{"id":"https://openalex.org/W2765377191","doi":"https://doi.org/10.1088/1361-6560/aa9475","title":"A microvascular compartment model validated using 11 C-methylglucose liver PET in pigs","display_name":"A microvascular compartment model validated using 11 C-methylglucose liver PET in pigs","publication_year":2017,"publication_date":"2017-10-18","ids":{"openalex":"https://openalex.org/W2765377191","doi":"https://doi.org/10.1088/1361-6560/aa9475","mag":"2765377191","pmid":"https://pubmed.ncbi.nlm.nih.gov/29045236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5968454"},"language":"en","primary_location":{"id":"doi:10.1088/1361-6560/aa9475","doi":"https://doi.org/10.1088/1361-6560/aa9475","is_oa":false,"landing_page_url":"https://doi.org/10.1088/1361-6560/aa9475","pdf_url":null,"source":{"id":"https://openalex.org/S20241394","display_name":"Physics in Medicine and Biology","issn_l":"0031-9155","issn":["0031-9155","1361-6560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physics in Medicine &amp; Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5968454","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047632381","display_name":"Ole Lajord Munk","orcid":"https://orcid.org/0000-0002-7232-5088","observed_orcids":["https://orcid.org/0000-0002-7232-5088"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Ole L Munk","raw_affiliation_strings":["Author to whom any correspondence should be addressed","Department of Nuclear Medicine & PET Center, Aarhus University Hospital, 8000 Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-7232-5088","affiliations":[{"raw_affiliation_string":"Author to whom any correspondence should be addressed","institution_ids":[]},{"raw_affiliation_string":"Department of Nuclear Medicine & PET Center, Aarhus University Hospital, 8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067335445","display_name":"Susanne Keiding","orcid":"https://orcid.org/0000-0002-7555-9971","observed_orcids":["https://orcid.org/0000-0002-7555-9971"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Susanne Keiding","raw_affiliation_strings":["Department of Hepatology & Gastroenterology, Aarhus University Hospital, 8000 Aarhus, Denmark","Department of Nuclear Medicine & PET Center, Aarhus University Hospital, 8000 Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology & Gastroenterology, Aarhus University Hospital, 8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Nuclear Medicine & PET Center, Aarhus University Hospital, 8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016727614","display_name":"Charles M. Baker","orcid":"https://orcid.org/0000-0001-6633-4300","observed_orcids":["https://orcid.org/0000-0001-6633-4300"]},"institutions":[{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]},{"id":"https://openalex.org/I4210141844","display_name":"Australian e-Health Research Centre","ror":"https://ror.org/04ywhbc61","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801244131","https://openalex.org/I2801453606","https://openalex.org/I4210141844","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Charles Baker","raw_affiliation_strings":["The Australian e-Health Research Centre, Royal Brisbane and Women's Hospital, Herston 4029, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Australian e-Health Research Centre, Royal Brisbane and Women's Hospital, Herston 4029, Queensland, Australia","institution_ids":["https://openalex.org/I2799393793","https://openalex.org/I4210141844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109333796","display_name":"L. Bass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Ludvik Bass","raw_affiliation_strings":["Department of Mathematics, University of Queensland, Brisbane 4072, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Queensland, Brisbane 4072, Queensland, Australia","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016727614","https://openalex.org/A5047632381","https://openalex.org/A5067335445","https://openalex.org/A5109333796"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I2799393793","https://openalex.org/I2802335433","https://openalex.org/I4210141844"],"apc_list":{"value":3325,"currency":"USD","value_usd":3325},"apc_paid":null,"fwci":0.2034,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.558653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"63","issue":"1","first_page":"015032","last_page":"015032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-perfusion","display_name":"liver perfusion","score":0.9120000004768372},{"id":"https://openalex.org/keywords/dynamic-pet","display_name":"dynamic PET","score":0.4620000123977661},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.32100000977516174},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.5},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.8961020708084106},{"id":"https://openalex.org/C2778863792","wikidata":"https://www.wikidata.org/wiki/Q16909918","display_name":"TRACER","level":2,"score":0.8762564659118652},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.6072196960449219},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4262707531452179},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3741118311882019},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23080378770828247},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.1341816484928131},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.09606805443763733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.085969477891922},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019325","descriptor_name":"3-O-Methylglucose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1088/1361-6560/aa9475","doi":"https://doi.org/10.1088/1361-6560/aa9475","is_oa":false,"landing_page_url":"https://doi.org/10.1088/1361-6560/aa9475","pdf_url":null,"source":{"id":"https://openalex.org/S20241394","display_name":"Physics in Medicine and Biology","issn_l":"0031-9155","issn":["0031-9155","1361-6560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physics in Medicine &amp; Biology","raw_type":"journal-article"},{"id":"pmid:29045236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29045236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physics in medicine and biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5276891","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5968454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5968454","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5968454","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Phys Med Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/3da9b3ff-9f59-4e9d-83f2-924a0ffeb763","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/3da9b3ff-9f59-4e9d-83f2-924a0ffeb763","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Munk, O L, Keiding, S, Baker, C & Bass, L 2017, 'A microvascular compartment model validated using 11 C-methylglucose liver PET in pigs', Physics in Medicine and Biology, vol. 63, no. 1, 015032, pp. 015032. https://doi.org/10.1088/1361-6560/aa9475","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5276891","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5968454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G101603185","display_name":"Pathophysiological Interpretations of Dynamic PET/CT of Molecular Liver Biology","funder_award_id":"R01DK074419","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W617896656","https://openalex.org/W1972769931","https://openalex.org/W1974393218","https://openalex.org/W2006458313","https://openalex.org/W2033648669","https://openalex.org/W2035143394","https://openalex.org/W2057955349","https://openalex.org/W2065552431","https://openalex.org/W2065951074","https://openalex.org/W2107969388","https://openalex.org/W2120053582","https://openalex.org/W2120267286","https://openalex.org/W2129364596","https://openalex.org/W2142635246","https://openalex.org/W2144838695","https://openalex.org/W2154824780","https://openalex.org/W2171263166","https://openalex.org/W2221302579","https://openalex.org/W2286499419","https://openalex.org/W2288088487","https://openalex.org/W2399287373","https://openalex.org/W2465745915"],"related_works":["https://openalex.org/W2120053582","https://openalex.org/W2114208723","https://openalex.org/W2033648669","https://openalex.org/W2085053580","https://openalex.org/W2010865516","https://openalex.org/W2127487303","https://openalex.org/W1995551414","https://openalex.org/W2133107592","https://openalex.org/W2286499419","https://openalex.org/W2031464563"],"abstract_inverted_index":{"Abstract":[0],"The":[1,14,35,74,166,215,276],"standard":[2,164,196],"compartment":[3,49],"model":[4,50],"(CM)":[5],"is":[6,16,84],"widely":[7],"used":[8],"to":[9,18,21,41,86,273],"analyse":[10],"dynamic":[11,107,154,169],"PET":[12,108,123,155,170],"data.":[13],"CM":[15,100,151,175,192,263],"fitted":[17,168],"time\u2013activity":[19],"curves":[20],"estimate":[22],"rate":[23],"constants":[24],"that":[25,52,146,153,208,284,289],"describe":[26],"the":[27,62,69,97,102,125,133,147,150,174,222,233,241,245,248,254,262,279,299],"transport":[28],"of":[29,37,104,110,119,251,281,302],"a":[30,45,72,257],"tracer":[31,55,126,269,304],"between":[32,217],"well-mixed":[33],"compartments.":[34],"aim":[36],"this":[38],"study":[39],"was":[40,227,235],"develop":[42],"and":[43,65,88,99,138,152,186,198,221,288],"validate":[44],"more":[46,286],"realistic":[47],"microvascular":[48],"(MCM)":[51],"includes":[53],"capillary":[54,274,307],"concentration":[56,292],"gradients,":[57],"backflux":[58,270],"from":[59,271],"cells":[60,272],"into":[61],"perfused":[63],"capillaries":[64],"multiple":[66],"re-uptakes":[67],"during":[68],"passage":[70],"through":[71],"capillary.":[73],"MCM":[75,98,148,167,184,224,246],"incorporates":[76],"only":[77],"parameters":[78],"with":[79,212],"clear":[80],"physiological":[81],"meaning,":[82],"it":[83,89,265],"easy":[85],"implement,":[87],"does":[90,266],"not":[91,267],"require":[92],"numerical":[93],"solution.":[94],"We":[95,144],"compared":[96],"for":[101,182,190],"analysis":[103],"3":[105],"min":[106],"data":[109,156,171],"pig":[111],"livers":[112],"(":[113],"N":[114],"=":[115],"5)":[116],"following":[117],"injection":[118],"11":[120],"C-methylglucose.":[121],"During":[122],"scans,":[124],"concentrations":[127,252],"in":[128,132,210,253,305],"blood":[129,206],"were":[130,178,209],"measured":[131],"abdominal":[134],"aorta,":[135],"portal":[136],"vein":[137,140],"liver":[139,255],"by":[141],"manual":[142],"sampling.":[143],"found":[145],"outperformed":[149],"include":[157,285],"information":[158],"which":[159],"cannot":[160],"be":[161,295],"extracted":[162,199],"using":[163,240,261,282],"CM.":[165,242],"better":[172],"than":[173],"(Akaike":[176],"values":[177],"46":[179],"\u00b1":[180,188,195,229,237],"4":[181],"best":[183,191,223],"fits,":[185],"82":[187],"8":[189],"fits;":[193],"mean":[194],"deviation)":[197],"physiologically":[200],"reasonable":[201],"parameter":[202],"estimates":[203,220,226],"such":[204],"as":[205,264],"perfusion":[207,219,225],"agreement":[211],"independent":[213],"measurements.":[214],"difference":[216,234],"model-independent":[218],"\u22120.01":[228],"0.05":[230],"ml/ml/min,":[231],"whereas":[232],"0.30":[236],"0.13":[238],"ml/ml/min":[239],"In":[243],"addition,":[244],"predicted":[247],"time":[249],"course":[250],"vein,":[256],"prediction":[258],"fundamentally":[259],"unobtainable":[260],"return":[268],"blood.":[275],"results":[277],"demonstrate":[278],"benefit":[280],"models":[283,290],"physiology":[287],"including":[291],"gradients":[293],"should":[294],"preferred":[296],"when":[297],"analysing":[298],"blood-cell":[300],"exchange":[301],"any":[303,306],"bed.":[308]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-11-10T00:00:00"}
