{"id":"https://openalex.org/W2763543567","doi":"https://doi.org/10.1093/eurheartj/ehx504.p4365","title":"P4365Heart failure with preserved ejection fraction is associated with cardioembolic stroke independent of history of atrial fibrillation","display_name":"P4365Heart failure with preserved ejection fraction is associated with cardioembolic stroke independent of history of atrial fibrillation","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2763543567","doi":"https://doi.org/10.1093/eurheartj/ehx504.p4365","mag":"2763543567"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehx504.p4365","doi":"https://doi.org/10.1093/eurheartj/ehx504.p4365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehx504.p4365","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/38/suppl_1/ehx504.P4365/19628759/ehx504.P4365.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartj/article-pdf/38/suppl_1/ehx504.P4365/19628759/ehx504.P4365.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003588646","display_name":"Indraneil Ray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Basu Ray","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020798138","display_name":"Gregory Schwing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Schwing","raw_affiliation_strings":["Tulane University, Neurology, New Orleans, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University, Neurology, New Orleans, United States of America","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057258110","display_name":"Thomas G. Middour","orcid":"https://orcid.org/0000-0003-1255-6500","observed_orcids":["https://orcid.org/0000-0003-1255-6500"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Middour","raw_affiliation_strings":["Tulane University, Neurology, New Orleans, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University, Neurology, New Orleans, United States of America","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068791121","display_name":"Dominique J Monlezun","orcid":"https://orcid.org/0000-0001-7671-1886","observed_orcids":["https://orcid.org/0000-0001-7671-1886"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Monlezun","raw_affiliation_strings":["Tulane University, Neurology, New Orleans, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University, Neurology, New Orleans, United States of America","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074181234","display_name":"Joseph Allencherril","orcid":"https://orcid.org/0000-0003-4940-0374","observed_orcids":["https://orcid.org/0000-0003-4940-0374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Allencherril","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061294013","display_name":"Sheryl Martin\u2010Schild","orcid":"https://orcid.org/0000-0003-3168-3521","observed_orcids":["https://orcid.org/0000-0003-3168-3521"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Martin-Schild","raw_affiliation_strings":["Tulane University, Neurology, New Orleans, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University, Neurology, New Orleans, United States of America","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028368864","display_name":"Ketan Koranne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Koranne","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022389057","display_name":"Mehdi Razavi","orcid":"https://orcid.org/0000-0001-7176-5586","observed_orcids":["https://orcid.org/0000-0001-7176-5586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Razavi","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018453695","display_name":"Jie Cheng","orcid":"https://orcid.org/0000-0002-0500-4233","observed_orcids":["https://orcid.org/0000-0002-0500-4233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Cheng","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113827207","display_name":"Stephanie Coulter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Coulter","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091368697","display_name":"A. Rasek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Rasek","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112325900","display_name":"Mohammed Saeed","orcid":"https://orcid.org/0000-0002-9214-521X","observed_orcids":["https://orcid.org/0000-0002-9214-521X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Saeed","raw_affiliation_strings":["Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Heart Institute, Cardiac Electrophysiology, Houston, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.24578018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"38","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.35010001063346863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.13570000231266022,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.12300000339746475,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":1.0},{"id":"https://openalex.org/keywords/cardioembolic-stroke","display_name":"cardioembolic stroke","score":0.9789999723434448},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.9950000047683716},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/spontaneous-echo-contrast","display_name":"spontaneous echo contrast","score":0.7580000162124634},{"id":"https://openalex.org/keywords/chads2-score","display_name":"CHADS2 score","score":0.8859999775886536},{"id":"https://openalex.org/keywords/thromboembolic-risk","display_name":"thromboembolic risk","score":0.7129999995231628},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9845031499862671},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8465998768806458},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7955536842346191},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7949114441871643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7299429774284363},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.584794819355011},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.46524274349212646},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehx504.p4365","doi":"https://doi.org/10.1093/eurheartj/ehx504.p4365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehx504.p4365","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/38/suppl_1/ehx504.P4365/19628759/ehx504.P4365.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehx504.p4365","doi":"https://doi.org/10.1093/eurheartj/ehx504.p4365","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehx504.p4365","pdf_url":"https://academic.oup.com/eurheartj/article-pdf/38/suppl_1/ehx504.P4365/19628759/ehx504.P4365.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2763543567.pdf","grobid_xml":"https://content.openalex.org/works/W2763543567.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4207030337","https://openalex.org/W2891746874","https://openalex.org/W2481234813","https://openalex.org/W1971710084","https://openalex.org/W2072108749","https://openalex.org/W2028196543","https://openalex.org/W2920829402","https://openalex.org/W3188428900","https://openalex.org/W2053992978","https://openalex.org/W2093528096"],"abstract_inverted_index":{"Background:":[0],"It":[1],"has":[2],"been":[3],"hypothesized":[4],"that":[5,37],"Diastolic":[6],"Dysfunction":[7],"(DD)":[8],"may":[9],"be":[10,191,207],"associated":[11,57,208],"with":[12,26,58,68,90,144,173,194,209],"a":[13,34],"thrombotic":[14],"milieu":[15],"even":[16],"in":[17,166],"the":[18,44,111],"absence":[19],"of":[20,46,62,126,213,217,226],"AF.":[21],"However,":[22],"presently":[23],"Heart":[24],"failure":[25],"preserved":[27],"ejection":[28],"fraction":[29],"(HFpEF)":[30],"is":[31,56],"not":[32],"considered":[33],"risk":[35,212],"factor":[36],"merits":[38],"anticoagulation":[39],"on":[40],"its":[41],"own":[42],"without":[43,179],"presence":[45],"systolic":[47,95],"dysfunction.":[48],"Purpose:":[49],"We":[50],"sought":[51],"to":[52,71,109,190,206],"determine":[53],"if":[54],"HFpEF":[55],"cardioembolic":[59,69,146,214],"stroke":[60,70,114,147,227],"independent":[61,216],"atrial":[63,135,138],"fibrillation.":[64,139],"Methods:":[65],"Patients":[66],"diagnosed":[67],"our":[72,87],"center":[73],"between":[74,113],"June":[75],"2008":[76],"and":[77,93,115,124,137,177],"May":[78],"2014":[79],"undergoing":[80],"transthoracic":[81],"echocardiogram":[82],"(TTE)":[83],"were":[84,98],"identified":[85],"from":[86,100],"registry.":[88],"Those":[89],"inpatient":[91],"strokes":[92],"significant":[94,158,164,174,201],"dysfunction":[96,160,176,203],"(EF<50%)":[97],"excluded":[99],"retrospective":[101],"cohort":[102],"review.":[103],"Multivariate":[104],"logistic":[105],"regression":[106,199],"was":[107,169,188,204],"performed":[108],"investigate":[110],"association":[112],"diastolic":[116,159,175,202],"dysfunction,":[117],"while":[118],"adjusting":[119],"for":[120,151],"age,":[121,219],"race,":[122,220],"sex,":[123],"history":[125,225],"congestive":[127],"heart":[128],"failure,":[129],"hypertension,":[130],"diabetes,":[131],"prior":[132],"stroke,":[133,215],"left":[134],"enlargement,":[136],"Results:":[140],"414":[141],"patients":[142,156,172],"presenting":[143],"acute":[145],"met":[148],"inclusion":[149],"criteria":[150],"this":[152],"investigation.":[153],"240":[154],"(45.2%)":[155],"demonstrated":[157],"(grade":[161],">1).":[162],"No":[163],"difference":[165],"CHADS2":[167],"score":[168],"noted":[170],"amongst":[171],"those":[178],"(1.8":[180],"vs":[181],"1.9,":[182],"p=0.114).":[183],"However":[184],"spontaneous":[185],"echo":[186],"contract":[187],"found":[189,205],"more":[192],"common":[193],"DD>1":[195],"(p=0.001)":[196],"On":[197],"multivariable":[198],"analysis,":[200],"significantly":[210],"elevated":[211],"AF,":[218],"CHF,":[221],"HTN,":[222],"DM,":[223],"or":[224],"(OR":[228],"2.00,":[229],"95%":[230],"CI":[231],"1.20\u20133.32,":[232],"p=0.008).":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2025-10-10T00:00:00"}