{"id":"https://openalex.org/W2760127331","doi":"https://doi.org/10.1002/tkm2.1079","title":"Randomized, dose\u2010controlled double\u2010blind trial: Efficacy of an ethanolic kava ( Piper methysticum rhizome) extract for the treatment of anxiety in elderly patients","display_name":"Randomized, dose\u2010controlled double\u2010blind trial: Efficacy of an ethanolic kava ( Piper methysticum rhizome) extract for the treatment of anxiety in elderly patients","publication_year":2017,"publication_date":"2017-09-26","ids":{"openalex":"https://openalex.org/W2760127331","doi":"https://doi.org/10.1002/tkm2.1079","mag":"2760127331"},"language":"en","primary_location":{"id":"doi:10.1002/tkm2.1079","doi":"https://doi.org/10.1002/tkm2.1079","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tkm2.1079","pdf_url":null,"source":{"id":"https://openalex.org/S4210210637","display_name":"Traditional & Kampo Medicine","issn_l":"2053-4515","issn":["2053-4515"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traditional &amp; Kampo Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040623562","display_name":"Kenny Kuchta","orcid":"https://orcid.org/0000-0002-9739-5971","observed_orcids":["https://orcid.org/0000-0002-9739-5971"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I74656192","display_name":"University of G\u00f6ttingen","ror":"https://ror.org/01y9bpm73","country_code":"DE","type":"education","lineage":["https://openalex.org/I74656192"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kenny Kuchta","raw_affiliation_strings":["Clinic for Gastroenterology and Gastrointestinal Oncology University of G\u00f6ttingen  G\u00f6ttingen Germany"],"raw_orcid":"https://orcid.org/0000-0002-9739-5971","affiliations":[{"raw_affiliation_string":"Clinic for Gastroenterology and Gastrointestinal Oncology University of G\u00f6ttingen  G\u00f6ttingen Germany","institution_ids":["https://openalex.org/I4210116730","https://openalex.org/I74656192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028321784","display_name":"Pietro de Nicola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro de Nicola","raw_affiliation_strings":["University Hospital for Gerontology, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital for Gerontology, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103072836","display_name":"Mathias Schmidt","orcid":"https://orcid.org/0000-0002-4488-4026","observed_orcids":["https://orcid.org/0000-0002-4488-4026"]},"institutions":[{"id":"https://openalex.org/I4210115702","display_name":"Praxis f\u00fcr Humangenetik T\u00fcbingen","ror":"https://ror.org/02met5w95","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115702"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mathias Schmidt","raw_affiliation_strings":["Herbresearch Germany, Tussenhausen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4488-4026","affiliations":[{"raw_affiliation_string":"Herbresearch Germany, Tussenhausen, Germany","institution_ids":["https://openalex.org/I4210115702"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103072836"],"corresponding_institution_ids":["https://openalex.org/I4210115702"],"apc_list":{"value":2870,"currency":"USD","value_usd":2870},"apc_paid":null,"fwci":0.8902,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77248207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"3","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kava","display_name":"kava","score":0.9950000047683716},{"id":"https://openalex.org/keywords/kavalactones","display_name":"kavalactones","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9129999876022339},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9470000267028809},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hamilton-anxiety-rating-scale","display_name":"Hamilton Anxiety Rating Scale","score":0.9350000023841858},{"id":"https://openalex.org/keywords/safety","display_name":"safety","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C2776910463","wikidata":"https://www.wikidata.org/wiki/Q161067","display_name":"Kava","level":2,"score":0.9482721090316772},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.6640605330467224},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6051461100578308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5172284841537476},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.49189019203186035},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4830111265182495},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.42944082617759705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3128153085708618},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1285713016986847}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/tkm2.1079","doi":"https://doi.org/10.1002/tkm2.1079","is_oa":false,"landing_page_url":"https://doi.org/10.1002/tkm2.1079","pdf_url":null,"source":{"id":"https://openalex.org/S4210210637","display_name":"Traditional & Kampo Medicine","issn_l":"2053-4515","issn":["2053-4515"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Traditional &amp; Kampo Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W636781072","https://openalex.org/W653793003","https://openalex.org/W1499454018","https://openalex.org/W1550997271","https://openalex.org/W1650482470","https://openalex.org/W1963741464","https://openalex.org/W1976871312","https://openalex.org/W1990333198","https://openalex.org/W1999361285","https://openalex.org/W2027578336","https://openalex.org/W2054728714","https://openalex.org/W2075095243","https://openalex.org/W2134504821","https://openalex.org/W2214570109","https://openalex.org/W2328863511","https://openalex.org/W2463859753"],"related_works":["https://openalex.org/W2075095243","https://openalex.org/W1550997271","https://openalex.org/W2060990700","https://openalex.org/W2498361262","https://openalex.org/W2108706323","https://openalex.org/W1499454018","https://openalex.org/W2463859753","https://openalex.org/W2042376377","https://openalex.org/W7099301511","https://openalex.org/W3027563399"],"abstract_inverted_index":{"ABSTRACT":[0],"Aim":[1],"Kava,":[2],"an":[3,68],"aqueous":[4],"drink":[5],"from":[6],"the":[7,13,38,51,64,74,79,118,126,133,142,146,156,159,162,170,184],"roots":[8],"and":[9,23,98,129,191,196],"peeled":[10],"rootstock":[11],"of":[12,35,56,67,88,161,165,172,199,208],"plant":[14],"Piper":[15],"methysticum":[16],"G.Forst.,":[17],"is":[18],"renowned":[19],"in":[20,81,122,125,132],"Melanesia,":[21],"Polynesia":[22],"Micronesia":[24],"for":[25,194],"its":[26,192],"relaxant":[27],"effect.":[28,232],"Modern":[29],"extract":[30,91],"preparations":[31,227],"with":[32,112,204],"defined":[33],"contents":[34],"kavalactones":[36,96,107],"\u2013":[37,42],"major":[39],"active":[40],"constituents":[41],"are":[43],"well":[44],"established":[45],"as":[46],"herbal":[47],"medicinal":[48],"products":[49],"on":[50,63,169,187,218],"European":[52],"market.":[53],"The":[54,136,176],"aim":[55],"this":[57],"trial":[58],"was":[59,139,145,153,167,179],"to":[60,93,104,183,213],"present":[61,75],"data":[62],"clinical":[65,77,82],"efficacy":[66,152],"ethanolic":[69,89],"kava":[70,90],"extract.":[71],"Methods":[72],"In":[73],"double\u2010blind":[76],"trial,":[78],"differences":[80],"outcome":[83],"between":[84],"a":[85,99,205,229],"low":[86],"dose":[87,102],"(equivalent":[92,103],"20":[94],"mg":[95,106],"daily)":[97,108],"respective":[100],"high":[101],"200":[105],"were":[109,115],"investigated.":[110],"Patients":[111],"anxiety":[113,148,200],"disorders":[114],"randomized":[116],"into":[117],"two":[119],"groups,":[120],"resulting":[121],"33":[123],"patients":[124,131],"high\u2010dose":[127,177],"group":[128,178,186],"36":[130],"low\u2010dose":[134,185],"group.":[135],"study":[137],"duration":[138],"4":[140],"weeks;":[141],"primary":[143],"parameter":[144],"Hamilton":[147],"(HAMA)":[149],"score.":[150],"Global":[151],"rated":[154],"by":[155],"physician":[157],"at":[158],"end":[160],"study.":[163],"Safety":[164],"application":[166],"based":[168],"documentation":[171],"adverse":[173,222],"events.":[174],"Results":[175],"statistically":[180],"significantly":[181],"superior":[182],"HAMA":[188,215],"total":[189,206,216],"score":[190,217],"subscores":[193],"psychological":[195],"physical":[197],"manifestations":[198],"(P":[201],"<":[202],"0.001),":[203],"improvement":[207],"\u221241.5%":[209],"versus":[210],"\u221213.6%":[211],"relative":[212],"baseline":[214],"day":[219],"28.":[220],"No":[221],"events":[223],"occurred.":[224],"Conclusion":[225],"Kava":[226],"have":[228],"dose\u2010dependent":[230],"anxiolytic":[231]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-06T00:00:00"}