{"id":"https://openalex.org/W275836874","doi":null,"title":"On fusidic acid resistance in Staphylococcus Aureus.","display_name":"On fusidic acid resistance in Staphylococcus Aureus.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W275836874","mag":"275836874"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-7846","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7846","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7846","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075710175","display_name":"Tobias Norstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tobias Norstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075710175"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fusidic-acid-resistance","display_name":"fusidic acid resistance","score":0.9309999942779541},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/topical-antibiotics","display_name":"topical antibiotics","score":0.4779999852180481},{"id":"https://openalex.org/keywords/superficial-skin-infections","display_name":"superficial skin infections","score":0.6990000009536743},{"id":"https://openalex.org/keywords/streptococcus-pyogenes","display_name":"Streptococcus pyogenes","score":0.9620000123977661},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.6330000162124634},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/bactericidal-and-bacteriostatic-effects","display_name":"bactericidal and bacteriostatic effects","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2780483375","wikidata":"https://www.wikidata.org/wiki/Q259930","display_name":"Fusidic acid","level":4,"score":0.9825092554092407},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7980221509933472},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7210543155670166},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6234055161476135},{"id":"https://openalex.org/C2778246068","wikidata":"https://www.wikidata.org/wiki/Q413578","display_name":"Mupirocin","level":5,"score":0.5751089453697205},{"id":"https://openalex.org/C2779306812","wikidata":"https://www.wikidata.org/wiki/Q131271","display_name":"Streptococcus pyogenes","level":4,"score":0.5001120567321777},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4677707552909851},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.42141368985176086},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.27991151809692383},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.21724086999893188},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08733421564102173}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-7846","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7846","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:275836874","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:170180/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-7846","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7846","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W313549055","https://openalex.org/W1493879424","https://openalex.org/W1506811449","https://openalex.org/W1550947577","https://openalex.org/W1929362934","https://openalex.org/W1929869272","https://openalex.org/W1969871580","https://openalex.org/W1977420386","https://openalex.org/W1978087809","https://openalex.org/W1978954365","https://openalex.org/W1980239916","https://openalex.org/W1981123411","https://openalex.org/W1981247481","https://openalex.org/W1981323072","https://openalex.org/W1986125365","https://openalex.org/W1989380853","https://openalex.org/W1994937222","https://openalex.org/W1995121199","https://openalex.org/W1998202375","https://openalex.org/W2003421192","https://openalex.org/W2005853237","https://openalex.org/W2008561095","https://openalex.org/W2011253627","https://openalex.org/W2015019111","https://openalex.org/W2016654377","https://openalex.org/W2022802506","https://openalex.org/W2024094744","https://openalex.org/W2026018003","https://openalex.org/W2027902382","https://openalex.org/W2033719139","https://openalex.org/W2037133767","https://openalex.org/W2037541009","https://openalex.org/W2046501778","https://openalex.org/W2047195572","https://openalex.org/W2047914173","https://openalex.org/W2048910398","https://openalex.org/W2049127551","https://openalex.org/W2051652026","https://openalex.org/W2051879580","https://openalex.org/W2058136274","https://openalex.org/W2064532429","https://openalex.org/W2073913372","https://openalex.org/W2075359954","https://openalex.org/W2075476726","https://openalex.org/W2077881229","https://openalex.org/W2079606085","https://openalex.org/W2079774537","https://openalex.org/W2079988639","https://openalex.org/W2084399584","https://openalex.org/W2086533489","https://openalex.org/W2090583956","https://openalex.org/W2093547566","https://openalex.org/W2096213478","https://openalex.org/W2096241980","https://openalex.org/W2098624337","https://openalex.org/W2099548344","https://openalex.org/W2102771608","https://openalex.org/W2102975216","https://openalex.org/W2106492667","https://openalex.org/W2108740591","https://openalex.org/W2109096817","https://openalex.org/W2111622710","https://openalex.org/W2111870344","https://openalex.org/W2114921811","https://openalex.org/W2119567467","https://openalex.org/W2120254858","https://openalex.org/W2121427588","https://openalex.org/W2122984717","https://openalex.org/W2126115772","https://openalex.org/W2130261670","https://openalex.org/W2131272563","https://openalex.org/W2131716231","https://openalex.org/W2131727615","https://openalex.org/W2131767961","https://openalex.org/W2133350424","https://openalex.org/W2134126932","https://openalex.org/W2134856487","https://openalex.org/W2138731773","https://openalex.org/W2143004077","https://openalex.org/W2143697487","https://openalex.org/W2150775872","https://openalex.org/W2151269876","https://openalex.org/W2151674226","https://openalex.org/W2159895435","https://openalex.org/W2161263829","https://openalex.org/W2163104929","https://openalex.org/W2168787141","https://openalex.org/W2170241617","https://openalex.org/W2171780167","https://openalex.org/W2174071034","https://openalex.org/W2177846120","https://openalex.org/W2304292976","https://openalex.org/W2314649741","https://openalex.org/W2332067624","https://openalex.org/W2461143071","https://openalex.org/W2512312375"],"related_works":["https://openalex.org/W600471468","https://openalex.org/W579142918","https://openalex.org/W2222687983","https://openalex.org/W1840852119","https://openalex.org/W2185273864","https://openalex.org/W2158844262","https://openalex.org/W2747929134","https://openalex.org/W2118586938","https://openalex.org/W2106762064","https://openalex.org/W4240952898"],"abstract_inverted_index":{"Controlling":[0],"bacterial":[1,13,43],"infections":[2,39],"with":[3,213,223,277,292],"antibiotics":[4,16],"is":[5,221,289],"central":[6],"to":[7,15,36,58,158,235],"modern":[8],"health":[9],"care.":[10],"However,":[11],"increasing":[12],"resistance":[14,57,167,288],"threatens":[17],"effective":[18],"therapy.":[19],"This":[20],"thesis":[21],"concerns":[22],"the":[23,26,42,125,163,172,182,214,245,278,282,293],"use":[24],"of":[25,33,71,184,206,244,254,287],"antibiotic":[27],"fusidic":[28,34,59,72,127,199],"acid,":[29,35],"and":[30,86,99,133,146,237],"novel":[31,126,204],"analogues":[32,74],"treat":[37],"topical":[38,105,122],"caused":[40],"by":[41,52,76,148,156],"pathogen":[44],"Staphylococcu":[45],"aureus.":[46],"It":[47],"also":[48,290],"addresses":[49],"genetic":[50],"mechanisms":[51,168],"which":[53,220],"S.":[54,84,131,134,211],"aureus":[55,85,132,212],"develops":[56],"acid.":[60,200],"Pre-clinical":[61],"microbiological":[62],"tests":[63],"were":[64,81],"made":[65],"on":[66,162,274],"two":[67,203],"structurally":[68],"different":[69],"groups":[70],"acid":[73,128,152],"developed":[75,108,147],"Leo":[77,149],"Pharma.":[78,150],"These":[79],"drugs":[80],"tested":[82,145],"against":[83,130],"Streptococcus":[87],"pyogenes":[88],"strains,":[89,181],"measuring":[90],"MIC,":[91],"in":[92,100,103,171,179,210,250,261],"vitro":[93],"concentration-dependent":[94],"bacteriocidal":[95],"or":[96,189,241],"bacteriostatic":[97],"effects,":[98],"vivo":[101],"efficacy":[102],"clearing":[104],"infections.":[106,225],"We":[107,201],"a":[109,185,193],"new":[110,137],"superficial":[111],"skin":[112],"infection":[113],"animal":[114],"model":[115],"(the":[116],"\u2018tape-stripping":[117],"model\u2019)":[118],"designed":[119],"for":[120,175,192,239],"testing":[121],"antibiotics,":[123],"including":[124],"analogues,":[129],"pyogenes.":[135],"Some":[136,243],"compounds":[138],"giving":[139],"promising":[140],"results":[141],"will":[142],"be":[143],"further":[144],"Fusidic":[151],"inhibits":[153],"protein":[154,194],"synthesis":[155],"binding":[157],"elongation":[159],"factor":[160],"EF-G":[161,176,197,255],"ribosome.":[164],"Previously":[165],"described":[166],"are":[169,229,249,268],"mutations":[170,248,258],"gene":[173,186],"coding":[174,191],"(fusA),":[177],"or,":[178],"some":[180],"presence":[183],"(fusB,":[187],"fusC":[188],"fusD)":[190],"that":[195,284],"protects":[196],"from":[198],"discovered":[202],"classes":[205],"spontaneous":[207],"FusR":[208,227,246,266],"mutants":[209],"small":[215],"colony":[216],"variant":[217],"(SCV)":[218],"phenotype":[219],"associated":[222,291],"persistent":[224],"The":[226,264],"SCV\u2019s":[228,267],"very":[230],"frequent,":[231],"slow":[232],"growing,":[233],"cross-resistant":[234],"aminoglycosides,":[236],"auxotrophic":[238],"hemin":[240],"menadione.":[242],"SCV":[247],"structural":[251],"domain":[252,262],"V":[253],"(classic":[256],"fusA":[257],"map":[259],"overwhelmingly":[260],"III).":[263],"remaining":[265],"unmapped":[269],"but":[270],"their":[271,285],"additive":[272],"effect":[273],"MIC":[275],"together":[276],"fusB":[279],"plasmid":[280],"suggests":[281],"possibility":[283],"mechanism":[286],"translation":[294],"machinery.":[295]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-06-24T00:00:00"}
