{"id":"https://openalex.org/W2760953441","doi":"https://doi.org/10.1038/nature24146","title":"Genome jail-break triggers lockdown","display_name":"Genome jail-break triggers lockdown","publication_year":2017,"publication_date":"2017-10-03","ids":{"openalex":"https://openalex.org/W2760953441","doi":"https://doi.org/10.1038/nature24146","mag":"2760953441","pmid":"https://pubmed.ncbi.nlm.nih.gov/28976957"},"language":"en","primary_location":{"id":"doi:10.1038/nature24146","doi":"https://doi.org/10.1038/nature24146","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature24146","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020725514","display_name":"Neil T. Umbreit","orcid":"https://orcid.org/0000-0001-6147-9009","observed_orcids":["https://orcid.org/0000-0001-6147-9009","https://orcid.org/0009-0007-7664-6712"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil T. Umbreit","raw_affiliation_strings":["Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA, and the Department of Cell Biology, Harvard Medical School, Boston","Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA, and the Department of Cell Biology, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024739591","display_name":"David S. Pellman","orcid":"https://orcid.org/0000-0001-5306-8031","observed_orcids":["https://orcid.org/0000-0001-5306-8031"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Pellman","raw_affiliation_strings":["Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA, and the Department of Cell Biology, Harvard Medical School, Boston","Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA, and the Department of Cell Biology, Harvard Medical School, Boston","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024739591"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":1.5557,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.81611052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"550","issue":"7676","first_page":"340","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.3086000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cytoplasmic-dna","display_name":"cytoplasmic DNA","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.875},{"id":"https://openalex.org/keywords/proinflammatory-response","display_name":"pro-inflammatory response","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.6809999942779541},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.5669999718666077},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5199999809265137},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7609928846359253},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6511309146881104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6399237513542175},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.56632399559021},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5624215602874756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.531010091304779},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5285485982894897},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4892110824584961},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4709677994251251},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4281899631023407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3262422978878021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29165956377983093},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001695","descriptor_name":"Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/nature24146","doi":"https://doi.org/10.1038/nature24146","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature24146","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:28976957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28976957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"News"},{"id":"pmh:oai:RePEc:nat:nature:v:550:y:2017:i:7676:d:10.1038_nature24146","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature24146","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8747130344","display_name":"Polyploidy, Aneuploidy and Genome Stability","funder_award_id":"R01CA213404","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W239602587","https://openalex.org/W1601755300","https://openalex.org/W1642873092","https://openalex.org/W1976635482","https://openalex.org/W2016131266","https://openalex.org/W2026134797","https://openalex.org/W2077145482","https://openalex.org/W2090067193","https://openalex.org/W2090507360","https://openalex.org/W2147030667","https://openalex.org/W2150748567","https://openalex.org/W2159591471","https://openalex.org/W2591766939","https://openalex.org/W2618634776","https://openalex.org/W2733154631","https://openalex.org/W2738136165","https://openalex.org/W2742007963","https://openalex.org/W2762611634"],"related_works":["https://openalex.org/W2762611634","https://openalex.org/W2742007963","https://openalex.org/W2752930858","https://openalex.org/W2795875233","https://openalex.org/W4245013888","https://openalex.org/W7165548410","https://openalex.org/W2767652619","https://openalex.org/W4293171720","https://openalex.org/W4413833438","https://openalex.org/W7218790932"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-20T00:00:00"}
