{"id":"https://openalex.org/W2763501010","doi":"https://doi.org/10.1016/j.jcma.2017.08.014","title":"Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice","display_name":"Nephroprotective effect of electrolyzed reduced water against cisplatin-induced kidney toxicity and oxidative damage in mice","publication_year":2017,"publication_date":"2017-10-13","ids":{"openalex":"https://openalex.org/W2763501010","doi":"https://doi.org/10.1016/j.jcma.2017.08.014","mag":"2763501010","pmid":"https://pubmed.ncbi.nlm.nih.gov/29030026"},"language":"en","primary_location":{"id":"doi:10.1016/j.jcma.2017.08.014","doi":"https://doi.org/10.1016/j.jcma.2017.08.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcma.2017.08.014","pdf_url":null,"source":{"id":"https://openalex.org/S187201833","display_name":"Journal of the Chinese Medical Association","issn_l":"1726-4901","issn":["1726-4901","1728-7731"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chinese Medical Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jcma.2017.08.014","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039212060","display_name":"Tse\u2010Chou Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136334","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210136334"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tse-Chou Cheng","raw_affiliation_strings":["Department of Urology, Chi Mei Medical Center, Tainan, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Chi Mei Medical Center, Tainan, Taiwan, ROC","institution_ids":["https://openalex.org/I4210136334"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024001750","display_name":"Yu\u2010Wen Hsu","orcid":"https://orcid.org/0000-0002-6126-8938","observed_orcids":["https://orcid.org/0000-0002-6126-8938"]},"institutions":[{"id":"https://openalex.org/I130510345","display_name":"Dayeh University","ror":"https://ror.org/03c6e8r26","country_code":"TW","type":"education","lineage":["https://openalex.org/I130510345"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Wen Hsu","raw_affiliation_strings":["Department of Optometry, Da-Yeh University, Changhua, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Optometry, Da-Yeh University, Changhua, Taiwan, ROC","institution_ids":["https://openalex.org/I130510345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047291470","display_name":"Fung\u2010Jou Lu","orcid":"https://orcid.org/0000-0003-3765-7535","observed_orcids":["https://orcid.org/0000-0003-3765-7535"]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Fung-Jou Lu","raw_affiliation_strings":["Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014336231","display_name":"Ya-Yu Chen","orcid":"https://orcid.org/0000-0003-2584-1079","observed_orcids":["https://orcid.org/0000-0003-2584-1079"]},"institutions":[{"id":"https://openalex.org/I130510345","display_name":"Dayeh University","ror":"https://ror.org/03c6e8r26","country_code":"TW","type":"education","lineage":["https://openalex.org/I130510345"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ya-Yu Chen","raw_affiliation_strings":["Department of Optometry, Da-Yeh University, Changhua, Taiwan, ROC; Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC","Department of Optometry, Da-Yeh University, Changhua, Taiwan, ROC","Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Optometry, Da-Yeh University, Changhua, Taiwan, ROC; Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I91279580"]},{"raw_affiliation_string":"Department of Optometry, Da-Yeh University, Changhua, Taiwan, ROC","institution_ids":["https://openalex.org/I130510345"]},{"raw_affiliation_string":"Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087662823","display_name":"Nu\u2010Man Tsai","orcid":"https://orcid.org/0000-0002-2629-1833","observed_orcids":["https://orcid.org/0000-0002-2629-1833"]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nu-Man Tsai","raw_affiliation_strings":["School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026314186","display_name":"Wen\u2010Kang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116739771","display_name":"National Tainan Institute of Nursing","ror":"https://ror.org/01v7zwf98","country_code":"TW","type":"education","lineage":["https://openalex.org/I116739771"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Kang Chen","raw_affiliation_strings":["Department of Applied Cosmetology, National Tainan Junior College of Nursing, Tainan, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Cosmetology, National Tainan Junior College of Nursing, Tainan, Taiwan, ROC","institution_ids":["https://openalex.org/I116739771"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111825415","display_name":"Chia-Fang Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802999704","display_name":"TransWorld University","ror":"https://ror.org/0314ahf24","country_code":"TW","type":"education","lineage":["https://openalex.org/I2802999704"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chia-Fang Tsai","raw_affiliation_strings":["Department of Biotechnology, TransWorld University, Yunlin, Taiwan, ROC. Electronic address: tsaicf@twu.edu.tw","Department of Biotechnology, TransWorld University, Yunlin, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, TransWorld University, Yunlin, Taiwan, ROC. Electronic address: tsaicf@twu.edu.tw","institution_ids":["https://openalex.org/I2802999704"]},{"raw_affiliation_string":"Department of Biotechnology, TransWorld University, Yunlin, Taiwan, ROC","institution_ids":["https://openalex.org/I2802999704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5111825415"],"corresponding_institution_ids":["https://openalex.org/I2802999704"],"apc_list":null,"apc_paid":null,"fwci":1.5029,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81443513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"81","issue":"2","first_page":"119","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrolyzed-reduced-water","display_name":"electrolyzed reduced water","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.925000011920929},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.5920000076293945},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9490000009536743},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.7179999947547913},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/glutathione-reductase","display_name":"glutathione reductase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.7009999752044678},{"id":"https://openalex.org/keywords/blood-urea-nitrogen","display_name":"blood urea nitrogen","score":0.8339999914169312},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.8871544003486633},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.7761620283126831},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6951145529747009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6837606430053711},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.6435885429382324},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.6337220072746277},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5668988823890686},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5667022466659546},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5586197376251221},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5540136098861694},{"id":"https://openalex.org/C2778176769","wikidata":"https://www.wikidata.org/wiki/Q764079","display_name":"Blood urea nitrogen","level":3,"score":0.544953465461731},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5347752571105957},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.4963286519050598},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4418486952781677},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.43250900506973267},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4289499521255493},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.404354453086853},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3884795904159546},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.3854774534702301},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.3813885450363159},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3640546202659607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21394583582878113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19717562198638916},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1746075451374054},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09615075588226318}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004572","descriptor_name":"Electrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jcma.2017.08.014","doi":"https://doi.org/10.1016/j.jcma.2017.08.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcma.2017.08.014","pdf_url":null,"source":{"id":"https://openalex.org/S187201833","display_name":"Journal of the Chinese Medical Association","issn_l":"1726-4901","issn":["1726-4901","1728-7731"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chinese Medical Association","raw_type":"journal-article"},{"id":"pmid:29030026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29030026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chinese Medical Association : JCMA","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jcma.2017.08.014","doi":"https://doi.org/10.1016/j.jcma.2017.08.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jcma.2017.08.014","pdf_url":null,"source":{"id":"https://openalex.org/S187201833","display_name":"Journal of the Chinese Medical Association","issn_l":"1726-4901","issn":["1726-4901","1728-7731"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Chinese Medical Association","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323969","display_name":"Chi Mei Medical Center","ror":"https://ror.org/02y2htg06"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1759773337","https://openalex.org/W1965788245","https://openalex.org/W1969660549","https://openalex.org/W1970905917","https://openalex.org/W1971137608","https://openalex.org/W1974683714","https://openalex.org/W1984780674","https://openalex.org/W1991925837","https://openalex.org/W1993444512","https://openalex.org/W2001993344","https://openalex.org/W2003091758","https://openalex.org/W2008232708","https://openalex.org/W2031952905","https://openalex.org/W2035507839","https://openalex.org/W2048848435","https://openalex.org/W2055715450","https://openalex.org/W2061352029","https://openalex.org/W2062453634","https://openalex.org/W2064557378","https://openalex.org/W2066906561","https://openalex.org/W2071167046","https://openalex.org/W2072898466","https://openalex.org/W2086630756","https://openalex.org/W2091214272","https://openalex.org/W2099277561","https://openalex.org/W2110209176","https://openalex.org/W2112154618","https://openalex.org/W2120038538","https://openalex.org/W2150947229","https://openalex.org/W2164277862","https://openalex.org/W2164391817","https://openalex.org/W2164404095","https://openalex.org/W2169657429","https://openalex.org/W2902301425"],"related_works":["https://openalex.org/W2041846620","https://openalex.org/W3015539956","https://openalex.org/W3209929541","https://openalex.org/W2134849159","https://openalex.org/W3200871156","https://openalex.org/W2000208253","https://openalex.org/W4205954655","https://openalex.org/W4393193366","https://openalex.org/W7097875857","https://openalex.org/W2003572460"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cisplatin":[1],"is":[2],"a":[3,109],"potent":[4,257],"chemotherapeutic":[5],"drug":[6],"for":[7,89],"cancer":[8],"therapy,":[9],"but":[10],"it":[11],"has":[12],"serious":[13],"side":[14],"effects":[15,259],"in":[16,93,125,163,170,175,202,235,264,272],"clinical":[17],"treatment,":[18],"particularly":[19],"nephrotoxicity.":[20],"The":[21],"purpose":[22],"of":[23,32,84,87,102,117,130,133,138,150,190,200,224,279],"this":[24],"study":[25],"was":[26,213],"to":[27,216,231,247,268],"evaluate":[28],"the":[29,94,114,118,122,128,136,148,181,198,203,222,236,249,270,277],"protective":[30],"effect":[31],"electrolyzed":[33],"reduced":[34],"water":[35],"(ERW)":[36],"on":[37,113,260],"renal":[38,177,245],"injury":[39,178,246],"caused":[40],"by":[41,82,208],"cisplatin.":[42,209],"METHODS:":[43],"Animals":[44,92],"were":[45,72,172,206],"divided":[46],"into":[47],"four":[48],"groups":[49],"as":[50,108],"follows:":[51],"normal":[52,76],"control":[53,56,59],"group,":[54,57],"cisplatin":[55,64,88,95,103],"ERW":[58,62,79,211,241,255],"group":[60,67,96],"and":[61,127,141,147,159,165,192,197,228,230,251,276],"+":[63],"group.":[65],"Each":[66],"comprised":[68],"10":[69],"animals,":[70],"which":[71],"orally":[73],"treated":[74],"with":[75],"saline":[77],"or":[78],"daily":[80],"companion":[81],"administration":[83],"one":[85],"dose":[86,112],"28":[90],"days.":[91],"received":[97],"an":[98],"intraperitoneal":[99],"single-dose":[100],"injection":[101],"(20":[104],"mg/kg":[105],"body":[106],"weight)":[107],"single":[110],"i.p.":[111],"25th":[115],"day":[116],"experiment.":[119],"We":[120],"determined":[121],"hydration":[123],"state":[124],"urine":[126,171],"level":[129],"serum":[131,188],"markers":[132],"kidney":[134,164,262],"function,":[135],"levels":[137,146,169,189,199],"glutathione":[139,151,154],"(GSH)":[140],"thiobarbituric":[142],"acid-reactive":[143],"substances":[144],"(TBARS)":[145],"activities":[149,223],"peroxidase":[152],"(GPx),":[153],"reductase":[155],"(GR),":[156],"catalase":[157],"(CAT)":[158],"superoxidase":[160],"dismutase":[161],"(SOD)":[162],"histopathological":[166],"changes.":[167],"RESULTS:":[168],"significantly":[173,185],"decreased":[174,186],"cisplatin-induced":[176,244,261],"mice.":[179],"Besides,":[180],"results":[182],"demonstrated":[183],"that":[184,205,240],"elevated":[187],"creatinine":[191],"blood":[193],"urea":[194],"nitrogen":[195],"(BUN)":[196],"TBARS":[201],"kidneys":[204],"induced":[207],"Moreover,":[210],"treatment":[212],"also":[214],"found":[215],"markedly":[217],"increase":[218,232,271],"(p":[219],"<":[220],"0.05)":[221],"GPx,":[225],"GR,":[226],"CAT":[227],"SOD,":[229],"GSH":[233],"content":[234],"kidneys.":[237],"Histopathology":[238],"showed":[239],"protects":[242],"against":[243],"both":[248,269],"proximal":[250],"distal":[252],"tubules.":[253],"CONCLUSION:":[254],"exhibits":[256],"nephroprotective":[258],"damage":[263],"mice,":[265],"likely":[266],"due":[267],"antioxidant-defense":[273],"system":[274],"activity":[275],"inhibition":[278],"lipid":[280],"peroxidation.":[281]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-10-20T00:00:00"}