{"id":"https://openalex.org/W2760045522","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.7513","title":"An evaluation of the chronic lymphocytic leukemia (CLL) international prognostic index as a prognostic tool in patients with relapsed/refractory CLL in idelalisib phase 3 randomized studies.","display_name":"An evaluation of the chronic lymphocytic leukemia (CLL) international prognostic index as a prognostic tool in patients with relapsed/refractory CLL in idelalisib phase 3 randomized studies.","publication_year":2016,"publication_date":"2016-05-20","ids":{"openalex":"https://openalex.org/W2760045522","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.7513","mag":"2760045522"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.15_suppl.7513","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.7513","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.7513","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088343926","display_name":"Jacob Drobnyk Soumerai","orcid":"https://orcid.org/0000-0002-3062-6819","observed_orcids":["https://orcid.org/0000-0002-3062-6819"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Drobnyk Soumerai","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075229974","display_name":"Jacqueline C. Barrientos","orcid":"https://orcid.org/0000-0001-6018-5535","observed_orcids":["https://orcid.org/0000-0001-6018-5535"]},"institutions":[{"id":"https://openalex.org/I139290212","display_name":"Hofstra University","ror":"https://ror.org/03pm18j10","country_code":"US","type":"education","lineage":["https://openalex.org/I139290212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Claudia Barrientos","raw_affiliation_strings":["Hofstra North Shore-LIJ School of Medicine, Hempstead, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hofstra North Shore-LIJ School of Medicine, Hempstead, NY;","institution_ids":["https://openalex.org/I139290212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077834","display_name":"Michael J. Hallek","orcid":"https://orcid.org/0000-0002-7425-4455","observed_orcids":["https://orcid.org/0000-0002-7425-4455"]},"institutions":[{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Hallek","raw_affiliation_strings":["Department of Internal Medicine and Center of Integrated Oncology, Cologne Bonn, University Hospital, Cologne, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Center of Integrated Oncology, Cologne Bonn, University Hospital, Cologne, Germany;","institution_ids":["https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Kipps","raw_affiliation_strings":["University of California San Diego/Moores Cancer Center, La Jolla, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego/Moores Cancer Center, La Jolla, CA;","institution_ids":["https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102896676","display_name":"Jeffrey Alan Jones","orcid":"https://orcid.org/0000-0001-9557-0820","observed_orcids":["https://orcid.org/0000-0001-9557-0820"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Alan Jones","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH;","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019866348","display_name":"Stephan Stilgenbauer","orcid":"https://orcid.org/0000-0002-6830-9296","observed_orcids":["https://orcid.org/0000-0002-6830-9296"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Stilgenbauer","raw_affiliation_strings":["University of Ulm, Ulm, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ulm, Ulm, Germany;","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081758381","display_name":"Guan Xing","orcid":"https://orcid.org/0000-0001-6011-3267","observed_orcids":["https://orcid.org/0000-0001-6011-3267"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guan Xing","raw_affiliation_strings":["Gilead Sciences, Inc., Foster City, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Inc., Foster City, CA;","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024631406","display_name":"Nai\u2010Shun Yao","orcid":"https://orcid.org/0000-0001-9489-3898","observed_orcids":["https://orcid.org/0000-0001-9489-3898"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nai-Shun Yao","raw_affiliation_strings":["Gilead Sciences, Inc., Foster City, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences, Inc., Foster City, CA;","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013649293","display_name":"Lo\u00efc Ysebaert","orcid":"https://orcid.org/0000-0003-4102-7261","observed_orcids":["https://orcid.org/0000-0003-4102-7261","https://orcid.org/0000-0001-8478-5623"]},"institutions":[{"id":"https://openalex.org/I4210098740","display_name":"Institut universitaire du cancer de Toulouse Oncopole","ror":"https://ror.org/014hxhm89","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210098740","https://openalex.org/I4210128666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Loic Ysebaert","raw_affiliation_strings":["Department of Haematology, Institut Universitaire du Cancer de Toulouse- Oncop\u00f4le, Toulouse, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Institut Universitaire du Cancer de Toulouse- Oncop\u00f4le, Toulouse, France;","institution_ids":["https://openalex.org/I4210098740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061964017","display_name":"Andrew David Zelenetz","orcid":"https://orcid.org/0000-0003-1403-6883","observed_orcids":["https://orcid.org/0000-0003-1403-6883"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew David Zelenetz","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY;","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"15_suppl","first_page":"7513","last_page":"7513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.906000018119812},{"id":"https://openalex.org/keywords/relapsed-refractory-cll","display_name":"relapsed/refractory CLL","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cll-ipi","display_name":"CLL-IPI","score":0.6330000162124634},{"id":"https://openalex.org/keywords/idelalisib","display_name":"idelalisib","score":0.9340000152587891},{"id":"https://openalex.org/keywords/prognostic-scoring","display_name":"prognostic scoring","score":0.6489999890327454},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/del-17p-tp53-mutation","display_name":"del(17p)/TP53 mutation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ighv-mutation-status","display_name":"IGHV mutation status","score":0.765999972820282},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ofatumumab","display_name":"ofatumumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.48500001430511475},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6029999852180481},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8982441425323486},{"id":"https://openalex.org/C2779260929","wikidata":"https://www.wikidata.org/wiki/Q5908266","display_name":"Idelalisib","level":5,"score":0.7971519827842712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7332344055175781},{"id":"https://openalex.org/C2778714382","wikidata":"https://www.wikidata.org/wiki/Q410656","display_name":"Ofatumumab","level":4,"score":0.6621848344802856},{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.6534140110015869},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.515575110912323},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4837246239185333},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4669042229652405},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.45280906558036804},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.43800753355026245},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.41614818572998047},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40002748370170593},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.27339667081832886},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.22032886743545532},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.19176554679870605},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.15282517671585083}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2016.34.15_suppl.7513","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.7513","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.7513","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:27553","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/27553/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899659979","https://openalex.org/W2988602549","https://openalex.org/W2246620886","https://openalex.org/W7037825053","https://openalex.org/W2552879919","https://openalex.org/W2517897937","https://openalex.org/W2766562288","https://openalex.org/W4399853818","https://openalex.org/W4232033488","https://openalex.org/W2488520017"],"abstract_inverted_index":{"7513":[0],"Background:":[1],"The":[2,45,96,174],"International":[3],"Prognostic":[4],"Index":[5],"for":[6,20,160,190,235],"patients":[7],"(pts)":[8],"with":[9,17,82,104,108,136,150,212,215],"CLL":[10,36,81,106],"(CLL-IPI)":[11],"is":[12,47,259],"a":[13,48,194],"validated":[14,204],"scoring":[15],"system":[16],"prognostic":[18,234,260],"value":[19],"overall":[21],"survival":[22,181],"(OS)":[23],"in":[24,33,80,101,132,146,205,218,237,252,263],"untreated":[25],"CLL,":[26,214],"but":[27,241],"it":[28],"has":[29],"not":[30,242],"been":[31],"studied":[32],"relapsed/refractory":[34],"(R/R)":[35],"(Kutsch":[37],"et":[38],"al.":[39],"J":[40],"Clin":[41],"Oncol.33":[42],"(suppl),":[43],"2015).":[44],"CLL-IPI":[46,91,97,167,201,221,231,257,297],"risk-weighted":[49],"model":[50],"comprising":[51],"the":[52,86,171,200,206,227,230,238,253,256,269],"risk":[53,92,168,222],"factors":[54],"age":[55],"(relative":[56],"weight,":[57],"1),":[58],"stage":[59],"(1),":[60],"del(17p)/TP53":[61],"mutation":[62,66],"(\u221217p/TP53M)":[63],"(4),":[64],"IGHV":[65],"status":[67],"(2),":[68],"and":[69,145,164,185],"\u03b22-microglobulin":[70],"(2).":[71],"We":[72],"hypothesized":[73],"that":[74],"idelalisib":[75],"(IDELA),":[76],"an":[77],"agent":[78],"active":[79],"\u221217p/TP53M,":[83],"can":[84],"overcome":[85],"negative":[87,270],"impact":[88,271],"of":[89,128,197,209,261,274,282],"high":[90,166],"on":[93,272],"OS.":[94,191],"Methods:":[95],"score":[98,202,232,258],"was":[99,158,177,203,233],"analyzed":[100],"460":[102],"pts":[103,134,148,211,249],"R/R":[105,213,254,264],"treated":[107,135,149],"IDELA":[109,119,137,243,266,325],"+":[110,115,120,138,141],"rituximab":[111],"(R)":[112],"vs":[113,123],"placebo":[114],"R":[116,139,151],"(NCT01539512)":[117],"or":[118,140,152],"ofatumumab":[121],"(O)":[122],"O":[124,142,153],"(NCT01659021).":[125],"Subgroup":[126],"analyses":[127],"OS":[129,157,219,236,262,273],"were":[130],"performed":[131],"274":[133],"(IDELA":[143],"cohort)":[144],"186":[147],"alone":[154],"(control).":[155],"Median":[156],"estimated":[159],"low,":[161],"intermediate,":[162],"high,":[163],"very":[165,275],"groups":[169,184,223],"using":[170],"Kaplan-Meier":[172],"method.":[173],"log-rank":[175],"test":[176,323,342,360],"used":[178],"to":[179],"compare":[180],"distributions":[182],"across":[183,220],"estimate":[186],"hazard":[187],"ratios":[188],"(HRs)":[189],"Results:":[192],"At":[193],"median":[195],"follow-up":[196],"14.7":[198],"months,":[199],"pooled":[207],"cohort":[208,244,326],"all":[210],"significant":[216],"differences":[217],"(P=0.0001;":[224],"table).":[225],"In":[226],"subgroup":[228],"analysis,":[229],"control":[239],"(P=0.0007)":[240],"(P=0.0859).":[245],"Conclusions:":[246],"Although":[247],"low-risk":[248],"are":[250,290],"uncommon":[251],"setting,":[255],"CLL.":[265],"partially":[267],"overcomes":[268],"high-risk":[276],"disease":[277],"driven":[278],"by":[279],"\u221217p/TP53M.":[280],"Analyses":[281],"data":[283],"derived":[284],"from":[285],"another":[286],"phase":[287],"3":[288],"study":[289],"ongoing.":[291],"Clinical":[292],"trial":[293],"information:":[294],"NCT01659021,":[295],"NCT01539512.OS":[296],"Low":[298],"(0\u20131)":[299],"Intermediate":[300],"(2\u20133)":[301],"High":[302,305],"(4\u20136)":[303],"Very":[304],"(7\u201310)":[306],"All":[307],"(N=460)":[308],"n=6":[309],"n=38":[310],"n=228":[311],"n=188":[312],"HR":[313,332,350],"(95%":[314,333,351],"CI)":[315,334,352],"0":[316,335,353],"0.22":[317],"(0.08\u20130.6)":[318],"0.57":[319],"(0.4\u20130.8)":[320],"1":[321,340,358],"Log-rank":[322,341,359],"P=0.0001":[324],"(n=274)":[327],"n=4":[328],"n=20":[329],"n=141":[330],"n=109":[331],"0.37":[336],"(0.11\u20131.21)":[337],"0.67":[338],"(0.41\u20131.09)":[339],"P=0.0859":[343],"Control":[344],"(n=186)":[345],"n=2":[346],"n=18":[347],"n=87":[348],"n=79":[349],"0.09":[354],"(0.01\u20130.64)":[355],"0.42":[356],"(0.28\u20130.77)":[357],"P=0.0007":[361]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-06T00:00:00"}