{"id":"https://openalex.org/W2760835389","doi":null,"title":"DEVELOPMENT OF LONG-TERM STABLE MIXED SODIUM CASEINATE AND PEA PROTEIN ISOLATE-STABILIZED NANOEMULSIONS FOR THE DELIVERY OF CURCUMIN","display_name":"DEVELOPMENT OF LONG-TERM STABLE MIXED SODIUM CASEINATE AND PEA PROTEIN ISOLATE-STABILIZED NANOEMULSIONS FOR THE DELIVERY OF CURCUMIN","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2760835389","mag":"2760835389"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/7317","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/7317","pdf_url":"https://harvest.usask.ca/bitstreams/f017b723-ba47-4aff-8940-77d1058fe9af/download","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://harvest.usask.ca/bitstreams/f017b723-ba47-4aff-8940-77d1058fe9af/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039426085","display_name":"Manispuritha Yerramilli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Manispuritha Yerramilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039426085"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10411","display_name":"Proteins in Food Systems","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11915","display_name":"Pickering emulsions and particle stabilization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12048","display_name":"Microencapsulation and Drying Processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoemulsions","display_name":"nanoemulsions","score":0.9869999885559082},{"id":"https://openalex.org/keywords/curcumin-delivery","display_name":"curcumin delivery","score":0.7269999980926514},{"id":"https://openalex.org/keywords/sodium-caseinate","display_name":"sodium caseinate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pea-protein-isolate","display_name":"pea protein isolate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oil-in-water-emulsions","display_name":"oil-in-water emulsions","score":0.8970000147819519},{"id":"https://openalex.org/keywords/long-term-storage-stability","display_name":"long-term storage stability","score":0.8309999704360962},{"id":"https://openalex.org/keywords/creaming","display_name":"creaming","score":0.7329999804496765},{"id":"https://openalex.org/keywords/flocculation","display_name":"flocculation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/droplet-size","display_name":"droplet size","score":0.6890000104904175},{"id":"https://openalex.org/keywords/emulsion-gels","display_name":"emulgel","score":0.5379999876022339},{"id":"https://openalex.org/keywords/in-vitro-digestion","display_name":"in vitro digestion","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8190000057220459},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.3370000123977661},{"id":"https://openalex.org/keywords/emulsifier-replacement","display_name":"emulsifier replacement","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C2909458168","wikidata":"https://www.wikidata.org/wiki/Q193970","display_name":"Sodium Caseinate","level":2,"score":0.8916853666305542},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.88898104429245},{"id":"https://openalex.org/C2781283633","wikidata":"https://www.wikidata.org/wiki/Q7157196","display_name":"Pea protein","level":2,"score":0.6421756744384766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5719863176345825},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.546995997428894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28519406914711}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/7317","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/7317","pdf_url":"https://harvest.usask.ca/bitstreams/f017b723-ba47-4aff-8940-77d1058fe9af/download","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/7317","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/7317","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2760835389","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/bitstream/10388/7317/1/YERRAMILLI-THESIS-2016.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.usask.ca:10388/7317","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/7317","pdf_url":"https://harvest.usask.ca/bitstreams/f017b723-ba47-4aff-8940-77d1058fe9af/download","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310866","display_name":"Ministry of Agriculture - Saskatchewan","ror":"https://ror.org/02g5xq267"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320322709","display_name":"Ministry of Advanced Education","ror":"https://ror.org/00n0e2d34"},{"id":"https://openalex.org/F4320334595","display_name":"Agriculture and Agri-Food Canada","ror":"https://ror.org/051dzs374"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2760835389.pdf","grobid_xml":"https://content.openalex.org/works/W2760835389.grobid-xml"},"referenced_works_count":127,"referenced_works":["https://openalex.org/W257374524","https://openalex.org/W296450459","https://openalex.org/W1494121972","https://openalex.org/W1498533479","https://openalex.org/W1568988128","https://openalex.org/W1828339576","https://openalex.org/W1857572907","https://openalex.org/W1939574446","https://openalex.org/W1963730110","https://openalex.org/W1967148304","https://openalex.org/W1968860088","https://openalex.org/W1969268232","https://openalex.org/W1970055948","https://openalex.org/W1970085269","https://openalex.org/W1971721872","https://openalex.org/W1972326477","https://openalex.org/W1975392350","https://openalex.org/W1976119364","https://openalex.org/W1976194786","https://openalex.org/W1976342724","https://openalex.org/W1977182897","https://openalex.org/W1977814588","https://openalex.org/W1979791843","https://openalex.org/W1982301999","https://openalex.org/W1985710341","https://openalex.org/W1986821148","https://openalex.org/W1989787327","https://openalex.org/W1990440588","https://openalex.org/W1992906189","https://openalex.org/W1993620799","https://openalex.org/W1993862987","https://openalex.org/W1994812138","https://openalex.org/W1995394163","https://openalex.org/W2000509643","https://openalex.org/W2000581595","https://openalex.org/W2001985777","https://openalex.org/W2005716758","https://openalex.org/W2006399057","https://openalex.org/W2009386192","https://openalex.org/W2011749104","https://openalex.org/W2012964397","https://openalex.org/W2013203839","https://openalex.org/W2014022956","https://openalex.org/W2014033384","https://openalex.org/W2014606799","https://openalex.org/W2015288355","https://openalex.org/W2016888241","https://openalex.org/W2018053443","https://openalex.org/W2021429166","https://openalex.org/W2022375711","https://openalex.org/W2022747291","https://openalex.org/W2023150880","https://openalex.org/W2024603514","https://openalex.org/W2026012172","https://openalex.org/W2026989650","https://openalex.org/W2027273564","https://openalex.org/W2034644440","https://openalex.org/W2040802315","https://openalex.org/W2041305210","https://openalex.org/W2041764058","https://openalex.org/W2045265522","https://openalex.org/W2047281591","https://openalex.org/W2047597496","https://openalex.org/W2048217429","https://openalex.org/W2050727193","https://openalex.org/W2051165046","https://openalex.org/W2051708950","https://openalex.org/W2055354851","https://openalex.org/W2055609979","https://openalex.org/W2056154275","https://openalex.org/W2057149139","https://openalex.org/W2058369613","https://openalex.org/W2059778834","https://openalex.org/W2059828577","https://openalex.org/W2060351479","https://openalex.org/W2061301715","https://openalex.org/W2062086531","https://openalex.org/W2065379666","https://openalex.org/W2065966132","https://openalex.org/W2066020267","https://openalex.org/W2066089221","https://openalex.org/W2069663215","https://openalex.org/W2069971189","https://openalex.org/W2070396908","https://openalex.org/W2071312678","https://openalex.org/W2071959445","https://openalex.org/W2072741719","https://openalex.org/W2072843687","https://openalex.org/W2073886105","https://openalex.org/W2078111373","https://openalex.org/W2078593198","https://openalex.org/W2079380796","https://openalex.org/W2079598736","https://openalex.org/W2081916925","https://openalex.org/W2082732127","https://openalex.org/W2083714190","https://openalex.org/W2084472233","https://openalex.org/W2085578211","https://openalex.org/W2088242076","https://openalex.org/W2089220405","https://openalex.org/W2091846020","https://openalex.org/W2092032160","https://openalex.org/W2093043300","https://openalex.org/W2093231351","https://openalex.org/W2098865968","https://openalex.org/W2100520064","https://openalex.org/W2101096732","https://openalex.org/W2108284238","https://openalex.org/W2111505323","https://openalex.org/W2119122429","https://openalex.org/W2120623773","https://openalex.org/W2120717497","https://openalex.org/W2127995177","https://openalex.org/W2129995310","https://openalex.org/W2130829888","https://openalex.org/W2130911623","https://openalex.org/W2134134853","https://openalex.org/W2135126013","https://openalex.org/W2138016964","https://openalex.org/W2147694870","https://openalex.org/W2149189556","https://openalex.org/W2158608791","https://openalex.org/W2159175180","https://openalex.org/W2159900974","https://openalex.org/W2171689215","https://openalex.org/W2332243313","https://openalex.org/W2948766939"],"related_works":["https://openalex.org/W2809165506","https://openalex.org/W1992778855","https://openalex.org/W2534540407","https://openalex.org/W3009322491","https://openalex.org/W2561662979","https://openalex.org/W4388900072","https://openalex.org/W4389915212","https://openalex.org/W2889861256","https://openalex.org/W2969805673","https://openalex.org/W4206439241"],"abstract_inverted_index":{"Nanoemulsions":[0],"(NEs)":[1],"with":[2,179,187,224,229,282,354,378,438],"extremely":[3],"small":[4],"droplet":[5,153,233,311,356,387,556,573],"size":[6],"(radius":[7],"<100":[8],"nm)":[9],"were":[10,26,82,116,299],"found":[11,27,38],"to":[12,28,30,39,55,84,94,201,239,251,304,383,406,460,493,546,553,564,592,607],"possess":[13],"characteristics":[14],"that":[15,193,394,500,530,547,588],"have":[16],"many":[17],"advantages":[18],"over":[19,501,519],"conventional":[20,242],"emulsion":[21,325],"systems.":[22],"These":[23],"nano-sized":[24],"droplets":[25],"contribute":[29],"higher":[31,316,540],"stability":[32,134,604],"of":[33,43,51,64,112,125,167,172,203,215,265,276,318,351,372,398,433,467,475,483,503,522,533,566,624,633],"the":[34,41,91,119,123,260,324,331,348,370,375,395,409,425,444,465,470,473,476,494,509,517,531,559,572,582,608,622],"NEs":[35,59,81,129,144,236,268,297,308,596],"and":[36,70,99,130,227,255,262,279,284,312,321,334,344,367,389,400,419,481,491,599,642],"also":[37,300,436,627],"improve":[40],"bioavailability":[42,100,482],"poorly":[44],"water-soluble":[45],"bioactive":[46,87,486,635],"components.":[47],"The":[48,77,140,452,612],"overall":[49],"aim":[50],"this":[52,148],"thesis":[53],"is":[54,93,590],"develop":[56,593],"oil-in-water":[57],"(O/W)":[58],"stabilized":[60,80,143],"by":[61,414,579],"a":[62,86,230,287,293,457,520,554],"mixture":[63],"sodium":[65,113,141],"caseinate":[66,114,142],"(a":[67,74],"dairy":[68],"protein)":[69],"pea":[71,245],"protein":[72,79,183,196,225,246,267,313,363,561,568,577,595],"isolates":[73],"pulse":[75,618],"protein).":[76],"mixed":[78,266,332,560,594],"utilized":[83,250,617],"encapsulate":[85],"compound,":[88,487],"curcumin,":[89],"where":[90],"goal":[92],"investigate":[95],"its":[96],"stability,":[97,479],"delivery":[98,480],"through":[101],"in":[102,122,147,182,185,222,232,259,286,386,448,464,508,516,558,581,621,631,640],"vitro":[103,526],"digestion":[104,527],"studies.":[105,189],"Various":[106],"concentrations":[107,317],"(2.5":[108],"\u2013":[109],"10":[110,280,322],"wt%)":[111],"(SC)":[115],"used":[117],"as":[118],"sole":[120],"emulsifier":[121],"development":[124,466,623],"5":[126],"wt%":[127],"O/W":[128],"their":[131],"long-term":[132,263],"storage":[133],"for":[135,162,478,637],"6":[136,168,352],"months":[137,353],"was":[138,191,207,249,270,290,392,412,489,498,506,514,538,551,586],"investigated.":[139,271],"(SCEs)":[145],"developed":[146],"work":[149],"displayed":[150,174,602],"an":[151,163,180,220,484],"average":[152,355],"diameter":[154,357],"less":[155,574],"than":[156,241],"200":[157],"nm,":[158],"which":[159,177,206,411,550,601],"remained":[160,345],"unchanged":[161],"experimental":[164,349],"time":[165],"fame":[166],"months.":[169],"However,":[170],"all":[171],"them":[173],"rapid":[175],"creaming,":[176],"increased":[178],"increase":[181,221],"concentration,":[184],"accordance":[186],"previous":[188],"It":[190,391,497],"postulated":[192],"excess":[194],"unabsorbed":[195],"caused":[197],"depletion":[198,216,430],"flocculation":[199,240,431],"leading":[200],"creaming":[202,341],"oil":[204],"droplets,":[205],"confirmed":[208,413],"using":[209],"confocal":[210],"laser":[211],"scanning":[212],"microscopy.":[213],"Calculation":[214],"interaction":[217],"energy":[218],"showed":[219,628],"attraction":[223],"concentration":[226,275],"decrease":[228],"reduction":[231],"size,":[234],"making":[235,571],"more":[237],"resistant":[238],"emulsions.":[243],"Next,":[244],"isolate":[247],"(PPI),":[248],"partially":[252],"replace":[253],"SC":[254,283,333,379,399],"thereby":[256,441,570],"PPIs":[257],"efficacy":[258,474],"formation":[261,388],"stabilization":[264,454],"(MPEs)":[269],"Total":[272],"aqueous":[273],"phase-protein":[274],"5,":[277],"7.5":[278],"wt%,":[281],"PPI":[285,302,319,373,401,439,598],"1:1":[288],"ratio,":[289],"used.":[291],"As":[292],"control":[294],"individual":[295,449,609],"PPI-stabilized":[296,335],"(PPIE)":[298],"prepared.":[301],"failed":[303],"produce":[305],"stable":[306,346],"flowable":[307],"displaying":[309],"excessive":[310],"aggregation.":[314],"At":[315],"(7.5":[320],"wt%),":[323],"transformed":[326],"into":[327],"viscoelastic":[328],"gels.":[329],"Interestingly,":[330],"NE":[336,562],"did":[337],"not":[338,427,542,615],"display":[339],"any":[340],"or":[342],"aggregation":[343,440],"throughout":[347],"timeframe":[350],"<200":[358],"nm.":[359],"Results":[360],"from":[361,536,548],"interfacial":[362],"composition":[364],"(surface":[365],"load)":[366],"SDS-PAGE":[368],"indicated":[369,529],"presence":[371,397,565],"at":[374],"interface":[376,557],"along":[377],"confirming":[380],"PPI\u2019s":[381],"ability":[382],"take":[384],"part":[385],"stabilization.":[390],"hypothesized":[393],"mutual":[396],"during":[402],"high-pressure":[403],"homogenization":[404],"led":[405],"interactions":[407],"between":[408,424],"proteins,":[410],"FTIR":[415],"spectroscopy,":[416],"intrinsic":[417],"fluorescence":[418],"surface":[420],"hydrophobicity":[421],"measurements.":[422],"Interactions":[423],"proteins":[426,463],"only":[428,512,616],"prevented":[429],"effect":[432],"SC,":[434,600],"but":[435,626],"interfered":[437],"preventing":[442],"both":[443],"destabilizing":[445],"mechanisms":[446],"seen":[447,499],"protein-stabilized":[450,610],"NEs.":[451,468,611],"mixed-protein":[453],"could":[455],"be":[456],"novel":[458],"way":[459],"utilize":[461],"plant":[462],"In":[469,525],"final":[471],"part,":[472],"MPE":[477],"encapsulated":[485,504],"curcumin":[488,505,535],"investigated":[490],"compared":[492,545,606],"SCE":[495,518,537],".":[496],"54%":[502],"degraded":[507,515],"MPE,":[510,549],"while":[511],"~42%":[513],"period":[521],"8":[523],"weeks.":[524],"studies":[528],"amount":[532],"bioavailable":[534],"slightly":[539],"(although":[541],"statistically":[543],"significant)":[544],"attributed":[552],"thicker":[555],"(due":[563],"globular":[567],"PPI),":[569],"susceptible":[575],"towards":[576],"hydrolysis":[578],"pepsin":[580],"stomach.":[583],"Overall,":[584],"it":[585,589],"concluded":[587],"possible":[591],"utilizing":[597],"better":[603],"when":[605],"presented":[613],"approach":[614],"protein,":[619],"PPI,":[620],"NEs,":[625],"good":[629],"applicability":[630],"terms":[632],"encapsulating":[634],"ingredients":[636],"prospective":[638],"applications":[639],"food":[641],"pharmaceutical":[643],"industries.":[644]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2017-10-20T00:00:00"}
