{"id":"https://openalex.org/W2764095945","doi":"https://doi.org/10.1002/lary.26949","title":"Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL\u20106 production in vitro","display_name":"Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL\u20106 production in vitro","publication_year":2017,"publication_date":"2017-10-10","ids":{"openalex":"https://openalex.org/W2764095945","doi":"https://doi.org/10.1002/lary.26949","mag":"2764095945","pmid":"https://pubmed.ncbi.nlm.nih.gov/28994126"},"language":"en","primary_location":{"id":"doi:10.1002/lary.26949","doi":"https://doi.org/10.1002/lary.26949","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.26949","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ruj.uj.edu.pl/xmlui/handle/item/49056","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012564514","display_name":"Jae Murphy","orcid":"https://orcid.org/0000-0002-9995-5338","observed_orcids":["https://orcid.org/0000-0002-9995-5338"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jae Murphy","raw_affiliation_strings":["Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia"],"raw_orcid":"https://orcid.org/0000-0002-9995-5338","affiliations":[{"raw_affiliation_string":"Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079882375","display_name":"Mahnaz Ramezanpour","orcid":"https://orcid.org/0000-0001-6218-2071","observed_orcids":["https://orcid.org/0000-0001-6218-2071"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mahnaz Ramezanpour","raw_affiliation_strings":["Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034195057","display_name":"Natalia Stach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Natalia Stach","raw_affiliation_strings":["Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004399066","display_name":"Grzegorz Dubin","orcid":"https://orcid.org/0000-0002-5535-5760","observed_orcids":["https://orcid.org/0000-0002-5535-5760"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Grzegorz Dubin","raw_affiliation_strings":["Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008000581","display_name":"Alkis  James Psaltis","orcid":"https://orcid.org/0000-0003-2967-1855","observed_orcids":["https://orcid.org/0000-0003-2967-1855"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alkis James Psaltis","raw_affiliation_strings":["Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048548771","display_name":"Peter\u2010John Wormald","orcid":"https://orcid.org/0000-0001-7753-7277","observed_orcids":["https://orcid.org/0000-0001-7753-7277"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter\u2010John Wormald","raw_affiliation_strings":["Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012778267","display_name":"Sarah Vreugde","orcid":"https://orcid.org/0000-0003-4719-9785","observed_orcids":["https://orcid.org/0000-0003-4719-9785"]},"institutions":[{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Sarah Vreugde","raw_affiliation_strings":["Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia"],"raw_orcid":"https://orcid.org/0000-0003-4719-9785","affiliations":[{"raw_affiliation_string":"Department of Surgery\u2013Otolaryngology, Head and Neck Surgery The University of Adelaide Woodville South SA Australia","institution_ids":["https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012778267"],"corresponding_institution_ids":["https://openalex.org/I5681781"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":4.4796,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.94506059,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"128","issue":"1","first_page":"E8","last_page":"E15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/v8-protease","display_name":"V8 protease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/airway-epithelial-barrier","display_name":"airway epithelial barrier","score":0.8320000171661377},{"id":"https://openalex.org/keywords/chronic-rhinosinusitis","display_name":"chronic rhinosinusitis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.6399999856948853},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/claudin-1","display_name":"claudin-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.9580000042915344},{"id":"https://openalex.org/keywords/epithelial-permeability","display_name":"epithelial permeability","score":0.8500000238418579},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9769999980926514},{"id":"https://openalex.org/keywords/exfoliative-toxin-a","display_name":"exfoliative toxin A","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nasal-epithelial-cells","display_name":"nasal epithelial cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mucosal-immunity","display_name":"mucosal immunity","score":0.703000009059906},{"id":"https://openalex.org/keywords/bacterial-virulence-factors","display_name":"bacterial virulence factors","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.9164634346961975},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7022714614868164},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.6575933694839478},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6440237760543823},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6244134306907654},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.6163106560707092},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5133220553398132},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.4874906539916992},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.44867679476737976},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.41616183519363403},{"id":"https://openalex.org/C68324877","wikidata":"https://www.wikidata.org/wiki/Q421859","display_name":"Interleukin 8","level":3,"score":0.4110970199108124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40457475185394287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3983847498893738},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.344299852848053},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33087772130966187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3193628489971161},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.255113810300827},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2291104793548584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15395912528038025},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.12896180152893066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003124","descriptor_name":"Colorimetry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009297","descriptor_name":"Nasal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/lary.26949","doi":"https://doi.org/10.1002/lary.26949","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lary.26949","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},{"id":"pmid:28994126","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28994126","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"Journal Article"},{"id":"pmh:oai:ruj.uj.edu.pl:item/49056","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/49056","pdf_url":null,"source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"artyku\u0142 w czasopi\u015bmie"}],"best_oa_location":{"id":"pmh:oai:ruj.uj.edu.pl:item/49056","doi":null,"is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/49056","pdf_url":null,"source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"artyku\u0142 w czasopi\u015bmie"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321859","display_name":"Garnett Passe and Rodney Williams Memorial Foundation","ror":"https://ror.org/042wjyc34"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W34163939","https://openalex.org/W1504820480","https://openalex.org/W1515606683","https://openalex.org/W1534165134","https://openalex.org/W1566189373","https://openalex.org/W1588385880","https://openalex.org/W1594796409","https://openalex.org/W1781669521","https://openalex.org/W1902385211","https://openalex.org/W1972704410","https://openalex.org/W1983274316","https://openalex.org/W1987118400","https://openalex.org/W1987294201","https://openalex.org/W1988599738","https://openalex.org/W1996955331","https://openalex.org/W2000854876","https://openalex.org/W2002012748","https://openalex.org/W2004063413","https://openalex.org/W2004764283","https://openalex.org/W2012647075","https://openalex.org/W2013536071","https://openalex.org/W2015888867","https://openalex.org/W2035343171","https://openalex.org/W2046587579","https://openalex.org/W2049294748","https://openalex.org/W2060624893","https://openalex.org/W2070162280","https://openalex.org/W2076492408","https://openalex.org/W2077009700","https://openalex.org/W2080427486","https://openalex.org/W2085056791","https://openalex.org/W2086514296","https://openalex.org/W2090002704","https://openalex.org/W2091064926","https://openalex.org/W2094124133","https://openalex.org/W2094667070","https://openalex.org/W2095499340","https://openalex.org/W2100792873","https://openalex.org/W2102361871","https://openalex.org/W2110463517","https://openalex.org/W2137679519","https://openalex.org/W2147502243","https://openalex.org/W2149391184","https://openalex.org/W2149760554","https://openalex.org/W2161559362","https://openalex.org/W2279981039","https://openalex.org/W2404920363","https://openalex.org/W2422502396","https://openalex.org/W2739999456","https://openalex.org/W4210825460"],"related_works":["https://openalex.org/W2137679519","https://openalex.org/W2900863875","https://openalex.org/W2967179254","https://openalex.org/W7162117018","https://openalex.org/W3127964527","https://openalex.org/W1781669521","https://openalex.org/W3033463315","https://openalex.org/W3092922750","https://openalex.org/W3149386754","https://openalex.org/W2809505662"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Staphylococcus":[1],"aureus":[2,36,74,209],"(S.":[3],"aureus)":[4],"infection":[5,44],"is":[6,56,235],"known":[7],"to":[8,10,26,39,91,119,148,178,195,245,247],"contribute":[9,246],"the":[11,28,62,71,110,125,232,243],"severity":[12],"and":[13,19,45,85,107,115,129,138,155,172,218,240],"recalcitrance":[14],"of":[15,64,109,124,145,214,221],"chronic":[16],"rhinosinusitis":[17],"(CRS),":[18],"its":[20],"secreted":[21,33],"products":[22],"have":[23],"been":[24],"shown":[25],"alter":[27],"airway":[29,52,68],"barrier.":[30,224],"Extracellular":[31],"proteases":[32,66,75,126],"by":[34,237],"S.":[35,73,208],"are":[37],"thought":[38],"be":[40],"important":[41],"in":[42,158,185,202,227],"epithelial":[43,69,94],"immune":[46],"evasion;":[47],"however,":[48],"their":[49],"effect":[50],"on":[51,67,127],"mucosal":[53,215,233],"barrier":[54,121,216],"function":[55,219],"not":[57],"known.":[58],"METHODS:":[59],"To":[60],"investigate":[61],"impact":[63],"extracellular":[65],"integrity,":[70],"purified":[72],"V8":[76,146,186,210],"protease,":[77],"Staphopain":[78,80],"A,":[79,84],"B,":[81],"Exfoliative":[82],"toxin":[83],"serine":[86],"protease-like":[87],"A-F":[88],"were":[89,117,132],"applied":[90],"human":[92],"nasal":[93],"cell":[95,130,203],"air-liquid":[96],"interface":[97],"(HNEC-ALI)":[98],"cultures.":[99],"Transepithelial":[100],"electrical":[101],"resistance":[102],"(TEER),":[103],"permeability":[104],"(Papp)":[105],"measurements,":[106],"immuno-localization":[108,176],"tight":[111],"junction":[112],"proteins":[113],"claudin-1":[114],"ZO-1":[116,175],"used":[118],"assess":[120],"integrity.":[122],"Effects":[123],"inflammation":[128],"viability":[131,204],"measured":[133],"using":[134],"interleukin-6":[135],"(IL-6)":[136],"ELISA":[137],"a":[139,152,164,173,222],"lactate":[140],"dehydrogenase":[141],"assay.":[142],"RESULTS:":[143],"Application":[144],"protease":[147,211,239],"HNEC-ALI":[149],"cultures":[150],"caused":[151],"significant":[153],"concentration":[154],"time-dependent":[156],"decrease":[157],"TEER":[159],"(22.67%,":[160],"P":[161,169,191],"<":[162,170],"0.0001),":[163],"reciprocal":[165],"Papp":[166],"increase":[167],"(20.14-fold,":[168],"0.05),":[171],"discontinuous":[174],"compared":[177,194],"control.":[179],"IL-6":[180,228],"production":[181],"was":[182,205],"significantly":[183],"reduced":[184],"protease-treated":[187],"cells":[188],"(153.5":[189],"pg/mL,":[190],"=":[192],"0.0069)":[193],"control":[196],"(548.3":[197],"pg/mL),":[198],"whereas":[199],"no":[200],"difference":[201],"observed.":[206],"CONCLUSION:":[207],"causes":[212],"dysfunction":[213],"structure":[217],"indicative":[220],"leaky":[223],"A":[225],"reduction":[226],"levels":[229],"suggests":[230],"that":[231],"immunity":[234],"impaired":[236],"this":[238],"thus":[241],"has":[242],"potential":[244],"CRS":[248],"recalcitrance.":[249],"LEVEL":[250],"OF":[251],"EVIDENCE:":[252],"NA.":[253],"Laryngoscope,":[254],"128:E8-E15,":[255],"2018.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-10-20T00:00:00"}
