{"id":"https://openalex.org/W2760148976","doi":"https://doi.org/10.1159/000479693","title":"Bioavailability of House Dust Mite Allergens in Sublingual Allergy Tablets Is Highly Dependent on the Formulation","display_name":"Bioavailability of House Dust Mite Allergens in Sublingual Allergy Tablets Is Highly Dependent on the Formulation","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2760148976","doi":"https://doi.org/10.1159/000479693","mag":"2760148976","pmid":"https://pubmed.ncbi.nlm.nih.gov/28950271"},"language":"en","primary_location":{"id":"doi:10.1159/000479693","doi":"https://doi.org/10.1159/000479693","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000479693","pdf_url":null,"source":{"id":"https://openalex.org/S205866209","display_name":"International Archives of Allergy and Immunology","issn_l":"1018-2438","issn":["1018-2438","1423-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082311245","display_name":"Katsuyo Ohashi\u2010Doi","orcid":"https://orcid.org/0000-0002-5104-6952","observed_orcids":["https://orcid.org/0000-0002-5104-6952"]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyo Ohashi-Doi","raw_affiliation_strings":["Torii Pharmaceutical Co. Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torii Pharmaceutical Co. Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4405265357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047679961","display_name":"Hirokazu Kito","orcid":"https://orcid.org/0009-0001-0582-7723","observed_orcids":["https://orcid.org/0009-0001-0582-7723"]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Kito","raw_affiliation_strings":["Torii Pharmaceutical Co. Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torii Pharmaceutical Co. Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4405265357"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weibin Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Weibin Du","raw_affiliation_strings":["Torii Pharmaceutical Co. Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torii Pharmaceutical Co. Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4405265357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105690110","display_name":"Hiroshi Nakazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265357","display_name":"Torii Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/04jjqsg28","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265357"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Nakazawa","raw_affiliation_strings":["Torii Pharmaceutical Co. Ltd., Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torii Pharmaceutical Co. Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4405265357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113617867","display_name":"Henrik Ipsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik Ipsen","raw_affiliation_strings":["ALK A/S, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALK A/S, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010582795","display_name":"Pernille Gudmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Pernille Gudmann","raw_affiliation_strings":["ALK A/S, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALK A/S, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004635365","display_name":"Kaare Lund","orcid":"https://orcid.org/0000-0002-3520-7744","observed_orcids":["https://orcid.org/0000-0002-3520-7744"]},"institutions":[{"id":"https://openalex.org/I4210127808","display_name":"ALK-Abell\u00f3 (Denmark)","ror":"https://ror.org/03gyzpb04","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210127808"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kaare Lund","raw_affiliation_strings":["ALK A/S, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALK A/S, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210127808"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2788,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.96410749,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"174","issue":"1","first_page":"26","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/house-dust-mite-allergens","display_name":"house dust mite allergens","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tablet-formulation","display_name":"tablet formulation","score":0.878000020980835},{"id":"https://openalex.org/keywords/compressed-tablets","display_name":"compressed tablets","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dissolution-kinetics","display_name":"dissolution kinetics","score":0.6729999780654907},{"id":"https://openalex.org/keywords/der-f-1","display_name":"Der f 1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/der-p-1","display_name":"Der p 1","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.8165798187255859},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7884901762008667},{"id":"https://openalex.org/C2777037608","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Sublingual immunotherapy","level":4,"score":0.6262596845626831},{"id":"https://openalex.org/C2778166374","wikidata":"https://www.wikidata.org/wiki/Q29938","display_name":"House dust mite","level":4,"score":0.6062098145484924},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5900241136550903},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5079196095466614},{"id":"https://openalex.org/C2779350572","wikidata":"https://www.wikidata.org/wiki/Q784720","display_name":"Sublingual administration","level":2,"score":0.4333457946777344},{"id":"https://openalex.org/C199215989","wikidata":"https://www.wikidata.org/wiki/Q79239196","display_name":"Slit","level":2,"score":0.41938576102256775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4124409556388855},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36900395154953003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3660590946674347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09813454747200012},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000286","descriptor_name":"Administration, Sublingual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039741","descriptor_name":"Antigens, Dermatophagoides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D039981","descriptor_name":"Pyroglyphidae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D063729","descriptor_name":"Sublingual Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000479693","doi":"https://doi.org/10.1159/000479693","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000479693","pdf_url":null,"source":{"id":"https://openalex.org/S205866209","display_name":"International Archives of Allergy and Immunology","issn_l":"1018-2438","issn":["1018-2438","1423-0097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Immunology","raw_type":"journal-article"},{"id":"pmid:28950271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28950271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International archives of allergy and immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309809","display_name":"Cell Science Research Foundation","ror":"https://ror.org/01v3bqg10"},{"id":"https://openalex.org/F4320316817","display_name":"Torii Pharmaceutical","ror":"https://ror.org/04jjqsg28"},{"id":"https://openalex.org/F4320323316","display_name":"Shionogi","ror":"https://ror.org/01v3bqg10"},{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1132113666","https://openalex.org/W1583008465","https://openalex.org/W1997729446","https://openalex.org/W2005107727","https://openalex.org/W2009788522","https://openalex.org/W2011079863","https://openalex.org/W2019497021","https://openalex.org/W2028803867","https://openalex.org/W2030046937","https://openalex.org/W2040637363","https://openalex.org/W2053968592","https://openalex.org/W2091191662","https://openalex.org/W2092045389","https://openalex.org/W2092076937","https://openalex.org/W2134618923","https://openalex.org/W2141856163","https://openalex.org/W2150203626","https://openalex.org/W2154185834","https://openalex.org/W2156236180","https://openalex.org/W2302277303","https://openalex.org/W2312829609","https://openalex.org/W2344044328","https://openalex.org/W2346674349","https://openalex.org/W2409794036","https://openalex.org/W2490422819","https://openalex.org/W2514219278","https://openalex.org/W2554771773","https://openalex.org/W2570512305"],"related_works":["https://openalex.org/W2947653195","https://openalex.org/W2921288370","https://openalex.org/W2968639985","https://openalex.org/W4283316230","https://openalex.org/W4405954556","https://openalex.org/W3047122035","https://openalex.org/W1525527590","https://openalex.org/W7160602635","https://openalex.org/W2784211463","https://openalex.org/W4210530447"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"sublingual":[2,180,281],"immunotherapy":[3],"(SLIT),":[4],"the":[5,19,22,36,40,83,86,132,152,167,178,184,187,192,215,240,254,258,274,279],"immune":[6],"system":[7],"is":[8,26,95],"addressed":[9],"by":[10,28],"solubilized":[11],"allergen":[12,34,37,59,93,101,107,142,188,249,270],"that":[13,54,213,238,272],"interacts":[14],"with":[15,56,166],"immunocompetent":[16],"cells":[17],"of":[18,24,32,85,118,147,191,214,239,265],"oral":[20],"mucosa,":[21],"efficiency":[23],"which":[25],"governed":[27],"2":[29,127],"main":[30],"factors":[31],"SLIT":[33,50,87,247],"bioavailability:":[35],"concentration":[38,115],"and":[39,75,79,106,125,207,221,227,232,268],"mucosal":[41],"contact":[42],"time.":[43,283],"Recently,":[44],"3":[45],"house":[46],"dust":[47],"mite":[48],"(HDM)":[49],"tablets":[51,154,261],"were":[52,110,128],"developed":[53],"differ":[55],"regard":[57],"to":[58,223],"content,":[60,102],"nominal":[61,275],"strength":[62],"(maintenance":[63],"doses:":[64],"6":[65,242],"SQ-HDM/10,000":[66,243],"Japanese":[67],"Allergen":[68],"Units":[69],"[JAU],":[70],"12":[71,217],"SQ-HDM/":[72],"20,000":[73],"JAU,":[74],"300":[76,194],"IR/57,000":[77,195],"JAU),":[78],"formulation":[80,89],"(freeze-dried/compressed).":[81],"Here,":[82],"importance":[84],"tablet":[88,103,197,220,248,255,276],"for":[90,141,183],"HDM":[91,99,148],"major":[92,100,149],"bioavailability":[94,189,250],"examined.":[96],"METHODS:":[97],"The":[98,145],"disintegration":[104],"times,":[105],"release":[108,146,163],"kinetics":[109,113],"determined.":[111],"Dissolution":[112],"(allergen":[114],"vs.":[116],"time)":[117],"Der":[119,122,126],"f":[120,201,225],"1,":[121,124],"p":[123,205,230],"measured.":[129],"Area":[130],"under":[131],"curve":[133],"(AUC)":[134,190],"was":[135,155,164,198],"used":[136],"as":[137],"a":[138],"surrogate":[139],"parameter":[140],"bioavailability.":[143],"RESULTS:":[144],"allergens":[150,267],"from":[151],"freeze-dried":[153,185,216,241,260],"complete":[156],"after":[157,171],"30":[158],"s,":[159],"while":[160],"only":[161],"partial":[162],"achieved":[165],"compressed":[168,193],"tablets,":[169,186],"even":[170],"prolonged":[172],"dissolution.":[173],"At":[174],"1":[175],"min,":[176],"i.e.,":[177],"recommended":[179,280],"holding":[181,282],"time":[182],"JAU":[196,219,244],"4.7-fold":[199],"(Der":[200,204,209,224,229,234],"1),":[202,206],"10.8-fold":[203],"23.6-fold":[208],"2)":[210,235],"lower":[211,236],"than":[212,237],"SQ-HDM/20,000":[218],"similar":[222],"1)":[226,231],"5.3-fold":[228],"12.5-fold":[233],"tablet.":[245],"CONCLUSIONS:":[246],"depends":[251],"highly":[252],"on":[253],"formulation.":[256],"Only":[257],"fast-dissolving":[259],"provide":[262],"maximal":[263],"delivery":[264],"soluble":[266],"achieve":[269],"concentrations":[271],"reflect":[273],"strengths":[277],"within":[278]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-06T00:00:00"}