra Benavente-P\u00e9rez","orcid":"https://orcid.org/0000-0002-2385-9032","observed_orcids":["https://orcid.org/0000-0002-2385-9032"]},"institutions":[{"id":"https://openalex.org/I87377408","display_name":"SUNY College of Optometry","ror":"https://ror.org/02v9m6h26","country_code":"US","type":"education","lineage":["https://openalex.org/I87377408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Benavente","raw_affiliation_strings":["SUNY College of Optometry New York NY USA","SUNY College of Optometry, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY College of Optometry New York NY USA","institution_ids":["https://openalex.org/I87377408"]},{"raw_affiliation_string":"SUNY College of Optometry, New York, NY, USA","institution_ids":["https://openalex.org/I87377408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041623984","display_name":"Jessica C. Ramella\u2010Roman","orcid":"https://orcid.org/0000-0002-5710-6004","observed_orcids":["https://orcid.org/0000-0002-5710-6004"]},"institutions":[{"id":"https://openalex.org/I19700959","display_name":"Florida International University","ror":"https://ror.org/02gz6gg07","country_code":"US","type":"education","lineage":["https://openalex.org/I19700959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Ramella\u2010Roman","raw_affiliation_strings":["Department of Biomedical Engineering Florida International University Miami FL USA","Department of Cellular Biology and Pharmacology and Ophthalmology Herbert Wertheim College of Medicine Miami FL USA","Department of Biomedical Engineering, Florida International University, Miami, FL, USA","Department of Cellular Biology and Pharmacology and Ophthalmology, Herbert Wertheim College of Medicine, Miami, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering Florida International University Miami FL USA","institution_ids":["https://openalex.org/I19700959"]},{"raw_affiliation_string":"Department of Cellular Biology and Pharmacology and Ophthalmology Herbert Wertheim College of Medicine Miami FL USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering, Florida International University, Miami, FL, USA","institution_ids":["https://openalex.org/I19700959"]},{"raw_affiliation_string":"Department of Cellular Biology and Pharmacology and Ophthalmology, Herbert Wertheim College of Medicine, Miami, FL, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058421098"],"corresponding_institution_ids":["https://openalex.org/I203088144"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":2.011,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.87109215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"96","issue":"3","first_page":"e366","last_page":"e376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":1.0},{"id":"https://openalex.org/keywords/transcorneal-electrical-stimulation","display_name":"transcorneal electrical stimulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/electroacupuncture","display_name":"electroacupuncture","score":0.9660000205039978},{"id":"https://openalex.org/keywords/retinal-blood-flow","display_name":"retinal blood flow","score":0.8960000276565552},{"id":"https://openalex.org/keywords/visual-function","display_name":"visual function","score":0.9549999833106995},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/contrast-sensitivity","display_name":"contrast sensitivity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/visual-field","display_name":"visual field","score":0.6600000262260437},{"id":"https://openalex.org/keywords/scotopic-sensitivity","display_name":"scotopic sensitivity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/colour-doppler-imaging","display_name":"colour Doppler imaging","score":0.7250000238418579},{"id":"https://openalex.org/keywords/sham-acupuncture","display_name":"sham acupuncture","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7874267101287842},{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.7578400373458862},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.7276608943939209},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6702268719673157},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.652407705783844},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5657889246940613},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5188325643539429},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5109235644340515},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.4750135838985443},{"id":"https://openalex.org/C7243750","wikidata":"https://www.wikidata.org/wiki/Q2343133","display_name":"Scotopic vision","level":3,"score":0.4345845580101013},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.41592922806739807},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2341059148311615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1499788463115692},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10501745343208313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06772255897521973},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012161","descriptor_name":"Retinal Artery","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012161","descriptor_name":"Retinal Artery","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012161","descriptor_name":"Retinal Artery","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012161","descriptor_name":"Retinal Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012161","descriptor_name":"Retinal Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012161","descriptor_name":"Retinal Artery","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014794","descriptor_name":"Visual Fields","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014794","descriptor_name":"Visual Fields","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014794","descriptor_name":"Visual Fields","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015350","descriptor_name":"Contrast Sensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015350","descriptor_name":"Contrast Sensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015350","descriptor_name":"Contrast Sensitivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018615","descriptor_name":"Ultrasonography, Doppler, Color","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018615","descriptor_name":"Ultrasonography, Doppler, Color","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018615","descriptor_name":"Ultrasonography, Doppler, Color","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/aos.13581","doi":"https://doi.org/10.1111/aos.13581","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.13581","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},{"id":"pmid:29130647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29130647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta ophthalmologica","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5920686","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5920686","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Ophthalmol","raw_type":"Text"},{"id":"pmh:oai:nsuworks.nova.edu:hpd_hs_facarticles-1165","doi":null,"is_oa":false,"landing_page_url":"https://nsuworks.nova.edu/hpd_hs_facarticles/166","pdf_url":null,"source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Health Sciences Faculty Articles","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5920686","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5920686","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Acta Ophthalmol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3610244282","display_name":"Modulating Ocular/Retinal Blood Flow and Visual Function in Retinitis Pigmentosa","funder_award_id":"R21EY023720","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W44893264","https://openalex.org/W998103276","https://openalex.org/W1578803515","https://openalex.org/W1901067568","https://openalex.org/W1965745465","https://openalex.org/W1974941078","https://openalex.org/W1979586282","https://openalex.org/W1984359455","https://openalex.org/W1988462439","https://openalex.org/W1999769433","https://openalex.org/W2008025759","https://openalex.org/W2009566839","https://openalex.org/W2011142784","https://openalex.org/W2014413421","https://openalex.org/W2015019097","https://openalex.org/W2017515548","https://openalex.org/W2026598470","https://openalex.org/W2028161619","https://openalex.org/W2032610026","https://openalex.org/W2036968044","https://openalex.org/W2050381624","https://openalex.org/W2055682921","https://openalex.org/W2059776112","https://openalex.org/W2059793432","https://openalex.org/W2061653113","https://openalex.org/W2061743336","https://openalex.org/W2066155990","https://openalex.org/W2069021198","https://openalex.org/W2074564726","https://openalex.org/W2089560508","https://openalex.org/W2103799174","https://openalex.org/W2115362439","https://openalex.org/W2123805988","https://openalex.org/W2125837678","https://openalex.org/W2127281007","https://openalex.org/W2166083778","https://openalex.org/W2316197291","https://openalex.org/W2340371639","https://openalex.org/W2342983162","https://openalex.org/W2425058220","https://openalex.org/W2508159265","https://openalex.org/W2510041981","https://openalex.org/W2521301622","https://openalex.org/W2581794159","https://openalex.org/W2756108017"],"related_works":["https://openalex.org/W2769165005","https://openalex.org/W2657285047","https://openalex.org/W6998860172","https://openalex.org/W2770876226","https://openalex.org/W2625625186","https://openalex.org/W2578752751","https://openalex.org/W3032833803","https://openalex.org/W2008025759","https://openalex.org/W7000196068","https://openalex.org/W2966372822"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1,113],"examined":[2],"changes":[3],"in":[4,19,92,118,164,166,199,267,273],"visual":[5,65,73,207,241,270],"function":[6,208,271],"and":[7,9,80,90,106,131,153,159,230],"ocular":[8],"retinal":[10,87],"blood":[11,255],"flow":[12,79,122,256],"(RBF)":[13],"among":[14],"retinitis":[15],"pigmentosa":[16],"(RP)":[17],"participants":[18,30],"a":[20,104,107,115,182,190,196,239],"randomized":[21,32],"controlled":[22],"trial":[23],"of":[24,60,84,142,184,202,219,225,232,244],"electro-stimulation":[25,258],"therapies.":[26],"METHODS:":[27],"Twenty-one":[28],"RP":[29,275],"were":[31,95],"(1:1:1)":[33],"to":[34,146,172,269],"transcorneal":[35],"electrical":[36,150],"stimulation":[37],"(TES)":[38,152],"at":[39,51,248],"6":[40],"weekly":[41],"half-hour":[42,53],"sessions,":[43,102],"electro-acupuncture":[44,132,154,227],"or":[45,189],"inactive":[46],"laser":[47],"acupuncture":[48],"(sham":[49],"control)":[50],"10":[52],"sessions":[54,188],"over":[55],"2":[56,100,140],"weeks.":[57],"Early":[58],"Treatment":[59],"Diabetic":[61],"Retinopathy":[62],"Study":[63],"(ETDRS)":[64],"acuity":[66],"(VA),":[67],"quick":[68],"contrast":[69],"sensitivity":[70],"function,":[71],"Goldmann":[72],"fields,":[74],"AdaptDx":[75],"scotopic":[76],"sensitivity,":[77],"spectral":[78],"colour":[81],"Doppler":[82],"imaging":[83],"the":[85,126,167,200,211,233],"central":[86],"artery":[88],"(CRA),":[89],"RBF":[91,165],"macular":[93,168],"capillaries":[94],"measured":[96,114],"twice":[97],"pre-treatment,":[98],"after":[99,109,139,192],"TES":[101,127,187,221],"within":[103,181],"week":[105,183],"month":[108,191],"intervention":[110,213],"completion.":[111],"RESULTS:":[112],"significant":[116,157,197,240],"improvement":[117,242],"retrobulbar":[119],"CRA":[120],"mean":[121],"velocity":[123],"for":[124],"both":[125],"(p":[128,134,175,215],"=":[129,135,179,216],"0.038)":[130],"groups":[133,214],"0.001)":[136],"on":[137],"average":[138],"weeks":[141],"treatment":[143],"when":[144,170,209],"compared":[145,171],"sham":[147,173],"controls.":[148],"Transcorneal":[149],"simulation":[151],"subjects":[155,222,228,236],"had":[156,205,238],"55%":[158],"34%":[160],"greater":[161],"increases,":[162],"respectively,":[163],"vessels":[169],"controls":[174],"<":[176],"0.001;":[177],"p":[178],"0.008)":[180],"completing":[185],"six":[186],"electro-acupuncture.":[193],"There":[194],"was":[195],"difference":[198],"proportion":[201],"eyes":[203],"that":[204,265],"improved":[206],"comparing":[210],"three":[212],"0.038):":[217],"four":[218],"seven":[220,226,234],"(57%),":[223],"two":[224,249],"(29%)":[229],"none":[231],"control":[235],"(0%)":[237],"outside":[243],"typical":[245],"test-retest":[246],"variability":[247],"consecutive":[250],"post-treatment":[251],"visits.":[252],"CONCLUSION:":[253],"Increased":[254],"following":[257],"therapies":[259],"is":[260],"an":[261],"objective,":[262],"physiological":[263],"change":[264],"occurred":[266],"addition":[268],"improvements":[272],"some":[274],"patients.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2017-11-10T00:00:00"}