{"id":"https://openalex.org/W2762270596","doi":null,"title":"Dietary fatty acids and cardiovascular disease risk in observational studies","display_name":"Dietary fatty acids and cardiovascular disease risk in observational studies","publication_year":2017,"publication_date":"2017-06-01","ids":{"openalex":"https://openalex.org/W2762270596","mag":"2762270596"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/353097","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/353097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/353097","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030957669","display_name":"Jaike Praagman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Praagman, J.","raw_affiliation_strings":["UMC Utrecht, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMC Utrecht, Utrecht, Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132898559","display_name":"Cardiovasculaire Epi Team 1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cardiovasculaire Epi Team 1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132917146","display_name":"JC onderzoeksprogramma Cardiovascular Health","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JC onderzoeksprogramma Cardiovascular Health","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054995024","display_name":"Yvonne T. van der Schouw","orcid":"https://orcid.org/0000-0002-4605-435X","observed_orcids":["https://orcid.org/0000-0002-4605-435X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"van der Schouw, Yvonne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085784987","display_name":"Joline W. J. Beulens","orcid":"https://orcid.org/0000-0002-4181-0937","observed_orcids":["https://orcid.org/0000-0002-4181-0937","https://orcid.org/0000-0002-6788-5232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beulens, Joline","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082985526","display_name":"Ivonne Sluijs","orcid":"https://orcid.org/0000-0001-7758-4911","observed_orcids":["https://orcid.org/0000-0001-7758-4911"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sluijs, Ivonne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030957669"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.30489999055862427,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.9919999837875366},{"id":"https://openalex.org/keywords/saturated-fat","display_name":"saturated fat","score":0.7979999780654907},{"id":"https://openalex.org/keywords/trans-fatty-acids","display_name":"trans fatty acids","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8240000009536743},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":1.0},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dietary-assessment-validity","display_name":"dietary assessment validity","score":0.75},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.8859999775886536},{"id":"https://openalex.org/keywords/observational-studies","display_name":"observational studies","score":0.7210000157356262},{"id":"https://openalex.org/keywords/confounding-factors","display_name":"confounding factors","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.8983849883079529},{"id":"https://openalex.org/C3020261727","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fat","level":3,"score":0.711266040802002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6647877097129822},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5390619039535522},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4395814836025238},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.43650922179222107},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.4262791574001312},{"id":"https://openalex.org/C2991897288","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fatty acid","level":3,"score":0.41126489639282227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3788178563117981},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.36697161197662354},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3588523268699646},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3452714681625366},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3398950397968292},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.206422358751297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18092840909957886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08098232746124268},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/353097","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/353097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/353097","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/353097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/353097","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/353097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/353097","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/353097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2222232325","https://openalex.org/W4210821864","https://openalex.org/W2032092092","https://openalex.org/W2097301645","https://openalex.org/W2742005424","https://openalex.org/W2070451449","https://openalex.org/W2341143659","https://openalex.org/W7095158331","https://openalex.org/W2523217664","https://openalex.org/W4211249386"],"abstract_inverted_index":{"Dietary":[0],"fat":[1,43,84,124,138,160,177],"is":[2,56,70,95,171],"a":[3,59,119,150,189,236],"valuable":[4],"component":[5],"of":[6,24,62,77,104,111,122,149,152,168,191,212,220,235],"the":[7,12,74,80,99,102,109,115,147,156,169,173,207,210,218,231,242],"diet":[8],"and":[9,44,85,108,139,161,178,202,233],"essential":[10],"for":[11,31,90],"human":[13],"body.":[14],"Over":[15],"time":[16],"it":[17],"has":[18,87],"become":[19],"clear":[20],"that":[21,41,118,194,203],"certain":[22],"types":[23],"fat(ty":[25],"acids)":[26],"are":[27],"also":[28],"potentially":[29,205],"harmful":[30,75],"our":[32],"health.":[33],"For":[34],"example,":[35],"we":[36,216,226],"know":[37],"from":[38],"intervention":[39,213],"studies":[40,131,154,222],"saturated":[42,83,123,137,176],"trans-fat":[45],"have":[46],"unfavourable":[47],"effects":[48,76],"on":[49,73,155,172,188],"serum":[50],"cholesterol":[51,127],"concentrations,":[52,128],"which":[53],"in":[54,197,223,228,239],"turn":[55],"related":[57],"to":[58],"higher":[60,120],"risk":[61],"coronary":[63],"heart":[64],"disease":[65,163],"(CHD).":[66],"In":[67,142],"general,":[68],"there":[69],"scientific":[71],"consensus":[72],"trans-fat,":[78],"but":[79],"link":[81],"between":[82,101,135,158,175],"CHD":[86,140],"been":[88],"debated":[89],"decennia":[91],"now.":[92],"This":[93],"debate":[94],"mainly":[96],"caused":[97],"by":[98,182],"discrepancy":[100],"results":[103,110,148,211,219],"randomized":[105],"controlled":[106],"trials":[107],"observational":[112,130,153,200],"studies.":[113,214],"Whereas":[114],"first":[116],"show":[117],"intake":[121],"raises":[125],"LDL":[126],"most":[129,198],"found":[132],"no":[133],"relation":[134],"dietary":[136,159,243],"risk.":[141,164],"this":[143,185],"thesis,":[144],"I":[145],"present":[146],"number":[151,190],"association":[157,174,186],"cardiovascular":[162],"The":[165],"main":[166],"focus":[167],"thesis":[170],"CHD.":[179],"We":[180],"started":[181],"investigating":[183],"whether":[184],"depends":[187],"predefined":[192],"factors":[193],"were":[195],"ignored":[196],"previous":[199],"studies,":[201],"could":[204],"explain":[206],"disagreement":[208],"with":[209],"Before":[215],"discuss":[217,227],"those":[221],"chapter":[224,229],"3,":[225],"2":[230],"validity":[232],"reproducibility":[234],"crucial":[237],"assessment":[238],"nutrition":[240],"research;":[241],"assessment.":[244]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2017-10-20T00:00:00"}