{"id":"https://openalex.org/W2761560873","doi":"https://doi.org/10.1186/s12964-017-0194-x","title":"Crosstalk between glial and glioblastoma cells triggers the \u201cgo-or-grow\u201d phenotype of tumor cells","display_name":"Crosstalk between glial and glioblastoma cells triggers the \u201cgo-or-grow\u201d phenotype of tumor cells","publication_year":2017,"publication_date":"2017-10-02","ids":{"openalex":"https://openalex.org/W2761560873","doi":"https://doi.org/10.1186/s12964-017-0194-x","mag":"2761560873","pmid":"https://pubmed.ncbi.nlm.nih.gov/28969644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5625790"},"language":"en","primary_location":{"id":"doi:10.1186/s12964-017-0194-x","doi":"https://doi.org/10.1186/s12964-017-0194-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-017-0194-x","pdf_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-017-0194-x","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-017-0194-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083321170","display_name":"Ana Isabel Oliveira","orcid":"https://orcid.org/0000-0002-3160-6596","observed_orcids":["https://orcid.org/0000-0002-3160-6596"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Isabel Oliveira","raw_affiliation_strings":["ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046205589","display_name":"Sandra Isabel Anjo","orcid":"https://orcid.org/0000-0003-2180-3518","observed_orcids":["https://orcid.org/0000-0003-2180-3518"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sandra I. Anjo","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal","Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067584346","display_name":"Joana Vieira de Castro","orcid":"https://orcid.org/0000-0002-9297-2207","observed_orcids":["https://orcid.org/0000-0002-9297-2207"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Vieira de Castro","raw_affiliation_strings":["ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051589662","display_name":"Sofia Cravino Serra","orcid":"https://orcid.org/0000-0003-2034-273X","observed_orcids":["https://orcid.org/0000-0003-2034-273X"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sofia C. Serra","raw_affiliation_strings":["ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070575402","display_name":"Ant\u00f3nio Jos\u00e9 Salgado","orcid":"https://orcid.org/0000-0003-3806-9823","observed_orcids":["https://orcid.org/0000-0003-3806-9823"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ant\u00f3nio J. Salgado","raw_affiliation_strings":["ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068927075","display_name":"Bruno J. Manadas","orcid":"https://orcid.org/0000-0002-2087-4042","observed_orcids":["https://orcid.org/0000-0002-2087-4042"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Bruno Manadas","raw_affiliation_strings":["CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069300297","display_name":"Bruno Marques Costa","orcid":"https://orcid.org/0000-0003-4861-7432","observed_orcids":["https://orcid.org/0000-0003-4861-7432"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Bruno M. Costa","raw_affiliation_strings":["ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal. bfmcosta@med.uminho.pt","Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal. bfmcosta@med.uminho.pt","ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal. bfmcosta@med.uminho.pt","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"Life and Health Sciences Research Institute (ICVS), School of Medicine, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal. bfmcosta@med.uminho.pt","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"ICVS/3B's - PT Government Associate Laboratory, Braga/Guimar\u00e3es, Campus de Gualtar, University of Minho, 4710-057, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069300297"],"corresponding_institution_ids":["https://openalex.org/I99682543"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.0943,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.89191855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"37","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.906000018119812},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.656000018119812},{"id":"https://openalex.org/keywords/secretome","display_name":"secretome","score":0.890999972820282},{"id":"https://openalex.org/keywords/gl261-cells","display_name":"GL261 cells","score":0.765999972820282},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9760000109672546},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7929999828338623},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.8573877811431885},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7216926217079163},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7036940455436707},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48848235607147217},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.43752869963645935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4361920952796936},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43157342076301575},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36194315552711487},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12897884845733643},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1285465955734253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12550780177116394},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12964-017-0194-x","doi":"https://doi.org/10.1186/s12964-017-0194-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-017-0194-x","pdf_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-017-0194-x","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4557739","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5625790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28969644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28969644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell communication and signaling : CCS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5625790","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5625790/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Commun Signal","raw_type":"Text"},{"id":"pmh:oai:estudogeral.uc.pt:10316/108123","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10316/108123","pdf_url":"https://estudogeral.uc.pt/bitstream/10316/108123/1/Crosstalk-between-glial-and-glioblastoma-cells-triggers-the-goorgrow-phenotype-of-tumor-cellsCell-Communication-and-Signaling.pdf","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:cd61e42af57c481aa67997b1f753e896","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cd61e42af57c481aa67997b1f753e896","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-12 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12964-017-0194-x","doi":"https://doi.org/10.1186/s12964-017-0194-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-017-0194-x","pdf_url":"https://biosignaling.biomedcentral.com/track/pdf/10.1186/s12964-017-0194-x","source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3907808495","display_name":"CNC. IBILI","funder_award_id":"UID/NEU/04539/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4197579315","display_name":null,"funder_award_id":"IF/00111","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4408784887","display_name":"Diagn\u00f3stico e progn\u00f3stico da esquizofrenia: a caminho de uma medicina personalizada?","funder_award_id":"PTDC/NEU-SCC/7051/2014","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4610309596","display_name":"DJ-1 NEURONAL RESCUE UNDER OXIDATIVE STRESS: IMPLICATIONS FOR PARKINSON\u2019S DISEASE","funder_award_id":"SFRH/BD/81495/2011","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G563888202","display_name":null,"funder_award_id":"PEst-C/SAU/LA0001/2013\u20132014","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5664389085","display_name":null,"funder_award_id":"IF/00601/2012","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6404247149","display_name":null,"funder_award_id":"REDE/1506/REM/2005","funder_id":"https://openalex.org/F4853140727","funder_display_name":"Rede Nacional de Espectrometria de Massa"},{"id":"https://openalex.org/G6440930574","display_name":"Mecanismos de protec\u00e7\u00e3o neuronal contra stress oxidativo mediados pela DJ-1: implica\u00e7\u00f5es na doen\u00e7a de Parkinson","funder_award_id":"PTDC/NEU-NMC/0205/2012","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6631619880","display_name":"IDENTIFICATION OF NOVEL CELL SURFACE PROTEINS IN GLIOBLASTOMA STEM CELLS: FROM NEW BIOMARKERS TO PUTATIVE THERAPEUTIC TARGETS","funder_award_id":"SFRH/BD/88121/2012","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G678920682","display_name":null,"funder_award_id":"SFRH/BD/52287/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8921111536","display_name":"O Transcriptoma da Homeoprote\u00edna Oncog\u00e9nica HOXA9 em Glioblastomas Humanos: Caracteriza\u00e7\u00e3o e Consequ\u00eancias Funcionais","funder_award_id":"PTDC/SAU-GMG/113795/2009","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320323335","display_name":"Funda\u00e7\u00e3o Calouste Gulbenkian","ror":"https://ror.org/04yxemn98"},{"id":"https://openalex.org/F4320327240","display_name":"Liga Portuguesa Contra o Cancro","ror":"https://ror.org/03r31ar10"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4853140727","display_name":"Rede Nacional de Espectrometria de Massa","ror":"https://ror.org/00fem8f23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2761560873.pdf","grobid_xml":"https://content.openalex.org/works/W2761560873.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1516589908","https://openalex.org/W1540414538","https://openalex.org/W1792532087","https://openalex.org/W1969150916","https://openalex.org/W1971593855","https://openalex.org/W1976824355","https://openalex.org/W1977807607","https://openalex.org/W1981573464","https://openalex.org/W1982481909","https://openalex.org/W1992359809","https://openalex.org/W1992478375","https://openalex.org/W1993302385","https://openalex.org/W1993457485","https://openalex.org/W1995205742","https://openalex.org/W2015414107","https://openalex.org/W2019629273","https://openalex.org/W2023010129","https://openalex.org/W2028554313","https://openalex.org/W2033987226","https://openalex.org/W2035471044","https://openalex.org/W2036314104","https://openalex.org/W2036908471","https://openalex.org/W2047710431","https://openalex.org/W2048014435","https://openalex.org/W2050869989","https://openalex.org/W2053693308","https://openalex.org/W2065374722","https://openalex.org/W2065578333","https://openalex.org/W2073128913","https://openalex.org/W2074515925","https://openalex.org/W2079843936","https://openalex.org/W2082892212","https://openalex.org/W2083942569","https://openalex.org/W2084472730","https://openalex.org/W2084566588","https://openalex.org/W2086900521","https://openalex.org/W2092481419","https://openalex.org/W2094592775","https://openalex.org/W2095224133","https://openalex.org/W2096661713","https://openalex.org/W2113536889","https://openalex.org/W2115852450","https://openalex.org/W2119535220","https://openalex.org/W2129269004","https://openalex.org/W2136380412","https://openalex.org/W2147342855","https://openalex.org/W2148977460","https://openalex.org/W2155703189","https://openalex.org/W2156389657","https://openalex.org/W2163859522","https://openalex.org/W2165708858","https://openalex.org/W2179676359","https://openalex.org/W2296095373","https://openalex.org/W2401143451","https://openalex.org/W2404876667","https://openalex.org/W2432909692","https://openalex.org/W4211107382","https://openalex.org/W4245392732"],"related_works":["https://openalex.org/W7135418057","https://openalex.org/W2908219275","https://openalex.org/W3102283691","https://openalex.org/W2004913788","https://openalex.org/W4321599676","https://openalex.org/W2759108689","https://openalex.org/W2810993654","https://openalex.org/W2090997666","https://openalex.org/W4223415056","https://openalex.org/W2965643807"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioblastoma":[1],"(GBM),":[2],"the":[3,19,64,85,126,138,154,161,202,224,231,240,251],"most":[4],"malignant":[5,65],"primary":[6,75],"brain":[7],"tumor,":[8],"leads":[9],"to":[10,84,104,131,137,144,238],"poor":[11],"and":[12,56,114,149,229],"unpredictable":[13],"clinical":[14],"outcomes.":[15],"Recent":[16],"studies":[17],"showed":[18],"tumor":[20,28,38],"microenvironment":[21],"has":[22],"a":[23,32,207,247],"critical":[24],"role":[25],"in":[26,101,108,173,246],"regulating":[27],"growth":[29],"by":[30,93,194],"establishing":[31],"complex":[33],"network":[34],"of":[35,67,74,87,116,128,140,156,196,210,226,233,242,255],"interactions":[36],"with":[37],"cells.":[39,69,159,257],"In":[40],"this":[41,58],"context,":[42],"we":[43],"investigated":[44],"how":[45,57],"GBM":[46,68,89,102,134,174,190,227,234,256],"cells":[47,90,103,130,135,169,183,185,191,220,235],"modulate":[48,239],"resident":[49],"glial":[50,77,129,158,168,182,219,244],"cells,":[51,245],"particularly":[52],"their":[53,106],"paracrine":[54],"activity,":[55],"modulation":[59],"can":[60,221],"influence":[61],"back":[62],"on":[63,189,223],"phenotype":[66],"METHODS:":[70],"Conditioned":[71],"media":[72],"(CM)":[73],"mouse":[76],"cultures":[78],"unexposed":[79],"(unprimed)":[80],"or":[81],"exposed":[82],"(primed)":[83],"secretome":[86,155,232,241],"GL261":[88],"were":[91,99,192],"analyzed":[92],"proteomic":[94,122],"analysis.":[95],"Additionally,":[96],"these":[97],"CM":[98,132,164,179],"used":[100],"evaluate":[105],"impact":[107,222],"glioma":[109],"cell":[110,147,175,211],"viability,":[111],"migration":[112,176],"capacity":[113],"activation":[115,195],"tumor-related":[117],"intracellular":[118,198],"pathways.":[119],"RESULTS:":[120],"The":[121],"analysis":[123],"revealed":[124],"that":[125,218,230,249],"pre-exposure":[127],"from":[133,166,180],"led":[136],"upregulation":[139],"several":[141],"proteins":[142],"related":[143],"inflammatory":[145],"response,":[146],"adhesion":[148],"extracellular":[150],"structure":[151],"organization":[152],"within":[153],"primed":[157,181],"At":[160],"functional":[162],"levels,":[163],"derived":[165],"unprimed":[167],"favored":[170],"an":[171],"increase":[172],"capacity,":[177],"while":[178],"promoted":[184],"viability.":[186],"These":[187],"effects":[188],"accompanied":[193],"particular":[197],"cancer-related":[199],"pathways,":[200],"mainly":[201],"MAPK/ERK":[203],"pathway,":[204],"which":[205],"is":[206,236],"known":[208],"regulator":[209],"proliferation.":[212],"CONCLUSIONS:":[213],"Together,":[214],"our":[215],"results":[216],"suggest":[217],"pathophysiology":[225],"tumors,":[228],"able":[237],"neighboring":[243],"way":[248],"regulates":[250],"\"go-or-grow\"":[252],"phenotypic":[253],"switch":[254]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2017-10-20T00:00:00"}