{"id":"https://openalex.org/W2761998386","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.e18559","title":"Interaction between ring sideroblasts and treatment with hypomethylating agents (HMA) in patients with refractory anemia with ring sideroblasts.","display_name":"Interaction between ring sideroblasts and treatment with hypomethylating agents (HMA) in patients with refractory anemia with ring sideroblasts.","publication_year":2017,"publication_date":"2017-05-20","ids":{"openalex":"https://openalex.org/W2761998386","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.e18559","mag":"2761998386"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2017.35.15_suppl.e18559","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.e18559","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.e18559","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016703891","display_name":"Rama Nanah","orcid":"https://orcid.org/0000-0003-2163-9578","observed_orcids":["https://orcid.org/0000-0003-2163-9578"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rama Nanah","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032947311","display_name":"Darci Zblewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darci Zblewski","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079731167","display_name":"Rong Lucy He","orcid":"https://orcid.org/0000-0001-6116-8163","observed_orcids":["https://orcid.org/0000-0001-6116-8163","https://orcid.org/0000-0002-6011-5964"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong He","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101488224","display_name":"Phuong L. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phuong L. Nguyen","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002643270","display_name":"Naseema Gangat","orcid":"https://orcid.org/0000-0002-9104-6172","observed_orcids":["https://orcid.org/0000-0002-9104-6172"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naseema Gangat","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080965667","display_name":"Kebede H. Begna","orcid":"https://orcid.org/0000-0003-2730-8593","observed_orcids":["https://orcid.org/0000-0003-2730-8593"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kebede Begna","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064374340","display_name":"Michelle Ann Elliott","orcid":"https://orcid.org/0000-0002-7366-9886","observed_orcids":["https://orcid.org/0000-0002-7366-9886"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle A. Elliott","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084606047","display_name":"William J. Hogan","orcid":"https://orcid.org/0000-0002-5841-4105","observed_orcids":["https://orcid.org/0000-0002-5841-4105"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Hogan","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072463255","display_name":"Mrinal M. Patnaik","orcid":"https://orcid.org/0000-0001-6998-662X","observed_orcids":["https://orcid.org/0000-0001-6998-662X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mrinal Patnaik","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Robert Litzow","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aref Al-Kali","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"15_suppl","first_page":"e18559","last_page":"e18559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/refractory-anemia-with-ringed-sideroblasts","display_name":"refractory anemia with ringed sideroblasts","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.8619999885559082},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.875},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":1.0},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ring-sideroblasts","display_name":"ring sideroblasts","score":0.949999988079071},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.8460000157356262},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8830000162124634},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7300000190734863},{"id":"https://openalex.org/keywords/bone-marrow-biopsy","display_name":"bone marrow biopsy","score":0.4480000138282776},{"id":"https://openalex.org/keywords/ineffective-hematopoiesis","display_name":"ineffective hematopoiesis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.46700000762939453},{"id":"https://openalex.org/keywords/therapy-related-myelodysplastic-syndrome","display_name":"therapy-related myelodysplastic syndrome","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9188598394393921},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.8172842860221863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.746270477771759},{"id":"https://openalex.org/C2780240888","wikidata":"https://www.wikidata.org/wiki/Q6052586","display_name":"International Prognostic Scoring System","level":4,"score":0.6754715442657471},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.6532204151153564},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.5436245203018188},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4609746038913727},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4532911479473114},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37316104769706726},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.359323114156723},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3227623701095581},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.30769598484039307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2017.35.15_suppl.e18559","doi":"https://doi.org/10.1200/jco.2017.35.15_suppl.e18559","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2017.35.15_suppl.e18559","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3095763814","https://openalex.org/W2987991669","https://openalex.org/W2576174906","https://openalex.org/W4283322270","https://openalex.org/W2504974068","https://openalex.org/W4239836009","https://openalex.org/W2890204086","https://openalex.org/W4417004836","https://openalex.org/W2985429448","https://openalex.org/W2586125700"],"abstract_inverted_index":{"e18559":[0],"Background:":[1],"Myelodysplastic":[2],"syndromes":[3],"(MDS)":[4],"are":[5],"a":[6,35,55,288,308,319],"group":[7],"of":[8,21,37,73,80,149,178,184,215,249,265,290,322,353,357],"myeloid":[9,25],"neoplasms":[10],"defined":[11,39],"by":[12,40,135,287],"ineffective":[13],"hematopoiesis,":[14],"dysplastic":[15],"morphologic":[16],"features,":[17],"and":[18,44,137,207,274],"variable":[19],"risks":[20],"progression":[22],"to":[23,271,314,336,341,349],"acute":[24],"leukemia":[26],"(AML).":[27],"Refractory":[28],"anemia":[29],"with":[30,162,174,328],"ring":[31,47,185,281,354],"sideroblasts":[32,48,186,282,355],"(RARS)":[33],"is":[34,54,68,318,325],"subtype":[36,321],"MDS":[38,82,127,323],"<":[41],"5%":[42],"basts":[43],">":[45],"15%":[46,291],"(per":[49],"2008":[50],"WHO).":[51],"Because":[52],"RARS":[53,155,252,317,359],"lower":[56],"risk":[57],"disease":[58],"which":[59],"does":[60],"not":[61],"frequently":[62],"require":[63],"HMA":[64,74,118,262,285,329,337,346],"therapy,":[65,263],"very":[66],"little":[67],"known":[69,342],"about":[70],"the":[71,150,195,231,250,269,296,351],"effects":[72],"on":[75,126,364],"RARS.":[76,121],"Methods:":[77],"A":[78],"total":[79],"1325":[81,152],"patients\u2019":[83],"data":[84],"from":[85,312],"1993-2016":[86],"at":[87,106,188],"Mayo":[88],"Clinic":[89],"were":[90,110,133,142,154,160,172,267,276],"reviewed":[91,105],"after":[92,261,284],"appropriate":[93],"IRB":[94],"approval":[95],"was":[96,123,166,190,219,339],"obtained.":[97],"All":[98,243],"cases":[99],"had":[100,255,304,307],"their":[101,120,256],"bone":[102,257],"marrow":[103,258],"slides":[104],"our":[107,113,332],"center.":[108],"Patients":[109],"considered":[111],"for":[112,119,217,226],"study":[114],"if":[115,367],"they":[116,294],"received":[117,200,209,246],"Response":[122,334],"identified":[124],"based":[125],"IWG":[128],"2006":[129],"criteria.":[130],"Prognostic":[131],"factors":[132],"analyzed":[134],"univariate":[136],"multivariate":[138],"analyses.":[139],"Survival":[140],"estimates":[141],"calculated":[143],"using":[144],"Kaplan-Meier":[145],"curves.":[146],"Results:":[147],"168":[148],"initial":[151],"patient":[153,302],"(14%);":[156],"only":[157,236],"14":[158,196,232,251],"(8%)":[159],"treated":[161,327,363],"HMA.":[163],"Median":[164],"age":[165],"72":[167],"years":[168],"(range,":[169,221,228],"51-85);":[170],"half":[171],"males,":[173],"median":[175,182,213,289],"overall":[176],"survival":[177],"91.3":[179],"months.":[180],"The":[181,212],"number":[183,214,352],"(RS)":[187],"diagnosis":[189],"40%":[191],"(range":[192,292],"10-85%).":[193],"Of":[194,230],"patients,":[197,280],"11":[198],"(79%)":[199],"azacitidine":[201],"(AZA),":[202],"2":[203],"(14%)":[204],"decitabine":[205],"(DAC)":[206],"one":[208,301],"both":[210],"(7%).":[211],"cycles":[216,225],"AZA":[218,272],"6.5":[220],"2-28)":[222],"vs":[223],"6":[224,248],"DAC":[227],"1-24).":[229],"patients":[233,253,360],"receiving":[234],"HMA,":[235],"3":[237,244,264,275],"responded":[238],"(21%)":[239,338],"achieving":[240],"hematologic":[241],"improvement.":[242],"responders":[245,270],"AZA.":[247],"(43%)":[254],"biopsy":[259],"repeated":[260],"whom":[266],"among":[268],"therapy":[273,286,347],"non-responders.":[277],"In":[278],"5":[279],"decreased":[283],"0-80);":[293],"remained":[295],"same":[297],"in":[298,310,331,344],"1":[299],"patient;":[300],"who":[303],"developed":[305],"AML":[306],"decrease":[309,350],"RS":[311],"85%":[313],"5%.":[315],"Conclusions:":[316],"low-risk":[320],"that":[324],"infrequently":[326],"(8%":[330],"study).":[333],"rate":[335],"inferior":[340],"rates":[343],"MDS.":[345],"seems":[348],"irrespective":[356],"response.":[358],"should":[361],"be":[362],"clinical":[365],"trials":[366],"available.":[368]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-10-20T00:00:00"}
