{"id":"https://openalex.org/W2765746249","doi":"https://doi.org/10.1016/j.jalz.2017.07.214","title":"[O2\u201312\u201305]: CUMULATIVE EXPOSURE TO ELEVATED BLOOD PRESSURE THROUGHOUT ADULTHOOD AND LATE\u2010LIFE DEMENTIA RISK","display_name":"[O2\u201312\u201305]: CUMULATIVE EXPOSURE TO ELEVATED BLOOD PRESSURE THROUGHOUT ADULTHOOD AND LATE\u2010LIFE DEMENTIA RISK","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2765746249","doi":"https://doi.org/10.1016/j.jalz.2017.07.214","mag":"2765746249"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2017.07.214","doi":"https://doi.org/10.1016/j.jalz.2017.07.214","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.07.214","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.07.214","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.07.214","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018360070","display_name":"Elizabeth Rose Mayeda","orcid":"https://orcid.org/0000-0002-6326-0163","observed_orcids":["https://orcid.org/0000-0002-6326-0163"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth Rose Mayeda","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA","University of California, Davis, Sacramento, CA, USA","University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]},{"raw_affiliation_string":"University of California, Davis, Sacramento, CA, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004781553","display_name":"M. Maria Glymour","orcid":"https://orcid.org/0000-0001-9644-3081","observed_orcids":["https://orcid.org/0000-0001-9644-3081"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Glymour","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047272145","display_name":"Dan Mungas","orcid":"https://orcid.org/0000-0003-2035-7085","observed_orcids":["https://orcid.org/0000-0003-2035-7085"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Mungas","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087266700","display_name":"Paola Gilsanz","orcid":"https://orcid.org/0000-0002-7635-381X","observed_orcids":["https://orcid.org/0000-0002-7635-381X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Gilsanz","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052785465","display_name":"Charles P. Quesenberry","orcid":"https://orcid.org/0000-0001-8272-9126","observed_orcids":["https://orcid.org/0000-0001-8272-9126"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles P. Quesenberry","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091019550","display_name":"Rachel A. Whitmer","orcid":"https://orcid.org/0009-0006-9511-6138","observed_orcids":["https://orcid.org/0009-0006-9511-6138"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Whitmer","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018360070"],"corresponding_institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I84218800"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20870761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7S_Part_11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.8541983962059021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7473117113113403},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.7440611124038696},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6793528199195862},{"id":"https://openalex.org/C118190526","wikidata":"https://www.wikidata.org/wiki/Q7239981","display_name":"Prehypertension","level":3,"score":0.6737392544746399},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.49017032980918884},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4373587965965271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4073004722595215},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.37707486748695374},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3621726632118225},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2017.07.214","doi":"https://doi.org/10.1016/j.jalz.2017.07.214","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.07.214","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.07.214","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2017.07.214","doi":"https://doi.org/10.1016/j.jalz.2017.07.214","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.07.214","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.07.214","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2765746249.pdf","grobid_xml":"https://content.openalex.org/works/W2765746249.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3188663447","https://openalex.org/W2767297946","https://openalex.org/W2129684069","https://openalex.org/W2808600489","https://openalex.org/W2968003786","https://openalex.org/W2118729903","https://openalex.org/W2000781871","https://openalex.org/W2116520869","https://openalex.org/W4206452899","https://openalex.org/W4295925152"],"abstract_inverted_index":{"Hypertension,":[0],"particularly":[1,34],"in":[2,35,94,254,341],"midlife,":[3,33],"is":[4,16,72,335],"associated":[5,336],"with":[6,62,138,155,193,197,337],"increased":[7,286,305],"dementia":[8,64,113,195,251,273,284,303,339],"risk.":[9],"Cumulative":[10,125,326],"exposure":[11,27,51,126,229,238,281,300,315,327],"to":[12,24,28,45,52,127,164,230,239,282,301,316,328],"elevated":[13,29,53,128,317,329],"blood":[14,30,55,130,147,178,186,319,331],"pressure":[15,31,56,105,131,148,179,187,212,320,332],"likely":[17],"relevant,":[18],"but":[19],"few":[20],"studies":[21],"have":[22],"data":[23],"estimate":[25],"cumulative":[26,50,173,228,237,280,299,314],"throughout":[32,333],"ethnically":[36,343],"diverse":[37,344],"populations.":[38],"The":[39,311],"objective":[40],"of":[41,49,76,100,175,217,250,265,268,279,298],"this":[42],"study":[43,75],"was":[44,106,115,136,213,232,241,256],"examine":[46],"the":[47,141,158,170,248],"association":[48,171,312],"systolic":[54,129,146,318,330],"between":[57,172,189,222,313],"ages":[58,92,133,190,225],"30":[59],"and":[60,68,80,96,160,183,209],"50":[61],"late-life":[63,194,338],"risk":[65,285,304,340],"among":[66],"black":[67,78],"white":[69,81],"Americans.":[70],"This":[71],"a":[73,263],"cohort":[74],"n=6,168":[77],"(35%)":[79],"(65%)":[82],"Kaiser":[83],"Permanente":[84],"Northern":[85],"California":[86],"health":[87],"plan":[88],"members":[89,98],"who":[90],"were":[91,271],"30\u201335":[93],"1964\u20131973":[95],"remained":[97],"as":[99,157],"January":[101,120],"1,":[102,121],"1996.":[103],"Blood":[104,211],"measured":[107,214],"at":[108,132,247],"clinical":[109],"exams":[110],"between1964\u20131985.":[111],"Late-life":[112],"diagnosis":[114],"collected":[116],"from":[117,150],"medical":[118],"records":[119],"1996-October":[122],"15,":[123],"2015.":[124],"30\u201350":[134,191],"years":[135,174,192,258,267,278,297],"estimated":[137,227,236],"\u201carea":[139],"under":[140],"curve\u201d":[142],"for":[143,166,203],"each":[144],"person's":[145],"trajectory":[149],"linear":[151],"mixed":[152],"effects":[153],"models":[154,201],"age":[156,204,246],"timescale":[159],"restricted":[161],"cubic":[162],"splines":[163],"account":[165],"nonlinearities.":[167],"We":[168],"examined":[169],"hypertension":[176,240],"(systolic":[177,185],">=":[180],"140":[181],"mmHg)":[182],"pre-hypertension":[184],"120\u2013139mmHg)":[188],"incidence":[196],"Cox":[198],"proportional":[199],"hazards":[200],"adjusting":[202],"(as":[205],"timescale),":[206],"sex,":[207],"race,":[208],"education.":[210],"an":[215,342],"average":[216],"3.3":[218],"times":[219],"(range":[220,259],"1\u201313)":[221],"1964\u20131985.":[223],"Between":[224],"30\u201350,":[226],"prehypertension":[231],"high":[233],"(mean=12.7":[234],"years);":[235],"lower":[242],"(mean=1.2":[243],"years).":[244,261],"Mean":[245],"start":[249],"follow":[252],"up":[253],"1996":[255],"59":[257],"53\u201367":[260],"Over":[262],"mean":[264],"15.2":[266],"follow-up,":[269],"there":[270],"n=522":[272],"cases.":[274],"For":[275,294],"every":[276,295],"5":[277,296],"pre-hypertension,":[283],"by":[287,306,324],"8%":[288],"(hazard":[289],"ratio":[290],"(HR)=1.08;":[291],"95%":[292,309],"CI=1.02\u20131.14).":[293],"hypertension,":[302],"24%":[307],"(HR=1.24;":[308],"CI=1.12\u20131.36).":[310],"did":[321],"not":[322],"differ":[323],"race.":[325],"adulthood":[334],"population.":[345]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-11-10T00:00:00"}