{"id":"https://openalex.org/W2765709999","doi":"https://doi.org/10.1093/annonc/mdx602.001","title":"Incidence and clinical relevance of ESR1 mutations in estrogen receptor positive breast cancer patients","display_name":"Incidence and clinical relevance of ESR1 mutations in estrogen receptor positive breast cancer patients","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2765709999","doi":"https://doi.org/10.1093/annonc/mdx602.001","mag":"2765709999"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdx602.001","doi":"https://doi.org/10.1093/annonc/mdx602.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdx602.001","pdf_url":"https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx602.001/21525072/mdx602.001.pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx602.001/21525072/mdx602.001.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087154078","display_name":"Takashi Takeshita","orcid":"https://orcid.org/0000-0002-8559-8181","observed_orcids":["https://orcid.org/0000-0002-8559-8181"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Takeshita","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041066302","display_name":"Mai Tomiguchi","orcid":"https://orcid.org/0000-0002-1210-2894","observed_orcids":["https://orcid.org/0000-0002-1210-2894"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mai Tomiguchi","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018788633","display_name":"Aiko Sueta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aiko Sueta","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113540644","display_name":"Sumiko Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sumiko Nishimura","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044478653","display_name":"Yoshitaka Fujiki","orcid":"https://orcid.org/0000-0001-8557-0683","observed_orcids":["https://orcid.org/0000-0001-8557-0683"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitaka Fujiki","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006533621","display_name":"Risa Goto","orcid":"https://orcid.org/0000-0002-5956-3209","observed_orcids":["https://orcid.org/0000-0002-5956-3209"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Risa Goto","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022256083","display_name":"Mutsuko Ibusuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mutsuko Ibusuki","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024725726","display_name":"Yutaka Yamamoto","orcid":"https://orcid.org/0000-0001-6147-6828","observed_orcids":["https://orcid.org/0000-0001-6147-6828"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Yamamoto","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035071748","display_name":"Hirotaka Iwase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Iwase","raw_affiliation_strings":["Department of Breast and Endocrine surgery, Kumamoto University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast and Endocrine surgery, Kumamoto University","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.168,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41915423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"28","issue":null,"first_page":"ix51","last_page":"ix51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4625999927520752,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.4625999927520752,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.3662000000476837,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esr1-mutations","display_name":"ESR1 mutations","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/aromatase-inhibitor-resistance","display_name":"aromatase inhibitor resistance","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.9760000109672546},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.5379999876022339},{"id":"https://openalex.org/keywords/visceral-disease","display_name":"visceral disease","score":0.7739999890327454},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.7608846426010132},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7575544714927673},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6924523115158081},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6817184686660767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5692360997200012},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5556787252426147},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5195439457893372},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49362027645111084},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.4742400050163269},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4315207898616791},{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.42143556475639343},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35776692628860474},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.08545941114425659}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/annonc/mdx602.001","doi":"https://doi.org/10.1093/annonc/mdx602.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdx602.001","pdf_url":"https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx602.001/21525072/mdx602.001.pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdx602.001","doi":"https://doi.org/10.1093/annonc/mdx602.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdx602.001","pdf_url":"https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx602.001/21525072/mdx602.001.pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2765709999.pdf","grobid_xml":"https://content.openalex.org/works/W2765709999.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2593239796","https://openalex.org/W2554965207","https://openalex.org/W2997271963","https://openalex.org/W3174541278","https://openalex.org/W2341628019","https://openalex.org/W3033048134","https://openalex.org/W3000366541","https://openalex.org/W2768030020","https://openalex.org/W2281217383","https://openalex.org/W4255558289"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-11-10T00:00:00"}