{"id":"https://openalex.org/W2765559488","doi":"https://doi.org/10.1016/j.jalz.2017.06.585","title":"[P1\u2013569]: MIDLIFE PULMONARY FUNCTION AND RISK OF DEMENTIA LATER IN LIFE","display_name":"[P1\u2013569]: MIDLIFE PULMONARY FUNCTION AND RISK OF DEMENTIA LATER IN LIFE","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2765559488","doi":"https://doi.org/10.1016/j.jalz.2017.06.585","mag":"2765559488"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2017.06.585","doi":"https://doi.org/10.1016/j.jalz.2017.06.585","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.585","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.585","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.585","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087266700","display_name":"Paola Gilsanz","orcid":"https://orcid.org/0000-0002-7635-381X","observed_orcids":["https://orcid.org/0000-0002-7635-381X"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paola Gilsanz","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA","University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006407762","display_name":"Jason D. Flatt","orcid":"https://orcid.org/0000-0003-1244-738X","observed_orcids":["https://orcid.org/0000-0003-1244-738X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Flatt","raw_affiliation_strings":["UCSF School of Medicine, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF School of Medicine, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052785465","display_name":"Charles P. Quesenberry","orcid":"https://orcid.org/0000-0001-8272-9126","observed_orcids":["https://orcid.org/0000-0001-8272-9126"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles P. Quesenberry","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091019550","display_name":"Rachel A. Whitmer","orcid":"https://orcid.org/0009-0006-9511-6138","observed_orcids":["https://orcid.org/0009-0006-9511-6138"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Whitmer","raw_affiliation_strings":["Kaiser Permanente Division of Research, Oakland, CA, USA","University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente Division of Research, Oakland, CA, USA","institution_ids":["https://openalex.org/I1343052199"]},{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087266700"],"corresponding_institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20515251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7S_Part_10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dementia-risk","display_name":"dementia risk","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8255974054336548},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7354910373687744},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5750380754470825},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.5297865867614746},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5279502272605896},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.518402099609375},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4944751262664795},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.47336360812187195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44949647784233093},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.42784979939460754},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.4205719530582428},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4148738384246826},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3398987054824829},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2170458436012268},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0678156316280365},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2017.06.585","doi":"https://doi.org/10.1016/j.jalz.2017.06.585","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.585","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.585","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2017.06.585","doi":"https://doi.org/10.1016/j.jalz.2017.06.585","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.585","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.585","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2765559488.pdf","grobid_xml":"https://content.openalex.org/works/W2765559488.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019120256","https://openalex.org/W2793541866","https://openalex.org/W1995037140","https://openalex.org/W2765473993","https://openalex.org/W7074078759","https://openalex.org/W3006417369","https://openalex.org/W4250267627","https://openalex.org/W2900940998","https://openalex.org/W4406220013","https://openalex.org/W2024778887"],"abstract_inverted_index":{"Poor":[0],"pulmonary":[1,31,77,158,322],"function":[2,32,78,159,323],"is":[3,22,26,43,337],"associated":[4,325],"with":[5,211,326],"worse":[6],"cognition":[7],"and":[8,14,35,37,55,94,102,134,139,160,166,194,207,251,261,309,333],"greater":[9,290],"brain":[10],"atrophy":[11],"in":[12,33,85,181,221,228,281],"midlife":[13,34,157,264,275,303,321],"increased":[15],"risk":[16,48,162,168,292,304,327],"of":[17,61,74,123,156,187,200,216,225,232,285,320,328,331],"dementia-associated":[18],"mortality.":[19],"However,":[20],"it":[21],"unclear":[23],"if":[24,38],"there":[25],"a":[27],"longitudinal":[28],"association":[29,42,151],"between":[30,68,92,111,152,204],"dementia,":[36],"so,":[39],"whether":[40],"the":[41,150,153,171,222,229,282,341],"spurious":[44],"due":[45],"to":[46,120,219,238,339],"mutual":[47],"factors":[49,169,305],"such":[50],"as":[51,73,146],"hypertension,":[52,307],"vascular":[53,167],"disease,":[54],"smoking.":[56,334],"We":[57],"evaluated":[58,149],"10,067":[59],"members":[60,72,220,227],"Kaiser":[62],"Permanente":[63],"Northern":[64],"California":[65],"ages":[66],"40\u201345":[67],"1964\u20131973":[69,93],"who":[70],"remained":[71],"1/1/96.":[75],"Midlife":[76],"was":[79,191,269],"assessed":[80],"by":[81],"forced":[82],"expiratory":[83],"volume":[84],"one":[86],"second":[87],"(FEV1)":[88],"during":[89],"clinical":[90],"exams":[91],"ranked":[95],"into":[96],"quintiles.":[97],"Height,":[98],"weight,":[99],"race,":[100,300],"education,":[101,301],"smoking":[103,276],"(current,":[104],"past,":[105],"or":[106,185],"never)":[107],"were":[108,118,174,209,234,324],"also":[109],"collected":[110],"1964\u20131973.":[112],"Electronic":[113],"health":[114,182],"records":[115],"from":[116],"1/1/1996\u201310/1/2015":[117],"used":[119],"identify":[121,340],"cases":[122],"dementia":[124,161,177,212,240,291,329],"(ICD-9":[125],"codes":[126],"331.0,":[127],"290.4x,":[128],"290.0,":[129],"290.1x,":[130],"290.2x,":[131],"290.3,":[132],"294.2x,":[133],"294.8),":[135],"stroke,":[136],"heart":[137,315],"failure,":[138,316],"diabetes.":[140],"Cox":[141],"proportional":[142],"hazard":[143],"models":[144],"(age":[145],"time":[147],"scale)":[148],"lowest":[154,198,230,283],"quintile":[155,199,224,231,284],"adjusted":[163],"for":[164,249,259,274,297],"sociodemographics":[165],"across":[170],"lifecourse.":[172],"Participants":[173],"censored":[175],"at":[176,263],"diagnosis,":[178],"death,":[179],"gap":[180],"plan":[183],"membership,":[184],"end":[186],"study.":[188],"The":[189,197],"cohort":[190],"55%":[192],"female":[193],"73%":[195],"White.":[196],"FEV1":[201,233,286],"values":[202],"ranged":[203],"0.2\u20132":[205],"liters":[206],"30%":[208,289],"diagnosed":[210],"over":[213],"20":[214],"years":[215],"follow-up.":[217],"Compared":[218],"highest":[223],"FEV1,":[226],"20%":[235],"more":[236],"likely":[237],"develop":[239],"(adjusted":[241],"Hazards":[242],"Ratio":[243],"(aHR)=1.20;":[244],"95%":[245,266,278,294],"Confidence":[246],"Interval:1.02\u20131.40)":[247],"adjusting":[248,296],"height":[250],"sociodemographics.":[252],"This":[253],"relationship":[254],"persisted":[255],"after":[256,272],"further":[257],"adjustment":[258],"BMI":[260],"hypertension":[262,332],"(aHR=1.18;":[265],"CI:1.01\u20131.38)":[267],"but":[268],"slightly":[270],"attenuated":[271],"controlling":[273],"(aHR=1.17;":[277],"CI:0.99\u20131.37).":[279],"Members":[280],"had":[287],"almost":[288],"(aHR=1.29;":[293],"CI:1.10\u20131.51)":[295],"height,":[298],"sex,":[299],"smoking,":[302],"(BMI,":[306],"smoking)":[308],"late":[310],"life":[311],"medical":[312],"conditions":[313],"(diabetes,":[314],"stroke).":[317],"Low":[318],"levels":[319],"independent":[330],"Further":[335],"research":[336],"needed":[338],"relevant":[342],"pathogenic":[343],"mechanisms.":[344]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-11-10T00:00:00"}