{"id":"https://openalex.org/W2761298076","doi":"https://doi.org/10.3233/ch-170281","title":"Effects of venotonic drugs on the microcirculation: Comparison between Ruscus extract and micronized diosmine1","display_name":"Effects of venotonic drugs on the microcirculation: Comparison between Ruscus extract and micronized diosmine1","publication_year":2017,"publication_date":"2017-10-10","ids":{"openalex":"https://openalex.org/W2761298076","doi":"https://doi.org/10.3233/ch-170281","mag":"2761298076","pmid":"https://pubmed.ncbi.nlm.nih.gov/29036797"},"language":"en","primary_location":{"id":"doi:10.3233/ch-170281","doi":"https://doi.org/10.3233/ch-170281","is_oa":false,"landing_page_url":"https://doi.org/10.3233/ch-170281","pdf_url":null,"source":{"id":"https://openalex.org/S74293116","display_name":"Clinical Hemorheology and Microcirculation","issn_l":"1386-0291","issn":["1386-0291","1875-8622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Hemorheology and Microcirculation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111523792","display_name":"Fatima Z. G. A. Cyrino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fatima Zely Garcia de Almeida Cyrino","raw_affiliation_strings":["Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045276166","display_name":"Daniela Signorelli Balthazar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniela Signorelli Balthazar","raw_affiliation_strings":["Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087459820","display_name":"Fernando Lencastre Sicuro","orcid":"https://orcid.org/0000-0002-2091-1712","observed_orcids":["https://orcid.org/0000-0002-2091-1712"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Lencastre Sicuro","raw_affiliation_strings":["Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I40034438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026374836","display_name":"Eliete Bouskela","orcid":"https://orcid.org/0000-0002-9621-8252","observed_orcids":["https://orcid.org/0000-0002-9621-8252"]},"institutions":[{"id":"https://openalex.org/I40034438","display_name":"Universidade do Estado do Rio de Janeiro","ror":"https://ror.org/0198v2949","country_code":"BR","type":"education","lineage":["https://openalex.org/I40034438"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Eliete Bouskela","raw_affiliation_strings":["Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical and Experimental Research on Vascular Biology, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil","institution_ids":["https://openalex.org/I40034438"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026374836"],"corresponding_institution_ids":["https://openalex.org/I40034438"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.1108,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.75424778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"4","first_page":"371","last_page":"382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.05299999937415123,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-venous-disease","display_name":"chronic venous disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lower-extremity-venous-insufficiency","display_name":"lower limb venous insufficiency","score":0.7670000195503235},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/macromolecular-permeability","display_name":"macromolecule permeability","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ischemia-reperfusion","display_name":"ischemia-reperfusion","score":0.9269999861717224},{"id":"https://openalex.org/keywords/leukocyte-endothelial-interaction","display_name":"leukocyte-endothelium interaction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/leukocyte-adhesion","display_name":"leukocyte adhesion","score":0.9139999747276306},{"id":"https://openalex.org/keywords/leukocyte-rolling","display_name":"leukocyte rolling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6710000038146973},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/hamster-cheek-pouch","display_name":"hamster cheek pouch","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C34439696","wikidata":"https://www.wikidata.org/wiki/Q95539","display_name":"Cheek pouch","level":3,"score":0.8949325084686279},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.590592622756958},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.5846653580665588},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5682321190834045},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5174123048782349},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.48480358719825745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4472011923789978},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.4467492699623108},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.39067697525024414},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.35034433007240295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3384537100791931},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2741173505783081},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1651587188243866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13184702396392822},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.11482340097427368}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014689","descriptor_name":"Venous Insufficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D031443","descriptor_name":"Ruscus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/ch-170281","doi":"https://doi.org/10.3233/ch-170281","is_oa":false,"landing_page_url":"https://doi.org/10.3233/ch-170281","pdf_url":null,"source":{"id":"https://openalex.org/S74293116","display_name":"Clinical Hemorheology and Microcirculation","issn_l":"1386-0291","issn":["1386-0291","1875-8622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Hemorheology and Microcirculation","raw_type":"journal-article"},{"id":"pmid:29036797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29036797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical hemorheology and microcirculation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W630039957","https://openalex.org/W1834747511","https://openalex.org/W1901522417","https://openalex.org/W1992557032","https://openalex.org/W2000618872","https://openalex.org/W2005814805","https://openalex.org/W2011276475","https://openalex.org/W2027656987","https://openalex.org/W2032007744","https://openalex.org/W2034503575","https://openalex.org/W2040851167","https://openalex.org/W2047519792","https://openalex.org/W2056664761","https://openalex.org/W2058161222","https://openalex.org/W2060321368","https://openalex.org/W2088997546","https://openalex.org/W2093401720","https://openalex.org/W2093617433","https://openalex.org/W2105734164","https://openalex.org/W2108260545","https://openalex.org/W2136778295","https://openalex.org/W2139713539","https://openalex.org/W2146776730","https://openalex.org/W2158901494","https://openalex.org/W2164586159","https://openalex.org/W2339610197","https://openalex.org/W2410073880","https://openalex.org/W2413816242","https://openalex.org/W2470033876","https://openalex.org/W2551550786","https://openalex.org/W2567933683"],"related_works":["https://openalex.org/W2056664761","https://openalex.org/W2032007744","https://openalex.org/W2061643731","https://openalex.org/W2288723500","https://openalex.org/W53148783","https://openalex.org/W180625481","https://openalex.org/W7015139572","https://openalex.org/W4223452866","https://openalex.org/W4378083608","https://openalex.org/W160378947"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chronic":[1],"venous":[2],"disease":[3],"of":[4,20,36,49,95,130,133,141,147,161],"the":[5,47,61,83,109,122,128,131,139,142,145,148],"lower":[6],"limbs":[7],"is":[8],"a":[9,92,194],"common":[10],"public":[11],"health":[12],"problem":[13],"worldwide":[14],"with":[15,24],"negative":[16],"impact":[17],"on":[18,60,114,164],"quality":[19],"life":[21],"and":[22,57,78,116,135,177],"results":[23,170],"drugs":[25,90,151,174],"used":[26,52],"to":[27,34],"treat":[28],"it":[29],"are":[30],"sparse,":[31],"probably":[32],"due":[33],"lack":[35],"good":[37],"experimental":[38],"models.":[39],"OBJECTIVE:":[40],"In":[41],"this":[42],"investigation":[43],"we":[44],"have":[45,175],"tested":[46],"effects":[48,154],"two":[50,74],"commonly":[51],"venotonic":[53],"substances,":[54],"Ruscus":[55,110,123,156,181,191],"extract":[56,111,124,157,182,192],"micronized":[58],"diosmine,":[59],"microcirculation":[62],"in":[63,127],"vivo.":[64],"METHODS:":[65],"These":[66],"substances":[67],"were":[68,80],"given":[69],"orally,":[70],"by":[71,101,106],"gavage,":[72],"during":[73],"weeks,":[75],"twice":[76],"daily":[77],"observations":[79],"made":[81],"using":[82],"hamster":[84],"cheek":[85],"pouch":[86],"preparation.":[87],"RESULTS:":[88],"The":[89],"elicited":[91],"dose-dependent":[93],"inhibition":[94,129],"(1)":[96],"macromolecular":[97],"permeability":[98],"increase":[99],"induced":[100],"histamine":[102],"or":[103],"ischemia":[104],"followed":[105],"reperfusion,":[107],"being":[108,121,180],"more":[112,125,183],"active":[113],"both":[115,150,173],"(2)":[117],"leukocyte-endothelium":[118],"interaction,":[119],"again":[120],"effective":[126],"number":[132],"adherent":[134],"rolling":[136],"leukocytes.":[137],"About":[138],"duration":[140],"effect":[143,163],"after":[144],"end":[146],"treatment,":[149],"had":[152],"similar":[153],"but":[155],"showed":[158,193],"greater":[159],"permanence":[160],"its":[162],"all":[165],"observed":[166],"parameters.":[167],"CONCLUSIONS:":[168],"Our":[169],"suggest":[171],"that":[172,189],"antioxidant":[176],"anti-inflammatory":[178],"properties":[179],"active.":[184],"It":[185],"should":[186],"be":[187],"added":[188],"only":[190],"significant":[195],"venular":[196],"constriction.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-10-20T00:00:00"}