{"id":"https://openalex.org/W2765724149","doi":"https://doi.org/10.1016/j.jalz.2017.06.770","title":"[P2\u2013120]: INVESTIGATION OF GENETIC INFLUENCES ON ATROPHY RATE DURING THE MCI DISEASE STAGE USING A BOOTSTRAP\u2010ENHANCED SPARSE ASSOCIATION MODEL","display_name":"[P2\u2013120]: INVESTIGATION OF GENETIC INFLUENCES ON ATROPHY RATE DURING THE MCI DISEASE STAGE USING A BOOTSTRAP\u2010ENHANCED SPARSE ASSOCIATION MODEL","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2765724149","doi":"https://doi.org/10.1016/j.jalz.2017.06.770","mag":"2765724149"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2017.06.770","doi":"https://doi.org/10.1016/j.jalz.2017.06.770","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.770","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033058550","display_name":"V. Vinesh Raja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinesh Raja","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IL, USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018610871","display_name":"Shannon L. Risacher","orcid":"https://orcid.org/0000-0002-3304-7943","observed_orcids":["https://orcid.org/0000-0002-3304-7943"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon L. Risacher","raw_affiliation_strings":["Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087302585","display_name":"Kwangsik T. Nho","orcid":"https://orcid.org/0000-0002-7624-3872","observed_orcids":["https://orcid.org/0000-0002-7624-3872"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwangsik Nho","raw_affiliation_strings":["Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333320","display_name":"Li Shen","orcid":"https://orcid.org/0000-0002-5443-0503","observed_orcids":["https://orcid.org/0000-0002-5443-0503"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Shen","raw_affiliation_strings":["Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026257338","display_name":"Andrew J. Saykin","orcid":"https://orcid.org/0000-0002-1376-8532","observed_orcids":["https://orcid.org/0000-0002-1376-8532"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Saykin","raw_affiliation_strings":["Indiana Alzheimer Disease Center, Indianapolis, IN, USA","Indiana University Network Science Institute, Bloomington, IN, USA","Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Alzheimer Disease Center, Indianapolis, IN, USA","institution_ids":[]},{"raw_affiliation_string":"Indiana University Network Science Institute, Bloomington, IN, USA","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103218500","display_name":"Jingwen Yan","orcid":"https://orcid.org/0000-0001-9066-4908","observed_orcids":["https://orcid.org/0000-0001-9066-4908"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingwen Yan","raw_affiliation_strings":["Indiana University Purdue University Indianapolis, Indianapolis, IN, USA","Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University Purdue University Indianapolis, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I55769427"]},{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20816249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7S_Part_13","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-atrophy-rate","display_name":"brain atrophy rate","score":0.871999979019165},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.8097421526908875},{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.7234653830528259},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6129152774810791},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.6066757440567017},{"id":"https://openalex.org/C18183760","wikidata":"https://www.wikidata.org/wiki/Q6002833","display_name":"Imaging genetics","level":3,"score":0.58624666929245},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5784809589385986},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.5369614958763123},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.5085111856460571},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4817352592945099},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.455695778131485},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38293054699897766},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.38127401471138},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3504732847213745},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3412194848060608},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.32703351974487305},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2977612018585205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27840563654899597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2623056173324585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2573806345462799},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.25306594371795654},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.22833138704299927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18713298439979553},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11724087595939636},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1005968451499939}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2017.06.770","doi":"https://doi.org/10.1016/j.jalz.2017.06.770","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.770","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4245551014","https://openalex.org/W2536101657","https://openalex.org/W4230617961","https://openalex.org/W4397033657","https://openalex.org/W2532288663","https://openalex.org/W2534698948","https://openalex.org/W3195218685","https://openalex.org/W2142357951","https://openalex.org/W2950331006","https://openalex.org/W4313237692"],"abstract_inverted_index":{"Brain":[0],"imaging":[1,29,169],"genetics":[2,344],"is":[3,64],"an":[4],"emerging":[5],"topic":[6],"in":[7,78,129,209,252,292,327],"Alzheimer's":[8],"disease":[9,309],"(AD)":[10],"that":[11,53],"aims":[12],"to":[13,66,104,187,225,249,256,289],"explore":[14],"the":[15,38,44,48,54,112,161,166,277,282,298,331],"genetic":[16,76,192,216,301,321],"architectures":[17],"underlying":[18,75,332],"neuroimaging":[19],"phenotypes.":[20],"While":[21],"many":[22],"existing":[23],"work":[24],"focuses":[25],"on":[26],"cross-sectional":[27],"brain":[28,55,80,99,122,189,213,228,304],"data,":[30],"it":[31],"may":[32],"not":[33],"yield":[34],"optimal":[35],"results":[36],"considering":[37],"static":[39],"nature":[40],"of":[41,47,126,279,284],"genome":[42],"and":[43,72,111,139,148,157,178,191,215,240,245,281,303,316],"dynamic":[45],"changes":[46],"brain.":[49],"Here,":[50],"we":[51],"hypothesize":[52],"atrophy":[56,113,155,305],"rate":[57,114,156,306],"during":[58,115,307],"mild":[59],"cognitive":[60],"impairment":[61],"(MCI)":[62],"stage":[63,117,310],"closer":[65],"a":[67,79,84,219,313],"constant":[68],"for":[69,120,173],"each":[70,210],"individual":[71],"investigate":[73],"its":[74],"basis":[77],"wide":[81],"space":[82],"using":[83,109],"bootstrap":[85,314],"based":[86],"sparse":[87,183],"association":[88,299],"model.":[89],"Data":[90],"was":[91,118,199],"downloaded":[92],"from":[93,102,136,165,223,275],"AD":[94,131],"Neuroimaging":[95],"Initiative(ADNI)":[96],"(adni.loni.usc.edu).":[97],"Structural":[98],"MRI":[100],"data":[101,125],"baseline":[103,174],"36":[105],"months":[106],"were":[107,134,143,171,206,254],"processed":[108],"Freesurfer[1],":[110],"MCI":[116,154,308,328],"calculated":[119],"99":[121],"regions.":[123],"Genotype":[124],"7517":[127],"SNPs":[128,247,268],"22":[130],"risk":[132],"genes[2](boundary:100kb)":[133],"extracted":[135],"quality":[137],"controlled":[138],"imputed":[140],"data.":[141,159],"There":[142],"363":[144],"participants":[145],"(173":[146],"converted":[147],"190":[149],"non-converted":[150],"MCIs)":[151],"with":[152,194,261,269],"both":[153],"genotype":[158],"With":[160],"regression":[162],"weights":[163],"derived":[164],"healthy":[167],"controls,":[168],"measures":[170],"pre-adjusted":[172],"age,":[175],"gender,":[176],"education":[177],"handedness.":[179],"We":[180,296],"applied":[181],"traditional":[182,317],"canonical":[184],"correlation":[185],"analysis(SCCA)":[186],"select":[188],"regions":[190,214,229],"variants":[193,217,302],"strong":[195],"associations.":[196],"This":[197],"experiment":[198],"repeated":[200],"1000":[201],"times,":[202],"where":[203],"80%":[204],"samples":[205],"randomly":[207],"selected":[208],"run.":[211],"All":[212],"obtained":[218],"selection":[220,262,271],"probability":[221,263,272],"ranging":[222],"0":[224],"1.":[226],"Four":[227],"(left":[230],"pars":[231],"opercularis,":[232],"left":[233],"transverse":[234],"temporal":[235,243],"pole,":[236],"central":[237],"corpus":[238],"callosum":[239],"right":[241],"superior":[242],"gyri)":[244],"181":[246],"(mapped":[248],"genes":[250],"shown":[251],"Table.1)":[253],"found":[255],"be":[257,290],"strongly":[258],"associated,":[259],"all":[260],"greater":[264],"than":[265],"50%.":[266],"Top":[267,320],"highest":[270],"are":[273,287],"mainly":[274],"TOMM40,":[276],"upstream":[278],"CD2AP":[280],"downstream":[283],"SORL1,":[285],"which":[286],"reported":[288],"involved":[291],"transmembrane":[293],"transportation":[294],"activities.":[295],"examined":[297],"between":[300],"by":[311],"combining":[312],"strategy":[315],"SCCA":[318],"models.":[319],"markers":[322],"identified":[323],"suggest":[324],"affected":[325],"endocytosis":[326],"converters,":[329],"but":[330],"mechanism":[333],"still":[334],"warrants":[335],"future":[336],"investigation.":[337],"References":[338],"[1]":[339],"Bioinformatics":[340],"28(12).i127\u2013136,2012.":[341],"[2]":[342],"Nature":[343],"45(12),1452\u20131458,2014.":[345]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-11-10T00:00:00"}