{"id":"https://openalex.org/W2761099692","doi":null,"title":"F-11 Spermidine attenuated bleomycin induced lung injury/fibrosis by inhibition of endoplasmic reticulum stress (ERS) induced apoptosis and cellular Senescence","display_name":"F-11 Spermidine attenuated bleomycin induced lung injury/fibrosis by inhibition of endoplasmic reticulum stress (ERS) induced apoptosis and cellular Senescence","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2761099692","mag":"2761099692"},"language":"en","primary_location":{"id":"mag:2761099692","doi":null,"is_oa":false,"landing_page_url":"http://www.papersearch.net/google_link/fulltext.asp?file_name=0y911357.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306496805","display_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009409119","display_name":"\ubc15\uc131\uc6b0","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\ubc15\uc131\uc6b0","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088876796","display_name":"\uae40\ubbf8\uc18c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uae40\ubbf8\uc18c","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\uc774\uc9c0\ubbfc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uc774\uc9c0\ubbfc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052882874","display_name":"\ubc31\uc560\ub9b0","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\ubc31\uc560\ub9b0","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072546829","display_name":"Jong Suk Park","orcid":"https://orcid.org/0000-0002-5385-1373","observed_orcids":["https://orcid.org/0000-0002-5385-1373"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jong Suk Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5385-1373","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"\uc774\uc900\ud601","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uc774\uc900\ud601","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009661715","display_name":"\uc7a5\uc548\uc218","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uc7a5\uc548\uc218","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078698483","display_name":"\uae40\ub3c4\uc9c4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uae40\ub3c4\uc9c4","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017739440","display_name":"\uc5b4\uc218\ud0dd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uc5b4\uc218\ud0dd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008471876","display_name":"\uae40\uc6a9\ud6c8","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uae40\uc6a9\ud6c8","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012559714","display_name":"\ubc15\ucd98\uc2dd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\ubc15\ucd98\uc2dd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":null,"first_page":"90","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":1.0},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9829999804496765},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.578000009059906},{"id":"https://openalex.org/keywords/ire1alpha","display_name":"IRE1\u03b1","score":0.7269999980926514},{"id":"https://openalex.org/keywords/atf6","display_name":"ATF6","score":0.9919999837875366},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.8339999914169312},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9039999842643738},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7300000190734863},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.9599568843841553},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.7896913290023804},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6500636339187622},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6211745142936707},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.47610434889793396},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.45462536811828613},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41855859756469727},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4161013662815094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3542587459087372},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35065001249313354},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33623039722442627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3332779109477997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3254265785217285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2851715087890625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1503273844718933},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10238796472549438},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06289836764335632}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2761099692","doi":null,"is_oa":false,"landing_page_url":"http://www.papersearch.net/google_link/fulltext.asp?file_name=0y911357.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306496805","display_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\uacb0\ud575\ubc0f\ud638\ud761\uae30\ud559\ud68c \ucd94\uacc4\ud559\uc220\ubc1c\ud45c\ucd08\ub85d\uc9d1","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3110927580","https://openalex.org/W2970779247","https://openalex.org/W1989069086","https://openalex.org/W4413372024","https://openalex.org/W2443980019","https://openalex.org/W2484965531","https://openalex.org/W7129065603","https://openalex.org/W4282943776","https://openalex.org/W2948000182","https://openalex.org/W2991543550"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,59],"AIMS:":[2],"Spermidine":[3,87,161],"is":[4,27],"an":[5],"endogenous":[6],"biological":[7],"polyamine":[8],"that":[9,24,140],"exhibits":[10],"broad":[11],"longevity-extending":[12],"roles":[13],"including":[14],"anti-oxidative,":[15],"anti-aging,":[16],"and":[17,53,69,105,118,130,153,164,188],"cell":[18],"growth-promoting":[19],"activities.":[20],"We":[21],"previously":[22],"reported":[23],"spermidine":[25,48,71,125,141],"level":[26],"significantly":[28,91,115],"reduced":[29],"in":[30,78,157,172],"the":[31,37,43],"IPF":[32],"lung.":[33],"The":[34,122,149],"aim":[35],"of":[36,47,102,124,151,184],"present":[38],"study":[39],"was":[40,63,72,155],"to":[41,112,179],"assess":[42],"potential":[44],"beneficial":[45,175],"effects":[46,166],"on":[49],"lung":[50,93,103,170],"injury/":[51],"fibrosis":[52],"determine":[54],"its":[55],"possible":[56],"mechanism.":[57],"METHODS":[58],"RESULTS:":[60],"Lung":[61],"injury/fibrosis":[62,171],"established":[64],"by":[65,74],"bleomycin-":[66],"inhaled":[67],"mice,":[68],"exogenous":[70],"administered":[73],"intraperitoneal":[75],"injection":[76],"(50mg/kg":[77],"PBS,":[79],"D0-10":[80],"for":[81,84],"preventive,":[82],"D10-21":[83],"therapeutic":[85,165],"effect).":[86],"treated":[88],"mice":[89],"had":[90],"less":[92],"inflammation,":[94],"collagen":[95],"deposition":[96],"as":[97,99],"well":[98],"decreased":[100],"levels":[101],"IL-1b,TNF-a":[104],"TGF-b1.":[106],"Bronchial":[107],"epithelial":[108],"cells":[109],"were":[110,177],"exposed":[111],"H2O2":[113,127],"showed":[114,139],"increased":[116],"apoptosis":[117,129],"ERS":[119,131,186],"related":[120,132,178],"mediators.":[121],"addition":[123],"attenuated":[126],"induced":[128,145,169],"pathway;":[133],"IRE1a,":[134],"ATF6.":[135],"Senescence-associated":[136],"beta-gal":[137],"staining":[138],"interferes":[142],"with":[143],"bleomycin":[144,168],"premature":[146],"cellular":[147],"senescence.":[148],"expression":[150],"p16":[152],"pRB":[154],"lower":[156],"spermidine-treated":[158],"cells.":[159],"CONCLUSIONS:":[160],"have":[162],"protective":[163],"against":[167],"mice.":[173],"This":[174],"effect":[176],"anti-apoptotic":[180],",":[181],"down":[182],"regulation":[183],"excessive":[185],"pathway":[187],"anti-senescence":[189],"effect.":[190]},"counts_by_year":[],"updated_date":"2026-07-14T23:32:53.992493","created_date":"2017-10-20T00:00:00"}
