{"id":"https://openalex.org/W2759614878","doi":"https://doi.org/10.3389/fimmu.2017.01146","title":"Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses","display_name":"Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses","publication_year":2017,"publication_date":"2017-09-25","ids":{"openalex":"https://openalex.org/W2759614878","doi":"https://doi.org/10.3389/fimmu.2017.01146","mag":"2759614878","pmid":"https://pubmed.ncbi.nlm.nih.gov/28993767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5622154"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2017.01146","doi":"https://doi.org/10.3389/fimmu.2017.01146","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2017.01146","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.01146/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.01146/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081225209","display_name":"Widad Dantoft","orcid":"https://orcid.org/0000-0002-8546-5514","observed_orcids":["https://orcid.org/0000-0002-8546-5514"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Widad Dantoft","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001820397","display_name":"Pablo Mart\u00ednez\u2010Vicente","orcid":"https://orcid.org/0000-0001-9277-1950","observed_orcids":["https://orcid.org/0000-0001-9277-1950"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Pablo Mart\u00ednez-Vicente","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014801946","display_name":"James Jafali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Jafali","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061303685","display_name":"Lara P\u00e9rez\u2010Mart\u00ednez","orcid":"https://orcid.org/0000-0002-6435-0566","observed_orcids":["https://orcid.org/0000-0002-6435-0566"]},"institutions":[{"id":"https://openalex.org/I4210165538","display_name":"Institute of Molecular Biology","ror":"https://ror.org/05kxtq558","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165538"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Lara P\u00e9rez-Mart\u00ednez","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","Quantitative Proteomics, Institute of Molecular Biology, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Quantitative Proteomics, Institute of Molecular Biology, Mainz, Germany","institution_ids":["https://openalex.org/I4210165538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080240495","display_name":"K. Martin","orcid":"https://orcid.org/0000-0002-3052-461X","observed_orcids":["https://orcid.org/0000-0002-3052-461X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kim Martin","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","Synexa Life Sciences, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Synexa Life Sciences, Cape Town, South Africa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006960879","display_name":"Konstantinos Kotzamanis","orcid":"https://orcid.org/0000-0002-6846-7761","observed_orcids":["https://orcid.org/0000-0002-6846-7761"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Konstantinos Kotzamanis","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001955749","display_name":"Marie Craigon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marie Craigon","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022408863","display_name":"Manfred Auer","orcid":"https://orcid.org/0000-0001-8920-3522","observed_orcids":["https://orcid.org/0000-0001-8920-3522"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Manfred Auer","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","SynthSys-Centre for Synthetic and Systems Biology, School of Engineering, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"SynthSys-Centre for Synthetic and Systems Biology, School of Engineering, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102303089","display_name":"Neil T. Young","orcid":"https://orcid.org/0009-0001-1941-0275","observed_orcids":["https://orcid.org/0009-0001-1941-0275"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil T. Young","raw_affiliation_strings":["Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046492167","display_name":"Paul Walsh","orcid":"https://orcid.org/0000-0002-4988-6901","observed_orcids":["https://orcid.org/0000-0002-4988-6901"]},"institutions":[{"id":"https://openalex.org/I4210100923","display_name":"Munster Technological University","ror":"https://ror.org/013xpqh61","country_code":"IE","type":"facility","lineage":["https://openalex.org/I4210100923"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Paul Walsh","raw_affiliation_strings":["NSilico Life Science and Department of Computing, Institute of Technology, Cork, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NSilico Life Science and Department of Computing, Institute of Technology, Cork, Ireland","institution_ids":["https://openalex.org/I4210100923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011424051","display_name":"Arnaud Marchant","orcid":"https://orcid.org/0000-0003-0578-0467","observed_orcids":["https://orcid.org/0000-0003-0578-0467"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Arnaud Marchant","raw_affiliation_strings":["Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Charleroi, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles, Charleroi, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002148348","display_name":"Ana Angulo","orcid":"https://orcid.org/0000-0002-5792-1164","observed_orcids":["https://orcid.org/0000-0002-5792-1164"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Angulo","raw_affiliation_strings":["Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Unit, Department of Biomedical Sciences, Medical School, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064045642","display_name":"Thorsten Forster","orcid":"https://orcid.org/0000-0002-4483-3069","observed_orcids":["https://orcid.org/0000-0002-4483-3069"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thorsten Forster","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065696246","display_name":"Peter Ghazal","orcid":"https://orcid.org/0000-0003-0035-2228","observed_orcids":["https://orcid.org/0000-0003-0035-2228"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Peter Ghazal","raw_affiliation_strings":["Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065696246","https://openalex.org/A5081225209"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.0339,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76802309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":null,"first_page":"1146","last_page":"1146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/congenital-cytomegalovirus-infection","display_name":"congenital cytomegalovirus infection","score":0.9390000104904175},{"id":"https://openalex.org/keywords/neonatal-immunity","display_name":"neonatal immunity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.6899999976158142},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/protocadherins","display_name":"protocadherins","score":0.8270000219345093},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.5419999957084656},{"id":"https://openalex.org/keywords/gpr146","display_name":"GPR146","score":0.7279999852180481},{"id":"https://openalex.org/keywords/rgs16","display_name":"RGS16","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gpr84","display_name":"GPR84","score":0.8289999961853027},{"id":"https://openalex.org/keywords/rds","display_name":"RDS","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ccl17","display_name":"CCL17","score":0.9480000138282776},{"id":"https://openalex.org/keywords/sort1","display_name":"SORT1","score":0.972000002861023},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.5220000147819519},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/transcriptomic-response","display_name":"transcriptomic response","score":0.4390000104904175},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.5529999732971191},{"id":"https://openalex.org/keywords/immune-plasticity","display_name":"immune plasticity","score":0.5759999752044678},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6834341287612915},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6635399460792542},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6348371505737305},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.6116092205047607},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.5514694452285767},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5454859733581543},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5264236330986023},{"id":"https://openalex.org/C2776051438","wikidata":"https://www.wikidata.org/wiki/Q12045567","display_name":"Plasmacytoid dendritic cell","level":4,"score":0.45529747009277344},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2936752438545227},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":10,"locations":[{"id":"doi:10.3389/fimmu.2017.01146","doi":"https://doi.org/10.3389/fimmu.2017.01146","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2017.01146","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.01146/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5622154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5622154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:28993767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28993767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/3bbe09a7-3352-4a2d-aaf5-e4e4b98da6a6","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/3bbe09a7-3352-4a2d-aaf5-e4e4b98da6a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alsheikhly Dantoft, W, Martinez, P, Jafali, J, Perez-Martinez, L, Martin, K, Kotzamanis, K, Craigon, M, Auer, M, Young, N, Walsh, P, Marchant, A, Forster, T & Ghazal, P 2017, 'Genomic programming of human neonatal dendritic cells in congenital systemic and in vitro cytomegalovirus infection reveal plastic and robust immune pathway biology responses', Frontiers in Immunology. https://doi.org/10.3389/fimmu.2017.01146","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:110057","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/110057/1/fimmu-08-01146.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/110057/1/fimmu-08-01146.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:recercat.cat:2072/360939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/138780","pdf_url":"http://hdl.handle.net/2445/138780","source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:aura.abdn.ac.uk:2164/9538","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2164/9538","pdf_url":null,"source":{"id":"https://openalex.org/S4306400966","display_name":"Aberdeen University Research Archive (Aberdeen University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I195460627","host_organization_name":"University of Aberdeen","host_organization_lineage":["https://openalex.org/I195460627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:diposit.ub.edu:2445/138780","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/138780","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Articles publicats en revistes (Biomedicina)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/259085","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/259085","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in immunology, 8 (9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d9077d58e65b4a29a7a12f22c62445c4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d9077d58e65b4a29a7a12f22c62445c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 8 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2017.01146","doi":"https://doi.org/10.3389/fimmu.2017.01146","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2017.01146","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.01146/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1636909500","display_name":null,"funder_award_id":"WT 066784/Z/02/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2160003213","display_name":null,"funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6537836360","display_name":"MicroRNA coupling of the sterol metabolic network to the antiviral immune response","funder_award_id":"BB/K019112/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G922893353","display_name":"Centre for Systems Biology at Edinburgh","funder_award_id":"BB/D019621/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2759614878.pdf","grobid_xml":"https://content.openalex.org/works/W2759614878.grobid-xml"},"referenced_works_count":148,"referenced_works":["https://openalex.org/W84988101","https://openalex.org/W1486866108","https://openalex.org/W1494340137","https://openalex.org/W1514353293","https://openalex.org/W1529674879","https://openalex.org/W1581533309","https://openalex.org/W1595547013","https://openalex.org/W1834505123","https://openalex.org/W1867481372","https://openalex.org/W1873909974","https://openalex.org/W1880035041","https://openalex.org/W1963945738","https://openalex.org/W1964444099","https://openalex.org/W1965223661","https://openalex.org/W1969072247","https://openalex.org/W1973094248","https://openalex.org/W1974594271","https://openalex.org/W1974937503","https://openalex.org/W1976905332","https://openalex.org/W1977548433","https://openalex.org/W1978527132","https://openalex.org/W1983598990","https://openalex.org/W1985380245","https://openalex.org/W1989277387","https://openalex.org/W1990136945","https://openalex.org/W1990545433","https://openalex.org/W1991253843","https://openalex.org/W1993947112","https://openalex.org/W1994845424","https://openalex.org/W1995913875","https://openalex.org/W1998041119","https://openalex.org/W1998551845","https://openalex.org/W2002908678","https://openalex.org/W2007741088","https://openalex.org/W2007766444","https://openalex.org/W2009823940","https://openalex.org/W2014165627","https://openalex.org/W2019804835","https://openalex.org/W2020541351","https://openalex.org/W2022293913","https://openalex.org/W2023668858","https://openalex.org/W2023882799","https://openalex.org/W2026119866","https://openalex.org/W2027242478","https://openalex.org/W2029451306","https://openalex.org/W2031808495","https://openalex.org/W2032980461","https://openalex.org/W2034662297","https://openalex.org/W2034809501","https://openalex.org/W2035421116","https://openalex.org/W2035659802","https://openalex.org/W2036496674","https://openalex.org/W2038610464","https://openalex.org/W2041726757","https://openalex.org/W2043253380","https://openalex.org/W2045772297","https://openalex.org/W2046134625","https://openalex.org/W2046595127","https://openalex.org/W2049768278","https://openalex.org/W2051146104","https://openalex.org/W2052685738","https://openalex.org/W2056167090","https://openalex.org/W2058752249","https://openalex.org/W2058914749","https://openalex.org/W2060053956","https://openalex.org/W2060121054","https://openalex.org/W2061154433","https://openalex.org/W2063520656","https://openalex.org/W2065674919","https://openalex.org/W2066472475","https://openalex.org/W2068551986","https://openalex.org/W2068888193","https://openalex.org/W2069310363","https://openalex.org/W2073637502","https://openalex.org/W2082632613","https://openalex.org/W2084802063","https://openalex.org/W2086333472","https://openalex.org/W2086601777","https://openalex.org/W2086876304","https://openalex.org/W2091141292","https://openalex.org/W2092842081","https://openalex.org/W2094279541","https://openalex.org/W2096173332","https://openalex.org/W2096831872","https://openalex.org/W2104146721","https://openalex.org/W2107435587","https://openalex.org/W2108449521","https://openalex.org/W2109357160","https://openalex.org/W2111048324","https://openalex.org/W2114755206","https://openalex.org/W2116753863","https://openalex.org/W2119907069","https://openalex.org/W2120865735","https://openalex.org/W2120976912","https://openalex.org/W2121044470","https://openalex.org/W2122224350","https://openalex.org/W2122935607","https://openalex.org/W2126711569","https://openalex.org/W2127187639","https://openalex.org/W2131794266","https://openalex.org/W2133730856","https://openalex.org/W2133846320","https://openalex.org/W2137369708","https://openalex.org/W2138349401","https://openalex.org/W2138553385","https://openalex.org/W2140391606","https://openalex.org/W2141659272","https://openalex.org/W2142774522","https://openalex.org/W2143314736","https://openalex.org/W2144618115","https://openalex.org/W2146512944","https://openalex.org/W2147718057","https://openalex.org/W2151727155","https://openalex.org/W2155290641","https://openalex.org/W2156829363","https://openalex.org/W2157408286","https://openalex.org/W2159096710","https://openalex.org/W2159508608","https://openalex.org/W2159685069","https://openalex.org/W2162589834","https://openalex.org/W2163594990","https://openalex.org/W2163783674","https://openalex.org/W2164522180","https://openalex.org/W2170432219","https://openalex.org/W2170680089","https://openalex.org/W2180610752","https://openalex.org/W2220411730","https://openalex.org/W2323113905","https://openalex.org/W2324837010","https://openalex.org/W2418334496","https://openalex.org/W2463949285","https://openalex.org/W2487565286","https://openalex.org/W2507616175","https://openalex.org/W2520147769","https://openalex.org/W2553180860","https://openalex.org/W2571039466","https://openalex.org/W2590378086","https://openalex.org/W2593104383","https://openalex.org/W2598721814","https://openalex.org/W2602069647","https://openalex.org/W2609239411","https://openalex.org/W2611305033","https://openalex.org/W2612526179","https://openalex.org/W2620877422","https://openalex.org/W2625822122","https://openalex.org/W3145050390","https://openalex.org/W4233208848","https://openalex.org/W4241938061"],"related_works":["https://openalex.org/W2157408286","https://openalex.org/W4405967847","https://openalex.org/W2145687844","https://openalex.org/W2031940516","https://openalex.org/W1121883659","https://openalex.org/W2071748081","https://openalex.org/W2038341013","https://openalex.org/W7171559206","https://openalex.org/W7099474772","https://openalex.org/W2142712000"],"abstract_inverted_index":{"Neonates":[0],"and":[1,39,44,67,135,147,172,180,192,220,230,301,310,324,342],"especially":[2],"premature":[3],"infants":[4],"are":[5,37,239,259],"highly":[6,299],"susceptible":[7],"to":[8,59,123,285,297,329],"infection":[9,54,125,295],"but":[10,282],"still":[11],"can":[12],"have":[13,25],"a":[14,99,105,161,197,269,298,318,335],"remarkable":[15],"resilience":[16,284],"that":[17,23,234,292],"is":[18,32,73,203],"poorly":[19],"understood.":[20],"The":[21],"view":[22],"neonates":[24],"an":[26,129],"incomplete":[27],"or":[28],"deficient":[29],"immune":[30],"system":[31],"changing.":[33],"Human":[34],"neonatal":[35,91,118,208,221,236,248,280,293],"studies":[36],"challenging":[38],"elucidating":[40],"host":[41,340],"protective":[42],"responses":[43,217,232,246,332],"underlying":[45],"cognate":[46],"pathway":[47],"biology,":[48],"in":[49,55,121,126,144,207,245,253,308,311,314,331,334],"the":[50,74,95,139],"context":[51,336],"of":[52,78,86,98,115,117,141,164,201,211,218,247,262,305,321],"viral":[53],"early":[56,130],"life,":[57],"remains":[58],"be":[60],"fully":[61],"explored.":[62],"In":[63,287],"both":[64],"resource":[65],"rich":[66],"poor":[68],"settings":[69],"human":[70],"cytomegalovirus":[71],"(HCMV)":[72],"most":[75],"common":[76],"cause":[77],"congenital":[79,101],"infection.":[80,286],"By":[81,195],"using":[82],"unbiased":[83],"systems":[84],"analyses":[85],"transcriptomic":[87],"resources":[88],"for":[89,250,276],"HCMV":[90,102,124,225,294],"infection,":[92,103,159,226],"we":[93,151],"find":[94],"systemic":[96],"response":[97,109,122],"pre-term":[100],"involves":[104],"focused":[106],"IFN":[107,251],"regulatory":[108,133],"associated":[110,157],"with":[111,158,255,316],"dendritic-cells.":[112],"Further":[113],"analysis":[114],"transcriptional-programming":[116],"dendritic":[119,222,237,306],"cells":[120,249,258,307],"culture":[127],"revealed":[128],"dominant":[131],"IFN-chemokine":[132],"sub-networks,":[134],"at":[136],"later":[137],"times":[138],"plasticity":[140,264],"pathways":[142],"implicated":[143],"cell-cycle":[145],"control":[146,271],"lipid":[148],"metabolism.":[149],"Further,":[150],"identify":[152],"previously":[153],"unknown":[154],"suppressed":[155],"networks":[156],"including":[160],"select":[162],"group":[163],"GPCRs.":[165],"Functional":[166],"siRNA":[167],"viral-growth":[168],"screen":[169],"targeting":[170],"516-GPCRs":[171],"subsequent":[173],"validation":[174],"identifies":[175],"novel":[176],"GPCR-dependent":[177],"antiviral":[178],"(ADORA1)":[179],"proviral":[181],"(GPR146,":[182],"RGS16,":[183],"PTAFR,":[184],"SCTR,":[185],"GPR84,":[186],"GPR85,":[187],"NMUR2,":[188],"FZ10,":[189],"RDS,":[190],"CCL17,":[191],"SORT1)":[193],"roles.":[194,214],"contrast":[196],"gene":[198],"family":[199],"cluster":[200],"protocadherins":[202],"significantly":[204],"differentially":[205],"induced":[206],"cells,":[209,223],"suggestive":[210,261],"possible":[212],"immune-modulatory":[213],"Unexpectedly,":[215],"programming":[216,304],"adult":[219,256],"upon":[224],"demonstrated":[227],"comparable":[228],"quantitative":[229,323],"qualitative":[231],"showing":[233],"functionally,":[235],"cell":[238],"not":[240,278],"overly":[241],"compromised.":[242],"A":[243],"delay":[244],"sub-networks":[252],"comparison":[254,315],"derived":[257],"notable,":[260],"subtle":[263,322],"differences.":[265],"These":[266],"findings":[267,290],"support":[268],"set-point":[270],"mechanism":[272],"rather":[273],"than":[274],"immaturity":[275],"explaining":[277],"only":[279],"susceptibility":[281,341],"also":[283],"summary,":[288],"our":[289],"show":[291],"leads":[296],"plastic":[300],"functional":[302],"robust":[303],"vivo":[309],"vitro,":[312],"although":[313],"adults,":[317],"small":[319],"number":[320],"temporal":[325],"differences":[326],"may":[327],"contribute":[328],"variability":[330],"that,":[333],"dependent":[337],"manner,":[338],"affect":[339],"resilience.":[343]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-06T00:00:00"}
