{"id":"https://openalex.org/W2765093044","doi":"https://doi.org/10.1080/10715762.2017.1395419","title":"Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans","display_name":"Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans","publication_year":2017,"publication_date":"2017-10-26","ids":{"openalex":"https://openalex.org/W2765093044","doi":"https://doi.org/10.1080/10715762.2017.1395419","mag":"2765093044","pmid":"https://pubmed.ncbi.nlm.nih.gov/29069955"},"language":"en","primary_location":{"id":"doi:10.1080/10715762.2017.1395419","doi":"https://doi.org/10.1080/10715762.2017.1395419","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10715762.2017.1395419","pdf_url":null,"source":{"id":"https://openalex.org/S23349031","display_name":"Free Radical Research","issn_l":"1029-2470","issn":["1029-2470","1071-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018511589","display_name":"Shachi Shuchi Smita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shachi Shuchi Smita","raw_affiliation_strings":["Laboratory of Aging Biology, Department of Microbial Technology and Nematology, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aging Biology, Department of Microbial Technology and Nematology, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, India;","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I68145777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037274188","display_name":"Shreesh Raj Sammi","orcid":"https://orcid.org/0000-0003-4163-8628","observed_orcids":["https://orcid.org/0000-0003-4163-8628"]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shreesh Raj Sammi","raw_affiliation_strings":["Laboratory of Aging Biology, Department of Microbial Technology and Nematology, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aging Biology, Department of Microbial Technology and Nematology, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, India;","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I68145777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011578809","display_name":"Tulsankar Sachin Laxman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tulsankar S. Laxman","raw_affiliation_strings":["Pharmacokinetics and Metabolism Division, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics and Metabolism Division, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007518427","display_name":"Rabi Sankar Bhatta","orcid":"https://orcid.org/0000-0003-4844-2388","observed_orcids":["https://orcid.org/0000-0003-4844-2388"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rabi S. Bhatta","raw_affiliation_strings":["Pharmacokinetics and Metabolism Division, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacokinetics and Metabolism Division, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111751176","display_name":"Rakesh Pandey","orcid":"https://orcid.org/0000-0003-0947-4272","observed_orcids":["https://orcid.org/0000-0003-0947-4272"]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rakesh Pandey","raw_affiliation_strings":["Laboratory of Aging Biology, Department of Microbial Technology and Nematology, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, India;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Aging Biology, Department of Microbial Technology and Nematology, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, India;","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I68145777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111751176"],"corresponding_institution_ids":["https://openalex.org/I66760702","https://openalex.org/I68145777"],"apc_list":null,"apc_paid":null,"fwci":1.0486,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.7336908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"51","issue":"11-12","first_page":"954","last_page":"969"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asparagus-racemosus","display_name":"Asparagus racemosus","score":0.9240000247955322},{"id":"https://openalex.org/keywords/steroidal-saponins","display_name":"steroidal saponins","score":0.9190000295639038},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.8339999914169312},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8429999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8450000286102295},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9259999990463257},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7739999890327454},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.593999981880188},{"id":"https://openalex.org/keywords/pdr-1","display_name":"pdr-1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.4390000104904175},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9290000200271606}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7634429335594177},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7505220174789429},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7042195200920105},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.5853164196014404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5249637961387634},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4941287338733673},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3631017804145813},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3544773459434509},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3399108648300171},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29342132806777954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.164783775806427},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1609368622303009},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15930795669555664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11403888463973999}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020734","descriptor_name":"Parkinsonian Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D027761","descriptor_name":"Asparagus Plant","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/10715762.2017.1395419","doi":"https://doi.org/10.1080/10715762.2017.1395419","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10715762.2017.1395419","pdf_url":null,"source":{"id":"https://openalex.org/S23349031","display_name":"Free Radical Research","issn_l":"1029-2470","issn":["1029-2470","1071-5762"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Research","raw_type":"journal-article"},{"id":"pmid:29069955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29069955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1028958669","https://openalex.org/W1488265246","https://openalex.org/W1566136977","https://openalex.org/W1848057444","https://openalex.org/W1853666055","https://openalex.org/W1944127002","https://openalex.org/W1964274784","https://openalex.org/W1968800738","https://openalex.org/W1970182011","https://openalex.org/W1980825524","https://openalex.org/W1981350000","https://openalex.org/W1989522802","https://openalex.org/W1990437598","https://openalex.org/W1991715802","https://openalex.org/W1995690659","https://openalex.org/W2000370520","https://openalex.org/W2002559713","https://openalex.org/W2004514374","https://openalex.org/W2004727220","https://openalex.org/W2012259571","https://openalex.org/W2012383052","https://openalex.org/W2012553919","https://openalex.org/W2013726070","https://openalex.org/W2016235840","https://openalex.org/W2025931289","https://openalex.org/W2034242780","https://openalex.org/W2037030597","https://openalex.org/W2039215765","https://openalex.org/W2042391279","https://openalex.org/W2050409452","https://openalex.org/W2052259733","https://openalex.org/W2055461360","https://openalex.org/W2056128097","https://openalex.org/W2066762007","https://openalex.org/W2073954164","https://openalex.org/W2076654506","https://openalex.org/W2081197670","https://openalex.org/W2085062185","https://openalex.org/W2087790613","https://openalex.org/W2089826056","https://openalex.org/W2099083422","https://openalex.org/W2101861123","https://openalex.org/W2104207184","https://openalex.org/W2110987512","https://openalex.org/W2113589107","https://openalex.org/W2114570899","https://openalex.org/W2117822586","https://openalex.org/W2122831507","https://openalex.org/W2123431154","https://openalex.org/W2124800531","https://openalex.org/W2126619846","https://openalex.org/W2130605000","https://openalex.org/W2131150217","https://openalex.org/W2131651816","https://openalex.org/W2133184149","https://openalex.org/W2134579258","https://openalex.org/W2137445017","https://openalex.org/W2137607459","https://openalex.org/W2141685111","https://openalex.org/W2146760369","https://openalex.org/W2148242921","https://openalex.org/W2152622902","https://openalex.org/W2166855962","https://openalex.org/W2189302564","https://openalex.org/W2200701933","https://openalex.org/W2315512556","https://openalex.org/W2335974826","https://openalex.org/W2345643767","https://openalex.org/W2399040283","https://openalex.org/W2518670444","https://openalex.org/W2526570540","https://openalex.org/W2546599223","https://openalex.org/W2565210269","https://openalex.org/W2568389087","https://openalex.org/W2580447227","https://openalex.org/W2585596724","https://openalex.org/W2592552882","https://openalex.org/W2608073292","https://openalex.org/W2616612259"],"related_works":["https://openalex.org/W2580447227","https://openalex.org/W3083427005","https://openalex.org/W3047183599","https://openalex.org/W1760211547","https://openalex.org/W4200108452","https://openalex.org/W2140063863","https://openalex.org/W4406133048","https://openalex.org/W4413422442","https://openalex.org/W2919265754","https://openalex.org/W7126318040"],"abstract_inverted_index":{"Shatavarin":[0],"IV":[1],"(SIV),":[2],"a":[3,7,56,189],"steroidal":[4],"saponin,":[5],"is":[6,28,188],"major":[8],"bioactive":[9,42,200],"phytomolecule":[10,54],"present":[11,65,163],"in":[12,33,37,90,137,192,203],"roots":[13],"of":[14,41,52,74,92,117,140,199],"Asparagus":[15],"racemosus":[16],"(Liliaceae)":[17],"known":[18],"for":[19,59,67],"its":[20,130],"anticancer":[21],"activity.":[22],"Age-associated":[23],"neurodegenerative":[24],"Parkinson's":[25],"disease":[26],"(PD)":[27],"characterised":[29],"by":[30,151,177],"alpha-synuclein":[31,154],"aggregation":[32],"dopaminergic":[34],"neuron":[35],"resulting":[36],"neurodegeneration.":[38],"The":[39],"invention":[40],"molecules":[43],"that":[44,133,166],"delay":[45],"aging":[46,77],"and":[47,78,106,127,143,158,173,183,196],"age-associated":[48],"disorders":[49],"endorses":[50],"development":[51],"natural":[53],"as":[55,98,100],"therapeutic":[57],"agent":[58],"curing":[60],"age-related":[61],"diseases.":[62],"Therefore,":[63,185],"the":[64,68,72,114,138,153,194],"study":[66,187],"first":[69],"time":[70],"explores":[71],"potential":[73,198],"SIV":[75,85,110,147,167,202],"against":[76],"Parkinsonism":[79],"utilising":[80,169],"Caenorhabditis":[81],"elegans":[82],"model":[83],"system.":[84],"significantly":[86,112],"attenuated":[87],"oxidative":[88,101,141,175],"stress":[89,118,142,176],"terms":[91],"intracellular":[93],"reactive":[94],"oxygen":[95],"species":[96],"(ROS)":[97],"well":[99],"damage":[102],"including":[103],"protein":[104],"carbonylation":[105],"also":[107,111],"promotes":[108],"longevity.":[109],"increased":[113],"mRNA":[115],"expression":[116],"responsive":[119],"genes":[120,180],"namely":[121],"sod-1,":[122],"sod-2,":[123],"sod-3,":[124],"gst-4,":[125],"gst-7":[126],"ctl-2":[128],"suggesting":[129],"anti-oxidant":[131],"property":[132],"might":[134],"be":[135],"contributed":[136],"modulation":[139],"promoting":[144],"lifespan.":[145],"Additionally,":[146],"improved":[148],"PD":[149],"symptoms":[150],"reducing":[152],"aggregation,":[155],"lipid":[156],"accumulation":[157],"enhancing":[159],"dopamine":[160],"level.":[161],"Altogether,":[162],"findings":[164],"indicate":[165],"possibly":[168],"ubiquitin-mediated":[170],"proteasomal":[171],"system":[172],"attenuating":[174],"up-regulating":[178],"PD-associated":[179],"pdr-1,":[181],"ubc-12":[182],"pink-1.":[184],"this":[186],"forward":[190],"step":[191],"exploring":[193],"anti-aging":[195],"anti-Parkinsonism":[197],"compound":[201],"C.":[204],"elegans.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-11-10T00:00:00"}