{"id":"https://openalex.org/W2761661840","doi":"https://doi.org/10.2174/0929867324666171006165942","title":"Sunitinib in the Treatment of Thyroid Cancer","display_name":"Sunitinib in the Treatment of Thyroid Cancer","publication_year":2017,"publication_date":"2017-10-10","ids":{"openalex":"https://openalex.org/W2761661840","doi":"https://doi.org/10.2174/0929867324666171006165942","mag":"2761661840","pmid":"https://pubmed.ncbi.nlm.nih.gov/28990511"},"language":"en","primary_location":{"id":"doi:10.2174/0929867324666171006165942","doi":"https://doi.org/10.2174/0929867324666171006165942","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0929867324666171006165942","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11568/884277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101601358","display_name":"Silvia Martina Ferrari","orcid":"https://orcid.org/0000-0002-5777-3384","observed_orcids":["https://orcid.org/0000-0002-5777-3384"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Martina Ferrari","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050301942","display_name":"Marco Centanni","orcid":"https://orcid.org/0000-0003-0661-1649","observed_orcids":["https://orcid.org/0000-0003-0661-1649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Centanni","raw_affiliation_strings":["Department of Medico-Surgical Sciences and Biotechnologies, , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medico-Surgical Sciences and Biotechnologies, , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025958746","display_name":"Camilla Virili","orcid":"https://orcid.org/0000-0002-4973-1950","observed_orcids":["https://orcid.org/0000-0002-4973-1950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla Virili","raw_affiliation_strings":["Department of Medico-Surgical Sciences and Biotechnologies, , Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medico-Surgical Sciences and Biotechnologies, , Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007252462","display_name":"Mario Miccoli","orcid":"https://orcid.org/0000-0002-8632-6145","observed_orcids":["https://orcid.org/0000-0002-8632-6145"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Miccoli","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056157710","display_name":"Paola Ferrari","orcid":"https://orcid.org/0000-0003-2983-9726","observed_orcids":["https://orcid.org/0000-0003-2983-9726"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Ferrari","raw_affiliation_strings":["Department of Oncology, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035006263","display_name":"Ilaria Ruffilli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Ruffilli","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032821362","display_name":"Francesca Ragusa","orcid":"https://orcid.org/0000-0002-9302-0267","observed_orcids":["https://orcid.org/0000-0002-9302-0267"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Ragusa","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038828476","display_name":"Alessandro Antonelli","orcid":"https://orcid.org/0000-0002-5211-6342","observed_orcids":["https://orcid.org/0000-0002-5211-6342"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandro Antonelli","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057155509","display_name":"Poupak Fallahi","orcid":"https://orcid.org/0000-0002-5455-4186","observed_orcids":["https://orcid.org/0000-0002-5455-4186"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Poupak Fallahi","raw_affiliation_strings":["Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038828476"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":null,"apc_paid":null,"fwci":0.6357,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.55479811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"26","issue":"6","first_page":"963","last_page":"972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":1.0},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dedifferentiated-thyroid-cancer","display_name":"dedifferentiated thyroid cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ret-ptc1","display_name":"RET/PTC1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/jnk-sapk-pathway","display_name":"SAPK/JNK pathway","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sodium-iodide-symporter","display_name":"sodium iodide symporter","score":0.9240000247955322},{"id":"https://openalex.org/keywords/drug-adverse-events","display_name":"drug adverse events","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.9243947267532349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8135504722595215},{"id":"https://openalex.org/C2780256643","wikidata":"https://www.wikidata.org/wiki/Q3658382","display_name":"Anaplastic thyroid cancer","level":4,"score":0.7091479301452637},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.6059814095497131},{"id":"https://openalex.org/C2908861226","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib malate","level":4,"score":0.5972590446472168},{"id":"https://openalex.org/C2780120053","wikidata":"https://www.wikidata.org/wiki/Q3493538","display_name":"Medullary thyroid cancer","level":4,"score":0.5799676179885864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5694509744644165},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5505846738815308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48896849155426025},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45805585384368896},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.42106518149375916},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4162149131298065},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.4101625084877014},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3776339292526245},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36407116055488586},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.25643429160118103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16528195142745972},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077210","descriptor_name":"Sunitinib","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/0929867324666171006165942","doi":"https://doi.org/10.2174/0929867324666171006165942","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0929867324666171006165942","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:28990511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28990511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/884277","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11568/884277","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1305710","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1305710","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:arpi.unipi.it:11568/884277","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11568/884277","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W17178929","https://openalex.org/W1797334397","https://openalex.org/W1865070410","https://openalex.org/W1964925118","https://openalex.org/W1965734230","https://openalex.org/W1967792499","https://openalex.org/W1984438193","https://openalex.org/W1986645168","https://openalex.org/W1989865812","https://openalex.org/W1992447553","https://openalex.org/W1996160109","https://openalex.org/W2000574361","https://openalex.org/W2003771649","https://openalex.org/W2011844188","https://openalex.org/W2016465176","https://openalex.org/W2024428343","https://openalex.org/W2027434493","https://openalex.org/W2031614751","https://openalex.org/W2033734331","https://openalex.org/W2036852888","https://openalex.org/W2039779867","https://openalex.org/W2039951880","https://openalex.org/W2042997851","https://openalex.org/W2043783615","https://openalex.org/W2044362172","https://openalex.org/W2049018291","https://openalex.org/W2062871120","https://openalex.org/W2063913716","https://openalex.org/W2067501886","https://openalex.org/W2068952887","https://openalex.org/W2074796794","https://openalex.org/W2077064608","https://openalex.org/W2079134837","https://openalex.org/W2082024899","https://openalex.org/W2082244817","https://openalex.org/W2091492800","https://openalex.org/W2093933802","https://openalex.org/W2099088585","https://openalex.org/W2100623243","https://openalex.org/W2102084843","https://openalex.org/W2112129582","https://openalex.org/W2112273796","https://openalex.org/W2113896257","https://openalex.org/W2116542352","https://openalex.org/W2119259252","https://openalex.org/W2119501407","https://openalex.org/W2123547490","https://openalex.org/W2124596857","https://openalex.org/W2125901224","https://openalex.org/W2126514702","https://openalex.org/W2127027386","https://openalex.org/W2129337940","https://openalex.org/W2129453496","https://openalex.org/W2135783842","https://openalex.org/W2139503156","https://openalex.org/W2139511378","https://openalex.org/W2147436031","https://openalex.org/W2149456801","https://openalex.org/W2152761874","https://openalex.org/W2153230380","https://openalex.org/W2158876360","https://openalex.org/W2159237542","https://openalex.org/W2159900041","https://openalex.org/W2161198425","https://openalex.org/W2162770707","https://openalex.org/W2164452916","https://openalex.org/W2168076926","https://openalex.org/W2171937826","https://openalex.org/W2202760937","https://openalex.org/W2266521291","https://openalex.org/W2284035444","https://openalex.org/W2299873647","https://openalex.org/W2336573931","https://openalex.org/W2346577893","https://openalex.org/W2413586934","https://openalex.org/W2490150882","https://openalex.org/W2509768156","https://openalex.org/W2526952316","https://openalex.org/W2530292833","https://openalex.org/W2600778287","https://openalex.org/W2964533106","https://openalex.org/W4240153240","https://openalex.org/W4300096957","https://openalex.org/W6600228653","https://openalex.org/W6695169989"],"related_works":["https://openalex.org/W2526952316","https://openalex.org/W1989865812","https://openalex.org/W2589845089","https://openalex.org/W2079134837","https://openalex.org/W4253368231","https://openalex.org/W2124596857","https://openalex.org/W2125901224","https://openalex.org/W2181514477","https://openalex.org/W7037650113","https://openalex.org/W1967066162"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sunitinib":[1,55,158],"(SU11248)":[2],"is":[3,56,116,137,161,194],"an":[4],"oral":[5],"multi-target":[6],"tyrosine":[7,31],"kinase":[8,32],"inhibitor":[9],"(TKI)":[10],"with":[11,147],"low":[12],"molecular":[13],"weight,":[14],"that":[15,86,135],"inhibits":[16],"platelet-derived":[17],"growth":[18,25],"factor":[19,26],"receptors":[20,27],"(PDGF-Rs)":[21],"and":[22,35,46,69,92,102,120,141,164,187,213],"vascular":[23],"endothelial":[24],"(VEGFRs),":[28],"c-KIT,":[29],"fms-related":[30],"3":[33],"(FLT3)":[34],"RET.":[36],"The":[37,166],"concurrent":[38],"inhibition":[39],"of":[40,61,105,130,199,226],"these":[41],"pathways":[42,94],"reduces":[43],"tumor":[44,53,65],"vascularization":[45],"causes":[47],"cancer":[48,126,151,156],"cell":[49,98,100,175],"apoptosis,":[50],"inducing":[51],"a":[52],"shrinkage.":[54],"approved":[57],"for":[58],"the":[59,76,89,96,131,197,223],"treatment":[60],"imatinib-resistant":[62],"gastrointestinal":[63],"stromal":[64],"(GIST),":[66],"renal":[67],"carcinoma,":[68],"pancreatic":[70],"neuroendocrine":[71],"tumors.":[72],"METHODS:":[73],"We":[74],"searched":[75],"literature":[77],"on":[78],"PubMed":[79],"library.":[80],"RESULTS:":[81],"In":[82],"vitro":[83,119],"studies":[84,133,209],"showed":[85],"sunitinib":[87,115,136,193,227],"targeted":[88],"cytosolic":[90],"MEK/ERK":[91],"SAPK/JNK":[93],"in":[95,111,118,121,145,173,196,219,228],"RET/PTC1":[97,112],"inhibiting":[99],"proliferation":[101],"causing":[103],"stimulation":[104],"sodium/iodide":[106],"symporter":[107],"(NIS)":[108],"gene":[109],"expression":[110],"cells.":[113,128],"Furthermore":[114],"active":[117],"vivo":[122],"against":[123],"anaplastic":[124],"thyroid":[125,150,155,201,230],"(ATC)":[127],"Most":[129],"clinical":[132],"report":[134],"effective":[138],"as":[139],"first-":[140],"second-line":[142],"TKI":[143],"therapy":[144,198],"patients":[146],"advanced":[148],"dedifferentiated":[149],"(DeTC),":[152],"or":[153],"medullary":[154],"(MTC).":[157],"37.5":[159],"mg/day":[160],"well":[162],"tolerated,":[163],"effective.":[165],"most":[167],"common":[168],"adverse":[169],"events":[170],"include:":[171],"reduction":[172],"blood":[174],"counts":[176],"(in":[177],"particular":[178],"leukocytes),":[179],"hand-foot":[180],"skin":[181],"reaction,":[182],"diarrhea,":[183],"fatigue,":[184],"nausea,":[185],"hypertension,":[186],"musculoskeletal":[188],"pain.":[189],"CONCLUSION:":[190],"Even":[191],"if":[192],"promising":[195],"differentiated":[200],"carcinoma":[202],"(DTC),":[203],"until":[204],"now":[205],"no":[206],"phase":[207],"III":[208],"have":[210],"been":[211],"published,":[212],"additional":[214],"prospective":[215],"researches":[216],"are":[217],"necessary":[218],"order":[220],"to":[221],"evaluate":[222],"real":[224],"efficacy":[225],"aggressive":[229],"cancer.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-20T00:00:00"}
