{"id":"https://openalex.org/W2763712464","doi":null,"title":"In vitro cytotoxicity assessment of selected nanoparticles using human skin fibroblasts","display_name":"In vitro cytotoxicity assessment of selected nanoparticles using human skin fibroblasts","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2763712464","mag":"2763712464"},"language":"en","primary_location":{"id":"pmh:oai:ro.uow.edu.au:sspapers-4089","doi":null,"is_oa":true,"landing_page_url":"https://ro.uow.edu.au/sspapers/3084","pdf_url":"https://ro.uow.edu.au/cgi/viewcontent.cgi?article=4089&context=sspapers","source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Social Sciences - Papers (Archive)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ro.uow.edu.au/cgi/viewcontent.cgi?article=4089&context=sspapers","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084088732","display_name":"Finance Dechsakulthorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Finance Dechsakulthorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103557109","display_name":"Amanda J. Hayes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Hayes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103035642","display_name":"Shahnaz Bakand","orcid":"https://orcid.org/0000-0002-1560-0960","observed_orcids":["https://orcid.org/0000-0002-1560-0960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahnaz Bakand","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1560-0960","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088230237","display_name":"Lucky Joeng","orcid":"https://orcid.org/0000-0002-6971-8294","observed_orcids":["https://orcid.org/0000-0002-6971-8294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucky Joeng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6971-8294","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113780513","display_name":"Chris Winder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chris Winder","raw_affiliation_strings":["University of New South Wales,#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New South Wales,#TAB#","institution_ids":["https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3404,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.80150451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"397","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticle-cytotoxicity","display_name":"nanoparticle cytotoxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/zinc-oxide-nanoparticles","display_name":"zinc oxide nanoparticles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/titanium-dioxide-nanoparticles","display_name":"titanium dioxide nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/human-dermal-fibroblasts","display_name":"human dermal fibroblasts","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sunscreen-ingredients","display_name":"sunscreen ingredients","score":0.921999990940094},{"id":"https://openalex.org/keywords/nanomaterial-toxicity","display_name":"nanomaterial toxicity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.8799999952316284},{"id":"https://openalex.org/keywords/noaec","display_name":"NOAEC","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mts-assay","display_name":"MTS assay","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.9066864848136902},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6179855465888977},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5653767585754395},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5649213790893555},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.5201292634010315},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.5043264627456665},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4812716841697693},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.46593087911605835},{"id":"https://openalex.org/C2777593239","wikidata":"https://www.wikidata.org/wiki/Q193521","display_name":"Titanium dioxide","level":2,"score":0.45849549770355225},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4349592924118042},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.43307602405548096},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40270063281059265},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23740720748901367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2344268560409546},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13339468836784363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0797819197177887},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.06963017582893372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:ro.uow.edu.au:sspapers-4089","doi":null,"is_oa":true,"landing_page_url":"https://ro.uow.edu.au/sspapers/3084","pdf_url":"https://ro.uow.edu.au/cgi/viewcontent.cgi?article=4089&context=sspapers","source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Social Sciences - Papers (Archive)","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.557.2316","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.557.2316","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.asas.or.jp/jsaae/zasshi/WC6_PC/paper397.pdf","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/27708378","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/In_vitro_cytotoxicity_assessment_of_selected_nanoparticles_using_human_skin_fibroblasts/27708378","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"mag:2763712464","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/cgi/viewcontent.cgi?article=4089&context=sspapers","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ro.uow.edu.au:sspapers-4089","doi":null,"is_oa":true,"landing_page_url":"https://ro.uow.edu.au/sspapers/3084","pdf_url":"https://ro.uow.edu.au/cgi/viewcontent.cgi?article=4089&context=sspapers","source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Social Sciences - Papers (Archive)","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2763712464.pdf","grobid_xml":"https://content.openalex.org/works/W2763712464.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1967331878","https://openalex.org/W1979284608","https://openalex.org/W1983379279","https://openalex.org/W1990495056","https://openalex.org/W1990998953","https://openalex.org/W1997505702","https://openalex.org/W2003240863","https://openalex.org/W2003753489","https://openalex.org/W2004490137","https://openalex.org/W2009569559","https://openalex.org/W2049271296","https://openalex.org/W2069574681","https://openalex.org/W2090107650","https://openalex.org/W2093743437","https://openalex.org/W2099191918","https://openalex.org/W2122284189","https://openalex.org/W2146233077","https://openalex.org/W2155118487","https://openalex.org/W2159920027","https://openalex.org/W2160877966","https://openalex.org/W2171047154","https://openalex.org/W2277395943"],"related_works":["https://openalex.org/W7098785452","https://openalex.org/W6965055140","https://openalex.org/W2589250259","https://openalex.org/W2527773985","https://openalex.org/W2567158272","https://openalex.org/W4408360597","https://openalex.org/W2970584976","https://openalex.org/W1964864756","https://openalex.org/W1968136612","https://openalex.org/W2767418513"],"abstract_inverted_index":{"Zinc":[0],"oxide":[1,5],"(ZnO)":[2],"and":[3,15,43,108,115,155,168,178,205,230,237,246],"Titanium":[4],"(TiO\u2082)":[6],"are":[7,28],"two":[8],"chemical":[9],"compound":[10],"with":[11,81,241],"very":[12],"wide":[13],"industrial":[14],"commercial":[16],"applications,":[17],"particularly":[18],"as":[19,31],"pigments.":[20],"Due":[21],"to":[22,47,55,74,102,227,260,266],"their":[23,71],"physical":[24],"properties,":[25],"both":[26,176,188,228],"compounds":[27],"also":[29],"used":[30,259],"sunscreen":[32,57],"ingredients":[33,67],"for":[34,206],"protect":[35],"from":[36],"UV":[37],"radiation.":[38],"At":[39,192],"the":[40,62,75,86,104,133,161,182,185,195,208,234,242],"nano-scale,":[41],"ZnO":[42,107,171,199,229],"TiO\u2082":[44,109,207,231],"have":[45,48],"proven":[46],"a":[49],"similar":[50],"level":[51],"of":[52,61,65,89,98,106,122,160,187,198,217],"protection":[53],"compared":[54,73],"normal-scale":[56],"particles.":[58,84],"An":[59],"advantage":[60],"topical":[63,263],"use":[64],"nano-scale":[66],"in":[68,128,138,244,247,254],"sunscreens":[69],"is":[70,92],"transparency":[72],"white":[76],"residue":[77],"left":[78],"on":[79],"skin":[80,130,223],"normal":[82],"scale":[83],"However,":[85],"potential":[87],"toxicity":[88,174,249],"these":[90,123],"nanoparticles":[91,189,232],"not":[93],"well":[94,240],"understood.":[95],"The":[96,120,251],"aim":[97],"this":[99,218,255],"study":[100,219,256],"was":[101,126,200,211],"assess":[103,261],"cytotoxicity":[105,121,186],"nanopowders":[110],"(particle":[111],"size":[112],"50-70":[113],"nm":[114],"less":[116],"than":[117],"150nm,":[118],"respectively).":[119],"selected":[124,267],"nanomaterials":[125],"investigated":[127],"human":[129,222,262],"fibroblasts":[131,224],"using":[132],"colourimetric":[134],"MTS":[135,235],"(3-(4.5-dimethylthiazol-2-yl)":[136],"-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-3Htetrazolium)":[137],"vitro":[139,245,248],"assay.":[140],"Cytotoxicity":[141],"endpoints":[142],"including":[143],"NOAEC":[144],"(no":[145],"observed":[146],"adverse":[147],"effect":[148],"concentration),":[149],"IC":[150,196,209],"\u2085\u2080":[151,197,210],"(50%":[152],"inhibitory":[153],"concentration)":[154,159],"TLC":[156],"(total":[157],"lethal":[158],"test":[162],"materials":[163],"were":[164,225],"determined":[165],"after":[166],"4":[167,177],"24h":[169,193],"exposure.":[170],"indicated":[172,220],"higher":[173],"at":[175],"24h.":[179],"By":[180],"increasing":[181],"exposure":[183,194,265],"time":[184],"increased":[190],"substantially.":[191],"49.56":[201],"\u00b1":[202,213],"12.89":[203],"ppm,":[204],"2.696":[212],"667":[214],"ppm.":[215],"Results":[216],"that":[221],"sensitive":[226],"though":[233],"assay":[236],"they":[238],"correlated":[239],"published":[243],"data.":[250],"data":[252],"generated":[253],"can":[257],"be":[258],"risk":[264],"nanomaterials.":[268]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-10-20T00:00:00"}