{"id":"https://openalex.org/W2765229376","doi":"https://doi.org/10.1016/j.jalz.2017.06.1123","title":"[P2\u2013466]: EFFECT OF THE APOLIPOPROTEIN E E2 (APOE2) ALLELE ON MEMORY DECLINE AND INCIDENCE AND TRANSITION TO ALZHEIMER's DISEASE (AD): RESULTS FROM THE EINSTEIN AGING STUDY (EAS)","display_name":"[P2\u2013466]: EFFECT OF THE APOLIPOPROTEIN E E2 (APOE2) ALLELE ON MEMORY DECLINE AND INCIDENCE AND TRANSITION TO ALZHEIMER's DISEASE (AD): RESULTS FROM THE EINSTEIN AGING STUDY (EAS)","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2765229376","doi":"https://doi.org/10.1016/j.jalz.2017.06.1123","mag":"2765229376"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2017.06.1123","doi":"https://doi.org/10.1016/j.jalz.2017.06.1123","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.1123","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108463869","display_name":"Mindy Joy Katz","orcid":"https://orcid.org/0009-0004-7524-0292","observed_orcids":["https://orcid.org/0009-0004-7524-0292"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mindy J. Katz","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057583303","display_name":"Cuiling Wang","orcid":"https://orcid.org/0000-0002-1399-1048","observed_orcids":["https://orcid.org/0000-0002-1399-1048"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cuiling Wang","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040281324","display_name":"Carol A. Derby","orcid":"https://orcid.org/0000-0002-5657-4519","observed_orcids":["https://orcid.org/0000-0002-5657-4519"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Derby","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000448269","display_name":"Richard B. Lipton","orcid":"https://orcid.org/0000-0003-2652-2897","observed_orcids":["https://orcid.org/0000-0003-2652-2897"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Lipton","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108463869"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19949747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7S_Part_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7381953001022339},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.6034720540046692},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5481396913528442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48125430941581726},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.47786444425582886},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47081953287124634},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4308618903160095},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.42841485142707825},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4252697825431824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42468225955963135},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.37647828459739685},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34563571214675903},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3243950605392456},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.22588536143302917},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.10230967402458191},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08660995960235596},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2017.06.1123","doi":"https://doi.org/10.1016/j.jalz.2017.06.1123","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.1123","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2104850453","https://openalex.org/W2152681705","https://openalex.org/W7099505979","https://openalex.org/W2290101922","https://openalex.org/W1981541008","https://openalex.org/W2986775635","https://openalex.org/W3188306461","https://openalex.org/W2078604891","https://openalex.org/W2076370468","https://openalex.org/W4205490228"],"abstract_inverted_index":{"Limited":[0],"research":[1],"suggests":[2],"that":[3],"ApoE2":[4,16,46,77,131,147,170,202,215,240],"is":[5,26,216],"neuroprotective":[6],"for":[7,105,165],"episodic":[8,50,219],"memory":[9,51,220],"decline":[10,145],"and":[11,56,61,82,100,108,156,167,191,222],"AD.":[12,23,228],"In":[13],"case-control":[14],"studies,":[15],"carriers":[17,148,171],"had":[18,192],"40%":[19],"reduced":[20,193,207],"risk":[21,208,225],"of":[22,45,49,144,195,209,226,230,239,247],"However,":[24],"there":[25],"limited":[27],"data":[28,36],"from":[29,37,54,177,186,197],"cohort":[30],"studies.":[31],"Analyses":[32,229],"are":[33],"based":[34],"on":[35,47,79],"the":[38,43,236,244],"EAS":[39,112],"cohort.":[40],"We":[41,70],"evaluated":[42],"effect":[44,238],"trajectories":[48],"(free":[52],"recall":[53],"Free":[55],"Cued":[57],"Reminding":[58],"Test":[59],"(FCSRT))":[60],"Logical":[62],"Memory":[63],"(LM),":[64],"using":[65],"linear":[66],"mixed":[67,84],"effects":[68,78,85],"models.":[69],"used":[71],"proportional":[72],"hazard":[73],"models":[74,86,103],"to":[75,87,175,179,184,188,199],"evaluate":[76],"incident":[80,134,210,227],"AD,":[81],"generalized":[83],"assess":[88],"transitions":[89,231],"across":[90],"cognitive":[91,97,233],"states":[92,234],"(cognitively":[93],"normal":[94],"(CN),":[95],"mild":[96],"impairment":[98],"(MCI)":[99],"dementia).":[101],"All":[102],"adjust":[104],"age,":[106],"gender":[107],"education.":[109],"Among":[110],"1053":[111],"participants":[113],"who":[114],"were":[115,130,172],"dementia-free":[116],"at":[117],"baseline":[118],"(60%":[119],"female,":[120],"68%":[121],"white,":[122],"26%":[123],"black,":[124],"mean":[125],"age":[126],"78.6":[127],"years),":[128],"17%":[129],"carriers.":[132],"89":[133],"AD":[135,211,248],"cases":[136],"developed":[137],"over":[138],"follow-up":[139],"(mean":[140],"4.7":[141],"years).":[142],"Rate":[143],"in":[146,243],"versus":[149],"non-carriers":[150],"was":[151,203],"0.26":[152],"(CI:":[153,158],"0.05\u20130.47,":[154],"p=0.014)":[155],"0.27":[157],"0.09\u20130.45,":[159],"p=0.003)":[160],"points":[161],"per":[162],"year":[163],"slower":[164],"FCSRT":[166],"LM,":[168],"respectively.":[169],"less":[173],"likely":[174,183],"transition":[176,185],"CN":[178,189],"dementia":[180,200],"(P=0.043),":[181],"more":[182],"MCI":[187,198],"(P=0.142)":[190],"probability":[194],"transitioning":[196],"(P=0.468).":[201],"associated":[204],"with":[205],"36%":[206],"(HR=0.64,":[212],"CI:":[213],"0.33\u20131.24).":[214],"protective":[217,237],"against":[218],"decline,":[221],"may":[223,241],"reduce":[224],"among":[232],"suggest":[235],"act":[242],"early":[245],"phase":[246],"development.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-11-10T00:00:00"}
