{"id":"https://openalex.org/W2765090685","doi":null,"title":"Axonal Transport in Animal models of Amyotrophic Lateral Sclerosis","display_name":"Axonal Transport in Animal models of Amyotrophic Lateral Sclerosis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2765090685","mag":"2765090685"},"language":"en","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-025017300","doi":null,"is_oa":false,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1098683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033424216","display_name":"Petar Marinkovi\u0107","orcid":"https://orcid.org/0000-0002-3072-972X","observed_orcids":["https://orcid.org/0000-0002-3072-972X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Petar Marinkovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033424216"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/axonal-transport","display_name":"axonal transport","score":0.9629999995231628},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.7429999709129333},{"id":"https://openalex.org/keywords/axon-degeneration","display_name":"axonal degeneration","score":0.890999972820282},{"id":"https://openalex.org/keywords/mitochondrial-transport","display_name":"mitochondrial transport","score":0.6880000233650208},{"id":"https://openalex.org/keywords/sod1-g93a-mice","display_name":"SOD1 G93A mice","score":0.7699999809265137},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/axonal-morphology","display_name":"axon morphology","score":0.7860000133514404},{"id":"https://openalex.org/keywords/animal-models-of-als","display_name":"animal models of ALS","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.9127437472343445},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.8508561849594116},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.7650188207626343},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7483302354812622},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.6765648126602173},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.509526789188385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4843900799751282},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.4174359142780304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2186659574508667},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21100595593452454},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19890376925468445},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1808468997478485},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-025017300","doi":null,"is_oa":false,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1098683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Hochschulschrift"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1098683","doi":null,"is_oa":false,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1098683","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"mag:2765090685","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1098683","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026780867","https://openalex.org/W3192879549","https://openalex.org/W1968683040","https://openalex.org/W2318897461","https://openalex.org/W2013473672","https://openalex.org/W1875290714","https://openalex.org/W2724283370","https://openalex.org/W2132498101","https://openalex.org/W2128175377","https://openalex.org/W200196257"],"abstract_inverted_index":{"The":[0],"work":[1],"in":[2,16,29,39,47,57,170],"this":[3],"PhD":[4],"thesis":[5],"was":[6],"focused":[7],"on":[8,74],"the":[9,20,75,87,101,116],"motor":[10,121],"neuron":[11],"disease":[12],"ALS,":[13,52,91,120],"because":[14],"\u2013":[15,19],"my":[17],"view":[18],"question":[21],"if":[22],"and":[23,42,63,65],"how":[24],"transport":[25,44,59,84,92,125,130,149,159],"impairments":[26],"are":[27,94,109,132,161],"involved":[28],"ALS":[30,173],"pathogenesis":[31],"is":[32,126],"still":[33],"not":[34,110,133],"settled.":[35],"By":[36],"imaging":[37],"changes":[38],"axonal":[40,58],"morphology":[41],"organelle":[43],"over":[45],"time":[46],"several":[48],"animal":[49],"models":[50],"of":[51,60,90,103,119],"I":[53],"found":[54],"that":[55,140,158],"deficits":[56,93,108,131,160],"organelles":[61],"(mitochondria":[62],"endosomes)":[64],"axon":[66,104,113,168],"degeneration":[67,169],"can":[68,80],"evolve":[69],"independently.":[70],"This":[71],"conclusion":[72],"rests":[73],"following":[76],"results:":[77],"(I)":[78],"Axons":[79],"survive":[81],"despite":[82],"long-lasting":[83],"deficits:":[85],"In":[86,115,138],"SODG93A":[88],"model":[89,118],"detected":[95],"soon":[96],"after":[97],"birth,":[98],"months":[99],"before":[100],"onset":[102],"degeneration.":[105],"(II)":[106],"Transport":[107],"necessary":[111,163],"for":[112],"degeneration:":[114,137],"SODG85R":[117],"axons":[122,146],"degenerate,":[123],"but":[124,151],"unaffected.":[127],"(III)":[128],"Axon":[129],"sufficient":[134,165],"to":[135,166],"cause":[136,167],"mice":[139],"over-express":[141],"wild-type":[142],"superoxide":[143],"dismutase-1":[144],"(SODWT),":[145],"show":[147],"chronic":[148],"deficits,":[150],"survive.":[152],"Taken":[153],"together":[154],"these":[155,171],"findings":[156],"indicate":[157],"neither":[162],"nor":[164],"classical":[172],"models.":[174]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-11-10T00:00:00"}
