{"id":"https://openalex.org/W2761661886","doi":"https://doi.org/10.1016/j.apjtb.2017.09.021","title":"Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy \u2013 a hypothesis","display_name":"Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy \u2013 a hypothesis","publication_year":2017,"publication_date":"2017-10-12","ids":{"openalex":"https://openalex.org/W2761661886","doi":"https://doi.org/10.1016/j.apjtb.2017.09.021","mag":"2761661886"},"language":"en","primary_location":{"id":"doi:10.1016/j.apjtb.2017.09.021","doi":"https://doi.org/10.1016/j.apjtb.2017.09.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtb.2017.09.021","pdf_url":null,"source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2761661886"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.apjtb.2017.09.021","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039259903","display_name":"Kaviyarasi Renu","orcid":"https://orcid.org/0000-0003-0991-8080","observed_orcids":["https://orcid.org/0000-0003-0991-8080"]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kaviyarasi Renu","raw_affiliation_strings":["School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057883372","display_name":"Abilash Valsala Gopalakrishnan","orcid":"https://orcid.org/0000-0003-0780-0492","observed_orcids":["https://orcid.org/0000-0003-0780-0492"]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V.G. Abilash","raw_affiliation_strings":["School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030160858","display_name":"P.B. Tirupathi Pichiah","orcid":"https://orcid.org/0000-0003-4713-1086","observed_orcids":["https://orcid.org/0000-0003-4713-1086"]},"institutions":[{"id":"https://openalex.org/I4076070","display_name":"Bharathidasan University","ror":"https://ror.org/02w7vnb60","country_code":"IN","type":"education","lineage":["https://openalex.org/I4076070"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P.B. Tirupathi Pichiah","raw_affiliation_strings":["Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu 620024, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu 620024, India","institution_ids":["https://openalex.org/I4076070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008599355","display_name":"Syeda Thabassum Akhtar Iqbal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I876193797","display_name":"Vellore Institute of Technology University","ror":"https://ror.org/00qzypv28","country_code":"IN","type":"education","lineage":["https://openalex.org/I876193797"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Thabassum Akthar Syeda","raw_affiliation_strings":["School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India","institution_ids":["https://openalex.org/I876193797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006630628","display_name":"Sankarganesh Arunachalam","orcid":"https://orcid.org/0000-0003-2857-4877","observed_orcids":["https://orcid.org/0000-0003-2857-4877"]},"institutions":[{"id":"https://openalex.org/I98499257","display_name":"Kalasalingam Academy of Research and Education","ror":"https://ror.org/04fm2fn75","country_code":"IN","type":"education","lineage":["https://openalex.org/I98499257"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sankarganesh Arunachalam","raw_affiliation_strings":["Department of Biotechnology, Kalasalingam University, Krishnankoil 626126, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Kalasalingam University, Krishnankoil 626126, Tamil Nadu, India","institution_ids":["https://openalex.org/I98499257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006630628"],"corresponding_institution_ids":["https://openalex.org/I98499257"],"apc_list":null,"apc_paid":null,"fwci":0.8311,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.74359516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"7","issue":"11","first_page":"1041","last_page":"1045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.4771000146865845,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.4771000146865845,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.2538999915122986,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.12370000034570694,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adriamycin-induced-cardiomyopathy","display_name":"adriamycin-induced cardiomyopathy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.796999990940094},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/systolic-and-diastolic-dysfunction","display_name":"systolic and diastolic dysfunction","score":0.9150000214576721},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9789999723434448},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9049999713897705},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.900540828704834},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.8374538421630859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7754436135292053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6592026948928833},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6354548931121826},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5094838738441467},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.49703195691108704},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4659717082977295},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4442934989929199},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.42647555470466614},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.4148308038711548},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3739262819290161},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08777958154678345},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.07152527570724487},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.apjtb.2017.09.021","doi":"https://doi.org/10.1016/j.apjtb.2017.09.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtb.2017.09.021","pdf_url":null,"source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5ad243057ad744d8bbd1ba2c363fe2ba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5ad243057ad744d8bbd1ba2c363fe2ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 11, Pp 1041-1045 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.apjtb.2017.09.021","doi":"https://doi.org/10.1016/j.apjtb.2017.09.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apjtb.2017.09.021","pdf_url":null,"source":{"id":"https://openalex.org/S2765002354","display_name":"Asian Pacific Journal of Tropical Biomedicine","issn_l":"2221-1691","issn":["2221-1691","2588-9222"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Tropical Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W109115322","https://openalex.org/W1596495551","https://openalex.org/W1758646032","https://openalex.org/W1909616616","https://openalex.org/W1966679399","https://openalex.org/W1972913443","https://openalex.org/W1975588412","https://openalex.org/W1976840082","https://openalex.org/W1978854975","https://openalex.org/W1979595579","https://openalex.org/W1986235853","https://openalex.org/W2001027155","https://openalex.org/W2002971066","https://openalex.org/W2010183849","https://openalex.org/W2015444321","https://openalex.org/W2018675111","https://openalex.org/W2026071606","https://openalex.org/W2043863942","https://openalex.org/W2056460928","https://openalex.org/W2059081636","https://openalex.org/W2063222168","https://openalex.org/W2065504943","https://openalex.org/W2066653136","https://openalex.org/W2072140679","https://openalex.org/W2074997611","https://openalex.org/W2084304742","https://openalex.org/W2086320092","https://openalex.org/W2090167726","https://openalex.org/W2096551466","https://openalex.org/W2098774487","https://openalex.org/W2099844154","https://openalex.org/W2113136873","https://openalex.org/W2114671826","https://openalex.org/W2121271900","https://openalex.org/W2137771843","https://openalex.org/W2141450595","https://openalex.org/W2144141910","https://openalex.org/W2145817464","https://openalex.org/W2152255333","https://openalex.org/W2162689981","https://openalex.org/W2319030457","https://openalex.org/W2343374611","https://openalex.org/W2395002907","https://openalex.org/W2407918174","https://openalex.org/W2415853500","https://openalex.org/W2489317406","https://openalex.org/W2524574476","https://openalex.org/W2546015924","https://openalex.org/W2550251732","https://openalex.org/W2586243829","https://openalex.org/W2586342722","https://openalex.org/W2591558322","https://openalex.org/W2592438112","https://openalex.org/W2593304502","https://openalex.org/W2599426809","https://openalex.org/W2601330602","https://openalex.org/W2604294853","https://openalex.org/W2604978076","https://openalex.org/W2620382283","https://openalex.org/W2622664296","https://openalex.org/W2625132864","https://openalex.org/W2726444801","https://openalex.org/W2733303138","https://openalex.org/W2735115050","https://openalex.org/W2807942571"],"related_works":["https://openalex.org/W2809425404","https://openalex.org/W1979595579","https://openalex.org/W2084241025","https://openalex.org/W2477314764","https://openalex.org/W2361255967","https://openalex.org/W2149067762","https://openalex.org/W2350461030","https://openalex.org/W1035140252","https://openalex.org/W3138946657","https://openalex.org/W7112925592"],"abstract_inverted_index":{"Diabetic":[0],"cardiomyopathy":[1,29,48,95,106,188,197],"is":[2,71],"one":[3],"of":[4,9,13,28,38,47,68,84,86,112,114,132,134,166],"the":[5,36,42,45,62,116,135,138,161,168,202],"life":[6],"threatening":[7],"complications":[8],"diabetes.":[10,90],"A":[11,82],"number":[12,83,111],"animal":[14,25,180],"models":[15],"are":[16,130,157],"being":[17,35,44],"used":[18,98,184],"for":[19,66,185,193],"studying":[20,186],"diabetic":[21,39,51,105,187],"cardiomyopathy.":[22,69,81],"In":[23,172],"laboratory":[24],"models,":[26],"induction":[27,37,46],"happens":[30],"in":[31,107,159,199],"two":[32],"stages:":[33],"first":[34],"condition":[40],"and":[41,123,128,154,189],"second":[43],"by":[49,77],"prolonging":[50],"condition.":[52],"It":[53],"takes":[54],"a":[55,100,110],"longer":[56],"time":[57,192],"to":[58,103],"develop":[59],"diabetes":[60],"with":[61],"limited":[63,76],"success":[64],"rate":[65],"development":[67],"Adriamycin":[70,87,177],"an":[72],"effective":[73],"anti-cancer":[74],"drug":[75],"its":[78],"major":[79],"side-effect":[80],"features":[85,113],"treatment":[88],"mimics":[89],"We":[91],"postulate":[92],"that":[93,176],"Adriamycin-induced":[94],"might":[96],"be":[97,183],"as":[99],"model":[101,181],"system":[102],"study":[104],"rodents":[108],"since":[109],"both":[115,133,160,167],"cardiomyopathies":[117,169],"overlap.":[118],"Left":[119],"ventricular":[120],"hypertrophy,":[121],"systolic":[122],"diastolic":[124],"dysfunction,":[125,151],"myofibrillar":[126],"loss,":[127],"fibrosis":[129],"hallmarks":[131],"cardiomyopathies.":[136,162],"At":[137],"molecular":[139],"level,":[140],"calcium":[141],"signaling,":[142],"endoplasmic":[143],"reticulum":[144],"stress,":[145],"advance":[146],"glycation":[147],"endproduct":[148],"activation,":[149],"mitochondrial":[150],"inflammation,":[152],"lipotoxicity":[153],"oxidative":[155],"stress":[156],"similar":[158],"The":[163],"signature":[164],"profile":[165],"shares":[170],"commonalities.":[171],"conclusion,":[173],"we":[174],"suggest":[175],"induced":[178],"cardiomyopathic":[179],"can":[182],"would":[190],"save":[191],"researchers":[194],"working":[195],"on":[196],"developed":[198],"rodent":[200],"using":[201],"traditional":[203],"method.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-10-20T00:00:00"}
