{"id":"https://openalex.org/W2761609290","doi":null,"title":"Integrated Genomic Biomarkers to Identify Aggressive Disease in African Americans with Prostate Cancer","display_name":"Integrated Genomic Biomarkers to Identify Aggressive Disease in African Americans with Prostate Cancer","publication_year":2016,"publication_date":"2016-09-01","ids":{"openalex":"https://openalex.org/W2761609290","mag":"2761609290"},"language":"en","primary_location":{"id":"mag:2761609290","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1034115.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087470378","display_name":"Albert M. Levin","orcid":"https://orcid.org/0000-0002-6993-1669","observed_orcids":["https://orcid.org/0000-0002-6993-1669"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Albert M. Levin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6993-1669","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087470378"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32680871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/african-american-men","display_name":"African American men","score":0.8429999947547913},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.9359999895095825},{"id":"https://openalex.org/keywords/somatic-copy-number-alterations","display_name":"somatic copy number alterations","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5440000295639038},{"id":"https://openalex.org/keywords/racial-disparities-in-cancer-mortality","display_name":"racial disparities in cancer mortality","score":0.7229999899864197},{"id":"https://openalex.org/keywords/recurrence-risk-prediction","display_name":"recurrence risk prediction","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6335368752479553},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.58281409740448},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5810347199440002},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5232504606246948},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5199928879737854},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5062943696975708},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48737961053848267},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4728793501853943},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4316450357437134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4244273602962494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4217655658721924},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36738866567611694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3630197048187256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25362446904182434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2508552670478821},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.1148093044757843},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2761609290","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/1034115.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042363635","https://openalex.org/W7098795619","https://openalex.org/W1569928645","https://openalex.org/W2278355657","https://openalex.org/W2274728014","https://openalex.org/W1815870121","https://openalex.org/W2921019065","https://openalex.org/W2603922887","https://openalex.org/W1590866704","https://openalex.org/W4244355447"],"abstract_inverted_index":{"Abstract":[0],":":[1],"The":[2,245],"purpose":[3],"of":[4,21,32,51,74,98,106,125,132,152,166,193,199,233,295],"our":[5,291],"research":[6],"is":[7],"to":[8,45,277],"identify":[9,68],"somatic":[10],"copy":[11,59,157,178,250,284],"number":[12,60,158,179,251,285],"alterations":[13,252,286],"and":[14,37,62,70,83,113,139,149,163,180,205,265],"methylation":[15,63,173,181,218],"markers":[16],"in":[17,40,43,77,94,202,224,235,257,272,290],"the":[18,47,65,103,133,147,156,161,170,176,191,195,296],"primary":[19],"tumors":[20,154,168],"African":[22],"American":[23,226],"(AA)":[24],"men":[25,80,227,261],"that":[26,209,253],"can":[27],"serve":[28],"as":[29],"a":[30],"component":[31],"their":[33],"recurrence":[34,76,201,223,234,289],"risk":[35,232],"assessment":[36],"be":[38,92],"applied":[39],"treatment":[41],"planning":[42],"attempt":[44],"reduce":[46],"racially":[48],"disparate":[49],"rates":[50],"mortality":[52],"from":[53,123,143,244],"prostate":[54,263],"cancer.":[55,274],"Through":[56],"whole":[57],"genome":[58],"alteration":[61],"scans,":[64],"study":[66,292],"will":[67,90],"individual":[69],"integrated":[71],"DNA-based":[72],"biomarkers":[73,89],"biochemical":[75,86,200,222,288],"200":[78,99],"AA":[79,100,203,236,258],"(100":[81],"with":[82,221,231,262,268,287],"100":[84],"without":[85],"recurrence).":[87],"These":[88],"then":[91],"validated":[93],"an":[95],"independent":[96],"set":[97],"men.":[101,237],"In":[102,238],"first":[104],"year":[105],"funding,":[107],"we":[108,183,240],"have":[109,116,128,184],"enumerated":[110],"both":[111],"discovery":[112,135,297],"validation":[114],"samples;":[115],"obtained":[117],"formalin":[118],"fixed":[119],"paraffin":[120],"embedded":[121],"blocks":[122],"300":[124],"these":[126,279],"men;":[127],"completed":[129,146,160],"pathology":[130],"review":[131],"complete":[134],"sample":[136],"tumors;":[137,145],"macrodissected":[138],"performed":[140],"DNA":[141],"extraction":[142],"141":[144],"running":[148,162],"quality":[150,164],"control":[151,165],"60":[153],"on":[155,169,249],"assay;":[159],"48":[167],"Illumina":[171],"EPIC":[172],"microarrays.":[174],"From":[175],"resulting":[177],"data,":[182],"preliminary":[185],"results":[186],"for":[187,197],"Aim":[188],"1":[189],"suggesting":[190],"utility":[192],"using":[194],"GEMCaP":[196],"prediction":[198],"men,":[204],"further":[206],"encouraging":[207],"findings":[208],"suggest":[210],"many,":[211],"but":[212],"not":[213],"all,":[214],"previously":[215],"identified":[216],"CpG":[217],"sites":[219],"associated":[220,230],"European":[225],"are":[228,266],"also":[229,241],"addition,":[239],"present":[242],"finding":[243],"Cancer":[246],"Genome":[247],"Atlas":[248],"differ":[254],"by":[255],"race-ethnicity":[256,269],"vs.":[259],"EA":[260],"cancer":[264],"consistent":[267],"differences":[270],"observed":[271],"breast":[273],"We":[275],"intend":[276],"test":[278],"cross":[280],"tumor":[281],"site":[282],"race-differentiated":[283],"following":[293],"completion":[294],"cohort.":[298]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-10-20T00:00:00"}