{"id":"https://openalex.org/W2765290339","doi":"https://doi.org/10.1186/s40035-017-0099-z","title":"Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments","display_name":"Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments","publication_year":2017,"publication_date":"2017-10-23","ids":{"openalex":"https://openalex.org/W2765290339","doi":"https://doi.org/10.1186/s40035-017-0099-z","mag":"2765290339","pmid":"https://pubmed.ncbi.nlm.nih.gov/29090092"},"language":"en","primary_location":{"id":"doi:10.1186/s40035-017-0099-z","doi":"https://doi.org/10.1186/s40035-017-0099-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-017-0099-z","pdf_url":"https://translationalneurodegeneration.biomedcentral.com/track/pdf/10.1186/s40035-017-0099-z","source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translationalneurodegeneration.biomedcentral.com/track/pdf/10.1186/s40035-017-0099-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010413277","display_name":"Panchanan Maiti","orcid":"https://orcid.org/0000-0003-3213-8015","observed_orcids":["https://orcid.org/0000-0003-3213-8015"]},"institutions":[{"id":"https://openalex.org/I1629065","display_name":"Central Michigan University","ror":"https://ror.org/02xawj266","country_code":"US","type":"education","lineage":["https://openalex.org/I1629065"]},{"id":"https://openalex.org/I27920566","display_name":"Saginaw Valley State University","ror":"https://ror.org/01y7m0485","country_code":"US","type":"education","lineage":["https://openalex.org/I27920566"]},{"id":"https://openalex.org/I4210089270","display_name":"Field Neurosciences Institute","ror":"https://ror.org/00c1f7q63","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089270"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Panchanan Maiti","raw_affiliation_strings":["Department of Biology, Saginaw Valley State University, Saginaw, MI 48604 USA","Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859 USA","Field Neurosciences Institute Laboratory for Restorative Neurology, Mt. Pleasant, MI 48859 USA","Field Neurosciences Institute, St. Mary's of Michigan, Saginaw, MI 48604 USA","Program in Neuroscience, Mt. Pleasant, MI 48859 USA","Field Neurosciences Institute Laboratory for Restorative Neurology, Mt. Pleasant, MI, 48859, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Saginaw Valley State University, Saginaw, MI 48604 USA","institution_ids":["https://openalex.org/I27920566"]},{"raw_affiliation_string":"Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859 USA","institution_ids":["https://openalex.org/I1629065"]},{"raw_affiliation_string":"Field Neurosciences Institute Laboratory for Restorative Neurology, Mt. Pleasant, MI 48859 USA","institution_ids":["https://openalex.org/I4210089270"]},{"raw_affiliation_string":"Field Neurosciences Institute, St. Mary's of Michigan, Saginaw, MI 48604 USA","institution_ids":["https://openalex.org/I4210089270"]},{"raw_affiliation_string":"Program in Neuroscience, Mt. Pleasant, MI 48859 USA","institution_ids":[]},{"raw_affiliation_string":"Field Neurosciences Institute Laboratory for Restorative Neurology, Mt. Pleasant, MI, 48859, USA","institution_ids":["https://openalex.org/I4210089270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053610970","display_name":"Jayeeta Manna","orcid":"https://orcid.org/0000-0002-2839-510X","observed_orcids":["https://orcid.org/0000-0002-2839-510X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayeeta Manna","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38105 USA","Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38105 USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38105, USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033684624","display_name":"Gary Leo Dunbar","orcid":"https://orcid.org/0000-0003-4730-9323","observed_orcids":["https://orcid.org/0000-0003-4730-9323"]},"institutions":[{"id":"https://openalex.org/I1629065","display_name":"Central Michigan University","ror":"https://ror.org/02xawj266","country_code":"US","type":"education","lineage":["https://openalex.org/I1629065"]},{"id":"https://openalex.org/I4210089270","display_name":"Field Neurosciences Institute","ror":"https://ror.org/00c1f7q63","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089270"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary L. Dunbar","raw_affiliation_strings":["Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859 USA","Field Neurosciences Institute Laboratory for Restorative Neurology, Mt. Pleasant, MI 48859 USA","Field Neurosciences Institute, St. Mary's of Michigan, Saginaw, MI 48604 USA","Program in Neuroscience, Mt. Pleasant, MI 48859 USA","Program in Neuroscience, Mt. Pleasant, MI, 48859, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Central Michigan University, Mt. Pleasant, MI 48859 USA","institution_ids":["https://openalex.org/I1629065"]},{"raw_affiliation_string":"Field Neurosciences Institute Laboratory for Restorative Neurology, Mt. Pleasant, MI 48859 USA","institution_ids":["https://openalex.org/I4210089270"]},{"raw_affiliation_string":"Field Neurosciences Institute, St. Mary's of Michigan, Saginaw, MI 48604 USA","institution_ids":["https://openalex.org/I4210089270"]},{"raw_affiliation_string":"Program in Neuroscience, Mt. Pleasant, MI 48859 USA","institution_ids":[]},{"raw_affiliation_string":"Program in Neuroscience, Mt. Pleasant, MI, 48859, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010413277","https://openalex.org/A5033684624"],"corresponding_institution_ids":["https://openalex.org/I1629065","https://openalex.org/I27920566","https://openalex.org/I4210089270"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":20.6548,"has_fulltext":true,"cited_by_count":525,"citation_normalized_percentile":{"value":0.99737328,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/molecular-pathways","display_name":"molecular pathways","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.921999990940094},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8460000157356262},{"id":"https://openalex.org/keywords/executive-dysfunction","display_name":"executive dysfunction","score":0.8529999852180481},{"id":"https://openalex.org/keywords/frontostriatal-circuits","display_name":"frontostriatal circuits","score":0.777999997138977},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.7239999771118164},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.984000027179718},{"id":"https://openalex.org/keywords/autophagy-lysosome-pathway","display_name":"autophagy-lysosome pathway","score":0.984000027179718},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.8889999985694885},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/surgical-treatment","display_name":"surgical treatment","score":0.48100000619888306},{"id":"https://openalex.org/keywords/rehabilitation-therapy","display_name":"rehabilitation therapy","score":0.6269999742507935},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.7507350444793701},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.7370966076850891},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.7346171736717224},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7173430323600769},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5885965824127197},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5771381258964539},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5492737293243408},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5349833369255066},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4672878384590149},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.42168277502059937},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37551411986351013},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33781641721725464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19899648427963257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1504715383052826},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s40035-017-0099-z","doi":"https://doi.org/10.1186/s40035-017-0099-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-017-0099-z","pdf_url":"https://translationalneurodegeneration.biomedcentral.com/track/pdf/10.1186/s40035-017-0099-z","source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},{"id":"pmid:29090092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29090092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational neurodegeneration","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4583019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5655877","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5655877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5655877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transl Neurodegener","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:0d9a9aab716249eb8c3867dc9f9b9fe5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0d9a9aab716249eb8c3867dc9f9b9fe5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Neurodegeneration, Vol 6, Iss 1, Pp 1-35 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40035-017-0099-z","doi":"https://doi.org/10.1186/s40035-017-0099-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40035-017-0099-z","pdf_url":"https://translationalneurodegeneration.biomedcentral.com/track/pdf/10.1186/s40035-017-0099-z","source":{"id":"https://openalex.org/S2764798395","display_name":"Translational Neurodegeneration","issn_l":"2047-9158","issn":["2047-9158","2096-6466"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neurodegeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310633","display_name":"Central Michigan University","ror":"https://ror.org/02xawj266"},{"id":"https://openalex.org/F4320311943","display_name":"Field Neurosciences Institute","ror":"https://ror.org/00c1f7q63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2765290339.pdf","grobid_xml":"https://content.openalex.org/works/W2765290339.grobid-xml"},"referenced_works_count":373,"referenced_works":["https://openalex.org/W12160438","https://openalex.org/W62603772","https://openalex.org/W91138707","https://openalex.org/W99034421","https://openalex.org/W149851263","https://openalex.org/W234358645","https://openalex.org/W753527770","https://openalex.org/W1270239926","https://openalex.org/W1480945180","https://openalex.org/W1504584187","https://openalex.org/W1505937405","https://openalex.org/W1510211954","https://openalex.org/W1511827873","https://openalex.org/W1518893426","https://openalex.org/W1532018345","https://openalex.org/W1534557128","https://openalex.org/W1550876205","https://openalex.org/W1553611555","https://openalex.org/W1571449885","https://openalex.org/W1573542929","https://openalex.org/W1584627577","https://openalex.org/W1587726204","https://openalex.org/W1588992136","https://openalex.org/W1591724033","https://openalex.org/W1592870082","https://openalex.org/W1596657747","https://openalex.org/W1618846043","https://openalex.org/W1676879554","https://openalex.org/W1681758390","https://openalex.org/W1713936066","https://openalex.org/W1726439078","https://openalex.org/W1764338820","https://openalex.org/W1765655507","https://openalex.org/W1784018576","https://openalex.org/W1874817816","https://openalex.org/W1877722768","https://openalex.org/W1877873625","https://openalex.org/W1899718884","https://openalex.org/W1902946357","https://openalex.org/W1936067042","https://openalex.org/W1947356649","https://openalex.org/W1952583315","https://openalex.org/W1954913131","https://openalex.org/W1963835612","https://openalex.org/W1964057486","https://openalex.org/W1965095016","https://openalex.org/W1965942744","https://openalex.org/W1966132436","https://openalex.org/W1966326621","https://openalex.org/W1966484475","https://openalex.org/W1967089050","https://openalex.org/W1967111894","https://openalex.org/W1967573239","https://openalex.org/W1968044305","https://openalex.org/W1968407662","https://openalex.org/W1971053395","https://openalex.org/W1971077835","https://openalex.org/W1971538426","https://openalex.org/W1972097907","https://openalex.org/W1972905929","https://openalex.org/W1974927898","https://openalex.org/W1975722154","https://openalex.org/W1976635107","https://openalex.org/W1976947622","https://openalex.org/W1978002644","https://openalex.org/W1980747379","https://openalex.org/W1981482014","https://openalex.org/W1983951782","https://openalex.org/W1984879946","https://openalex.org/W1986549301","https://openalex.org/W1986628169","https://openalex.org/W1987041769","https://openalex.org/W1988832314","https://openalex.org/W1989619853","https://openalex.org/W1989735540","https://openalex.org/W1989738074","https://openalex.org/W1990287702","https://openalex.org/W1990437598","https://openalex.org/W1991268892","https://openalex.org/W1992659717","https://openalex.org/W1994172268","https://openalex.org/W1997081993","https://openalex.org/W1997721689","https://openalex.org/W1997899716","https://openalex.org/W1998238590","https://openalex.org/W1998713597","https://openalex.org/W1999893655","https://openalex.org/W2000730441","https://openalex.org/W2002502410","https://openalex.org/W2003326996","https://openalex.org/W2003616915","https://openalex.org/W2004121740","https://openalex.org/W2004653921","https://openalex.org/W2004757774","https://openalex.org/W2005317701","https://openalex.org/W2005322339","https://openalex.org/W2005614483","https://openalex.org/W2005736754","https://openalex.org/W2005968087","https://openalex.org/W2006376003","https://openalex.org/W2006412287","https://openalex.org/W2007449774","https://openalex.org/W2007562206","https://openalex.org/W2008242624","https://openalex.org/W2008688731","https://openalex.org/W2009827892","https://openalex.org/W2010196533","https://openalex.org/W2010385249","https://openalex.org/W2010623074","https://openalex.org/W2011226249","https://openalex.org/W2012088452","https://openalex.org/W2012553386","https://openalex.org/W2013392189","https://openalex.org/W2014583561","https://openalex.org/W2014850190","https://openalex.org/W2016004296","https://openalex.org/W2016289276","https://openalex.org/W2017624408","https://openalex.org/W2018506106","https://openalex.org/W2019333118","https://openalex.org/W2019425905","https://openalex.org/W2019443502","https://openalex.org/W2019770130","https://openalex.org/W2019922647","https://openalex.org/W2020290141","https://openalex.org/W2021902440","https://openalex.org/W2022348337","https://openalex.org/W2022549426","https://openalex.org/W2022812113","https://openalex.org/W2022911097","https://openalex.org/W2024820040","https://openalex.org/W2024891592","https://openalex.org/W2025714022","https://openalex.org/W2026724654","https://openalex.org/W2027096397","https://openalex.org/W2029503022","https://openalex.org/W2029657151","https://openalex.org/W2029662475","https://openalex.org/W2029934358","https://openalex.org/W2030187260","https://openalex.org/W2031978571","https://openalex.org/W2032488669","https://openalex.org/W2032817175","https://openalex.org/W2032996762","https://openalex.org/W2033177577","https://openalex.org/W2033344011","https://openalex.org/W2034824946","https://openalex.org/W2035787181","https://openalex.org/W2038274451","https://openalex.org/W2039334290","https://openalex.org/W2039705224","https://openalex.org/W2041037209","https://openalex.org/W2041290559","https://openalex.org/W2041679645","https://openalex.org/W2041819417","https://openalex.org/W2041838846","https://openalex.org/W2041874445","https://openalex.org/W2042250149","https://openalex.org/W2042312044","https://openalex.org/W2042801621","https://openalex.org/W2043822937","https://openalex.org/W2044130121","https://openalex.org/W2046137414","https://openalex.org/W2046405586","https://openalex.org/W2046623850","https://openalex.org/W2046678117","https://openalex.org/W2046690778","https://openalex.org/W2048841722","https://openalex.org/W2052299360","https://openalex.org/W2052966244","https://openalex.org/W2054316612","https://openalex.org/W2054399886","https://openalex.org/W2055124287","https://openalex.org/W2055557007","https://openalex.org/W2056751278","https://openalex.org/W2056823686","https://openalex.org/W2058855163","https://openalex.org/W2060112329","https://openalex.org/W2060822439","https://openalex.org/W2061238607","https://openalex.org/W2061810292","https://openalex.org/W2062024327","https://openalex.org/W2062605045","https://openalex.org/W2062682736","https://openalex.org/W2062732021","https://openalex.org/W2063127941","https://openalex.org/W2063949102","https://openalex.org/W2064445049","https://openalex.org/W2065564530","https://openalex.org/W2067340670","https://openalex.org/W2067692987","https://openalex.org/W2068288454","https://openalex.org/W2068778836","https://openalex.org/W2069184891","https://openalex.org/W2071391660","https://openalex.org/W2071978545","https://openalex.org/W2073377890","https://openalex.org/W2074663587","https://openalex.org/W2075793841","https://openalex.org/W2075906033","https://openalex.org/W2076344205","https://openalex.org/W2078347978","https://openalex.org/W2080851974","https://openalex.org/W2080949995","https://openalex.org/W2081384093","https://openalex.org/W2081845158","https://openalex.org/W2081923532","https://openalex.org/W2081968259","https://openalex.org/W2082807630","https://openalex.org/W2084311288","https://openalex.org/W2084333768","https://openalex.org/W2084388057","https://openalex.org/W2084420014","https://openalex.org/W2084910880","https://openalex.org/W2086545814","https://openalex.org/W2087647407","https://openalex.org/W2087972264","https://openalex.org/W2087989878","https://openalex.org/W2088327714","https://openalex.org/W2088962120","https://openalex.org/W2090154776","https://openalex.org/W2090568130","https://openalex.org/W2090928072","https://openalex.org/W2091674068","https://openalex.org/W2093684043","https://openalex.org/W2095127925","https://openalex.org/W2095984716","https://openalex.org/W2096353737","https://openalex.org/W2096478757","https://openalex.org/W2096929469","https://openalex.org/W2097028758","https://openalex.org/W2097989918","https://openalex.org/W2100300726","https://openalex.org/W2100872265","https://openalex.org/W2101371798","https://openalex.org/W2101931293","https://openalex.org/W2102436080","https://openalex.org/W2103575789","https://openalex.org/W2104382960","https://openalex.org/W2104793567","https://openalex.org/W2104825387","https://openalex.org/W2105267783","https://openalex.org/W2106565509","https://openalex.org/W2107310556","https://openalex.org/W2109001751","https://openalex.org/W2109185691","https://openalex.org/W2110054485","https://openalex.org/W2110297253","https://openalex.org/W2111893944","https://openalex.org/W2112203605","https://openalex.org/W2112997000","https://openalex.org/W2115659432","https://openalex.org/W2116294828","https://openalex.org/W2117503265","https://openalex.org/W2117629050","https://openalex.org/W2118141360","https://openalex.org/W2118453700","https://openalex.org/W2119520931","https://openalex.org/W2120535664","https://openalex.org/W2121304044","https://openalex.org/W2123714584","https://openalex.org/W2124304098","https://openalex.org/W2124729399","https://openalex.org/W2125300464","https://openalex.org/W2126008330","https://openalex.org/W2126549314","https://openalex.org/W2126693299","https://openalex.org/W2128033750","https://openalex.org/W2128790723","https://openalex.org/W2130909417","https://openalex.org/W2130979925","https://openalex.org/W2133398254","https://openalex.org/W2136388422","https://openalex.org/W2136671766","https://openalex.org/W2137730033","https://openalex.org/W2139119152","https://openalex.org/W2139927152","https://openalex.org/W2142470955","https://openalex.org/W2143794453","https://openalex.org/W2143906078","https://openalex.org/W2143978324","https://openalex.org/W2144526889","https://openalex.org/W2145334223","https://openalex.org/W2145954079","https://openalex.org/W2147488750","https://openalex.org/W2147621768","https://openalex.org/W2149341227","https://openalex.org/W2150550276","https://openalex.org/W2150656456","https://openalex.org/W2150824378","https://openalex.org/W2151015629","https://openalex.org/W2151280274","https://openalex.org/W2151497983","https://openalex.org/W2152657141","https://openalex.org/W2154761807","https://openalex.org/W2154789444","https://openalex.org/W2155538983","https://openalex.org/W2155634762","https://openalex.org/W2157535220","https://openalex.org/W2157587576","https://openalex.org/W2158768021","https://openalex.org/W2159039297","https://openalex.org/W2159143135","https://openalex.org/W2160239222","https://openalex.org/W2161988018","https://openalex.org/W2162284422","https://openalex.org/W2164509693","https://openalex.org/W2164627569","https://openalex.org/W2164728918","https://openalex.org/W2165421565","https://openalex.org/W2168163562","https://openalex.org/W2169089437","https://openalex.org/W2171325190","https://openalex.org/W2171873547","https://openalex.org/W2179402427","https://openalex.org/W2185468729","https://openalex.org/W2199756599","https://openalex.org/W2211141668","https://openalex.org/W2214677303","https://openalex.org/W2230621856","https://openalex.org/W2267051237","https://openalex.org/W2293547289","https://openalex.org/W2339865699","https://openalex.org/W2341798214","https://openalex.org/W2401820359","https://openalex.org/W2402519955","https://openalex.org/W2411988134","https://openalex.org/W2415368356","https://openalex.org/W2417747301","https://openalex.org/W2421874192","https://openalex.org/W2472509986","https://openalex.org/W2507718676","https://openalex.org/W2520469409","https://openalex.org/W2556527569","https://openalex.org/W2558647963","https://openalex.org/W2574772695","https://openalex.org/W2579122492","https://openalex.org/W2581205836","https://openalex.org/W2587509039","https://openalex.org/W2588841770","https://openalex.org/W2592008353","https://openalex.org/W2594033044","https://openalex.org/W2594947121","https://openalex.org/W2599373832","https://openalex.org/W2602067988","https://openalex.org/W2604223861","https://openalex.org/W2604957791","https://openalex.org/W2610292304","https://openalex.org/W2610706870","https://openalex.org/W2612148354","https://openalex.org/W2614598599","https://openalex.org/W2616367270","https://openalex.org/W2619087985","https://openalex.org/W2621043313","https://openalex.org/W2621548695","https://openalex.org/W2623170282","https://openalex.org/W2626849072","https://openalex.org/W2724173643","https://openalex.org/W2726672065","https://openalex.org/W2734862190","https://openalex.org/W2737283516","https://openalex.org/W2738285228","https://openalex.org/W2739961516","https://openalex.org/W2746087605","https://openalex.org/W2748834724","https://openalex.org/W2749251498","https://openalex.org/W2973555955","https://openalex.org/W3151643942","https://openalex.org/W4210999919","https://openalex.org/W4213459747","https://openalex.org/W4248000073","https://openalex.org/W4252422141","https://openalex.org/W4296217171"],"related_works":["https://openalex.org/W2178039548","https://openalex.org/W2359931691","https://openalex.org/W3049065873","https://openalex.org/W154169386","https://openalex.org/W2884144427","https://openalex.org/W4248431072","https://openalex.org/W2035149159","https://openalex.org/W3216960204","https://openalex.org/W2913997818","https://openalex.org/W1993100025"],"abstract_inverted_index":{"Gradual":[0],"degeneration":[1],"and":[2,13,54,69,132,139,151,178],"loss":[3],"of":[4,16,34,51,77,113,117,129,141,146,187],"dopaminergic":[5,88],"neurons":[6],"in":[7,19,45,123,154],"the":[8,35,84,94,97,114,118,127,137,185],"substantia":[9],"nigra,":[10],"pars":[11],"compacta":[12],"subsequent":[14],"reduction":[15],"dopamine":[17],"levels":[18],"striatum":[20],"are":[21,63,70,156,191],"associated":[22],"with":[23],"motor":[24],"deficits":[25,44],"that":[26],"characterize":[27],"Parkinson's":[28],"disease":[29,95,190],"(PD).":[30],"In":[31,105,159],"addition,":[32,160],"half":[33],"PD":[36,62,155],"patients":[37],"also":[38,157],"exhibit":[39],"frontostriatal-mediated":[40],"executive":[41],"dysfunction,":[42],"including":[43,163],"attention,":[46],"short-term":[47],"working":[48],"memory,":[49],"speed":[50],"mental":[52],"processing,":[53],"impulsivity.":[55],"The":[56,144],"most":[57],"commonly":[58],"used":[59],"treatments":[60],"for":[61,99],"only":[64],"partially":[65],"or":[66,72,86,92,183],"transiently":[67],"effective":[68,101],"available":[71],"applicable":[73],"to":[74,136,181],"a":[75,110],"minority":[76],"patients.":[78],"Because,":[79],"these":[80],"therapies":[81,180],"neither":[82],"restore":[83],"lost":[85],"degenerated":[87],"neurons,":[89],"nor":[90],"prevent":[91,182],"delay":[93,184],"progression,":[96],"need":[98],"more":[100],"therapeutics":[102],"is":[103],"critical.":[104],"this":[106,142,188],"review,":[107],"we":[108],"provide":[109],"comprehensive":[111],"overview":[112],"current":[115],"understanding":[116],"molecular":[119,147],"signaling":[120],"pathways":[121],"involved":[122],"PD,":[124],"particularly":[125],"within":[126],"context":[128],"how":[130],"genetic":[131],"environmental":[133],"factors":[134],"contribute":[135],"initiation":[138],"progression":[140,186],"disease.":[143],"involvement":[145],"chaperones,":[148],"autophagy-lysosomal":[149],"pathways,":[150],"proteasome":[152],"systems":[153],"highlighted.":[158],"emerging":[161],"therapies,":[162],"pharmacological":[164],"manipulations,":[165],"surgical":[166],"procedures,":[167],"stem":[168],"cell":[169],"transplantation,":[170],"gene":[171],"therapy,":[172],"as":[173,175],"well":[174],"complementary,":[176],"supportive":[177],"rehabilitation":[179],"complex":[189],"reviewed.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":41},{"year":2025,"cited_by_count":63},{"year":2024,"cited_by_count":79},{"year":2023,"cited_by_count":71},{"year":2022,"cited_by_count":68},{"year":2021,"cited_by_count":74},{"year":2020,"cited_by_count":66},{"year":2019,"cited_by_count":42},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
