{"id":"https://openalex.org/W2761006836","doi":"https://doi.org/10.1093/eurheartj/ehx493.5761","title":"5761Relation of gut microbiota-dependent TMAO with aortic atherosclerosis: prognostic implication for patients with stroke","display_name":"5761Relation of gut microbiota-dependent TMAO with aortic atherosclerosis: prognostic implication for patients with stroke","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2761006836","doi":"https://doi.org/10.1093/eurheartj/ehx493.5761","mag":"2761006836"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehx493.5761","doi":"https://doi.org/10.1093/eurheartj/ehx493.5761","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehx493.5761","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021035896","display_name":"Arash Haghikia","orcid":"https://orcid.org/0000-0002-5646-3237","observed_orcids":["https://orcid.org/0000-0002-5646-3237"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Haghikia","raw_affiliation_strings":["Charite - Campus Benjamin Franklin, Cardiology, Berlin, Germany","Ruhr University Bochum (RUB), Neurology, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite - Campus Benjamin Franklin, Cardiology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Ruhr University Bochum (RUB), Neurology, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004453505","display_name":"X.S. Li","orcid":"https://orcid.org/0009-0003-5351-6457","observed_orcids":["https://orcid.org/0009-0003-5351-6457"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X.S. Li","raw_affiliation_strings":["Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067825430","display_name":"Thomas Liman","orcid":"https://orcid.org/0000-0002-8471-8049","observed_orcids":["https://orcid.org/0000-0002-8471-8049"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Liman","raw_affiliation_strings":["Charite, Neurology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Neurology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077437530","display_name":"Nils Bledau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N. Bledau","raw_affiliation_strings":["Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008821505","display_name":"Christian Widera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Widera","raw_affiliation_strings":["Heart Center Oldenburg, Cardiology, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Oldenburg, Cardiology, Oldenburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083504382","display_name":"Kristina Sonnenschein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Sonnenschein","raw_affiliation_strings":["Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021035896","display_name":"Arash Haghikia","orcid":"https://orcid.org/0000-0002-5646-3237","observed_orcids":["https://orcid.org/0000-0002-5646-3237"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Haghikia","raw_affiliation_strings":["Charite - Campus Benjamin Franklin, Cardiology, Berlin, Germany","Ruhr University Bochum (RUB), Neurology, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite - Campus Benjamin Franklin, Cardiology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Ruhr University Bochum (RUB), Neurology, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068739017","display_name":"Karin Wei\u00dfenborn","orcid":"https://orcid.org/0000-0002-1157-8938","observed_orcids":["https://orcid.org/0000-0002-1157-8938"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Weissenborn","raw_affiliation_strings":["Hannover Medical School, Neurology, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Neurology, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016118935","display_name":"Johann K Bauersachs","orcid":"https://orcid.org/0000-0002-9341-117X","observed_orcids":["https://orcid.org/0000-0002-9341-117X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Bauersachs","raw_affiliation_strings":["Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084259705","display_name":"Z. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Wang","raw_affiliation_strings":["Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022932679","display_name":"Weifei Zhu","orcid":"https://orcid.org/0000-0003-4355-134X","observed_orcids":["https://orcid.org/0000-0003-4355-134X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Zhu","raw_affiliation_strings":["Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003550139","display_name":"Udo Bavendiek","orcid":"https://orcid.org/0000-0003-3911-2571","observed_orcids":["https://orcid.org/0000-0003-3911-2571"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Bavendiek","raw_affiliation_strings":["Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School, Department of Cardiology and Angiology, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040647937","display_name":"Stanley L. Hazen","orcid":"https://orcid.org/0000-0001-7124-6639","observed_orcids":["https://orcid.org/0000-0001-7124-6639"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.L. Hazen","raw_affiliation_strings":["Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland, United States of America","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001101402","display_name":"Matthias Endres","orcid":"https://orcid.org/0000-0001-6520-3720","observed_orcids":["https://orcid.org/0000-0001-6520-3720"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Endres","raw_affiliation_strings":["Charite, Neurology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite, Neurology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080753934","display_name":"Ulf Landmesser","orcid":"https://orcid.org/0000-0002-0214-3203","observed_orcids":["https://orcid.org/0000-0002-0214-3203"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Landmesser","raw_affiliation_strings":["Charite - Campus Benjamin Franklin, Cardiology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charite - Campus Benjamin Franklin, Cardiology, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":null,"fwci":0.0974,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.3992441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"38","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9559999704360962},{"id":"https://openalex.org/keywords/aortic-atherosclerosis","display_name":"aortic atherosclerosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9750000238418579},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.8379999995231628},{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.8970000147819519},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8830000162124634},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4519999921321869},{"id":"https://openalex.org/keywords/transesophageal-echocardiography","display_name":"transesophageal echocardiography","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9551083445549011},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6760104894638062},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5811229348182678},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.474477082490921},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.44971713423728943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.383870005607605},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25642484426498413},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.08391210436820984},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/ehx493.5761","doi":"https://doi.org/10.1093/eurheartj/ehx493.5761","is_oa":false,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehx493.5761","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2888429051","https://openalex.org/W2889192088","https://openalex.org/W2856619263","https://openalex.org/W3120010377","https://openalex.org/W2990869118","https://openalex.org/W2178133650","https://openalex.org/W4302292682","https://openalex.org/W4224313210","https://openalex.org/W4298087966","https://openalex.org/W2744318576"],"abstract_inverted_index":{"Background:":[0],"In":[1,74,152,180],"experimental":[2],"studies":[3],"gut":[4,32],"microbiota-dependent":[5],"metabolites,":[6],"in":[7,60,97,124,128,197],"particular":[8],"trimethylamine":[9],"N-oxide":[10],"(TMAO),":[11],"have":[12],"recently":[13],"been":[14],"reported":[15],"to":[16],"promote":[17],"atherosclerosis":[18,89,149],"and":[19,47,49,55,63,108,120,127,144,232,239],"thrombosis.":[20],"Here,":[21],"we":[22],"examined":[23,123],"for":[24,225],"the":[25,28,31,37,43,50,78,85,125,145,153,181],"first":[26],"time":[27],"relation":[29,44,105],"of":[30,39,52,67,80,87,147,167,188,241,271],"microbe-dependent":[33],"metabolite":[34],"TMAO":[35,48,82,107,142,157,201,265],"with":[36,69,84,100,110,162,199,263],"severity":[38,86,146],"aortic":[40,88,148],"atherosclerosis.":[41],"Moreover,":[42,261],"between":[45,106,141],"choline":[46,109,217],"risk":[51,166,187,234,270],"cardiovascular":[53,113,168,189,233],"events":[54,114,169,190],"recurrent":[56,118,272],"stoke":[57],"was":[58,95,122,139,195,220],"determined":[59],"a":[61,64,75,129,171,184,192],"derivation":[62,76],"validation":[65,132,182],"cohort":[66,133],"patients":[68,98,198,262],"first-ever":[70],"ischemic":[71,101],"stroke.":[72],"Method:":[73],"study,":[77],"relationship":[79],"plasma":[81,158],"levels":[83,143,159,266],"as":[90],"assessed":[91],"by":[92],"transesophageal":[93],"echocardiography":[94],"characterized":[96],"admitted":[99],"stroke":[102,119,228,230,273],"(n=79).":[103],"The":[104],"subsequent":[111],"(1-year)":[112],"including":[115,236],"myocardial":[116,248],"infarction,":[117],"death":[121],"derivation,":[126],"second":[130],"independent":[131],"(n=593).":[134],"Results:":[135],"A":[136],"close":[137],"correlation":[138],"observed":[140,196,222],"(r=0.39,":[150],"P<0.01).":[151,179,282],"initial":[154],"study":[155],"higher":[156],"were":[160,267],"linked":[161],"an":[163],"increased":[164,186],"incident":[165],"over":[170,191],"1-year":[172,193],"follow-up":[173,194],"(HR:":[174],"2.31;":[175],"95%":[176,209,255,279],"CI:":[177,210,256,280],"1.25\u20134.23;":[178],"cohort,":[183],"markedly":[185],"high":[200,264],"((Quartile":[202],"(Q)":[203],"4":[204],"vs":[205,251,275],"Q1;":[206],"HR:":[207],"5.0,":[208],"1.7":[211],"-":[212,258],"14.8;":[213],"P<0.01),":[214],"but":[215],"not":[216],"levels.":[218],"This":[219],"also":[221],"after":[223],"adjustment":[224],"sex,":[226],"age,":[227],"severity,":[229],"etiology":[231],"factors":[235],"hypertension,":[237],"diabetes":[238],"history":[240],"peripheral":[242],"or":[243,247],"coronary":[244],"artery":[245],"disease":[246],"infarction":[249],"(Q4":[250,274],"Q1:":[252],"HR":[253,277],"3.5;":[254],"1.1.":[257],"11.2;":[259],"P=0.03).":[260],"at":[268],"greater":[269],"Q4:":[276],"2.7;":[278],"1.1.-6.1;":[281]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2017-10-20T00:00:00"}