{"id":"https://openalex.org/W2759112009","doi":null,"title":"Expression of phosphorylated eukaryotic initiation factor 2 alpha in neuronal apoptosis beta-amyloid toxicity","display_name":"Expression of phosphorylated eukaryotic initiation factor 2 alpha in neuronal apoptosis beta-amyloid toxicity","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2759112009","mag":"2759112009"},"language":"en","primary_location":{"id":"pmh:oai:hub.hku.hk:10722/95665","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/95665","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference_Paper"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071624932","display_name":"Raymond Chuen\u2010Chung Chang","orcid":"https://orcid.org/0000-0001-8538-7993","observed_orcids":["https://orcid.org/0000-0001-8538-7993"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raymond Chuen\u2010Chung Chang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8538-7993","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072195692","display_name":"KC Suen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KC Suen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042907511","display_name":"Ech Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ech Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28980892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/amyloid-beta-toxicity","display_name":"amyloid-beta toxicity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.8840000033378601},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.9139999747276306},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.9710000157356262},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/dna-condensation","display_name":"DNA condensation","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6284432411193848},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6096162796020508},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5646381974220276},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5338531732559204},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5298632979393005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49903321266174316},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44583678245544434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34516239166259766},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3439216613769531},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3245849013328552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1594265103340149},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1078285276889801},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:hub.hku.hk:10722/95665","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/95665","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference_Paper"},{"id":"mag:2759112009","doi":null,"is_oa":false,"landing_page_url":"http://hub.hku.hk/handle/10722/95665","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6980386058","https://openalex.org/W2013806485","https://openalex.org/W1934976150","https://openalex.org/W2024166740","https://openalex.org/W2086879787","https://openalex.org/W7097386033","https://openalex.org/W2046885716","https://openalex.org/W2077106716","https://openalex.org/W7116969180","https://openalex.org/W4415877900"],"abstract_inverted_index":{"Inhibition":[0],"of":[1,12,23,29,65,70,81,89,103,135,138,157,172,195,209,222],"protein":[2,17,24,74,154],"synthesis":[3,75],"has":[4],"been":[5],"demonstrated":[6],"in":[7,20,60,92,113,166,174,200],"experimental":[8],"ischemia.":[9],"Increasing":[10],"lines":[11],"evidence":[13],"show":[14],"that":[15,207],"inhibiting":[16,153],"translation":[18],"results":[19,205],"apoptosis.":[21,78,201,220],"Translation":[22],"is":[25,58,83,105],"initiated":[26],"by":[27,44,129,152,177,233],"binding":[28],"initiator":[30],"Met-tRNA":[31],"to":[32,77,85,99,110,193],"the":[33,40,46,68,87,106,121,204,218,227],"40S":[34],"ribosomal":[35,42],"subunit,":[36],"which":[37],"subsequently":[38],"joins":[39],"60S":[41],"subunit":[43],"hydrolyzing":[45],"GTP":[47,71],"into":[48],"GDP.":[49],"The":[50],"eukaryotic":[51],"initiation":[52],"factor":[53],"2":[54],"alpha":[55],"(eIF2a)-GDP":[56],"complex":[57],"released":[59],"exchange":[61,69],"for":[62],"GTP.":[63],"Phosphorylation":[64],"eIF2a":[66,104,139,167,210],"blocks":[67],"and":[72,147,170,197],"shutdowns":[73],"leading":[76,109,217],"Since":[79],"apoptosis":[80,112],"neurons":[82],"considered":[84],"be":[86,212],"one":[88],"death":[90],"pathways":[91],"Alzheimer's":[93],"disease":[94],"(AD),":[95],"this":[96,223],"study":[97],"aims":[98],"investigate":[100],"whether":[101],"phosphorylation":[102,137,194,208],"key-signaling":[107],"pathway":[108,216,224],"neuronal":[111,219],"AD.":[114,231],"\\nHuman":[115],"neuroblastoma":[116],"SH-SY5Y":[117],"cells":[118,158,175,186],"treated":[119,187],"with":[120,159,188],"calcium":[122],"ionophore":[123],"A23187":[124],"underwent":[125],"apoptosis,":[126],"as":[127,145],"reported":[128],"other":[130],"laboratories.":[131],"Early":[132],"after":[133,182],"treatment":[134],"A23187,":[136],"was":[140],"markedly":[141],"increased.":[142],"Flavonoids":[143],"such":[144],"genistein":[146],"quercetin":[148],"suppress":[149],"tumor":[150],"growth":[151],"synthesis.":[155],"Treatment":[156],"both":[160],"drugs":[161],"induced":[162],"a":[163,213],"marked":[164],"increase":[165],"phosphorylation.":[168],"Condensation":[169],"disintegration":[171],"DNA":[173],"shown":[176],"nuclear":[178],"staining":[179],"were":[180],"found":[181],"24":[183],"h.":[184],"Furthermore,":[185],"b-amyloid":[189],"peptide":[190],"(Ab25-35)":[191],"led":[192],"eIF2a,":[196],"eventually":[198],"resulted":[199],"\\nTaken":[202],"together,":[203],"suggest":[206],"may":[211,225],"key":[214],"molecular":[215],"Elucidation":[221],"reshape":[226],"therapeutic":[228],"interventions":[229],"against":[230],"\\nSupported":[232],"Research":[234],"Grant":[235],"Council,":[236],"Hong":[237],"Kong":[238],"SAR":[239]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-10-06T00:00:00"}
