{"id":"https://openalex.org/W2758777654","doi":"https://doi.org/10.1093/ofid/ofx163.1948","title":"Identification and Characterization of Mycobacterium tuberculosis (Mtb) Effector Proteins","display_name":"Identification and Characterization of Mycobacterium tuberculosis (Mtb) Effector Proteins","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2758777654","doi":"https://doi.org/10.1093/ofid/ofx163.1948","mag":"2758777654"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofx163.1948","doi":"https://doi.org/10.1093/ofid/ofx163.1948","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofx163.1948","pdf_url":"https://academic.oup.com/ofid/article-pdf/4/suppl_1/S722/20430229/ofx163.1948.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ofid/article-pdf/4/suppl_1/S722/20430229/ofx163.1948.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085612265","display_name":"Sujittra Chaisavaneeyakorn","orcid":"https://orcid.org/0000-0001-8166-8691","observed_orcids":["https://orcid.org/0000-0001-8166-8691"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujittra Chaisavaneeyakorn","raw_affiliation_strings":["Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091188819","display_name":"Chelsea E. Stamm","orcid":"https://orcid.org/0000-0003-4957-6070","observed_orcids":["https://orcid.org/0000-0003-4957-6070"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chelsea E Stamm","raw_affiliation_strings":["Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055178190","display_name":"Michael U. Shiloh","orcid":"https://orcid.org/0000-0003-4329-2253","observed_orcids":["https://orcid.org/0000-0003-4329-2253"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael U Shiloh","raw_affiliation_strings":["Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17952648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"suppl_1","first_page":"S722","last_page":"S723"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/effector-proteins","display_name":"effector proteins","score":0.8840000033378601},{"id":"https://openalex.org/keywords/secreted-virulence-factors","display_name":"secreted virulence factors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/membrane-binding","display_name":"membrane binding","score":0.6489999890327454},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8610000014305115},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mitochondrial-stress","display_name":"mitochondrial stress","score":0.6899999976158142},{"id":"https://openalex.org/keywords/macrophage-infection","display_name":"macrophage infection","score":0.718999981880188},{"id":"https://openalex.org/keywords/intracellular-niche","display_name":"intracellular niche","score":0.6230000257492065},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tuberculosis-pathogenesis","display_name":"tuberculosis pathogenesis","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.8446487188339233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.581438422203064},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5658580660820007},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5271139740943909},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5266057252883911},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5183585286140442},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.4740987718105316},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4697573184967041},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.41304540634155273},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.23445355892181396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2281884253025055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18206626176834106},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.15169554948806763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10640767216682434},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ofid/ofx163.1948","doi":"https://doi.org/10.1093/ofid/ofx163.1948","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofx163.1948","pdf_url":"https://academic.oup.com/ofid/article-pdf/4/suppl_1/S722/20430229/ofx163.1948.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofx163.1948","doi":"https://doi.org/10.1093/ofid/ofx163.1948","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofx163.1948","pdf_url":"https://academic.oup.com/ofid/article-pdf/4/suppl_1/S722/20430229/ofx163.1948.pdf","source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2758777654.pdf","grobid_xml":"https://content.openalex.org/works/W2758777654.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2548938864","https://openalex.org/W2888489294","https://openalex.org/W2948414188","https://openalex.org/W2764249483","https://openalex.org/W2021045359","https://openalex.org/W4363646767","https://openalex.org/W3093898180","https://openalex.org/W1982690187","https://openalex.org/W4411274334","https://openalex.org/W3136264346"],"abstract_inverted_index":{"Mycobacterium":[0],"tuberculosis":[1],"(Mtb),":[2],"the":[3,11,24,36,105,186,203,215,257],"causative":[4],"agent":[5],"of":[6,10,107,146,156,169,179,202,205,217,260,268],"tuberculosis,":[7],"is":[8,198,252],"one":[9],"most":[12],"successful":[13],"human":[14],"pathogens.":[15],"Mtb":[16,30,44,69,85,127,182,226,233,261,270],"has":[17],"evolved":[18],"to":[19,31,33,110,249],"survive":[20],"inside":[21],"macrophages.":[22],"However,":[23],"precise":[25],"molecular":[26,258],"mechanisms":[27],"employed":[28],"by":[29,137],"adapt":[32],"and":[34,58,80,159,225],"manipulate":[35],"host":[37,64,135],"environment":[38],"remain":[39],"unknown.":[40],"To":[41],"date,":[42],"few":[43],"secreted":[45,86,262],"virulence":[46,61,71],"factors":[47,62,72],"have":[48,229],"been":[49],"discovered.":[50],"Because":[51],"many":[52,59],"eukaryotic":[53,75,113,175],"cellular":[54,158],"processes":[55],"are":[56,212],"membrane-dependent,":[57],"bacterial":[60],"target":[63,74,240],"membranes,":[65],"we":[66],"hypothesized":[67],"that":[68,73,172],"secretes":[70],"membranes.":[76,176],"We":[77,93,102,122,228],"collated":[78],"proteomic":[79],"genomic":[81],"data":[82],"for":[83,129,275],"putative":[84],"proteins":[87,97,109,171,263],"with":[88,112,143,174,185,193,208],"possible":[89],"membrane":[90,234],"binding":[91,235],"activity.":[92],"then":[94],"screened":[95],"200":[96,170],"in":[98,153,221,246],"two":[99],"independent":[100],"assays.":[101,161],"first":[103],"tested":[104,152],"ability":[106],"individual":[108],"associate":[111],"membranes":[114],"using":[115,138],"a":[116,139,144,154],"unique":[117],"temperature":[118],"sensitive":[119],"yeast":[120,164],"screen.":[121],"further":[123],"characterized":[124],"these":[125,180,218],"membrane-associated":[126,181,190],"effectors":[128,183,191,220,239],"their":[130],"subcellular":[131],"localization":[132],"within":[133],"mammalian":[134],"cells":[136],"fluorescence":[140],"colocalization":[141],"study":[142],"panel":[145],"organelle":[147,243],"markers.":[148],"Hits":[149],"were":[150],"subsequently":[151],"variety":[155],"biochemical,":[157],"pathogenesis":[160],"The":[162,177],"initial":[163],"screen":[165],"identified":[166,230],"48":[167],"out":[168],"associated":[173],"majority":[178],"co-localized":[184,192],"endoplasmic":[187],"reticulum.":[188],"Four":[189,238],"mitochondria.":[194],"Since":[195],"mitochondrial":[196,223],"stress":[197],"an":[199,242],"important":[200],"determinant":[201],"outcome":[204],"macrophage":[206],"infection":[207],"Mtb,":[209],"ongoing":[210],"studies":[211],"focused":[213],"on":[214],"role":[216],"mitochondrial-localizing":[219],"modulating":[222],"function":[224,245],"pathogenesis.":[227],"multiple":[231],"novel":[232],"effector":[236],"proteins.":[237],"mitochondria,":[241],"whose":[244],"innate":[247],"immunity":[248],"intracellular":[250,273],"pathogens":[251],"not":[253],"well":[254],"known.":[255],"Identifying":[256],"functions":[259],"will":[264],"improve":[265],"our":[266],"understanding":[267],"how":[269],"modifies":[271],"its":[272],"niche":[274],"long-term":[276],"survival.":[277],"All":[278],"authors:":[279],"No":[280],"reported":[281],"disclosures.":[282]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2017-10-06T00:00:00"}