{"id":"https://openalex.org/W2760047200","doi":null,"title":"Characterization of a Novel Interaction Between Septins and the Adenomatous Polyposis Coli Tumor Suppressor.","display_name":"Characterization of a Novel Interaction Between Septins and the Adenomatous Polyposis Coli Tumor Suppressor.","publication_year":2010,"publication_date":"2010-12-14","ids":{"openalex":"https://openalex.org/W2760047200","mag":"2760047200"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/25426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/25426","pdf_url":"https://utoronto.scholaris.ca/bitstreams/6552f282-4ebc-48eb-b063-f3bfbb1ecd68/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/6552f282-4ebc-48eb-b063-f3bfbb1ecd68/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016431218","display_name":"Margaret Temitope Bejide","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Margaret Temitope Bejide","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016431218"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/septins","display_name":"septins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adenomatous-polyposis-coli","display_name":"adenomatous polyposis coli","score":0.9580000042915344},{"id":"https://openalex.org/keywords/apc-tumor-suppressor","display_name":"APC tumor suppressor","score":0.843999981880188},{"id":"https://openalex.org/keywords/septin-2","display_name":"SEPT2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/sept9","display_name":"SEPT9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.871999979019165},{"id":"https://openalex.org/keywords/chromosome-congression","display_name":"chromosome congression","score":0.9470000267028809},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cytokinesis","display_name":"cytokinesis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/abscission","display_name":"abscission","score":0.8149999976158142},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C179411191","wikidata":"https://www.wikidata.org/wiki/Q24720212","display_name":"Septin","level":5,"score":0.9273238182067871},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.8389270305633545},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.8287097215652466},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6424686312675476},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.637063205242157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5551347136497498},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5280227065086365},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36671334505081177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3403691351413727},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.27658921480178833},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.2679139971733093},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.254513144493103},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21059805154800415},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.16021278500556946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09967035055160522}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/25426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/25426","pdf_url":"https://utoronto.scholaris.ca/bitstreams/6552f282-4ebc-48eb-b063-f3bfbb1ecd68/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/25426","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/25426","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2760047200","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/25426","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/25426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/25426","pdf_url":"https://utoronto.scholaris.ca/bitstreams/6552f282-4ebc-48eb-b063-f3bfbb1ecd68/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5856999754905701}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2760047200.pdf","grobid_xml":"https://content.openalex.org/works/W2760047200.grobid-xml"},"referenced_works_count":155,"referenced_works":["https://openalex.org/W49637","https://openalex.org/W1483413992","https://openalex.org/W1489530964","https://openalex.org/W1535534560","https://openalex.org/W1546492519","https://openalex.org/W1679740469","https://openalex.org/W1780771399","https://openalex.org/W1809606297","https://openalex.org/W1822129150","https://openalex.org/W1843722816","https://openalex.org/W1963481639","https://openalex.org/W1965649202","https://openalex.org/W1967921405","https://openalex.org/W1969321922","https://openalex.org/W1969465539","https://openalex.org/W1969640026","https://openalex.org/W1970948460","https://openalex.org/W1972678218","https://openalex.org/W1973275541","https://openalex.org/W1976359234","https://openalex.org/W1977508482","https://openalex.org/W1978353502","https://openalex.org/W1978966221","https://openalex.org/W1979136506","https://openalex.org/W1980620631","https://openalex.org/W1982779711","https://openalex.org/W1982857584","https://openalex.org/W1989215255","https://openalex.org/W1991660576","https://openalex.org/W1991883398","https://openalex.org/W1992757392","https://openalex.org/W1996655643","https://openalex.org/W1996914468","https://openalex.org/W1996982933","https://openalex.org/W1996984755","https://openalex.org/W1997624549","https://openalex.org/W1998170462","https://openalex.org/W2001626652","https://openalex.org/W2003395833","https://openalex.org/W2003622132","https://openalex.org/W2003629016","https://openalex.org/W2005900617","https://openalex.org/W2010202610","https://openalex.org/W2015974087","https://openalex.org/W2018348035","https://openalex.org/W2018516624","https://openalex.org/W2019889495","https://openalex.org/W2020636908","https://openalex.org/W2029477751","https://openalex.org/W2029824690","https://openalex.org/W2032998587","https://openalex.org/W2033026766","https://openalex.org/W2034270890","https://openalex.org/W2035057863","https://openalex.org/W2036839079","https://openalex.org/W2037493963","https://openalex.org/W2038325071","https://openalex.org/W2046414788","https://openalex.org/W2046477340","https://openalex.org/W2050862757","https://openalex.org/W2050865324","https://openalex.org/W2053029064","https://openalex.org/W2054169477","https://openalex.org/W2055376777","https://openalex.org/W2056782727","https://openalex.org/W2059346525","https://openalex.org/W2060501484","https://openalex.org/W2061260618","https://openalex.org/W2062452071","https://openalex.org/W2065206120","https://openalex.org/W2066085022","https://openalex.org/W2070326039","https://openalex.org/W2077167882","https://openalex.org/W2077672072","https://openalex.org/W2078116784","https://openalex.org/W2080184799","https://openalex.org/W2080480789","https://openalex.org/W2080632801","https://openalex.org/W2080980430","https://openalex.org/W2082371917","https://openalex.org/W2082387343","https://openalex.org/W2086906637","https://openalex.org/W2088948270","https://openalex.org/W2089050775","https://openalex.org/W2089865002","https://openalex.org/W2090937576","https://openalex.org/W2091065187","https://openalex.org/W2091494325","https://openalex.org/W2092794803","https://openalex.org/W2093325895","https://openalex.org/W2093787840","https://openalex.org/W2095197305","https://openalex.org/W2096371251","https://openalex.org/W2098250898","https://openalex.org/W2098616171","https://openalex.org/W2100951721","https://openalex.org/W2104109084","https://openalex.org/W2105912776","https://openalex.org/W2108148669","https://openalex.org/W2108670406","https://openalex.org/W2110339897","https://openalex.org/W2112597950","https://openalex.org/W2113611763","https://openalex.org/W2114252625","https://openalex.org/W2114282435","https://openalex.org/W2115667307","https://openalex.org/W2117571939","https://openalex.org/W2118252933","https://openalex.org/W2119284420","https://openalex.org/W2120129786","https://openalex.org/W2120856608","https://openalex.org/W2120892838","https://openalex.org/W2121167030","https://openalex.org/W2121874812","https://openalex.org/W2122854619","https://openalex.org/W2123198733","https://openalex.org/W2123872388","https://openalex.org/W2128653641","https://openalex.org/W2129759722","https://openalex.org/W2133290275","https://openalex.org/W2135715423","https://openalex.org/W2136013159","https://openalex.org/W2136373114","https://openalex.org/W2136460759","https://openalex.org/W2139860130","https://openalex.org/W2140029287","https://openalex.org/W2140653565","https://openalex.org/W2141055054","https://openalex.org/W2141169141","https://openalex.org/W2145859343","https://openalex.org/W2146200179","https://openalex.org/W2146632337","https://openalex.org/W2148175003","https://openalex.org/W2148883613","https://openalex.org/W2151150093","https://openalex.org/W2151365378","https://openalex.org/W2154083988","https://openalex.org/W2154220396","https://openalex.org/W2154880168","https://openalex.org/W2159137674","https://openalex.org/W2159425480","https://openalex.org/W2160369364","https://openalex.org/W2160617617","https://openalex.org/W2167290154","https://openalex.org/W2167815875","https://openalex.org/W2168616898","https://openalex.org/W2168908838","https://openalex.org/W2169704403","https://openalex.org/W2171974881","https://openalex.org/W2189490860","https://openalex.org/W2279940596","https://openalex.org/W2331191863","https://openalex.org/W2403426800","https://openalex.org/W2417721535","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W2080480789","https://openalex.org/W2028969736","https://openalex.org/W2111725473","https://openalex.org/W4312065857","https://openalex.org/W2093325895","https://openalex.org/W2079956148","https://openalex.org/W2334670136","https://openalex.org/W1597363438","https://openalex.org/W1974302210","https://openalex.org/W2067944964"],"abstract_inverted_index":{"Septins":[0,16],"are":[1,23],"evolutionarily":[2],"conserved":[3],"proteins":[4],"with":[5,75,105,148],"roles":[6,53],"in":[7,78],"chromosome":[8,110],"congression":[9,100,111],"and":[10,13,19,49,54,89,101,112,142,145],"segregation,":[11],"cytokinesis":[12],"microtubule":[14],"destabilization.":[15],"form":[17],"homo-":[18],"hetero-oligomeric":[20],"complexes,":[21],"which":[22,123],"thought":[24],"to":[25,59,65,97],"act":[26],"as":[27,33],"dynamic":[28],"scaffolds.":[29],"We":[30],"identified":[31],"SEPT2/9/11/10":[32],"novel":[34],"interacting":[35],"partners":[36],"of":[37,135],"adenomatous":[38],"polyposis":[39],"coli":[40],"(APC),":[41],"a":[42],"bona":[43],"fide":[44],"tumor":[45],"suppressor.":[46],"Since":[47],"septins":[48,77],"APC":[50,73,90,106,141],"have":[51],"similar":[52],"knockdown":[55],"phenotypes,":[56],"I":[57,70,85],"sought":[58],"determine":[60],"if":[61],"they":[62],"work":[63],"together":[64],"perform":[66],"their":[67],"cellular":[68],"functions.":[69],"showed":[71],"that":[72,87],"co-immunoprecipitates":[74],"endogenous":[76],"colon":[79],"cancer":[80],"cell":[81],"lines.":[82],"Using":[83],"siRNA,":[84],"found":[86],"SEPT2":[88],"may":[91],"function":[92],"within":[93],"the":[94,109,133,136],"same":[95],"pathway":[96],"regulate":[98],"DNA":[99],"segregation.":[102],"Co-depleting":[103],"SEPT9":[104,143],"slightly":[107],"alleviates":[108],"segregation":[113],"defects":[114],"caused":[115],"by":[116,126],"siAPC":[117],"alone.":[118],"siSEPT9":[119],"increased":[120],"abscission":[121],"times,":[122],"was":[124],"rescued":[125],"co-depleting":[127],"APC.":[128],"Future":[129],"studies":[130],"should":[131],"elucidate":[132],"significance":[134],"rescue":[137],"data":[138],"obtained":[139],"upon":[140],"co-depletion":[144],"APC\u2019s":[146],"interactions":[147],"SEPT10/11.":[149]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-06T00:00:00"}