{"id":"https://openalex.org/W2761019554","doi":"https://doi.org/10.4049/jimmunol.196.supp.54.23","title":"Dysregulation of T helper-type cytokines appears prior to and concurrent with appearance of autoantibody specificities during early SLE pathogenesis and contributes to prognosis of transition to classified disease","display_name":"Dysregulation of T helper-type cytokines appears prior to and concurrent with appearance of autoantibody specificities during early SLE pathogenesis and contributes to prognosis of transition to classified disease","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2761019554","doi":"https://doi.org/10.4049/jimmunol.196.supp.54.23","mag":"2761019554"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.196.supp.54.23","doi":"https://doi.org/10.4049/jimmunol.196.supp.54.23","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.196.supp.54.23","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065514371","display_name":"Melissa E. Munroe","orcid":"https://orcid.org/0000-0002-6933-9745","observed_orcids":["https://orcid.org/0000-0002-6933-9745"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Munroe","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","1Oklahoma Med. Res. Fndn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001083935","display_name":"Rufei Lu","orcid":"https://orcid.org/0009-0007-3644-4702","observed_orcids":["https://orcid.org/0009-0007-3644-4702"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rufei Lu","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","1Oklahoma Med. Res. Fndn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032779152","display_name":"Joel M. Guthridge","orcid":"https://orcid.org/0000-0002-9308-237X","observed_orcids":["https://orcid.org/0000-0002-9308-237X"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel M Guthridge","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","1Oklahoma Med. Res. Fndn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055486497","display_name":"Krista M. Bean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krista M Bean","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","1Oklahoma Med. Res. Fndn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043483626","display_name":"Dustin A. Fife","orcid":"https://orcid.org/0000-0002-3368-968X","observed_orcids":["https://orcid.org/0000-0002-3368-968X"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin A Fife","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","1Oklahoma Med. Res. Fndn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380208","display_name":"Hua Chen","orcid":"https://orcid.org/0000-0002-0641-2837","observed_orcids":["https://orcid.org/0000-0002-0641-2837"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Chen","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","1Oklahoma Med. Res. Fndn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000883278","display_name":"Samantha R Slight-Webb","orcid":"https://orcid.org/0000-0003-2653-1005","observed_orcids":["https://orcid.org/0000-0003-2653-1005"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha R Slight-Webb","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","1Oklahoma Med. Res. Fndn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059105303","display_name":"Michael P. Keith","orcid":"https://orcid.org/0000-0003-2653-2614","observed_orcids":["https://orcid.org/0000-0003-2653-2614"]},"institutions":[{"id":"https://openalex.org/I2800363604","display_name":"Walter Reed National Military Medical Center","ror":"https://ror.org/025cem651","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800363604","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P Keith","raw_affiliation_strings":["Walter Reed Natl. Military Med. Ctr","2Walter Reed Natl. Military Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Natl. Military Med. Ctr","institution_ids":["https://openalex.org/I2800363604"]},{"raw_affiliation_string":"2Walter Reed Natl. Military Med. Ctr","institution_ids":["https://openalex.org/I2800363604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110152357","display_name":"John B. Harley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I4210143084","display_name":"Cincinnati VA Medical Center","ror":"https://ror.org/045r80n66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210127612","https://openalex.org/I4210143084"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B Harley","raw_affiliation_strings":["Cincinnati Children\u2019s Hosp. Med. Ctr","Cincinnati VA Med. Ctr","3Cincinnati Children\u2019s Hosp. Med. Ctr","4Cincinnati VA Med. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children\u2019s Hosp. Med. Ctr","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Cincinnati VA Med. Ctr","institution_ids":["https://openalex.org/I4210143084"]},{"raw_affiliation_string":"3Cincinnati Children\u2019s Hosp. Med. Ctr","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"4Cincinnati VA Med. Ctr","institution_ids":["https://openalex.org/I4210143084"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088206527","display_name":"Judith A. James","orcid":"https://orcid.org/0000-0002-9574-7355","observed_orcids":["https://orcid.org/0000-0002-9574-7355"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith A James","raw_affiliation_strings":["Oklahoma Med. Res. Fndn","Univ. of Oklahoma Hlth. Sci. Ctr","1Oklahoma Med. Res. Fndn","5Univ. of Oklahoma Hlth. Sci. Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Univ. of Oklahoma Hlth. Sci. Ctr","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"1Oklahoma Med. Res. Fndn","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"5Univ. of Oklahoma Hlth. Sci. Ctr","institution_ids":["https://openalex.org/I8692664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"196","issue":"1_Supplement","first_page":"54.23","last_page":"54.23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":1.0},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8930000066757202},{"id":"https://openalex.org/keywords/anti-ssa-antibodies","display_name":"anti-SSA antibodies","score":0.8920000195503235},{"id":"https://openalex.org/keywords/t-helper-cytokines","display_name":"T helper cytokines","score":0.6980000138282776},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.8569999933242798},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/soluble-mediators","display_name":"soluble mediators","score":0.753000020980835},{"id":"https://openalex.org/keywords/b-lymphocyte-stimulator","display_name":"B lymphocyte stimulator","score":0.8849999904632568},{"id":"https://openalex.org/keywords/april","display_name":"APRIL","score":1.0},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tnf-superfamily","display_name":"TNF superfamily","score":0.7979999780654907},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.6169999837875366},{"id":"https://openalex.org/keywords/autoantibody-specificity","display_name":"autoantibody specificity","score":0.5529999732971191},{"id":"https://openalex.org/keywords/random-forest-prediction-model","display_name":"random forest prediction","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.9215905070304871},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6666243672370911},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6567625403404236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6009784936904907},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5532731413841248},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5007040500640869},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.4577869176864624},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.45494580268859863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30931562185287476},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2891419529914856}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.196.supp.54.23","doi":"https://doi.org/10.4049/jimmunol.196.supp.54.23","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.196.supp.54.23","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2520210845","https://openalex.org/W2474315976","https://openalex.org/W4313386084","https://openalex.org/W2302024964","https://openalex.org/W2235732165","https://openalex.org/W2697845865","https://openalex.org/W4223484619","https://openalex.org/W2011809282","https://openalex.org/W2320868805","https://openalex.org/W7133233475"],"abstract_inverted_index":{"Abstract":[0],"Autoantibodies":[1],"and":[2,25,30,48,56,88,104,106,118,141,147,154,163,201],"immune":[3,189],"dysregulation":[4],"are":[5],"associated":[6],"with":[7,108,175],"systemic":[8],"lupus":[9],"erythematosus":[10],"(SLE),":[11],"but":[12,130],"how":[13],"these":[14],"factors":[15],"influence":[16],"disease":[17],"development":[18],"is":[19],"unknown.":[20],"This":[21],"study":[22],"evaluates":[23],"timing":[24],"changes":[26],"in":[27,34,94,125,132,145],"SLE-linked":[28],"autoantibodies":[29,197],"soluble":[31,77,121],"mediator":[32],"pathways":[33],"the":[35,64,110,194],"years":[36,99,181],"preceding":[37,198],"SLE":[38,44,128,170,202],"classification.":[39,183,203],"Serial":[40],"sera":[41],"from":[42,63],"84":[43],"cases":[45,95,126,146],"spanning":[46],"pre-":[47],"post-SLE":[49],"classification":[50],"(average":[51],"time":[52],"=":[53],"5.98":[54],"years)":[55],"matched":[57],"healthy":[58],"controls":[59],"(HC)":[60],"were":[61,91,143],"obtained":[62],"Department":[65],"of":[66,76,139,196],"Defense":[67],"Serum":[68],"Repository.":[69],"Adjusting":[70],"for":[71,193],"multiple":[72],"comparison,":[73],"a":[74],"number":[75],"mediators,":[78],"including":[79],"IL-5":[80],"(q=4.35\u00d710":[81],"\u22126":[82,86],"),":[83,87],"IL-6":[84],"(q=8.26\u00d710":[85],"IFN-\u03b3":[89,164],"(q=0.037),":[90],"significantly":[92],"elevated":[93],"vs.":[96],"HC":[97,133,148],">3.5":[98,180],"pre-classification,":[100],"prior":[101],"to":[102],"(IL-5":[103],"IL-6)":[105],"concurrent":[107],"(IFN-\u03b3)":[109],"earliest":[111],"SLE-specific":[112],"autoantibody":[113],"specificity,":[114],"anti-Ro/SSA.":[115],"Th1-type,":[116],"Th17-type,":[117],"TNF":[119],"superfamily":[120],"mediators":[122],"increased":[123],"longitudinally":[124],"approaching":[127],"classification,":[129],"not":[131],"(q<0.05).":[134],"In":[135],"particular,":[136],"serum":[137],"levels":[138,165],"BLyS":[140],"APRIL":[142],"comparable":[144],"until":[149],"<10":[150],"months":[151],"pre-classification":[152],"(q=0.003":[153],"q=0.019,":[155],"respectively).":[156],"Random":[157],"forest":[158],"models":[159,174],"incorporating":[160],"IL-5,":[161],"IL-6,":[162],"(79\u201382%":[166],"accuracy)":[167,179],"distinguished":[168],"future":[169],"patients":[171],"better":[172],"than":[173],"ANA":[176],"alone":[177],"(58%":[178],"before":[182],"These":[184],"data":[185],"indicate":[186],"that":[187],"pre-clinical":[188],"system":[190],"perturbations":[191],"allow":[192],"accumulation":[195],"clinical":[199],"symptoms":[200]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2017-10-20T00:00:00"}
