{"id":"https://openalex.org/W2765199874","doi":"https://doi.org/10.1093/jrr/rrx057","title":"Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy","display_name":"Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy","publication_year":2017,"publication_date":"2017-10-04","ids":{"openalex":"https://openalex.org/W2765199874","doi":"https://doi.org/10.1093/jrr/rrx057","mag":"2765199874","pmid":"https://pubmed.ncbi.nlm.nih.gov/29087492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5778494"},"language":"en","primary_location":{"id":"doi:10.1093/jrr/rrx057","doi":"https://doi.org/10.1093/jrr/rrx057","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jrr/rrx057","pdf_url":"https://academic.oup.com/jrr/article-pdf/59/1/91/31607081/rrx057.pdf","source":{"id":"https://openalex.org/S40303635","display_name":"Journal of Radiation Research","issn_l":"0449-3060","issn":["0449-3060","1349-9157"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/jrr/article-pdf/59/1/91/31607081/rrx057.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013082779","display_name":"Kenta Takada","orcid":"https://orcid.org/0009-0008-1815-9147","observed_orcids":["https://orcid.org/0009-0008-1815-9147"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenta Takada","raw_affiliation_strings":["Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040155646","display_name":"Tatsuhiko Sato","orcid":"https://orcid.org/0000-0001-9902-7083","observed_orcids":["https://orcid.org/0000-0001-9902-7083"]},"institutions":[{"id":"https://openalex.org/I117197279","display_name":"Japan Atomic Energy Agency","ror":"https://ror.org/05nf86y53","country_code":"JP","type":"government","lineage":["https://openalex.org/I117197279"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhiko Sato","raw_affiliation_strings":["Japan Atomic Energy Agency, 2-4, Shirakata, Tokai, Ibaraki 319-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Atomic Energy Agency, 2-4, Shirakata, Tokai, Ibaraki 319-1195, Japan","institution_ids":["https://openalex.org/I117197279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069962650","display_name":"Hiroaki Kumada","orcid":"https://orcid.org/0000-0002-1264-2380","observed_orcids":["https://orcid.org/0000-0002-1264-2380"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4210114927","display_name":"University of Tsukuba Hospital","ror":"https://ror.org/028fz3b89","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Kumada","raw_affiliation_strings":["Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan","Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan","institution_ids":["https://openalex.org/I4210114927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076805019","display_name":"Junichi Koketsu","orcid":"https://orcid.org/0000-0002-3279-2458","observed_orcids":["https://orcid.org/0000-0002-3279-2458"]},"institutions":[{"id":"https://openalex.org/I4210114927","display_name":"University of Tsukuba Hospital","ror":"https://ror.org/028fz3b89","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Koketsu","raw_affiliation_strings":["Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan","institution_ids":["https://openalex.org/I4210114927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110220962","display_name":"Hideyuki Takei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114927","display_name":"University of Tsukuba Hospital","ror":"https://ror.org/028fz3b89","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Takei","raw_affiliation_strings":["Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan","institution_ids":["https://openalex.org/I4210114927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091639568","display_name":"Hideyuki Sakurai","orcid":"https://orcid.org/0000-0002-0576-8639","observed_orcids":["https://orcid.org/0000-0002-0576-8639"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4210114927","display_name":"University of Tsukuba Hospital","ror":"https://ror.org/028fz3b89","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Sakurai","raw_affiliation_strings":["Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan","Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan","institution_ids":["https://openalex.org/I4210114927"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073848908","display_name":"Takeji Sakae","orcid":"https://orcid.org/0000-0001-8674-7751","observed_orcids":["https://orcid.org/0000-0001-8674-7751"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4210114927","display_name":"University of Tsukuba Hospital","ror":"https://ror.org/028fz3b89","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210114927"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeji Sakae","raw_affiliation_strings":["Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan","Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"Proton Beam Therapy Center, University of Tsukuba Hospital, 2-1-1, Amakubo, Tsukuba, Ibaraki, 305-8576, Japan","institution_ids":["https://openalex.org/I4210114927"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013082779"],"corresponding_institution_ids":["https://openalex.org/I146399215"],"apc_list":{"value":2430,"currency":"USD","value_usd":2430},"apc_paid":{"value":2430,"currency":"USD","value_usd":2430},"fwci":6.0351,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.97365034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"59","issue":"1","first_page":"91","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/relative-biological-effectiveness","display_name":"relative biological effectiveness","score":0.8220000267028809},{"id":"https://openalex.org/keywords/rbe-weighted-dose","display_name":"RBE-weighted dose","score":0.9580000042915344},{"id":"https://openalex.org/keywords/microdosimetric-kinetic-model","display_name":"microdosimetric kinetic model","score":0.996999979019165},{"id":"https://openalex.org/keywords/phits","display_name":"PHITS","score":0.796999990940094},{"id":"https://openalex.org/keywords/depth-dose-distribution","display_name":"depth dose distribution","score":0.7789999842643738},{"id":"https://openalex.org/keywords/spread-out-bragg-peak","display_name":"spread-out Bragg peak","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cell-survival-fraction","display_name":"cell survival fraction","score":0.6050000190734863},{"id":"https://openalex.org/keywords/treatment-planning-system","display_name":"treatment planning system","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2781298738","wikidata":"https://www.wikidata.org/wiki/Q18041535","display_name":"Sobp","level":4,"score":0.9542648792266846},{"id":"https://openalex.org/C2780944729","wikidata":"https://www.wikidata.org/wiki/Q897227","display_name":"Bragg peak","level":3,"score":0.700404942035675},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.676243782043457},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.6101152896881104},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.6076834201812744},{"id":"https://openalex.org/C168834538","wikidata":"https://www.wikidata.org/wiki/Q3705329","display_name":"Beam (structure)","level":2,"score":0.5391080975532532},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.5155417919158936},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4715345501899719},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.41823717951774597},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.35216808319091797},{"id":"https://openalex.org/C30475298","wikidata":"https://www.wikidata.org/wiki/Q909554","display_name":"Computational physics","level":1,"score":0.345251202583313},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.30610114336013794},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.17323178052902222},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12397107481956482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08426520228385925},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08203437924385071}],"mesh":[{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012062","descriptor_name":"Relative Biological Effectiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061766","descriptor_name":"Proton Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/jrr/rrx057","doi":"https://doi.org/10.1093/jrr/rrx057","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jrr/rrx057","pdf_url":"https://academic.oup.com/jrr/article-pdf/59/1/91/31607081/rrx057.pdf","source":{"id":"https://openalex.org/S40303635","display_name":"Journal of Radiation Research","issn_l":"0449-3060","issn":["0449-3060","1349-9157"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research","raw_type":"journal-article"},{"id":"pmid:29087492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29087492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of radiation research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5778494","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5778494/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Radiat Res","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:00843:0001635785","doi":null,"is_oa":true,"landing_page_url":"https://tsukuba.repo.nii.ac.jp/records/45602","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Radiation Research","raw_type":"journal article"},{"id":"pmh:oai:tsukuba.repo.nii.ac.jp:00045602","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2241/00150883","pdf_url":null,"source":{"id":"https://openalex.org/S4306402076","display_name":"Terrestrial Environment Research Center (University of Tsukuba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146399215","host_organization_name":"University of Tsukuba","host_organization_lineage":["https://openalex.org/I146399215"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1093/jrr/rrx057","doi":"https://doi.org/10.1093/jrr/rrx057","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jrr/rrx057","pdf_url":"https://academic.oup.com/jrr/article-pdf/59/1/91/31607081/rrx057.pdf","source":{"id":"https://openalex.org/S40303635","display_name":"Journal of Radiation Research","issn_l":"0449-3060","issn":["0449-3060","1349-9157"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Radiation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4079967452","display_name":"\u967d\u5b50\u7dda\u6cbb\u7642\u306b\u304a\u3051\u308b\u30e2\u30f3\u30c6\u30ab\u30eb\u30ed\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u7528\u3044\u305f\u64fe\u4e71\u4fc2\u6570\u306e\u89e3\u6790","funder_award_id":"17H00600","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6691658324","display_name":"Basic research for clinical application of next generation multiparticle therapy","funder_award_id":"15H04901","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8793436449","display_name":"Real-time dose estimation system for BNCT by combination with the tracking technology for patient movement","funder_award_id":"16H05236","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8924122735","display_name":"Development of a all modality treatment planning system which can perform dose estimations for every external radiation therapy","funder_award_id":"16K15343","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320323954","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2765199874.pdf","grobid_xml":"https://content.openalex.org/works/W2765199874.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1593118782","https://openalex.org/W1788427501","https://openalex.org/W1823727300","https://openalex.org/W1847687345","https://openalex.org/W1877981453","https://openalex.org/W1979445200","https://openalex.org/W1984269341","https://openalex.org/W1996093493","https://openalex.org/W1997533204","https://openalex.org/W2000593521","https://openalex.org/W2005775826","https://openalex.org/W2011374286","https://openalex.org/W2012303495","https://openalex.org/W2021640456","https://openalex.org/W2034292298","https://openalex.org/W2040145532","https://openalex.org/W2041602847","https://openalex.org/W2057917414","https://openalex.org/W2075266607","https://openalex.org/W2079250348","https://openalex.org/W2080634330","https://openalex.org/W2081844303","https://openalex.org/W2083770395","https://openalex.org/W2085852226","https://openalex.org/W2091705392","https://openalex.org/W2095148496","https://openalex.org/W2098188835","https://openalex.org/W2100654767","https://openalex.org/W2102819305","https://openalex.org/W2103506815","https://openalex.org/W2104358865","https://openalex.org/W2111524844","https://openalex.org/W2119846428","https://openalex.org/W2119860372","https://openalex.org/W2126291511","https://openalex.org/W2132034069","https://openalex.org/W2160440514","https://openalex.org/W2162329306","https://openalex.org/W2163082543","https://openalex.org/W2163654397","https://openalex.org/W2287874371","https://openalex.org/W2324796157","https://openalex.org/W2406988819"],"related_works":["https://openalex.org/W2973128315","https://openalex.org/W2912071408","https://openalex.org/W4401664085","https://openalex.org/W3121985432","https://openalex.org/W7222069774","https://openalex.org/W7058216518","https://openalex.org/W4282839287","https://openalex.org/W4390117404","https://openalex.org/W2604998704","https://openalex.org/W2899319616"],"abstract_inverted_index":{"The":[0,96,182,232],"microdosimetric":[1,217],"kinetic":[2],"model":[3],"(MKM)":[4],"is":[5,37],"widely":[6],"used":[7],"for":[8,15,81,105,160,227,244],"estimating":[9,123],"relative":[10],"biological":[11],"effectiveness":[12],"(RBE)-weighted":[13],"doses":[14,187],"various":[16,245],"radiotherapies":[17],"because":[18],"it":[19,36],"can":[20],"determine":[21],"the":[22,31,40,47,50,66,71,76,86,91,124,127,134,142,155,161,165,169,178,194,199,203,206,240],"surviving":[23],"fraction":[24],"of":[25,39,49,90,116,152,198,223],"irradiated":[26],"cells":[27],"based":[28,219],"on":[29,220],"only":[30],"lineal":[32,99,171],"energy":[33,100,172],"distribution,":[34,101],"and":[35,43,102,110,184,225],"independent":[38],"radiation":[41],"type":[42],"ion":[44],"species.":[45],"However,":[46],"applicability":[48],"method":[51],"to":[52],"proton":[53,82,93,230],"therapy":[54,83],"has":[55,213,236],"not":[56],"yet":[57],"been":[58],"investigated":[59],"thoroughly.":[60],"In":[61,122,164],"this":[62],"study,":[63],"we":[64],"validated":[65],"RBE-weighted":[67,103,166,186],"dose":[68,104,130,167],"calculated":[69,128,170,183],"by":[70,84,132,145,209],"MKM":[72,226],"in":[73,154,189,239],"tandem":[74],"with":[75,141,177],"Monte":[77],"Carlo":[78],"code":[79],"PHITS":[80,138,224],"considering":[85],"complete":[87],"simulation":[88],"geometry":[89],"clinical":[92,229],"beam":[94,115,136],"line.":[95],"physical":[97,125],"dose,":[98,126],"a":[106,146,215,221],"155":[107],"MeV":[108],"mono-energetic":[109,135,200],"spread-out":[111],"Bragg":[112,195],"peak":[113,196],"(SOBP)":[114],"60":[117],"mm":[118],"width":[119],"were":[120,188],"evaluated.":[121],"depth":[129,156],"distribution":[131,157],"irradiating":[133],"using":[137],"was":[139,158],"consistent":[140],"data":[143,208],"measured":[144,185,207],"diode":[147],"detector.":[148],"A":[149],"maximum":[150],"difference":[151],"3.1%":[153],"observed":[159],"SOBP":[162],"beam.":[163],"validation,":[168],"distributions":[173],"generally":[174],"agreed":[175],"well":[176],"published":[179],"measurement":[180],"data.":[181],"excellent":[190],"agreement,":[191],"except":[192],"at":[193],"region":[197],"beam,":[201],"where":[202],"calculation":[204],"overestimated":[205],"~15%.":[210],"This":[211],"research":[212],"provided":[214],"computational":[216],"approach":[218],"combination":[222],"typical":[228],"beams.":[231],"developed":[233],"RBE-estimator":[234],"function":[235],"potential":[237],"application":[238],"treatment":[241],"planning":[242],"system":[243],"radiotherapies.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2017-11-10T00:00:00"}