{"id":"https://openalex.org/W2762640183","doi":"https://doi.org/10.1139/cjc-2017-0407","title":"Common bed bugs can biosynthesize pheromone components from amino acid precursors in human blood","display_name":"Common bed bugs can biosynthesize pheromone components from amino acid precursors in human blood","publication_year":2017,"publication_date":"2017-10-10","ids":{"openalex":"https://openalex.org/W2762640183","doi":"https://doi.org/10.1139/cjc-2017-0407","mag":"2762640183"},"language":"en","primary_location":{"id":"doi:10.1139/cjc-2017-0407","doi":"https://doi.org/10.1139/cjc-2017-0407","is_oa":false,"landing_page_url":"https://doi.org/10.1139/cjc-2017-0407","pdf_url":null,"source":{"id":"https://openalex.org/S9189650","display_name":"Canadian Journal of Chemistry","issn_l":"0008-4042","issn":["0008-4042","1480-3291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/5f040ecd-174c-436a-8282-15413788287a/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113549037","display_name":"Regine M. Gries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Regine Gries","raw_affiliation_strings":["Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huimin Zhai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Huimin Zhai","raw_affiliation_strings":["Chemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029994369","display_name":"Andrew R. Lewis","orcid":"https://orcid.org/0000-0002-6291-6781","observed_orcids":["https://orcid.org/0000-0002-6291-6781"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew R. Lewis","raw_affiliation_strings":["Chemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014010162","display_name":"Robert Britton","orcid":"https://orcid.org/0000-0002-9335-0047","observed_orcids":["https://orcid.org/0000-0002-9335-0047"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Britton","raw_affiliation_strings":["Chemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Simon Fraser University, Burnaby, BC V5A 1S6, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076154696","display_name":"Gerhard Gries","orcid":"https://orcid.org/0000-0003-3115-8989","observed_orcids":["https://orcid.org/0000-0003-3115-8989"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gerhard Gries","raw_affiliation_strings":["Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada","institution_ids":["https://openalex.org/I18014758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I18014758"],"apc_list":null,"apc_paid":null,"fwci":0.9209,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72947721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"96","issue":"2","first_page":"212","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12321","display_name":"Insect Pheromone Research and Control","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12321","display_name":"Insect Pheromone Research and Control","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12329","display_name":"Hemiptera Insect Studies","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12116","display_name":"Dermatological diseases and infestations","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cimex-lectularius","display_name":"Cimex lectularius","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bed-bugs","display_name":"bed bugs","score":0.7720000147819519},{"id":"https://openalex.org/keywords/aggregation-pheromone","display_name":"aggregation pheromone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pheromone-biosynthesis","display_name":"pheromone synthesis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/dimethyl-disulfide","display_name":"dimethyl disulfide","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dimethyl-trisulfide","display_name":"dimethyl trisulfide","score":1.0},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.7720000147819519},{"id":"https://openalex.org/keywords/histidine","display_name":"histidine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/human-blood","display_name":"human blood","score":0.6399999856948853},{"id":"https://openalex.org/keywords/de-novo-synthesis","display_name":"de novo synthesis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/stable-isotope-labeling","display_name":"stable isotope labeling","score":0.6700000166893005},{"id":"https://openalex.org/keywords/fecal-extracts","display_name":"fecal extracts","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.817115306854248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7419254779815674},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6698926687240601},{"id":"https://openalex.org/C2908924393","wikidata":"https://www.wikidata.org/wiki/Q940337","display_name":"Cimex lectularius","level":3,"score":0.5799959301948547},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.5486541390419006},{"id":"https://openalex.org/C2781100537","wikidata":"https://www.wikidata.org/wiki/Q48385308","display_name":"Bed bug","level":2,"score":0.5211598873138428},{"id":"https://openalex.org/C2777328355","wikidata":"https://www.wikidata.org/wiki/Q167377","display_name":"Pheromone","level":2,"score":0.4680836796760559},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.46512719988822937},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4600204825401306},{"id":"https://openalex.org/C2779598325","wikidata":"https://www.wikidata.org/wiki/Q5277321","display_name":"Dimethyl trisulfide","level":4,"score":0.438679039478302},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4082337021827698},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3218728303909302},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22397589683532715},{"id":"https://openalex.org/C2775852224","wikidata":"https://www.wikidata.org/wiki/Q419800","display_name":"Dimethyl disulfide","level":3,"score":0.1990627646446228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15489399433135986},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.09778344631195068},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08772969245910645},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.08426675200462341},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.08074674010276794},{"id":"https://openalex.org/C2778908745","wikidata":"https://www.wikidata.org/wiki/Q26371","display_name":"Hemiptera","level":2,"score":0.0},{"id":"https://openalex.org/C518881349","wikidata":"https://www.wikidata.org/wiki/Q682","display_name":"Sulfur","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1139/cjc-2017-0407","doi":"https://doi.org/10.1139/cjc-2017-0407","is_oa":false,"landing_page_url":"https://doi.org/10.1139/cjc-2017-0407","pdf_url":null,"source":{"id":"https://openalex.org/S9189650","display_name":"Canadian Journal of Chemistry","issn_l":"0008-4042","issn":["0008-4042","1480-3291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:localhost:1807/80331","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/80331","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5f040ecd-174c-436a-8282-15413788287a/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/80331","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/80331","pdf_url":null,"source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:localhost:1807/80331","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/80331","pdf_url":"https://utoronto.scholaris.ca/bitstreams/5f040ecd-174c-436a-8282-15413788287a/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2762640183.pdf","grobid_xml":"https://content.openalex.org/works/W2762640183.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1547203551","https://openalex.org/W1604965434","https://openalex.org/W1967461245","https://openalex.org/W2005803297","https://openalex.org/W2008551786","https://openalex.org/W2021089228","https://openalex.org/W2021477822","https://openalex.org/W2050168385","https://openalex.org/W2050631663","https://openalex.org/W2074867843","https://openalex.org/W2078410199","https://openalex.org/W2136159261","https://openalex.org/W2139163102","https://openalex.org/W2154460304","https://openalex.org/W2176910918","https://openalex.org/W2193323577"],"related_works":["https://openalex.org/W2567308743","https://openalex.org/W4241459069","https://openalex.org/W2183645249","https://openalex.org/W3096386977","https://openalex.org/W1974229000","https://openalex.org/W2011601292","https://openalex.org/W3023538508","https://openalex.org/W149938515","https://openalex.org/W7095114727","https://openalex.org/W4242143020"],"abstract_inverted_index":{"We":[0,60],"have":[1],"recently":[2],"shown":[3],"that":[4,36,108,136,165],"the":[5,9,34,91,132,151],"aggregation":[6,92],"pheromone":[7,41],"of":[8,19,90,134,150],"common":[10],"bed":[11,37,67,85,109,137,166],"bug,":[12],"Cimex":[13],"lectularius,":[14],"comprises":[15],"a":[16,147],"six-component":[17],"blend":[18],"dimethyl":[20,23],"disulfide":[21],"(DMDS),":[22],"trisulfide":[24],"(DMTS),":[25],"(E)-2-hexenal,":[26],"(E)-2-octenal,":[27],"2-hexanone,":[28],"and":[29,52,56,72,94,102,115,117,140,145,170,174],"histamine.":[30],"Here,":[31],"we":[32],"tested":[33,61],"hypothesis":[35,63],"bugs":[38,68,110,138,167],"biosynthesize":[39,168],"some":[40],"components":[42],"from":[43,54,58],"amino":[44],"acid":[45],"precursors":[46],"in":[47,126,158],"human":[48,127],"blood,":[49],"namely":[50],"DMDS":[51,173],"DMTS":[53],"L-methionine":[55],"histamine":[57,135],"histidine.":[59],"this":[62],"by":[64,99],"(i)":[65],"allowing":[66],"to":[69,113,119,129,156],"feed":[70],"on":[71],"metabolize":[73],"sheep":[74],"blood":[75,128],"enriched":[76],"with":[77,142],"13C-labelled":[78],"histidine":[79,125],"or":[80],"2H-labelled":[81],"methionine,":[82],"(ii)":[83],"extracting":[84],"bug":[86],"feces":[87,97],"(a":[88],"source":[89],"pheromone),":[93],"(iii)":[95],"analyzing":[96],"extracts":[98],"GC-MS,":[100],"HPLC-MS":[101],"NMR":[103],"spectroscopy.":[104],"The":[105],"analyses":[106],"revealed":[107],"converted":[111,155],"2H-methionine":[112],"2H-DMDS":[114],"2H-DMTS,":[116],"13C-histidine":[118,153],"13C-histamine.":[120],"There":[121],"is":[122,163],"not":[123],"enough":[124],"account":[130],"for":[131],"amount":[133],"produce":[139],"excrete":[141],"their":[143],"feces,":[144],"only":[146],"small":[148],"proportion":[149],"available":[152],"was":[154],"13C-histamine":[157],"our":[159],"study.":[160],"Therefore,":[161],"it":[162],"likely":[164],"histamine,":[169],"possibly":[171],"also":[172],"DMTS,":[175],"primarily":[176],"de":[177],"novo.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-10-20T00:00:00"}
