{"id":"https://openalex.org/W2763325035","doi":"https://doi.org/10.1186/s12864-017-4028-4","title":"Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer","display_name":"Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2763325035","doi":"https://doi.org/10.1186/s12864-017-4028-4","mag":"2763325035","pmid":"https://pubmed.ncbi.nlm.nih.gov/28984209"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-017-4028-4","doi":"https://doi.org/10.1186/s12864-017-4028-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-017-4028-4","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-017-4028-4","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-017-4028-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028190064","display_name":"Yu\u2010Chiao Chiu","orcid":"https://orcid.org/0000-0003-1647-8634","observed_orcids":["https://orcid.org/0000-0003-1647-8634"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Yu-Chiao Chiu","raw_affiliation_strings":["Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan","Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077106946","display_name":"Li\u2010Ju Wang","orcid":"https://orcid.org/0000-0003-2745-2819","observed_orcids":["https://orcid.org/0000-0003-2745-2819"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Ju Wang","raw_affiliation_strings":["Research Center for Chinese Herbal Medicine, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Chinese Herbal Medicine, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109047519","display_name":"Tzu-Hung Hsiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091773","display_name":"Taichung Veterans General Hospital","ror":"https://ror.org/00e87hq62","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091773"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tzu-Hung Hsiao","raw_affiliation_strings":["Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. thsiao@vghtc.gov.tw","Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. thsiao@vghtc.gov.tw","institution_ids":["https://openalex.org/I4210091773"]},{"raw_affiliation_string":"Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210091773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062893898","display_name":"Eric Yao-Yu Chuang","orcid":"https://orcid.org/0000-0003-2530-0096","observed_orcids":["https://orcid.org/0000-0003-2530-0096"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Eric Y. Chuang","raw_affiliation_strings":["Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan. chuangey@ntu.edu.tw","Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan. chuangey@ntu.edu.tw","Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Biostatistics Core, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan. chuangey@ntu.edu.tw","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan. chuangey@ntu.edu.tw","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100689057","display_name":"Yidong Chen","orcid":"https://orcid.org/0000-0001-6806-2185","observed_orcids":["https://orcid.org/0000-0001-6806-2185"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yidong Chen","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ChenY8@uthscsa.edu","Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. ChenY8@uthscsa.edu","Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ChenY8@uthscsa.edu","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. ChenY8@uthscsa.edu","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062893898","https://openalex.org/A5100689057","https://openalex.org/A5109047519"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I16733864","https://openalex.org/I4210091773"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.2912,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53939216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"18","issue":"S6","first_page":"679","last_page":"679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.04019999876618385,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-interaction-networks","display_name":"gene interaction networks","score":0.7559999823570251},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8859999775886536},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7440000176429749},{"id":"https://openalex.org/keywords/esr1","display_name":"ESR1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sfrp1","display_name":"SFRP1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/network-modularity","display_name":"network modularity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5849999785423279},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/immune-related-genes","display_name":"immune-related genes","score":0.48399999737739563},{"id":"https://openalex.org/keywords/tumor-associated-genes","display_name":"tumor-associated genes","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6833245754241943},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.627359926700592},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6231560707092285},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5052657723426819},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.48642992973327637},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.46583810448646545},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4561563730239868},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.44989249110221863},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.43731608986854553},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4237295389175415},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4202796220779419},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4079715311527252},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3362240195274353},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2551279067993164}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12864-017-4028-4","doi":"https://doi.org/10.1186/s12864-017-4028-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-017-4028-4","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-017-4028-4","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmid:28984209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28984209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4560013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5629553","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5629553","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5629553","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:db076f7c8bbe4482b18b9826838641a1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/db076f7c8bbe4482b18b9826838641a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics, Vol 18, Iss S6, Pp 119-130 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12864-017-4028-4","doi":"https://doi.org/10.1186/s12864-017-4028-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-017-4028-4","pdf_url":"https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-017-4028-4","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8078516958","display_name":null,"funder_award_id":"EX106","funder_id":"https://openalex.org/F4320322845","funder_display_name":"National Health Research Institutes"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2763325035.pdf","grobid_xml":"https://content.openalex.org/works/W2763325035.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1497119867","https://openalex.org/W1546771547","https://openalex.org/W1723440469","https://openalex.org/W1908864745","https://openalex.org/W1935033970","https://openalex.org/W1936583519","https://openalex.org/W1965032353","https://openalex.org/W1968428572","https://openalex.org/W1974141553","https://openalex.org/W1976173969","https://openalex.org/W1983076949","https://openalex.org/W1990053396","https://openalex.org/W2002835770","https://openalex.org/W2042673932","https://openalex.org/W2044702943","https://openalex.org/W2050015555","https://openalex.org/W2055847177","https://openalex.org/W2082712591","https://openalex.org/W2082996869","https://openalex.org/W2114843025","https://openalex.org/W2118258530","https://openalex.org/W2118413367","https://openalex.org/W2128114333","https://openalex.org/W2133465414","https://openalex.org/W2139845570","https://openalex.org/W2147566730","https://openalex.org/W2149441684","https://openalex.org/W2157536408","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2159675211","https://openalex.org/W2159771450","https://openalex.org/W2163162632","https://openalex.org/W2163563958","https://openalex.org/W2221588520","https://openalex.org/W2297900194","https://openalex.org/W2466558384","https://openalex.org/W2560260782","https://openalex.org/W2560367415","https://openalex.org/W2593731814","https://openalex.org/W4242969382","https://openalex.org/W4294216483","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W2069695727","https://openalex.org/W1996185163","https://openalex.org/W2084813257","https://openalex.org/W2045929470","https://openalex.org/W2081127504","https://openalex.org/W2122223946","https://openalex.org/W4233500668","https://openalex.org/W1974145978","https://openalex.org/W1977867163","https://openalex.org/W2393426762"],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1],"the":[2,44,55,61,67,87,120,132,144,170,177,196,203,228,248,262],"advances":[3],"in":[4,72,163,176,208],"high-throughput":[5],"gene":[6,13,27,32,91,110,128,172],"profiling":[7],"technologies,":[8],"a":[9,48,76,99,123,135,149,187,237],"large":[10],"volume":[11],"of":[12,22,31,34,47,79,89,122,137,151,158,173,190,202,232,242,250,265],"interaction":[14,36,92,129,267],"maps":[15],"has":[16],"been":[17],"constructed.":[18],"A":[19],"higher-level":[20],"layer":[21,264],"gene-gene":[23,266],"interaction,":[24,28],"namely":[25],"modulate":[26],"is":[29,93],"composed":[30],"pairs":[33],"which":[35],"strengths":[37],"are":[38],"modulated":[39,90,263],"by":[40,57],"(i.e.,":[41],"dependent":[42],"on)":[43],"expression":[45,111],"level":[46],"key":[49,80,105,153,233],"modulator":[50,63,81,125,154,234],"gene.":[51],"Systematic":[52],"investigations":[53],"into":[54,261],"modulation":[56],"estrogen":[58],"receptor":[59],"(ER),":[60],"best-known":[62],"gene,":[64],"have":[65],"revealed":[66,206],"functional":[68],"and":[69,147,179,216,268],"prognostic":[70,188],"significance":[71],"breast":[73,139,166,191],"cancer.":[74],"However,":[75],"genome-wide":[77,109,238],"identification":[78],"genes":[82,235],"that":[83],"may":[84],"further":[85,272],"unveil":[86],"landscape":[88],"still":[94],"lacking.":[95],"RESULTS:":[96],"We":[97,113],"proposed":[98],"systematic":[100],"workflow":[101],"to":[102,118,126,134],"screen":[103],"for":[104,271],"modulators":[106,160,182,205,251],"based":[107],"on":[108,236],"profiles.":[112],"designed":[114],"four":[115],"modularity":[116,145,157],"parameters":[117,146,244],"measure":[119],"ability":[121],"putative":[124],"perturb":[127],"networks.":[130],"Applying":[131],"method":[133],"dataset":[136],"286":[138],"tumors,":[140],"we":[141,221,226],"comprehensively":[142],"characterized":[143],"identified":[148],"total":[150],"973":[152,204],"genes.":[155],"The":[156,240],"these":[159],"was":[161,194],"verified":[162],"three":[164],"independent":[165],"cancer":[167],"datasets.":[168],"ESR1,":[169],"encoding":[171],"ER,":[174],"appeared":[175],"list,":[178],"abundant":[180],"novel":[181],"were":[183,254],"illuminated.":[184],"For":[185],"instance,":[186],"predictor":[189],"cancer,":[192],"SFRP1,":[193],"found":[195],"second":[197],"modulator.":[198],"Functional":[199],"annotation":[200],"analysis":[201,231],"involvements":[207],"ER-related":[209],"cellular":[210],"processes":[211],"as":[212,214,223,225,245,247],"well":[213,246],"immune-":[215],"tumor-associated":[217],"functions.":[218],"CONCLUSIONS:":[219],"Here":[220],"present,":[222],"far":[224],"know,":[227],"first":[229],"comprehensive":[230],"scale.":[239],"validity":[241],"filtering":[243],"conservativity":[249],"among":[252],"cohorts":[253],"corroborated.":[255],"Our":[256],"data":[257],"bring":[258],"new":[259],"insights":[260],"provide":[269],"candidates":[270],"biological":[273],"investigations.":[274]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}