{"id":"https://openalex.org/W2765557965","doi":"https://doi.org/10.1002/ams2.320","title":"Promising novel therapy with hydrogen gas for emergency and critical care medicine","display_name":"Promising novel therapy with hydrogen gas for emergency and critical care medicine","publication_year":2017,"publication_date":"2017-10-24","ids":{"openalex":"https://openalex.org/W2765557965","doi":"https://doi.org/10.1002/ams2.320","mag":"2765557965","pmid":"https://pubmed.ncbi.nlm.nih.gov/29657720","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5891106"},"language":"en","primary_location":{"id":"doi:10.1002/ams2.320","doi":"https://doi.org/10.1002/ams2.320","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ams2.320","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ams2.320","source":{"id":"https://openalex.org/S4210219627","display_name":"Acute Medicine & Surgery","issn_l":"2052-8817","issn":["2052-8817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Medicine & Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ams2.320","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024722455","display_name":"Motoaki Sano","orcid":"https://orcid.org/0000-0003-1771-8310","observed_orcids":["https://orcid.org/0000-0003-1771-8310"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Motoaki Sano","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038274081","display_name":"Masaru Suzuki","orcid":"https://orcid.org/0000-0003-0964-5289","observed_orcids":["https://orcid.org/0000-0003-0964-5289"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Suzuki","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0964-5289","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110356836","display_name":"Koichiro Homma","orcid":"https://orcid.org/0000-0001-5223-9599","observed_orcids":["https://orcid.org/0000-0001-5223-9599"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichiro Homma","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050761741","display_name":"Kei Hayashida","orcid":"https://orcid.org/0000-0002-2287-3318","observed_orcids":["https://orcid.org/0000-0002-2287-3318"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kei Hayashida","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055556356","display_name":"Tomoyoshi Tamura","orcid":"https://orcid.org/0000-0001-7435-6534","observed_orcids":["https://orcid.org/0000-0001-7435-6534"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyoshi Tamura","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029130283","display_name":"Tadashi Matsuoka","orcid":"https://orcid.org/0000-0002-3837-8960","observed_orcids":["https://orcid.org/0000-0002-3837-8960"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Matsuoka","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016723644","display_name":"Yoshinori Katsumata","orcid":"https://orcid.org/0000-0001-5576-5789","observed_orcids":["https://orcid.org/0000-0001-5576-5789"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Katsumata","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012683445","display_name":"Shuko Onuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuko Onuki","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089292835","display_name":"Junichi Sasaki","orcid":"https://orcid.org/0000-0002-5190-8524","observed_orcids":["https://orcid.org/0000-0002-5190-8524"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Sasaki","raw_affiliation_strings":["Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024722455"],"corresponding_institution_ids":["https://openalex.org/I203951103"],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":3.3597,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.92568137,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"5","issue":"2","first_page":"113","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10811","display_name":"Hydrogen Storage and Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.847000002861023},{"id":"https://openalex.org/keywords/hydrogen-therapy","display_name":"hydrogen treatment","score":0.828000009059906},{"id":"https://openalex.org/keywords/emergency-medicine","display_name":"emergency medicine","score":0.8579999804496765},{"id":"https://openalex.org/keywords/critical-care","display_name":"intensive care","score":0.8240000009536743},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.8980000019073486},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.9660000205039978},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/regulatory-approval","display_name":"regulatory approval","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7238166928291321},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5022380352020264},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.47761696577072144},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.4375728368759155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2772711515426636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07869401574134827},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/ams2.320","doi":"https://doi.org/10.1002/ams2.320","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ams2.320","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ams2.320","source":{"id":"https://openalex.org/S4210219627","display_name":"Acute Medicine & Surgery","issn_l":"2052-8817","issn":["2052-8817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Medicine & Surgery","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4827896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5891106","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5891106","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5891106","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Med Surg","raw_type":"Text"},{"id":"pmid:29657720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29657720","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute medicine & surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ams2.320","doi":"https://doi.org/10.1002/ams2.320","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ams2.320","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ams2.320","source":{"id":"https://openalex.org/S4210219627","display_name":"Acute Medicine & Surgery","issn_l":"2052-8817","issn":["2052-8817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Medicine & Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5697430173","display_name":"Hydrogen gas inhalation improves survival in rats with lethal hemorrhagic shock.","funder_award_id":"16K21357","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G57992419","display_name":"Mechanism of blood pressure regulation by molecular hydrogen in chronic kiney disease","funder_award_id":"16K11420","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320316982","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2765557965.pdf","grobid_xml":"https://content.openalex.org/works/W2765557965.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1963789809","https://openalex.org/W1980489046","https://openalex.org/W1983888208","https://openalex.org/W2013140188","https://openalex.org/W2024431831","https://openalex.org/W2061514693","https://openalex.org/W2137818678","https://openalex.org/W2138293936","https://openalex.org/W2150197616","https://openalex.org/W2169657429","https://openalex.org/W2204382555","https://openalex.org/W2322688036","https://openalex.org/W2466448612","https://openalex.org/W2595623234","https://openalex.org/W2723182748"],"related_works":["https://openalex.org/W4414151526","https://openalex.org/W2114282036","https://openalex.org/W3115762959","https://openalex.org/W1503565493","https://openalex.org/W2143692885","https://openalex.org/W2783024037","https://openalex.org/W2099784544","https://openalex.org/W2559943991","https://openalex.org/W2565954670","https://openalex.org/W3175804637"],"abstract_inverted_index":{"It":[0],"has":[1,58],"been":[2,49,60],"reported":[3],"that":[4],"hydrogen":[5,46,56,81,92,95,110],"gas":[6,47,57,82,93,111],"exerts":[7],"a":[8,12],"therapeutic":[9,107],"effect":[10],"in":[11,112],"wide":[13],"range":[14],"of":[15,45,55,80,91,109,117],"disease":[16],"conditions,":[17],"from":[18],"acute":[19,124,131],"illness":[20,31],"such":[21,32],"as":[22,33],"ischemia-reperfusion":[23],"injury,":[24,133],"shock,":[25],"and":[26,38,42,73,86,94,119,134],"damage":[27],"healing":[28],"to":[29,70,87,114],"chronic":[30],"metabolic":[34],"syndrome,":[35,129],"rheumatoid":[36],"arthritis,":[37],"neurodegenerative":[39],"diseases.":[40],"Antioxidant":[41],"anti-inflammatory":[43],"properties":[44],"have":[48,104],"proposed,":[50],"but":[51],"the":[52,64,77,102],"molecular":[53],"target":[54],"not":[59],"identified.":[61],"We":[62],"established":[63],"Center":[65,103],"for":[66],"Molecular":[67],"Hydrogen":[68],"Medicine":[69],"promote":[71],"non-clinical":[72],"clinical":[74],"research":[75],"on":[76],"medical":[78,96],"use":[79],"through":[83],"industry-university":[84],"collaboration":[85],"obtain":[88],"regulatory":[89],"approval":[90],"devices":[97],"(http://www.karc.keio.ac.jp/center/center-55.html).":[98],"Studies":[99],"undertaken":[100],"by":[101],"suggested":[105],"possible":[106],"effects":[108],"relation":[113],"various":[115],"aspects":[116],"emergency":[118],"critical":[120],"care":[121],"medicine,":[122],"including":[123],"myocardial":[125],"infarction,":[126],"cardiopulmonary":[127],"arrest":[128],"contrast-induced":[130],"kidney":[132],"hemorrhagic":[135],"shock.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2017-11-10T00:00:00"}