{"id":"https://openalex.org/W2765546463","doi":"https://doi.org/10.1098/rsfs.2017.0030","title":"Factors affecting the physical stability (aggregation) of peptide therapeutics","display_name":"Factors affecting the physical stability (aggregation) of peptide therapeutics","publication_year":2017,"publication_date":"2017-10-20","ids":{"openalex":"https://openalex.org/W2765546463","doi":"https://doi.org/10.1098/rsfs.2017.0030","mag":"2765546463","pmid":"https://pubmed.ncbi.nlm.nih.gov/29147559","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5665799"},"language":"en","primary_location":{"id":"doi:10.1098/rsfs.2017.0030","doi":"https://doi.org/10.1098/rsfs.2017.0030","is_oa":false,"landing_page_url":"https://doi.org/10.1098/rsfs.2017.0030","pdf_url":null,"source":{"id":"https://openalex.org/S2485448675","display_name":"Interface Focus","issn_l":"2042-8898","issn":["2042-8898","2042-8901"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interface Focus","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5665799","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075630232","display_name":"Karolina L. Zapadka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karolina L. Zapadka","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066074108","display_name":"Frederik J. Becher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Frederik J. Becher","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102792177","display_name":"Ana L. Gomes dos Santos","orcid":"https://orcid.org/0000-0003-4618-1583","observed_orcids":["https://orcid.org/0000-0003-4618-1583"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. L. Gomes dos Santos","raw_affiliation_strings":["Formulation Sciences, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Formulation Sciences, MedImmune Ltd, Granta Park, Cambridge CB21 6GH, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022900338","display_name":"Sophie Jackson","orcid":"https://orcid.org/0000-0002-7470-9800","observed_orcids":["https://orcid.org/0000-0002-7470-9800"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sophie E. Jackson","raw_affiliation_strings":["Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK"],"raw_orcid":"https://orcid.org/0000-0002-7470-9800","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022900338","https://openalex.org/A5102792177"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":1.3384,"has_fulltext":false,"cited_by_count":425,"citation_normalized_percentile":{"value":0.8120965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"7","issue":"6","first_page":"20170030","last_page":"20170030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-peptides","display_name":"peptide therapeutics","score":0.9810000061988831},{"id":"https://openalex.org/keywords/physical-stability","display_name":"physical stability","score":0.9769999980926514},{"id":"https://openalex.org/keywords/peptide-aggregation","display_name":"peptide aggregation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/amorphous-aggregates","display_name":"amorphous aggregates","score":0.8119999766349792},{"id":"https://openalex.org/keywords/fibrillar-aggregates","display_name":"fibrillar aggregates","score":0.8420000076293945},{"id":"https://openalex.org/keywords/self-association","display_name":"self-association","score":0.7160000205039978},{"id":"https://openalex.org/keywords/peptide-sequence-effects","display_name":"peptide sequence effects","score":0.6290000081062317},{"id":"https://openalex.org/keywords/pharmaceutical-excipients","display_name":"pharmaceutical excipients","score":0.9829999804496765},{"id":"https://openalex.org/keywords/chemical-modification","display_name":"chemical modification","score":0.7799999713897705},{"id":"https://openalex.org/keywords/impurities","display_name":"impurities","score":0.6679999828338623},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.8220000267028809},{"id":"https://openalex.org/keywords/temperature-and-pressure-effects","display_name":"temperature and pressure effects","score":0.7289999723434448},{"id":"https://openalex.org/keywords/aggregation-mechanism","display_name":"aggregation mechanism","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.4851473271846771},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.46891292929649353},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4671337902545929},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.44507819414138794},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.4354051351547241},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3796535134315491},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30647414922714233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14291155338287354},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1098/rsfs.2017.0030","doi":"https://doi.org/10.1098/rsfs.2017.0030","is_oa":false,"landing_page_url":"https://doi.org/10.1098/rsfs.2017.0030","pdf_url":null,"source":{"id":"https://openalex.org/S2485448675","display_name":"Interface Focus","issn_l":"2042-8898","issn":["2042-8898","2042-8901"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interface Focus","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5244867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5665799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5665799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5665799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interface Focus","raw_type":"Text"},{"id":"pmid:29147559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29147559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interface focus","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5244867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5665799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":244,"referenced_works":["https://openalex.org/W5524691","https://openalex.org/W25571435","https://openalex.org/W57282146","https://openalex.org/W216000200","https://openalex.org/W295884092","https://openalex.org/W1497812247","https://openalex.org/W1511036913","https://openalex.org/W1580609715","https://openalex.org/W1586856478","https://openalex.org/W1609438619","https://openalex.org/W1638369591","https://openalex.org/W1661001637","https://openalex.org/W1768596487","https://openalex.org/W1811647626","https://openalex.org/W1841495572","https://openalex.org/W1963834832","https://openalex.org/W1964727310","https://openalex.org/W1965353176","https://openalex.org/W1966078980","https://openalex.org/W1967533373","https://openalex.org/W1967701034","https://openalex.org/W1968280815","https://openalex.org/W1968632585","https://openalex.org/W1970577444","https://openalex.org/W1970898345","https://openalex.org/W1972000849","https://openalex.org/W1972373962","https://openalex.org/W1975596071","https://openalex.org/W1975940232","https://openalex.org/W1977802438","https://openalex.org/W1978876908","https://openalex.org/W1980803588","https://openalex.org/W1981963802","https://openalex.org/W1982269968","https://openalex.org/W1983073430","https://openalex.org/W1983728938","https://openalex.org/W1983870655","https://openalex.org/W1984998234","https://openalex.org/W1985228835","https://openalex.org/W1985881176","https://openalex.org/W1985941856","https://openalex.org/W1986900626","https://openalex.org/W1987566286","https://openalex.org/W1987858383","https://openalex.org/W1987904524","https://openalex.org/W1988018861","https://openalex.org/W1988212012","https://openalex.org/W1990736367","https://openalex.org/W1990852255","https://openalex.org/W1991349307","https://openalex.org/W1994276318","https://openalex.org/W2000893833","https://openalex.org/W2001151797","https://openalex.org/W2001181358","https://openalex.org/W2001363066","https://openalex.org/W2002399569","https://openalex.org/W2002836226","https://openalex.org/W2003832326","https://openalex.org/W2006036698","https://openalex.org/W2007449704","https://openalex.org/W2007535730","https://openalex.org/W2009532270","https://openalex.org/W2009962980","https://openalex.org/W2011389604","https://openalex.org/W2012436507","https://openalex.org/W2012557883","https://openalex.org/W2012670394","https://openalex.org/W2012895864","https://openalex.org/W2013222571","https://openalex.org/W2013827851","https://openalex.org/W2014290130","https://openalex.org/W2014837879","https://openalex.org/W2019152247","https://openalex.org/W2019647705","https://openalex.org/W2021264738","https://openalex.org/W2021734242","https://openalex.org/W2027839322","https://openalex.org/W2029660291","https://openalex.org/W2029799719","https://openalex.org/W2030506356","https://openalex.org/W2031273125","https://openalex.org/W2032665239","https://openalex.org/W2034318538","https://openalex.org/W2034951358","https://openalex.org/W2035311386","https://openalex.org/W2036260921","https://openalex.org/W2037781436","https://openalex.org/W2039003502","https://openalex.org/W2039647080","https://openalex.org/W2040812195","https://openalex.org/W2042434150","https://openalex.org/W2043876754","https://openalex.org/W2045421895","https://openalex.org/W2045435448","https://openalex.org/W2045529907","https://openalex.org/W2045541909","https://openalex.org/W2045604879","https://openalex.org/W2045729747","https://openalex.org/W2047125616","https://openalex.org/W2047944726","https://openalex.org/W2048035431","https://openalex.org/W2050435499","https://openalex.org/W2051129391","https://openalex.org/W2051809212","https://openalex.org/W2052544304","https://openalex.org/W2052900362","https://openalex.org/W2053164047","https://openalex.org/W2053727980","https://openalex.org/W2054212962","https://openalex.org/W2057590353","https://openalex.org/W2057860875","https://openalex.org/W2058447504","https://openalex.org/W2059027334","https://openalex.org/W2059180465","https://openalex.org/W2060259421","https://openalex.org/W2063431000","https://openalex.org/W2063627711","https://openalex.org/W2064294763","https://openalex.org/W2064367582","https://openalex.org/W2066170812","https://openalex.org/W2066462612","https://openalex.org/W2067848480","https://openalex.org/W2069531937","https://openalex.org/W2069595298","https://openalex.org/W2070919406","https://openalex.org/W2072398283","https://openalex.org/W2073775320","https://openalex.org/W2075577253","https://openalex.org/W2076399332","https://openalex.org/W2076416971","https://openalex.org/W2077118080","https://openalex.org/W2077245767","https://openalex.org/W2078004069","https://openalex.org/W2078067526","https://openalex.org/W2080462298","https://openalex.org/W2080592458","https://openalex.org/W2080831965","https://openalex.org/W2081042330","https://openalex.org/W2081455828","https://openalex.org/W2081481124","https://openalex.org/W2081640562","https://openalex.org/W2082287616","https://openalex.org/W2082343819","https://openalex.org/W2082746669","https://openalex.org/W2083419051","https://openalex.org/W2084219899","https://openalex.org/W2085687763","https://openalex.org/W2087357689","https://openalex.org/W2088380087","https://openalex.org/W2088519860","https://openalex.org/W2090246366","https://openalex.org/W2090288759","https://openalex.org/W2090628735","https://openalex.org/W2091321623","https://openalex.org/W2091913778","https://openalex.org/W2094059322","https://openalex.org/W2094190981","https://openalex.org/W2095184733","https://openalex.org/W2095253097","https://openalex.org/W2095320977","https://openalex.org/W2101614182","https://openalex.org/W2105066593","https://openalex.org/W2105598295","https://openalex.org/W2105908180","https://openalex.org/W2107853929","https://openalex.org/W2109302654","https://openalex.org/W2110114053","https://openalex.org/W2110227826","https://openalex.org/W2111766718","https://openalex.org/W2113126462","https://openalex.org/W2115180879","https://openalex.org/W2117506839","https://openalex.org/W2119711780","https://openalex.org/W2121977115","https://openalex.org/W2123733934","https://openalex.org/W2126888693","https://openalex.org/W2126969300","https://openalex.org/W2127265740","https://openalex.org/W2128879174","https://openalex.org/W2129497723","https://openalex.org/W2130144581","https://openalex.org/W2131928227","https://openalex.org/W2132114565","https://openalex.org/W2132858917","https://openalex.org/W2133271843","https://openalex.org/W2133425057","https://openalex.org/W2134439639","https://openalex.org/W2134625581","https://openalex.org/W2135004341","https://openalex.org/W2139201850","https://openalex.org/W2139284540","https://openalex.org/W2140389961","https://openalex.org/W2141690555","https://openalex.org/W2142144368","https://openalex.org/W2143417213","https://openalex.org/W2144778679","https://openalex.org/W2146708753","https://openalex.org/W2146844611","https://openalex.org/W2148669320","https://openalex.org/W2150411892","https://openalex.org/W2152569314","https://openalex.org/W2154466271","https://openalex.org/W2154721456","https://openalex.org/W2158221911","https://openalex.org/W2158640432","https://openalex.org/W2159793157","https://openalex.org/W2161551526","https://openalex.org/W2165752272","https://openalex.org/W2168236041","https://openalex.org/W2169145856","https://openalex.org/W2171733899","https://openalex.org/W2188597575","https://openalex.org/W2219937983","https://openalex.org/W2225657959","https://openalex.org/W2261386528","https://openalex.org/W2261903771","https://openalex.org/W2279088384","https://openalex.org/W2281597363","https://openalex.org/W2291658560","https://openalex.org/W2309356304","https://openalex.org/W2318080800","https://openalex.org/W2318764651","https://openalex.org/W2321908007","https://openalex.org/W2326840043","https://openalex.org/W2341223762","https://openalex.org/W2341682650","https://openalex.org/W2342156993","https://openalex.org/W2343517491","https://openalex.org/W2391066200","https://openalex.org/W2407515421","https://openalex.org/W2411210806","https://openalex.org/W2507573110","https://openalex.org/W2514215772","https://openalex.org/W2534547085","https://openalex.org/W2545029575","https://openalex.org/W2551436709","https://openalex.org/W2553402145","https://openalex.org/W2554222455","https://openalex.org/W2555151293","https://openalex.org/W2556148213","https://openalex.org/W2585597953","https://openalex.org/W2953235932","https://openalex.org/W2968895639","https://openalex.org/W4234708696"],"related_works":["https://openalex.org/W2974748655","https://openalex.org/W3211937611","https://openalex.org/W4205430985","https://openalex.org/W3159164068","https://openalex.org/W7125354540","https://openalex.org/W6941092270","https://openalex.org/W7126030359","https://openalex.org/W6887797426","https://openalex.org/W2015094387","https://openalex.org/W7205009322"],"abstract_inverted_index":{"The":[0,103],"number":[1,21],"of":[2,44,84,100,105,128,144,147,156],"biological":[3],"therapeutic":[4,101],"agents":[5],"in":[6,27,38],"the":[7,16,20,28,39,76,81,126,145,157],"clinic":[8],"and":[9,19,42,89,114,117,119,136],"development":[10],"pipeline":[11],"has":[12],"increased":[13],"dramatically":[14],"over":[15],"last":[17],"decade":[18],"will":[22],"undoubtedly":[23],"continue":[24],"to":[25,50,60],"increase":[26],"coming":[29],"years.":[30],"Despite":[31],"this":[32],"fact,":[33],"there":[34],"are":[35,55,99,121,138],"considerable":[36],"challenges":[37],"development,":[40],"production":[41],"formulation":[43],"such":[45,131],"biologics":[46],"particularly":[47],"with":[48,96],"respect":[49],"their":[51,71,160],"physical":[52,82,129],"stabilities.":[53],"There":[54],"many":[56],"cases":[57],"where":[58],"self-association":[59],"form":[61],"either":[62],"amorphous":[63],"aggregates":[64,148],"or":[65],"highly":[66],"structured":[67],"fibrillar":[68],"species":[69],"limits":[70],"use.":[72],"Here,":[73],"we":[74],"review":[75],"numerous":[77],"factors":[78],"that":[79,98],"influence":[80],"stability":[83],"peptides":[85],"including":[86],"both":[87],"intrinsic":[88],"external":[90],"factors,":[91],"wherever":[92],"possible":[93],"illustrating":[94],"these":[95],"examples":[97],"interest.":[102],"effects":[104,127],"sequence,":[106],"concentration,":[107],"pH,":[108],"net":[109],"charge,":[110],"excipients,":[111],"chemical":[112],"degradation":[113],"modification,":[115],"surfaces":[116],"interfaces,":[118],"impurities":[120],"all":[122],"discussed.":[123],"In":[124],"addition,":[125],"parameters":[130],"as":[132,150,152],"pressure,":[133],"temperature,":[134],"agitation":[135],"lyophilization":[137],"described.":[139],"We":[140],"provide":[141],"an":[142],"overview":[143],"structures":[146],"formed,":[149],"well":[151],"our":[153],"current":[154],"knowledge":[155],"mechanisms":[158],"for":[159],"formation.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":68},{"year":2025,"cited_by_count":73},{"year":2024,"cited_by_count":75},{"year":2023,"cited_by_count":52},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":42},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-11-10T00:00:00"}